The role of the stress-activated protein kinase (SAPK/JNK) signaling pathway in radiation-induced apoptosis

Cell Death: The Significance of Apoptosis

1980 • 7,281 citations

Apoptosis in the Pathogenesis and Treatment of Disease

1995 • 6,610 citations

Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

1995 • 5,334 citations

Apoptosis by Death Factor

1997 • 5,038 citations

Caspases: the executioners of apoptosis

1997 • 4,674 citations

JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

1994 • 3,219 citations

The stress-activated protein kinase subfamily of c-Jun kinases

1994 • 2,616 citations

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme

1993 • 2,484 citations

Induction of Apoptosis by ASK1, a Mammalian MAPKKK That Activates SAPK/JNK and p38 Signaling Pathways

1997 • 2,284 citations

Apoptosis. Its significance in cancer and cancer Therapy

1994 • 2,148 citations

Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis

1996 • 1,784 citations

The small GTP-binding proteins Rac1 and Cdc42regulate the activity of the JNK/SAPK signaling pathway

1995 • 1,653 citations

Independent Human MAP-Kinase Signal Transduction Pathways Defined by MEK and MKK Isoforms

1995 • 1,562 citations

A brain serine/threonine protein kinase activated by Cdc42 and Rac1

1994 • 1,520 citations

Selective activation of the JNK signaling cascadeand c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs

1995 • 1,499 citations

Phosphorylation of c-jun mediated by MAP kinases

1991 • 1,495 citations

Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate

1996 • 1,493 citations

Transcription Factor ATF2 Regulation by the JNK Signal Transduction Pathway

1995 • 1,453 citations

Apoptosis in cancer therapy: Crossing the threshold

1994 • 1,351 citations

Selective interaction of JNK protein kinase isoforms with transcription factors.

1996 • 1,333 citations

Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity.

1991 • 1,300 citations

MKK3- and MKK6-Regulated Gene Expression Is Mediated by the p38 Mitogen-Activated Protein Kinase Signal Transduction Pathway

1996 • 1,286 citations

The sphingomyelin cycle and the second messenger function of ceramide.

1994 • 1,255 citations

An Essential Role for Rho, Rac, and Cdc42 GTPases in Cell Cycle Progression Through G ₁

1995 • 1,142 citations

Differential Activation of ERK and JNK Mitogen-Activated Protein Kinases by Raf-1 and MEKK

1994 • 1,092 citations

Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis

1996 • 980 citations

Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun

1994 • 978 citations

Integration of MAP Kinase Signal Transduction Pathways at the Serum Response Element

1995 • 935 citations

The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signaling

1994 • 934 citations

Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis.

1994 • 890 citations

The Role of c-Jun N-terminal Kinase (JNK) in Apoptosis Induced by Ultraviolet C and γ Radiation

1996 • 881 citations

A c-jun dominant negative mutant protects sympathetic neurons against programmed cell death

1995 • 800 citations

Daxx, a Novel Fas-Binding Protein That Activates JNK and Apoptosis

1997 • 797 citations

Acid Sphingomyelinase–Deficient Human Lymphoblasts and Mice Are Defective in Radiation-Induced Apoptosis

1996 • 795 citations

Identification of a Dual Specificity Kinase That Activates the Jun Kinases and p38-Mpk2

1995 • 775 citations

Rho Family GTPases Regulate p38 Mitogen-activated Protein Kinase through the Downstream Mediator Pak1

1995 • 733 citations

Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1

1994 • 706 citations

Cdc42 and PAK-mediated Signaling Leads to Jun Kinase and p38 Mitogen-activated Protein Kinase Activation

1995 • 639 citations

Sphingomyelin turnover induced by vitamin D3 in HL-60 cells

1989 • 629 citations

Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase.

1994 • 582 citations

The Regulation of Anoikis: MEKK-1 Activation Requires Cleavage by Caspases

1997 • 507 citations

Radiation-induced apoptosis: Relevance to radiotherapy

1995 • 504 citations

Activation of the c-Abl tyrosine kinase in the stress response to DMA-damaging agents

1995 • 486 citations

c-Jun N-terminal phosphorylation correlates with activation of the JNK subgroup but not the ERK subgroup of mitogen-activated protein kinases.

1994 • 463 citations

Persistent Activation of c-Jun N-terminal Kinase 1 (JNK1) in γ Radiation-induced Apoptosis

1996 • 460 citations

Induction of apoptotic DNA damage and cell death by activation of the sphingomyelin pathway.

