Cell-permeable Ceramides Prevent the Activation of Phospholipase D by ADP-ribosylation Factor and RhoA

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1959 • 47,127 citations

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1959 • 21,307 citations

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

Signaling through phosphatidylcholine breakdown.

1990 • 1,362 citations

The sphingomyelin cycle and the second messenger function of ceramide.

1994 • 1,255 citations

Quantitative measurement of sn-1,2-diacylglycerols present in platelets, hepatocytes, and ras- and sis-transformed normal rat kidney cells.

1986 • 999 citations

Molecular dissection of the secretory pathway

1992 • 985 citations

Phosphatidylcholine breakdown and signal transduction

1994 • 955 citations

The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signaling

1994 • 934 citations

ADP-ribosylation factor, a small GTP-dependent regulatory protein, stimulates phospholipase D activity

1993 • 900 citations

The regulation and cellular functions of phosphatidylcholine hydrolysis

1990 • 862 citations

Human ADP-ribosylation Factor-activated Phosphatidylcholine-specific Phospholipase D Defines a New and Highly Conserved Gene Family

1995 • 663 citations

Phospholipase D: a Downstream Effector of ARF in Granulocytes

1994 • 636 citations

Sphingomyelin turnover induced by vitamin D3 in HL-60 cells

1989 • 629 citations

Role of Rho in Chemoattractant-Activated Leukocyte Adhesion Through Integrins

1996 • 494 citations

Role of ceramide as a lipid mediator of 1 alpha,25-dihydroxyvitamin D3-induced HL-60 cell differentiation.

1990 • 476 citations

A Regulatory Role for ARF6 in Receptor-Mediated Endocytosis

1995 • 451 citations

Purification of a protein cofactor required for ADP-ribosylation of the stimulatory regulatory component of adenylate cyclase by cholera toxin.

1984 • 410 citations

Tumor necrosis factor receptor-mediated signaling pathways.

1994 • 389 citations

Rho as a regulator of the cytoskeleton

1995 • 386 citations

Phosphatidic acid is a specific activator of phosphatidylinositol-4-phosphate kinase.

1992 • 368 citations

Phosphatidic acid activation of protein kinase C-ζ overexpressed in COS cells: comparison with other protein kinase C isotypes and other acidic lipids

1994 • 308 citations

Activation of rat liver phospholipase D by the small GTP-binding protein RhoA

1994 • 265 citations

Regulation of Phospholipase D by Protein Kinase C Is Synergistic with ADP-ribosylation Factor and Independent of Protein Kinase Activity

1996 • 251 citations

Activation of rat brain phospholipase D by ADP-ribosylation factors 1,5, and 6: separation of ADP-ribosylation factor-dependent and oleate-dependent enzymes.

1994 • 250 citations

Protein tyrosine phosphorylation induced by lysophosphatidic acid in Rat-1 fibroblasts. Evidence that phosphorylation of map kinase is mediated by the Gi-p21ras pathway.

1994 • 239 citations

Activation of phospholipase D by protein kinase C. Evidence for a phosphorylation-independent mechanism.

1992 • 237 citations

Neutrophil phospholipase D is activated by a membrane-associated Rho family small molecular weight GTP-binding protein.

1993 • 229 citations

Inhibition of PMA-induced, LFA-1-dependent lymphocyte aggregation by ADP ribosylation of the small molecular weight GTP binding protein, rho.

1993 • 223 citations

Phosphatidic acid may stimulate membrane receptors mediating adenylate cyclase inhibition and phospholipid breakdown in 3T3 fibroblasts.

1987 • 219 citations

Rab proteins in regulated exocytosis

1994 • 197 citations

Cell-permeable ceramides inhibit the stimulation of DNA synthesis and phospholipase D activity by phosphatidate and lysophosphatidate in rat fibroblasts.

1994 • 188 citations

Analysis of the water-soluble products of phosphatidylcholine breakdown by ion-exchange chromatography. Bombesin and TPA (12-O-tetradecanoylphorbol 13-acetate) stimulate choline generation in Swiss 3T3 cells by a common mechanism

1989 • 188 citations

The regulation of phospholipase C-gamma 1 by phosphatidic acid. Assessment of kinetic parameters.

