Glutathione Regulation of Neutral Sphingomyelinase in Tumor Necrosis Factor-α-induced Cell Death

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Cell Death: The Significance of Apoptosis

1980 • 7,281 citations

Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: Applications to mammalian blood and other tissues

1969 • 6,007 citations

Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine

1980 • 4,407 citations

Caspases: killer proteases

1997 • 2,440 citations

Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

1995 • 2,402 citations

Involvement of MACH, a Novel MORT1/FADD-Interacting Protease, in Fas/APO-1- and TNF Receptor–Induced Cell Death

1996 • 2,306 citations

Oxidative stress as a mediator of apoptosis

1994 • 2,210 citations

Programmed Cell Death Induced by Ceramide

1993 • 1,779 citations

Glycosphingolipids in Cellular Interaction, Differentiation, and Oncogenesis

1981 • 1,650 citations

Functions of Ceramide in Coordinating Cellular Responses to Stress

1996 • 1,620 citations

TNF activates NF-κB by phosphatidylcholine-specific phospholipase C-induced “Acidic” sphingomyelin breakdown

1992 • 1,058 citations

Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: a cautionary note.

1989 • 937 citations

Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis.

1994 • 890 citations

Ceramide synthase mediates daunorubicin-induced apoptosis: An alternative mechanism for generating death signals

1995 • 835 citations

Acid Sphingomyelinase–Deficient Human Lymphoblasts and Mice Are Defective in Radiation-Induced Apoptosis

1996 • 795 citations

Functional dichotomy of neutral and acidic sphingomyelinases in tumor necrosis factor signaling

1994 • 726 citations

Oxidative stress during viral infection: A review

1996 • 648 citations

bcl-2 inhibits death of central neural cells induced by multiple agents.

1993 • 631 citations

Rapid Communication: Oxidative Stress Induces Apoptosis in Embryonic Cortical Neurons

1994 • 588 citations

Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase.

1994 • 582 citations

Role for Ceramide in Cell Cycle Arrest

1995 • 488 citations

Induction of apoptotic DNA damage and cell death by activation of the sphingomyelin pathway.

1994 • 459 citations

GTPase cascades choreographing cellular behavior: Movement, morphogenesis, and more

1995 • 394 citations

Rapid and Specific Efflux of Reduced Glutathione during Apoptosis Induced by Anti-Fas/APO-1 Antibody

1996 • 354 citations

A Novel Family of Viral Death Effector Domain-containing Molecules That Inhibit Both CD-95- and Tumor Necrosis Factor Receptor-1-induced Apoptosis

1997 • 343 citations

Role for ceramide as an endogenous mediator of Fas-induced cytotoxicity.

1995 • 323 citations

Glutathione depletion is an early and calcium elevation is a late event of thymocyte apoptosis.

1997 • 309 citations

Inhibition of the Neutral Magnesium-dependent Sphingomyelinase by Glutathione

1997 • 306 citations

Bcl-2 interrupts the ceramide-mediated pathway of cell death.

1996 • 302 citations

Zn2+-stimulated Sphingomyelinase Is Secreted by Many Cell Types and Is a Product of the Acid Sphingomyelinase Gene

1996 • 274 citations

Ceramide Inactivates Cellular Protein Kinase Cα

1996 • 251 citations

Substrate and Inhibitor Specificity of Interleukin-1β-converting Enzyme and Related Caspases

1997 • 243 citations

Fas mediates apoptosis in human monocytes by a reactive oxygen intermediate dependent pathway.

1996 • 228 citations

Cytokine Response Modifier A (CrmA) Inhibits Ceramide Formation in Response to Tumor Necrosis Factor (TNF)-α: CrmA and Bcl-2 Target Distinct Components in the Apoptotic Pathway

1997 • 210 citations

Characteristics and partial purification of a novel cytosolic, magnesium-independent, neutral sphingomyelinase activated in the early signal transduction of 1 alpha,25-dihydroxyvitamin D3-induced HL-60 cell differentiation.

