Modified low density lipoprotein delivers substrate for ceramide formation and stimulates the sphingomyelin‐ceramide pathway in human macrophages

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1993 • 10,730 citations

THE DISTRIBUTION AND CHEMICAL COMPOSITION OF ULTRACENTRIFUGALLY SEPARATED LIPOPROTEINS IN HUMAN SERUM

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The role of lipid peroxidation and antioxidants in oxidative modification of LDL

1992 • 2,335 citations

The sphingomyelin cycle and the second messenger function of ceramide.

1994 • 1,255 citations

TNF activates NF-κB by phosphatidylcholine-specific phospholipase C-induced “Acidic” sphingomyelin breakdown

1992 • 1,058 citations

Functional dichotomy of neutral and acidic sphingomyelinases in tumor necrosis factor signaling

1994 • 726 citations

Oxidation of human low density lipoprotein results in derivatization of lysine residues of apolipoprotein B by lipid peroxide decomposition products.

1987 • 625 citations

A Vital Stain for the Golgi Apparatus

1985 • 344 citations

Rabbit aorta and human atherosclerotic lesions hydrolyze the sphingomyelin of retained low-density lipoprotein. Proposed role for arterial-wall sphingomyelinase in subendothelial retention and aggregation of atherogenic lipoproteins.

1996 • 326 citations

Intracellular translocation of fluorescent sphingolipids in cultured fibroblasts: endogenously synthesized sphingomyelin and glucocerebroside analogues pass through the Golgi apparatus en route to the plasma membrane.

1985 • 297 citations

Sphingomyelin and derivatives as cellular signals

1991 • 275 citations

Interleukin-1-mediated PGE2 production and sphingomyelin metabolism. Evidence for the regulation of cyclooxygenase gene expression by sphingosine and ceramide.

1992 • 272 citations

Sphingomyelinase and ceramide activate mitogen-activated protein kinase in myeloid HL-60 cells

1993 • 262 citations

1,2-Diacylglycerols but not phorbol esters stimulate sphingomyelin hydrolysis in GH3 pituitary cells.

1987 • 211 citations

The role of diacylglycerol and ceramide in tumor necrosis factor and interleukin-1 signal transduction

1994 • 207 citations

Characteristics and partial purification of a novel cytosolic, magnesium-independent, neutral sphingomyelinase activated in the early signal transduction of 1 alpha,25-dihydroxyvitamin D3-induced HL-60 cell differentiation.

1994 • 198 citations

Lipoprotein lipase and sphingomyelinase synergistically enhance the association of atherogenic lipoproteins with smooth muscle cells and extracellular matrix. A possible mechanism for low density lipoprotein and lipoprotein(a) retention and macrophage foam cell formation.

1993 • 179 citations

Ceramide: a signal for apoptosis or mitogenesis?

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Ceramide 1-phosphate, a novel phospholipid in human leukemia (HL-60) cells. Synthesis via ceramide from sphingomyelin.

1990 • 165 citations

Role of Oxidized LDL and Antioxidants in Atherosclerosis

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Effects of oxidatively modified LDL on cholesterol esterification in cultured macrophages.

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Degradation of low density lipoprotein . dextran sulfate complexes associated with deposition of cholesteryl esters in mouse macrophages.

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The Sphingomyelin-Ceramide Signaling Pathway Is Involved in Oxidized Low Density Lipoprotein-induced Cell Proliferation

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Mechanism of Uptake of Copper-oxidized Low Density Lipoprotein in Macrophages Is Dependent on Its Extent of Oxidation

1996 • 97 citations

Stimulation of mitogen activated protein kinase by LDL and oxLDL in human U‐937 macrophage‐like cells

1996 • 55 citations

Transfer of phosphatidylcholine, phosphatidylethanolamine and sphingomyelin from low- and high-density lipoprotein to human platelets

1996 • 54 citations

Lipoprotein oxidation and gene expression in the artery wall

1993 • 51 citations

Oxidized Low-Density Lipoprotein Stimulates Protein Kinase C (PKC) and Induces Expression of PKC-Isotypes via Prostaglandin-H-Synthase in P388D₁Macrophage-Like Cells

1996 • 40 citations

Oxidized lipoproteins influence gene expression by causing oxidative stress and activating the transcription factor NF-κB

1993 • 40 citations

Nutrition and Biotechnology in Heart Disease and Cancer

1995 • 30 citations

Safety of Teaching Laparoscopic Cholecystectomy to Surgical Residents

1993 • 16 citations

Generation of reactive oxygen species and activity of platelet-activating factor acetylhydrolase in human monocyte-derived macrophages

1994 • 15 citations