Identification of a defect in the phospholipase D/diacylglycerol pathway in cellular senescence

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1959 • 47,127 citations

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1959 • 21,307 citations

The limited in vitro lifetime of human diploid cell strains

1965 • 5,595 citations

Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C

1992 • 4,480 citations

The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation

1991 • 3,396 citations

Quantitative analysis of phospholipids by thin‐layer chromatography and phosphorus analysis of spots

1966 • 1,582 citations

The regulation of transcription by phosphorylation

1992 • 1,316 citations

Quantitative measurement of sn-1,2-diacylglycerols present in platelets, hepatocytes, and ras- and sis-transformed normal rat kidney cells.

1986 • 999 citations

Phosphatidylcholine breakdown and signal transduction

1994 • 955 citations

ADP-ribosylation factor, a small GTP-dependent regulatory protein, stimulates phospholipase D activity

1993 • 900 citations

Replicative Senescence: the Human Fibroblast Comes of Age

1990 • 649 citations

Phospholipase D: a Downstream Effector of ARF in Granulocytes

1994 • 636 citations

Identification of sphingomyelin turnover as an effector mechanism for the action of tumor necrosis factor alpha and gamma-interferon. Specific role in cell differentiation.

1991 • 621 citations

Repression of c- fos Transcription and an Altered Genetic Program in Senescent Human Fibroblasts

1990 • 478 citations

Role of ceramide as a lipid mediator of 1 alpha,25-dihydroxyvitamin D3-induced HL-60 cell differentiation.

1990 • 476 citations

Tissue and cellular distribution of the extended family of protein kinase C isoenzymes

1992 • 441 citations

Protein kinase C, calcium and phospholipid degradation

1992 • 400 citations

Selectivity of ceramide-mediated biology. Lack of activity of erythro-dihydroceramide.

1993 • 305 citations

Activation of phospholipase D by protein kinase C. Evidence for a phosphorylation-independent mechanism.

1992 • 237 citations

Cell-permeable ceramides inhibit the stimulation of DNA synthesis and phospholipase D activity by phosphatidate and lysophosphatidate in rat fibroblasts.

1994 • 188 citations

Transcription factor AP-1 activity is required for initiation of DNA synthesis and is lost during cellular aging.

1992 • 187 citations

Dominance of the Senescent Phenotype in Heterokaryons Between Replicative and Post-Replicative Human Fibroblast-Like Cells

1974 • 157 citations

Involvement of functional protein kinase C in the mitogenic response to the H-ras oncogene product.

1987 • 131 citations

Induction of cellular senescence by transfection of cytosolic mortalin cDNA in NIH 3T3 cells.

1993 • 89 citations

Membrane-associated inhibitor of DNA synthesis in senescent human diploid fibroblasts: characterization and comparison to quiescent cell inhibitor.

1986 • 69 citations

Cellular senescence: A reflection of normal growth control, differentiation, or aging?

1991 • 63 citations

Signal-dependent activation of phosphatidylcholine hydrolysis: role of phospholipase D

1991 • 48 citations

Effect of the Tumor Promoter Phorbol 12-Myristate 13-Acetate (PMA) on Proliferation of Young and Senescent WI-38 Human Diploid Fibroblasts

1993 • 45 citations

Cell Cycle-Dependent Regulation of Ca2+ in Young and Senescent WI-38 Cells

1993 • 28 citations

The biochemistry of mammalian senescence

1992 • 26 citations

Why are transformed cells immortal? Is the process reversible?

1992 • 17 citations

Evidence for a new, high-molecular weight isoform of protein kinase C in rat hippocampus

1993 • 15 citations