On the complexities of ceramide changes in cells undergoing apoptosis: lack of evidence for a second messenger function in apoptotic induction

Caspases: the executioners of apoptosis

1997 • 4,674 citations

Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis

1996 • 1,784 citations

Functions of Ceramide in Coordinating Cellular Responses to Stress

1996 • 1,620 citations

Apoptosis signaling by death receptors

1998 • 976 citations

Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis.

1994 • 890 citations

Ceramide synthase mediates daunorubicin-induced apoptosis: An alternative mechanism for generating death signals

1995 • 835 citations

REGULATION OF CERAMIDE PRODUCTION AND APOPTOSIS

1998 • 804 citations

Functional dichotomy of neutral and acidic sphingomyelinases in tumor necrosis factor signaling

1994 • 726 citations

Sphingolipids—The Enigmatic Lipid Class: Biochemistry, Physiology, and Pathophysiology

1997 • 640 citations

FAS-induced apoptosis is mediated via a ceramide-initiated RAS signaling pathway

1995 • 411 citations

Daunorubicin-induced apoptosis: triggering of ceramide generation through sphingomyelin hydrolysis.

1996 • 371 citations

Role for ceramide as an endogenous mediator of Fas-induced cytotoxicity.

1995 • 323 citations

PROTEOLYTIC ACTIVITIES THAT MEDIATE APOPTOSIS

1998 • 282 citations

The Origin of Programmed Cell Death

1996 • 280 citations

Cloned mammalian neutral sphingomyelinase: Functions in sphingolipid signaling?

1998 • 267 citations

Cell-free reconstitution of Fas-, UV radiation- and ceramide-induced apoptosis.

1995 • 243 citations

The c-Jun N-Terminal Kinase Cascade Plays a Role in Stress-Induced Apoptosis in Jurkat Cells by Up-Regulating Fas Ligand Expression

1998 • 238 citations

Tumor necrosis factor-alpha (TNF-alpha) signal transduction through ceramide. Dissociation of growth inhibitory effects of TNF-alpha from activation of nuclear factor-kappa B.

1993 • 217 citations

Tumor necrosis factor activation of the sphingomyelin pathway signals nuclear factor kappa B translocation in intact HL-60 cells.

1993 • 179 citations

Ceramide Profiling of Complex Lipid Mixtures by Electrospray Ionization Mass Spectrometry

1997 • 157 citations

Simultaneous Quantitative Determination Method for Sphingolipid Metabolites by Liquid Chromatography/Ionspray Ionization Tandem Mass Spectrometry

1997 • 147 citations

Selective Activation of Caspases During Apoptotic Induction in HL-60 Cells

1997 • 138 citations

The IL-1 receptor signaling pathway

1994 • 132 citations

Fas-induced apoptosis of T cells occurs independently of ceramide generation

1997 • 123 citations

Geranylgeraniol Is a Potent Inducer of Apoptosis in Tumor Cells

1995 • 89 citations

Lack of ceramide generation in TF-1 human myeloid leukemic cells resistant to ionizing radiation

1998 • 79 citations

Mechanism of Farnesol Cytotoxicity: Further Evidence for the Role of PKC-Dependent Signal Transduction in Farnesol-Induced Apoptotic Cell Death

1995 • 73 citations

Apoptotic Signal of Fas Is Not Mediated by Ceramide

1998 • 66 citations

Tumor Necrosis Factor α Activates NF-κB in Acid Sphingomyelinase-deficient Mouse Embryonic Fibroblasts

1997 • 64 citations

Caspases are the main executioners of Fas-mediated apoptosis, irrespective of the ceramide signalling pathway

1998 • 55 citations

Evidence against an early signalling role for ceramide in Fas-mediated apoptosis

1997 • 55 citations

Ceramides perturb the structure of phosphatidylcholine bilayers and modulate the activity of phospholipase A 2

1998 • 48 citations

Geranylgeraniol Potently Induces Caspase-3-like Activity during Apoptosis in Human Leukemia U937 Cells

1997 • 34 citations

Physiology of Fas-Induced Programmed Cell Death

1996 • 9 citations