1994 • 198 citations

Nitrone spin traps and a nitroxide antioxidant inhibit a common pathway of thymocyte apoptosis

1995 • 189 citations

Cell-permeable ceramides inhibit the stimulation of DNA synthesis and phospholipase D activity by phosphatidate and lysophosphatidate in rat fibroblasts.

1994 • 188 citations

Apoptosis and altered redox state induced by caffeic acid phenethyl ester (CAPE) in transformed rat fibroblast cells.

1995 • 175 citations

Fas‐mediated apoptosis is modulated by intracellular glutathione in human T cells

1996 • 169 citations

1-beta-D-Arabinofuranosylcytosine stimulates ceramide and diglyceride formation in HL-60 cells.

1994 • 166 citations

Structure and Function of Sphingoglycolipids in Transmembrane Signalling and Cell-Cell Interactions

1993 • 163 citations

Phospholipase A2 Is Necessary for Tumor Necrosis Factor α-induced Ceramide Generation in L929 Cells

1997 • 161 citations

Expression of Neutral Sphingomyelinase Identifies a Distinct Pool of Sphingomyelin Involved in Apoptosis

1997 • 159 citations

Loss of GSH, Oxidative Stress, and Decrease of Intracellular pH as Sequential Steps in Viral Infection

1997 • 148 citations

A mechanism for glutamate toxicity in the C6 glioma cells involving inhibition of cystine uptake leading to glutathione depletion

1992 • 135 citations

Processing/Activation of At Least Four Interleukin-1β Converting Enzyme–like Proteases Occurs during the Execution Phase of Apoptosis in Human Monocytic Tumor Cells

1997 • 135 citations

Ceramide Inhibits Phospholipase D in a Cell-free System

1996 • 129 citations

Sphingomyelinases in cell regulation

1997 • 127 citations

A decrease in intracellular glutathione concentration precedes the onset of apoptosis in murine thymocytes.

1995 • 125 citations

A New Zn2+-stimulated Sphingomyelinase in Fetal Bovine Serum

1989 • 111 citations

DNA damage induced by tumour necrosis factor-alpha in L929 cells is mediated by mitochondrial oxygen radical formation.

1995 • 109 citations

Tumor necrosis factor-alpha-mediated decrease in glutathione increases the sensitivity of pulmonary vascular endothelial cells to H2O2.

1992 • 107 citations

Cell-permeable Ceramides Prevent the Activation of Phospholipase D by ADP-ribosylation Factor and RhoA

1997 • 106 citations

Evidence against involvement of the acid lysosomal sphingomyelinase in the tumor-necrosis-factor- and interleukin-1-induced sphingomyelin cycle and cell proliferation in human fibroblasts

1994 • 84 citations

Role of glutathione metabolism in the glutamate-induced programmed cell death of neuronal-like PC12 cells

1997 • 82 citations

Identification of an alkaline sphingomyelinase activity in human bile

1996 • 79 citations

Thiol-mediated inhibition of FAS and CD2 apoptotic signaling in activated human peripheral T cells

1997 • 73 citations

Ceramide inhibits IgE-mediated activation of phospholipase D, but not of phospholipase C, in rat basophilic leukemia (RBL-2H3) cells.

1996 • 64 citations

Glutathione depletion in fibroblasts is the basis for apoptosis-induction by endogenous reactive oxygen species

1997 • 62 citations

Ceramide Inhibits IgG-Dependent Phagocytosis in Human Polymorphonuclear Leukocytes

1997 • 59 citations

Elevated ceramide levels in GH4C1 cells treated with retinoic acid

1992 • 57 citations

Bcl-2 acts upstream of the PARP protease and prevents its activation

1997 • 34 citations

Cardiac cell toxicity induced by 4-hydroperoxycyclophosphamide is modulated by glutathione

1993 • 32 citations

Thiol depletion induces lethal cell injury in cultured cardiomyocytes

1992 • 31 citations

A Critical Role for Thiol, But Not ATP, Depletion in 95% O2-Mediated Injury of Preterm Pneumocytes in Vitro

1994 • 27 citations

Mechanism of the selective hypoxic cytotoxicity of 1-methyl-2-nitroimidazole

1994 • 18 citations