TNFR80-Dependent Enhancement of TNFR60-Induced Cell Death Is Mediated by TNFR-Associated Factor 2 and Is Specific for TNFR60

An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death

1996 • 3,094 citations

FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex

1996 • 3,065 citations

Identification and characterization of a new member of the TNF family that induces apoptosis

1995 • 2,890 citations

TNF- and Cancer Therapy-Induced Apoptosis: Potentiation by Inhibition of NF-κB

1996 • 2,665 citations

Suppression of TNF-α-Induced Apoptosis by NF-κB

1996 • 2,623 citations

Inhibition of death receptor signals by cellular FLIP

1997 • 2,577 citations

FADD, a novel death domain-containing protein, interacts with the death domain of fas and initiates apoptosis

1995 • 2,436 citations

Involvement of MACH, a Novel MORT1/FADD-Interacting Protease, in Fas/APO-1- and TNF Receptor–Induced Cell Death

1996 • 2,306 citations

Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor.

1995 • 2,142 citations

The TNF receptor 1-associated protein TRADD signals cell death and NF-κB activation

1995 • 1,979 citations

TRADD–TRAF2 and TRADD–FADD Interactions Define Two Distinct TNF Receptor 1 Signal Transduction Pathways

1996 • 1,976 citations

Dissection of TNF Receptor 1 Effector Functions: JNK Activation Is Not Linked to Apoptosis While NF-κB Activation Prevents Cell Death

1996 • 1,962 citations

The TNF receptor superfamily of cellular and viral proteins: Activation, costimulation, and death

1994 • 1,920 citations

Induction of Apoptosis by Apo-2 Ligand, a New Member of the Tumor Necrosis Factor Cytokine Family

1996 • 1,793 citations

Programmed Cell Death Induced by Ceramide

1993 • 1,779 citations

The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptor

1995 • 1,311 citations

A novel domain within the 55 kd TNF receptor signals cell death

1993 • 1,302 citations

TRAF6 is a signal transducer for interleukin-1

1996 • 1,287 citations

The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins

1995 • 1,237 citations

TNF-Dependent Recruitment of the Protein Kinase RIP to the TNF Receptor-1 Signaling Complex

1996 • 1,154 citations

Induction of apoptosis in mature T cells by tumour necrosis factor

1995 • 1,139 citations

TRAF2-Mediated Activation of NF-κB by TNF Receptor 2 and CD40

1995 • 1,046 citations

A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor

1994 • 1,043 citations

A Novel Protein That Interacts with the Death Domain of Fas/APO1 Contains a Sequence Motif Related to the Death Domain

1995 • 1,007 citations

The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family

1995 • 990 citations

RIP: A novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death

1995 • 964 citations

FADD: Essential for Embryo Development and Signaling from Some, But Not All, Inducers of Apoptosis

1998 • 893 citations

Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-κB control

1997 • 875 citations

A novel protein domain required for apoptosis. Mutational analysis of human Fas antigen

1993 • 857 citations

Ceramide synthase mediates daunorubicin-induced apoptosis: An alternative mechanism for generating death signals

1995 • 835 citations

Two tumour necrosis factor receptors: structure and function

1995 • 800 citations

Acid Sphingomyelinase–Deficient Human Lymphoblasts and Mice Are Defective in Radiation-Induced Apoptosis

1996 • 795 citations

Early Lethality, Functional NF-κB Activation, and Increased Sensitivity to TNF-Induced Cell Death in TRAF2-Deficient Mice

1997 • 791 citations

FADD/MORT1 Is a Common Mediator of CD95 (Fas/APO-1) and Tumor Necrosis Factor Receptor-induced Apoptosis

1996 • 780 citations

Functional dichotomy of neutral and acidic sphingomyelinases in tumor necrosis factor signaling

1994 • 726 citations

Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1

1998 • 704 citations

Inhibition of NF-kappaB/Rel induces apoptosis of murine B cells.

1996 • 604 citations

Involvement of CRAF1, a relative of TRAF, in CD40 signaling

1995 • 454 citations

TRAF2 Is Essential for JNK but Not NF-κB Activation and Regulates Lymphocyte Proliferation and Survival

1997 • 449 citations

Transducers of life and death: TNF receptor superfamily and associated proteins.

