Free Radicals in the Physiological Control of Cell Function

Free radicals in biology and medicine

1991 • 17,840 citations

Superoxide Dismutase

1969 • 12,578 citations

The Occurrence of Sleep-Disordered Breathing among Middle-Aged Adults

1993 • 10,139 citations

Aging: A Theory Based on Free Radical and Radiation Chemistry

1956 • 8,252 citations

The serial cultivation of human diploid cell strains

1961 • 7,886 citations

Cell Death: The Significance of Apoptosis

1980 • 7,281 citations

A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

1995 • 6,950 citations

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

1993 • 6,762 citations

Beyond Cholesterol

1989 • 6,533 citations

Oxidants, antioxidants, and the degenerative diseases of aging.

1993 • 6,011 citations

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

1995 • 5,971 citations

Hydroperoxide metabolism in mammalian organs.

1979 • 5,821 citations

The limited in vitro lifetime of human diploid cell strains

1965 • 5,595 citations

Telomeres shorten during ageing of human fibroblasts

1990 • 5,530 citations

Oxygen-Derived Free Radicals in Postischemic Tissue Injury

1985 • 5,488 citations

Prospective Study of the Association between Sleep-Disordered Breathing and Hypertension

2000 • 4,895 citations

Function and Activation of NF-kappaB in the Immune System

1994 • 4,698 citations

Caspases: the executioners of apoptosis

1997 • 4,674 citations

Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C

1992 • 4,480 citations

Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage

2000 • 4,169 citations

NITRIC OXIDE AND MACROPHAGE FUNCTION

1997 • 4,106 citations

The Free Radical Theory of Aging Matures

1998 • 3,846 citations

Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1.

1991 • 3,819 citations

Role of Oxidative Stress in Development of Complications in Diabetes

1991 • 3,774 citations

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

1993 • 3,465 citations

p21 is a universal inhibitor of cyclin kinases

1993 • 3,408 citations

The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation

1991 • 3,396 citations

The Biology of Oxygen Radicals

1978 • 3,361 citations

THE OXIDATIVE BURST IN PLANT DISEASE RESISTANCE

1997 • 3,171 citations

Oxidative Stress, Caloric Restriction, and Aging

1996 • 3,136 citations

An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death

1996 • 3,094 citations

NF-κB: Ten Years After

1996 • 3,008 citations

NAD(P)H Oxidase

2000 • 2,902 citations

AP-1 function and regulation

1997 • 2,833 citations

H2O2 from the oxidative burst orchestrates the plant hypersensitive disease resistance response

1994 • 2,757 citations

Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells.

1994 • 2,753 citations

Biochemistry of Nitric Oxide and Its Redox-Activated Forms

1992 • 2,725 citations

Protein Oxidation and Aging

1992 • 2,687 citations

TNF- and Cancer Therapy-Induced Apoptosis: Potentiation by Inhibition of NF-κB

1996 • 2,665 citations

The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen

1973 • 2,608 citations

Requirement for Generation of H ₂ O ₂ for Platelet-Derived Growth Factor Signal Transduction

1995 • 2,505 citations

Production of large amounts of hydrogen peroxide by human tumor cells.

1991 • 2,465 citations

The Regulation of AP-1 Activity by Mitogen-activated Protein Kinases

1995 • 2,441 citations

Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase

1991 • 2,371 citations

Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1

1998 • 2,360 citations

Induction of Apoptosis by ASK1, a Mammalian MAPKKK That Activates SAPK/JNK and p38 Signaling Pathways

1997 • 2,284 citations

Vitamin E Consumption and the Risk of Coronary Disease in Women

1993 • 2,158 citations

Structure, Regulation and Function of NF-kappaB

1994 • 2,110 citations

The Respiratory Chain and Oxidative Phosphorylation

1956 • 2,073 citations

Hydrogen peroxide mediates amyloid β protein toxicity

1994 • 2,065 citations

Regulation of hypoxia-inducible factor 1α is mediated by an O ₂ -dependent degradation domain via the ubiquitin-proteasome pathway

1998 • 2,044 citations

Antioxidant and redox regulation of gene transcription

1996 • 1,999 citations

Strategies of antioxidant defense

1993 • 1,963 citations

Cloning and Characterization of Inducible Nitric Oxide Synthase from Mouse Macrophages

1992 • 1,914 citations

Calcium signaling

1995 • 1,905 citations

The aging process.

1981 • 1,871 citations

Mitochondrial reactive oxygen species trigger hypoxia-induced transcription

1998 • 1,864 citations

Hypercholesterolemia increases endothelial superoxide anion production.

