Sphingosine mobilizes intracellular calcium in human neutrophils

Thapsigargin inhibits the sarcoplasmic or endoplasmic reticulum Ca-ATPase family of calcium pumps.

1991 • 1,282 citations

Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and in human platelets.

1986 • 1,150 citations

Sphingosine-1-phosphate, a novel lipid, involved in cellular proliferation.

1991 • 627 citations

Lysosphingolipids Inhibit Protein Kinase C: Implications for the Sphingolipidoses

1987 • 593 citations

Use of Manganese to Discriminate Between Calcium Influx and Mobilization From Internal Stores in Stimulated Human Neutrophils

1989 • 520 citations

Intracellular Calcium Release Mediated by Sphingosine Derivatives Generated in Cells

1990 • 391 citations

Inflammation: Basic Principles and Clinical Correlates

1988 • 275 citations

Structural requirements for long-chain (sphingoid) base inhibition of protein kinase C in vitro and for the cellular effects of these compounds

1989 • 247 citations

Sphingosine inhibits calmodulin-dependent enzymes.

1988 • 215 citations

Inhibition of Na,K-ATPase and sodium pump by protein kinase C regulators sphingosine, lysophosphatidylcholine, and oleic acid.

1990 • 159 citations

Sphingosine inhibition of agonist-dependent secretion and activation of human platelets implies that protein kinase C is a necessary and common event of the signal transduction pathways.

1987 • 156 citations

Sphinganine effects on chemoattractant-induced diacylglycerol generation, calcium fluxes, superoxide production, and on cell viability in the human neutrophil. Delivery of sphinganine with bovine serum albumin minimizes cytotoxicity without affecting inhibition of the respiratory burst.

1988 • 119 citations

Regulation of protein kinase C by sphingosine and lysosphingolipids

1989 • 101 citations

Sphingosine inhibits phosphatidate phosphohydrolase in human neutrophils by a protein kinase C-independent mechanism

1991 • 97 citations

Signal transduction by neutrophil immunoglobulin G Fc receptors. Dissociation of intracytoplasmic calcium concentration rise from inositol 1,4,5-trisphosphate.

1992 • 82 citations

Ca2+ transients and Mn2+ entry in human neutrophils induced by thapsigargin

1989 • 80 citations

The calcium signal and neutrophil activation

1990 • 75 citations

The Capacitative Model for Receptor-Activated Calcium Entry

1991 • 64 citations

Nonselective inhibition of neutrophil functions by sphinganine.

1987 • 63 citations

Inhibition of the insulin receptor tyrosine kinase by sphingosine

1991 • 62 citations

Synergistic stimulation of neutrophils. Possible involvement of 5-hydroxy-6,8,11,14-eicosatetraenoate in superoxide release.

1988 • 57 citations

Mn ions pass through calcium channels. A possible explanation.

1983 • 54 citations

Protein kinase C inhibition by sphingoid long-chain bases: Effects on secretion in human neutrophils

1987 • 42 citations

Staurosporine clamps cytosolic free Ca2+ concentrations of human neutrophils

1992 • 34 citations

Sphingosine stimulates calcium mobilization in rat parotid acinar cells

1991 • 27 citations

Use of <scp>d</scp>-erythro-sphingosine as a pharmacological inhibitor of protein kinase C in human platelets

1991 • 26 citations

Auranofin modulated cytoplasmic free calcium in neutrophils by mobilizing intracellular calcium and inhibiting protein kinase.

1990 • 25 citations

Sphingosine increases inositol trisphosphate in rat parotid acinar cells by a mechanism that is independent of protein kinase C but dependent on extracellular calcium

1990 • 16 citations

Multiple non-specific effects of sphingosine on adenylate cyclase and cyclic AMP accumulation in S49 lymphoma cells preclude its use as a specific inhibitor of protein kinase C

1990 • 15 citations

Differential effect of diltiazem and TA-3090 on calcium homeostasis of neutrophils

1991 • 3 citations