c-Jun N-terminal Kinase but Not Mitogen-activated Protein Kinase Is Sensitive to cAMP Inhibition in T Lymphocytes

JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

1994 • 3,219 citations

The stress-activated protein kinase subfamily of c-Jun kinases

1994 • 2,616 citations

Signal transduction by lymphocyte antigen receptors

1994 • 2,145 citations

Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain.

1993 • 1,902 citations

Differential Activation of ERK and JNK Mitogen-Activated Protein Kinases by Raf-1 and MEKK

1994 • 1,092 citations

Inhibition by cAMP of Ras-Dependent Activation of Raf

1993 • 955 citations

Inhibition of the EGF-Activated MAP Kinase Signaling Pathway by Adenosine 3′,5′-Monophosphate

1993 • 939 citations

JNK is involved in signal integration during costimulation of T lymphocytes

1994 • 929 citations

Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1

1994 • 706 citations

NF-kappa B activation by ultraviolet light not dependent on a nuclear signal

1993 • 646 citations

An Osmosensing Signal Transduction Pathway in Mammalian Cells

1994 • 584 citations

The adenylate cyclase-cAMP-protein kinase A pathway and regulation of the immune response

1988 • 533 citations

Activation of extracellular signal-regulated kinase, ERK2, by p21ras oncoprotein.

1992 • 490 citations

Protein kinase A antagonizes platelet-derived growth factor-induced signaling by mitogen-activated protein kinase in human arterial smooth muscle cells.

1993 • 465 citations

Increasing cAMP attenuates activation of mitogen-activated protein kinase.

1993 • 383 citations

cAMP antagonizes p21ras-directed activation of extracellular signal-regulated kinase 2 and phosphorylation of mSos nucleotide exchange factor.

1993 • 362 citations

Sequential protein kinase reactions controlling cell growth and differentiation

1994 • 342 citations

Mechanism of inhibition of Raf-1 by protein kinase A.

1994 • 311 citations

The native structure of the activated Raf protein kinase is a membrane-bound multi-subunit complex.

1994 • 261 citations

Prostaglandin E2 and other cyclic AMP-elevating agents modulate IL-2 and IL-2R alpha gene expression at multiple levels.

1992 • 200 citations

Regulation of interleukin 2 synthesis by cAMP in human T cells.

1987 • 197 citations

Interleukin 2 transcription factors as molecular targets of cAMP inhibition: delayed inhibition kinetics and combinatorial transcription roles.

1994 • 166 citations

cAMP abrogates the p21ras-mitogen-activated protein kinase pathway in fibroblasts.

1994 • 165 citations

B-Raf-dependent regulation of the MEK-1/mitogen-activated protein kinase pathway in PC12 cells and regulation by cyclic AMP.

1994 • 157 citations

T cell antigen receptor engagement stimulates c-raf phosphorylation and induces c-raf-associated kinase activity via a protein kinase C-dependent pathway.

1990 • 147 citations

Cyclic AMP concentrations modulate both calcium flux and hydrolysis of phosphatidylinositol phosphates in mouse T lymphocytes.

1988 • 129 citations

Stimulation of MAP-2 kinase activity in T lymphocytes by anti-CD3 or anti-Ti monoclonal antibody is partially dependent on protein kinase C.

1990 • 112 citations

Mitogen-Activated Protein (MAP) Kinase Phosphorylation of MAP Kinase Kinase: Determination of Phosphorylation Sites by Mass Spectrometry and Site-Directed Mutagenesis1

1994 • 100 citations

The regulation and function of p21ras in T cells

1992 • 98 citations

Extracellular signal-regulated kinases in T cells. Anti-CD3 and 4 beta-phorbol 12-myristate 13-acetate-induced phosphorylation and activation.

1992 • 93 citations

Enzymatic characteristics of the c-Raf-1 proteinkinase.

1994 • 87 citations

Aluminum fluoride induces phosphatidylinositol turnover, elevation of cytoplasmic free calcium, and phosphorylation of the T cell antigen receptor in murine T cells.

1987 • 86 citations

Interleukin-2-Triggered Raf-1 Expression, Phosphorylation, and Associated Kinase Activity Increase through G₁ and S in CD3-Stimulated Primary Human T Cells

1991 • 82 citations

Raf-1 is required for T cell IL2 production.

1993 • 78 citations

T lymphocyte response to bacteriophage lambda repressor cI protein. Recognition of the same peptide presented by Ia molecules of different haplotypes.

1987 • 68 citations

Activation of messenger-independent protein kinases in wild-type and phorbol ester-resistant EL4 thymoma cells

1991 • 59 citations

The role of Raf-1 in the regulation of extracellular signal-regulated kinase 2 by the T cell antigen receptor.

1994 • 59 citations

cAMP analogs prevent activation-induced apoptosis of T cell hybridomas.

1993 • 56 citations

T cell receptor gene usage in the response to lambda repressor cI protein. An apparent bias in the usage of a V alpha gene element.

1988 • 54 citations

Overexpression of mitogen-activated protein kinase (ERK1) enhances T- cell cytokine gene expression: role of AP1, NF-AT, and NF-KB

1993 • 54 citations