Role of ceramide in mitogenesis induced by exogenous sphingoid bases.

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1959 • 47,127 citations

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1959 • 21,307 citations

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

The Role of Polyamines in the Neutralization of Bacteriophage Deoxyribonucleic Acid

1960 • 2,598 citations

Inhibition of sphingolipid biosynthesis by fumonisins. Implications for diseases associated with Fusarium moniliforme

1991 • 1,094 citations

Quantitative measurement of sn-1,2-diacylglycerols present in platelets, hepatocytes, and ras- and sis-transformed normal rat kidney cells.

1986 • 999 citations

Bifunctional role of glycosphingolipids. Modulators for transmembrane signaling and mediators for cellular interactions.

1990 • 889 citations

Specific interaction between phosphatidylinositol 4,5-bisphosphate and profilactin

1985 • 824 citations

Inorganic and organic phosphate measurements in the nanomolar range

1987 • 726 citations

Sphingomyelin turnover induced by vitamin D3 in HL-60 cells

1989 • 629 citations

Sphingosine-1-phosphate, a novel lipid, involved in cellular proliferation.

1991 • 627 citations

Identification of sphingomyelin turnover as an effector mechanism for the action of tumor necrosis factor alpha and gamma-interferon. Specific role in cell differentiation.

1991 • 621 citations

Growth factor-like action of phosphatidic acid

1986 • 531 citations

Role of ceramide as a lipid mediator of 1 alpha,25-dihydroxyvitamin D3-induced HL-60 cell differentiation.

1990 • 476 citations

From signal to pseudopod

1989 • 460 citations

Tumor Necrosis Factor-α Activates the Sphingomyelin Signal Transduction Pathway in a Cell-Free System

1992 • 428 citations

Ceramide stimulates a cytosolic protein phosphatase.

1992 • 406 citations

Characterization of a ceramide-activated protein kinase: stimulation by tumor necrosis factor alpha.

1991 • 376 citations

The Effect of GTPase Activating Protein Upon Ras Is Inhibited by Mitogenically Responsive Lipids

1989 • 287 citations

Modulation of protein kinase C and diverse cell functions by sphingosine — a pharmacologically interesting compound linking sphingolipids and signal transduction

1989 • 281 citations

Microfilament Structure and Function in the Cortical Cytoskeleton

1991 • 276 citations

Sphingomyelin and derivatives as cellular signals

1991 • 275 citations

Interleukin-1-mediated PGE2 production and sphingomyelin metabolism. Evidence for the regulation of cyclooxygenase gene expression by sphingosine and ceramide.

1992 • 272 citations

Cell regulation by sphingosine and more complex sphingolipids

1991 • 242 citations

Sphingosine stimulates cellular proliferation via a protein kinase C-independent pathway.

1990 • 230 citations

Gelsolin-Polyphosphoinositide Interaction

1989 • 200 citations

Ganglioside GM3: an acidic membrane component that increases during macrophage-like cell differentiation can induce monocytic differentiation of human myeloid and monocytoid leukemic cell lines HL-60 and U937.

1986 • 199 citations

Human 55-kDa receptor for tumor necrosis factor coupled to signal transduction cascades.

1992 • 197 citations

Inhibition of sphingosine kinase in vitro and in platelets. Implications for signal transduction pathways.

1992 • 193 citations

Sphingolipid Biochemistry

1983 • 162 citations

Sphingosine-1-phosphate, a metabolite of sphingosine, increases phosphatidic acid levels by phospholipase D activation

1992 • 154 citations

Effect of harvesting methods, growth conditions and growth phase on diacylglycerol levels in cultured human adherent cells

1988 • 153 citations

Association of gelsolin with actin filaments and cell membranes of macrophages and platelets.

1989 • 151 citations

Diacylglycerol-Stimulated Formation of Actin Nucleation Sites at Plasma Membranes

1992 • 147 citations

Ceramide stimulates epidermal growth factor receptor phosphorylation in A431 human epidermoid carcinoma cells. Evidence that ceramide may mediate sphingosine action

1991 • 134 citations

Sphingomyelinase and cell-permeable ceramide analogs stimulate cellular proliferation in quiescent Swiss 3T3 fibroblasts.

1992 • 128 citations

Gangliosides as bimodal regulators of cell growth.

1987 • 128 citations

A specific enhancing effect of N,N-dimethylsphingosine on epidermal growth factor receptor autophosphorylation. Demonstration of its endogenous occurrence (and the virtual absence of unsubstituted sphingosine) in human epidermoid carcinoma A431 cells.

1990 • 115 citations

Sphingosylphosphorylcholine is a remarkably potent mitogen for a variety of cell lines

1991 • 109 citations

Increases in phosphatidic acid levels accompany sphingosine-stimulated proliferation of quiescent Swiss 3T3 cells.

1990 • 103 citations

Regulation of protein kinase C by sphingosine and lysosphingolipids

1989 • 101 citations

Modulation of renal epithelial cell growth by glucosylceramide. Association with protein kinase C, sphingosine, and diacylglycerol.

1991 • 98 citations

Association of profilin with filament-free regions of human leukocyte and platelet membranes and reversible membrane binding during platelet activation.

1989 • 94 citations

A ceramide analog inhibits T cell proliferative response through inhibition of glycosphingolipid synthesis and enhancement of N,N-dimethylsphingosine synthesis

1990 • 92 citations

Enzymatic quantification of sphingosine in the picomole range in cultured cells

1989 • 79 citations

Inhibition by phospholipids of the interaction between R-ras, rho, and their GTPase-activating proteins.

1989 • 66 citations

Incorporation and metabolism of exogenous GM1 ganglioside in rat liver

1986 • 65 citations

Mitogenesis of 3T3 fibroblasts induced by endogenous ganglioside is not mediated by cAMP, protein kinase C, or phosphoinositides turnover

1988 • 59 citations

A facile enzymatic synthesis of sphingosine-1-phosphate and dihydrosphingosine-1-phosphate.

1989 • 55 citations

Recycling of glucosylceramide and sphingosine for the biosynthesis of gangliosides and sphingomyelin in rat liver

1990 • 44 citations

Inhibition of protein kinase C-dependent cellular proliferation by interaction of endogenous ganglioside GM1 with the B subunit of cholera toxin

1989 • 38 citations

Differential effects of long-chain (sphingoid) bases on the monocytic differentiation of human leukemia (HL-60) cells induced by phorbol esters, 1 alpha, 25-dihydroxyvitamin D3, or ganglioside GM3.

1989 • 37 citations

An acidic glycosphingolipid, monosialo-ganglioside GM3, is a potent physiological inducer for monocytic differentiation of human promyelocytic leukemia cell line HL-60 cells

1985 • 37 citations

Phenotypic changes in 3T3 cells associated with the change of sphingolipid synthesis by a ceramide analog, 2‐decanoylamino‐3‐morpholino‐1‐phenylpropanol (compound RV538)

1988 • 35 citations

Occurrence of glycosylation and deglycosylation of exogenously administered ganglioside GM1 in mouse liver

1983 • 33 citations

Rapid kidney changes resulting from glycosphingolipid depletion by treatment with a glucosyltransferase inhibitor

1991 • 28 citations

Use of PDMP for the Study of Glycosphingolipid Functions.

1991 • 18 citations

Different metabolic recycling of the lipid components of exogenous sulphatide in human fibroblasts

1988 • 16 citations

Rapid turnover of sphingosine synthesized de novo from [14C]serine by Chinese hamster ovary cells

1988 • 13 citations

Protein Kinase C Regulation by Sphingosine/Lysosphingolipids

1988 • 12 citations