Ceramide Is Not a Signal for Tumor Necrosis Factor–Induced Gene Expression but Does Cause Programmed Cell Death in Human Vascular Endothelial Cells

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase

1988 • 6,107 citations

The stress-activated protein kinase subfamily of c-Jun kinases

1994 • 2,616 citations

TRADD–TRAF2 and TRADD–FADD Interactions Define Two Distinct TNF Receptor 1 Signal Transduction Pathways

1996 • 1,976 citations

Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain.

1993 • 1,902 citations

Programmed Cell Death Induced by Ceramide

1993 • 1,779 citations

Identification of an inducible endothelial-leukocyte adhesion molecule.

1987 • 1,639 citations

Transcription Factor ATF2 Regulation by the JNK Signal Transduction Pathway

1995 • 1,453 citations

Cytokines and endothelial cell biology

1990 • 1,275 citations

The sphingomyelin cycle and the second messenger function of ceramide.

1994 • 1,255 citations

TNF activates NF-κB by phosphatidylcholine-specific phospholipase C-induced “Acidic” sphingomyelin breakdown

1992 • 1,058 citations

TRAF2-Mediated Activation of NF-κB by TNF Receptor 2 and CD40

1995 • 1,046 citations

A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor

1994 • 1,043 citations

Quantitative measurement of sn-1,2-diacylglycerols present in platelets, hepatocytes, and ras- and sis-transformed normal rat kidney cells.

1986 • 999 citations

Functional dichotomy of neutral and acidic sphingomyelinases in tumor necrosis factor signaling

1994 • 726 citations

Ceramide activates heterotrimeric protein phosphatase 2A

1993 • 657 citations

Identification of sphingomyelin turnover as an effector mechanism for the action of tumor necrosis factor alpha and gamma-interferon. Specific role in cell differentiation.

1991 • 621 citations

Fos and Jun bind cooperatively to the AP-1 site: reconstitution in vitro.

1988 • 511 citations

A novel fluorescent ceramide analogue for studying membrane traffic in animal cells: accumulation at the Golgi apparatus results in altered spectral properties of the sphingolipid precursor.

1991 • 478 citations

Role of ceramide as a lipid mediator of 1 alpha,25-dihydroxyvitamin D3-induced HL-60 cell differentiation.

1990 • 476 citations

Characterization of the promoter for vascular cell adhesion molecule-1 (VCAM-1).

1992 • 476 citations

Protein kinase C zeta isoform is critical for kappa B-dependent promoter activation by sphingomyelinase.

1994 • 473 citations

Induction of apoptotic DNA damage and cell death by activation of the sphingomyelin pathway.

1994 • 459 citations

Activation of the Sphingomyelin Signaling Pathway in Intact EL4 Cells and in a Cell-Free System By IL-1β

1993 • 433 citations

Tumor Necrosis Factor-α Activates the Sphingomyelin Signal Transduction Pathway in a Cell-Free System

1992 • 428 citations

Characterization of a ceramide-activated protein kinase: stimulation by tumor necrosis factor alpha.

1991 • 376 citations

Identification of arachidonic acid as a mediator of sphingomyelin hydrolysis in response to tumor necrosis factor alpha.

1994 • 340 citations

Role for ceramide as an endogenous mediator of Fas-induced cytotoxicity.

1995 • 323 citations

Activation of endothelial-leukocyte adhesion molecule 1 (ELAM-1) gene transcription.

1991 • 273 citations

Identification of a Protein with Homology to hsp90 That Binds the Type 1 Tumor Necrosis Factor Receptor

1995 • 265 citations

An NFxB-like factor is essential but not sufficient for cytokine induction of endothelial leukocyte adhesion molecule 1 (ELAM-1) gene transcription

1991 • 245 citations

Retinoblastoma gene product as a downstream target for a ceramide-dependent pathway of growth arrest.

1995 • 226 citations

Tumor necrosis factor-alpha (TNF-alpha) signal transduction through ceramide. Dissociation of growth inhibitory effects of TNF-alpha from activation of nuclear factor-kappa B.

1993 • 217 citations

Renaturation and tumor necrosis factor-alpha stimulation of a 97-kDa ceramide-activated protein kinase.

1994 • 205 citations

Elevated cyclic AMP inhibits endothelial cell synthesis and expression of TNF-induced endothelial leukocyte adhesion molecule-1, and vascular cell adhesion molecule-1, but not intercellular adhesion molecule-1.

1993 • 192 citations

Ceramide: an endogenous regulator of apoptosis and growth suppresion

1995 • 181 citations

Tumor necrosis factor activation of the sphingomyelin pathway signals nuclear factor kappa B translocation in intact HL-60 cells.

1993 • 179 citations

Identification of a distinct pool of sphingomyelin involved in the sphingomyelin cycle.

1994 • 174 citations

Tumor necrosis factor receptors-structure and function

1992 • 155 citations

The Interferon-Inducible p202 Protein as a Modulator of Transcription: Inhibition of NF-κB, c-Fos, and c-Jun Activities

1996 • 152 citations

Cytokine-endothelial interactions in inflammation, immunity, and vascular injury.

1990 • 149 citations

HLA class I heavy-chain gene promoter elements mediating synergy between tumor necrosis factor and interferons.

1994 • 126 citations

Tumor necrosis factor activates human endothelial cells through the p55 tumor necrosis factor receptor but the p75 receptor contributes to activation at low tumor necrosis factor concentration.

1993 • 115 citations

Tumor necrosis factor induction of endothelial cell surface antigens is independent of protein kinase C activation or inactivation. Studies with phorbol myristate acetate and staurosporine.

1991 • 85 citations

cAMP and tumor necrosis factor competitively regulate transcriptional activation through and nuclear factor binding to the cAMP-responsive element/activating transcription factor element of the endothelial leukocyte adhesion molecule-1 (E-selectin) promoter.

1994 • 79 citations

Dissociation of endogenous cellular ceramide from NF-kappa B activation.

1994 • 67 citations

Identification of a protein kinase associated with the cytoplasmic domain of the p60 tumor necrosis factor receptor.

1994 • 52 citations

TNF receptor signal transduction. Ligand-dependent stimulation of a serine protein kinase activity associated with (CD120a) TNFR60.

1994 • 48 citations

Inhibition of ceramide pathway does not affect ability of TNF-alpha to activate nuclear factor-kappa B.

1994 • 47 citations