Protein kinase C inhibition induces apoptosis and ceramide production through activation of a neutral sphingomyelinase.

The Fas Death Factor

1995 • 4,070 citations

Programmed Cell Death Induced by Ceramide

1993 • 1,779 citations

Chelerythrine is a potent and specific inhibitor of protein kinase C

1990 • 1,208 citations

Calphostin C (UCN-1028C), a novel microbial compound, is a highly potent and specific inhibitor of protein kinase C

1989 • 1,126 citations

Quantitative measurement of sn-1,2-diacylglycerols present in platelets, hepatocytes, and ras- and sis-transformed normal rat kidney cells.

1986 • 999 citations

Functional dichotomy of neutral and acidic sphingomyelinases in tumor necrosis factor signaling

1994 • 726 citations

Protein kinase C zeta isoform is critical for kappa B-dependent promoter activation by sphingomyelinase.

1994 • 473 citations

Protein kinase C as the receptor for the phorbol ester tumor promoters: sixth Rhoads memorial award lecture.

1988 • 430 citations

Tumor Necrosis Factor-α Activates the Sphingomyelin Signal Transduction Pathway in a Cell-Free System

1992 • 428 citations

Basic fibroblast growth factor protects endothelial cells against radiation-induced programmed cell death in vitro and in vivo.

1994 • 333 citations

Protein kinase C mediates basic fibroblast growth factor protection of endothelial cells against radiation-induced apoptosis.

1994 • 255 citations

A possible role of sphingosine in induction of apoptosis by tumor necrosis factor‐α, in human neutrophils

1994 • 168 citations

Ceramide 1-phosphate, a novel phospholipid in human leukemia (HL-60) cells. Synthesis via ceramide from sphingomyelin.

1990 • 165 citations

Evidence That Ceramide Selectively Inhibits Protein Kinase C-α Translocation and Modulates Bradykinin Activation of Phospholipase D

1995 • 139 citations

Ceramide Mediates the Apoptotic Response of WEHI 231 Cells to Anti-immunoglobulin, Corticosteroids and Irradiation

1994 • 129 citations

Identification of a defect in the phospholipase D/diacylglycerol pathway in cellular senescence

1994 • 117 citations

Sphingomyelinase action inhibits phorbol ester-induced differentiation of human promyelocytic leukemic (HL-60) cells

1989 • 81 citations

Deletion analysis of protein kinase c inactivation by calphostin C

1995 • 52 citations

Resistance to anti‐IgM‐induced apoptosis in a WEHI‐231 subline is due to insufficient production of ceramide

1995 • 41 citations

Cross-Talk between Ceramide and PKC Activity in the Control of Apoptosis in WEHI-231

1996 • 33 citations

Growth-dependent regulation of cellular ceramides in human T-cells

1994 • 32 citations

Physiological cell death in B lymphocytes: I. Differential susceptibility of WEHI-231 sublines to anti-lg inducedphysiological cell death and lack of correlation with bcl-2 expression

1994 • 26 citations

A Mutant of the WEHI-231 B Lymphocyte Line That Is Resistant to Phorbol Esters Is Still Sensitive to Antigen Receptor-Mediated Growth Inhibition

1994 • 9 citations