1996 • 423 citations

The tumor necrosis factor-inducible zinc finger protein A20 interacts with TRAF1/TRAF2 and inhibits NF-kappaB activation.

1996 • 414 citations

Casper Is a FADD- and Caspase-Related Inducer of Apoptosis

1997 • 398 citations

FAN, a Novel WD-Repeat Protein, Couples the p55 TNF-Receptor to Neutral Sphingomyelinase

1996 • 390 citations

Daunorubicin-induced apoptosis: triggering of ceramide generation through sphingomyelin hydrolysis.

1996 • 371 citations

A novel RING finger protein interacts with the cytoplasmic domain of CD40.

1994 • 345 citations

TRAF5, an Activator of NF-κB and Putative Signal Transducer for the Lymphotoxin-β Receptor

1996 • 343 citations

TRAF5, a novel tumor necrosis factor receptor-associated factor family protein, mediates CD40 signaling.

1996 • 339 citations

Role for ceramide as an endogenous mediator of Fas-induced cytotoxicity.

1995 • 323 citations

Tumor necrosis factor receptor superfamily members and their ligands

1994 • 313 citations

Divergent signalling via APO-1/Fas and the TNF receptor, two homologous molecules involved in physiological cell death.

1994 • 304 citations

TANK, a co-inducer with TRAF2 of TNF- and CD 40L-mediated NF-kappaB activation.

1996 • 283 citations

Ceramide: A stress signal and mediator of growth suppression and apoptosis

1995 • 233 citations

Presence of a New Conserved Domain in CART1, a Novel Member of the Tumor Necrosis Factor Receptor-associated Protein Family, Which Is Expressed in Breast Carcinoma

1995 • 229 citations

CD30-dependent degradation of TRAF2: implications for negative regulation of TRAF signaling and the control of cell survival

1997 • 224 citations

I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction.

1996 • 210 citations

A novel function of CD40: induction of cell death in transformed cells.

1996 • 202 citations

Fas antigen and p55 TNF receptor signal apoptosis through distinct pathways.

1994 • 198 citations

Cell death: TRAIL and its receptors

1997 • 196 citations

TRAF-interacting Protein (TRIP): A Novel Component of the Tumor Necrosis Factor Receptor (TNFR)- and CD30-TRAF Signaling Complexes That Inhibits TRAF2-mediated NF-κB Activation

1997 • 196 citations

Enhancement of TNF receptor p60-mediated cytotoxicity by TNF receptor p80: requirement of the TNF receptor-associated factor-2 binding site.

1997 • 183 citations

A novel member of the TRAF family of putative signal transducing proteins binds to the cytosolic domain of CD40

1995 • 177 citations

Cross-linking CD40 on B cells preferentially induces stress-activated protein kinases rather than mitogen-activated protein kinases.

1996 • 175 citations

T cell receptor-dependent cell death of T cell hybridomas mediated by the CD30 cytoplasmic domain in association with tumor necrosis factor receptor-associated factors.

1996 • 165 citations

A Novel Cytoplasmic Domain of the p55 Tumor Necrosis Factor Receptor Initiates the Neutral Sphingomyelinase Pathway

1996 • 150 citations

Dominant-negative FADD inhibits TNFR60-, Fas/Apo1- and TRAIL-R/Apo2-mediated cell death but not gene induction

1998 • 144 citations

Fas and tumor necrosis factor receptor-mediated cell death: similarities and distinctions.

1994 • 143 citations

A Regulatory Role for TRAF1 in Antigen-induced Apoptosis of T Cells

1997 • 132 citations

Tumor necrosis factor receptor p55 mediates deletion of peripheral cytotoxic T lymphocytes in vivo

1996 • 124 citations

A Mouse Fas-Associated Protein with Homology to the Human Mort1/FADD Protein Is Essential for Fas-Induced Apoptosis

1996 • 117 citations

RIP and FADD: two "death domain"-containing proteins can induce apoptosis by convergent, but dissociable, pathways.

1996 • 114 citations

Segregation of APO‐1/Fas antigen‐ and tumor necrosis factor receptor‐mediated apoptosis

1994 • 46 citations

TRAIL and its receptors

1997 • 17 citations