1994 • 459 citations

The stress-activated protein kinase pathway mediates cell death following injury induced by cis-platinum, UV irradiation or heat

1996 • 457 citations

Signal transduction by tumor necrosis factor mediated by JNK protein kinases.

1994 • 456 citations

Activation of the Sphingomyelin Signaling Pathway in Intact EL4 Cells and in a Cell-Free System By IL-1β

1993 • 433 citations

Induction of apoptosis by the transcription factor c-Jun

1997 • 421 citations

Regulation of Human Leukocyte p21-Activated Kinases Through G Protein—Coupled Receptors

1995 • 415 citations

FAS-induced apoptosis is mediated via a ceramide-initiated RAS signaling pathway

1995 • 411 citations

Heterodimer formation of cJun and ATF-2 is responsible for induction of c-jun by the 243 amino acid adenovirus E1A protein.

1993 • 380 citations

Ceramide Activates the Stress-activated Protein Kinases

1995 • 367 citations

A novel serine kinase activated by rac1/CDC42Hs-dependent autophosphorylation is related to PAK65 and STE20.

1995 • 365 citations

TAK1 Mediates the Ceramide Signaling to Stress-activated Protein Kinase/c-Jun N-terminal Kinase

1997 • 336 citations

Activation of Pyk2 by Stress Signals and Coupling with JNK Signaling Pathway

1996 • 310 citations

Fas Activation of the p38 Mitogen-Activated Protein Kinase Signalling Pathway Requires ICE/CED-3 Family Proteases

1997 • 285 citations

Interleukin-6 Inhibits Fas-Induced Apoptosis and Stress-Activated Protein Kinase Activation in Multiple Myeloma Cells

1997 • 278 citations

Sphingomyelin and derivatives as cellular signals

1991 • 275 citations

Mitogen-activated protein kinase-mediated Fas apoptotic signaling pathway

1997 • 268 citations

A role for Jun-N-terminal kinase in anoikis; suppression by bcl-2 and crmA.

1996 • 250 citations

HPK1, a hematopoietic protein kinase activating the SAPK/JNK pathway.

1996 • 227 citations

Mechanism of action of a dominant-negative mutant of c-Jun.

1994 • 207 citations

The p53 gene as a modifier of intrinsic radiosensitivity: implications for radiotherapy

1996 • 195 citations

CD28 signals through acidic sphingomyelinase.

1995 • 194 citations

Activation of Raf by ionizing radiation

1996 • 158 citations

c-Jun NH2-terminal Kinase Regulation of the Apoptotic Response of Small Cell Lung Cancer Cells to Ultraviolet Radiation

1997 • 151 citations

JNK, but not MAPK, activation is associated with Fas‐mediated apoptosis in human T cells

1996 • 142 citations

CD95 (APO-1/Fas) induces activation of SAP kinases downstream of ICE-like proteases.

1996 • 130 citations

Ceramide Mediates the Apoptotic Response of WEHI 231 Cells to Anti-immunoglobulin, Corticosteroids and Irradiation

1994 • 129 citations

Activation of a CrmA-insensitive, p35-sensitive Pathway in Ionizing Radiation-induced Apoptosis

1997 • 125 citations

Direct Evidence for an Important Role of Sphingomyelinase in Ultraviolet-induced Activation of c-Jun N-Terminal Kinase

1997 • 113 citations

Ceramide induces apoptosis in PC12 cells

1997 • 101 citations

Naturally Occurring (Programmed) and Radiation‐induced Apoptosis are Associated with Selective c‐Jun Expression in the Developing Rat Brain

1996 • 78 citations

Stereospecific Induction of Apoptosis in U937 Cells by N‐Octanoyl‐Sphingosine Stereoisomers and N‐Octyl‐Sphingosine

1996 • 75 citations

Review: The molecular regulation of apoptosis and implications for radiation oncology

1997 • 71 citations

Ceramide: a novel second messenger.

1993 • 65 citations

Radiosensitivity and oxidative signalling in ataxia telangiectasia: an update

1998 • 49 citations

Molecular aspects of cellular responses to radiotherapy

1997 • 43 citations

Radiation, hypoxia and genetic stimulation: implications for future therapies

1997 • 32 citations

Interleukin-6 Inhibits Fas-Induced Apoptosis and Stress-Activated Protein Kinase Activation in Multiple Myeloma Cells

1997 • 25 citations

Of what use is molecular biology to the practicing radiation oncologist?

1998 • 9 citations