1993 • 181 citations

The properties and extracellular location of 5′-nucleotidase of the rat fat-cell plasma membrane

1975 • 170 citations

Quantitative measurement of sn-1,2-diacylglycerols

1987 • 166 citations

Phosphatidic acid as a second messenger in human polymorphonuclear leukocytes. Effects on activation of NADPH oxidase.

1991 • 165 citations

Interaction of Ceramides, Sphingosine, and Sphingosine 1-Phosphate in Regulating DNA Synthesis and Phospholipase D Activity

1995 • 153 citations

Regulation of Phospholipase D in HL60 Cells

1995 • 145 citations

Phosphatidate Phosphohydrolase Catalyzes the Hydrolysis of Ceramide 1-Phosphate, Lysophosphatidate, and Sphingosine 1-Phosphate

1996 • 141 citations

Evidence That Ceramide Selectively Inhibits Protein Kinase C-α Translocation and Modulates Bradykinin Activation of Phospholipase D

1995 • 139 citations

Phospholipase D activation in a cell-free system from human neutrophils by phorbol 12-myristate 13-acetate and guanosine 5'-O-(3-thiotriphosphate). Activation is calcium dependent and requires protein factors in both the plasma membrane and cytosol.

1991 • 134 citations

Ceramide stimulates epidermal growth factor receptor phosphorylation in A431 human epidermoid carcinoma cells. Evidence that ceramide may mediate sphingosine action

1991 • 134 citations

Signal-activated phospholipases

1994 • 134 citations

Ceramide Inhibits Phospholipase D in a Cell-free System

1996 • 129 citations

Resolved Phospholipase D Activity Is Modulated by Cytosolic Factors Other than Arf

1995 • 129 citations

Regulation of Phospholipase D by Protein Kinase C in Human Neutrophils

1995 • 122 citations

Ceramide As a Modulator of Endocytosis

1995 • 121 citations

Phosphatidate phosphohydrolase and signal transduction

1996 • 119 citations

Regulation of Membrane-bound Phospholipase D by Protein Kinase C in HL60 Cells

1996 • 118 citations

Identification of a defect in the phospholipase D/diacylglycerol pathway in cellular senescence

1994 • 117 citations

ADP-ribosylation Factor Functions Synergistically with a 50-kDa Cytosolic Factor in Cell-free Activation of Human Neutrophil Phospholipase D

1995 • 101 citations

ADP-ribosylation Factor Translocation Correlates with Potentiation of GTPγS-stimulated Phospholipase D Activity in Membrane Fractions of HL-60 Cells

1995 • 95 citations

Ceramide regulates oxidant release in adherent human neutrophils

1994 • 77 citations

Decreased activities of phosphatidate phosphohydrolase and phospholipase D in ras and tyrosine kinase (fps) transformed fibroblasts.

1993 • 71 citations

Ceramide is a competitive inhibitor of diacylglycerol kinase in vitro and in intact human leukemia (HL-60) cells.

1992 • 69 citations

Low Molecular Weight GTP-binding Proteins in HL-60 Granulocytes

1995 • 68 citations

Ceramide inhibits IgE-mediated activation of phospholipase D, but not of phospholipase C, in rat basophilic leukemia (RBL-2H3) cells.

1996 • 64 citations

A Synthetic Peptide Corresponding to the Rab4 Hypervariable Carboxyl-terminal Domain Inhibits Insulin Action on Glucose Transport in Rat Adipocytes

1996 • 63 citations

Differential effects of insulin and exercise on Rab4 distribution in rat skeletal muscle.

1996 • 51 citations

Activation of Phospholipase D and Phosphatidylinositol 4-Phosphate 5-Kinase in HL60 Membranes Is Mediated by Endogenous Arf but Not Rho

1996 • 46 citations

Metabolic effects of short‐chain ceramide and glucosylceramide on sphingolipids and protein kinase C

1992 • 45 citations

Hepatic monoacylglycerol acyltransferase is regulated by sn-1,2-diacylglycerol and by specific lipids in Triton X-100/phospholipid-mixed micelles.

1994 • 35 citations

Identification and characterisation of a type‐1 protein phosphatase from the okadaic acid‐producing marine dinoflagellate Prorocentrum lima

1993 • 24 citations

Multiple Forms of Phospholipase D Inhibitor from Rat Brain Cytosol

1996 • 24 citations