1993 • 1,799 citations

HIF-1: mediator of physiological and pathophysiological responses to hypoxia

2000 • 1,769 citations

Free radicals and tissue damage produced by exercise

1982 • 1,754 citations

Atmospheric carbon dioxide concentrations over the past 60 million years

2000 • 1,734 citations

The p66shc adaptor protein controls oxidative stress response and life span in mammals

1999 • 1,688 citations

TISSUE CHANGES FOLLOWING DEPRIVATION OF FAT-SOLUBLE A VITAMIN

1925 • 1,630 citations

Protein damage and degradation by oxygen radicals. I. general aspects.

1987 • 1,618 citations

Redox Regulation of Fos and Jun DNA-Binding Activity in Vitro

1990 • 1,592 citations

Mitogenic Signaling Mediated by Oxidants in Ras-Transformed Fibroblasts

1997 • 1,582 citations

Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death.

1995 • 1,556 citations

Signal transduction by the c-Jun N-terminal kinase (JNK) — from inflammation to development

1998 • 1,551 citations

Mortality and Apnea Index in Obstructive Sleep Apnea

1988 • 1,527 citations

Functional analysis of oxidative stress-activated mitogen-activated protein kinase cascade in plants

2000 • 1,499 citations

Gene Expression Profile of Aging and Its Retardation by Caloric Restriction

1999 • 1,483 citations

Extension of Life-Span by Overexpression of Superoxide Dismutase and Catalase in Drosophila melanogaster

1994 • 1,461 citations

Cell transformation by the superoxide-generating oxidase Mox1

1999 • 1,457 citations

pp125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions.

1992 • 1,456 citations

Inside the Neutrophil Phagosome: Oxidants, Myeloperoxidase, and Bacterial Killing

1998 • 1,443 citations

Three-dimensional structure of the tyrosine kinase c-Src

1997 • 1,402 citations

L-arginine is the physiological precursor for the formation of nitric oxide in endothelium-dependent relaxation

1988 • 1,379 citations

OXIDATION OF FREE AMINO ACIDS AND AMINO ACID RESIDUES IN PROTEINS BY RADIOLYSIS AND BY METAL-CATALYZED REACTIONS

1993 • 1,377 citations

The t(15;17) translocation of acute promyelocytic leukaemia fuses the retinoic acid receptor α gene to a novel transcribed locus

1990 • 1,349 citations

H2O2 and antioxidants have opposite effects on activation of NF-kappa B and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor.

1993 • 1,330 citations

The Role of the CD28 Receptor During T Cell Responses to Antigen

1993 • 1,320 citations

Enhanced cellular oxidant stress by the interaction of advanced glycation end products with their receptors/binding proteins

1994 • 1,311 citations

Oxidative stress and gene regulation

2000 • 1,298 citations

Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy

1992 • 1,290 citations

Heme oxygenase is the major 32-kDa stress protein induced in human skin fibroblasts by UVA radiation, hydrogen peroxide, and sodium arsenite.

1989 • 1,273 citations

Inside the Neutrophil Phagosome: Oxidants, Myeloperoxidase, and Bacterial Killing

1998 • 1,249 citations

Starvation in Man

1970 • 1,242 citations

Epidermal Growth Factor (EGF)-induced Generation of Hydrogen Peroxide

1997 • 1,208 citations

Activation of Mitogen-activated Protein Kinase by H2O2

1996 • 1,202 citations

Ubisemiquinone is the electron donor for superoxide formation by complex III of heart mitochondria

1985 • 1,201 citations

Oxygen sensing and molecular adaptation to hypoxia

1996 • 1,187 citations

Active Oxygen Species in the Induction of Plant Systemic Acquired Resistance by Salicylic Acid

1993 • 1,186 citations

Superoxide and hydrogen peroxide in relation to mammalian cell proliferation

1995 • 1,185 citations

Activation of Hypoxia-inducible Transcription Factor Depends Primarily upon Redox-sensitive Stabilization of Its α Subunit

1996 • 1,172 citations

The anti‐aggregating properties of vascular endothelium: interactions between prostacyclin and nitric oxide

1987 • 1,171 citations

MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo

1993 • 1,169 citations

Crystal structure of the Src family tyrosine kinase Hck

1997 • 1,165 citations

Activation of the OxyR Transcription Factor by Reversible Disulfide Bond Formation

1998 • 1,162 citations

Redox Regulation of Cellular Signalling

1999 • 1,146 citations

Free radicals and diabetes

1988 • 1,127 citations

Reactive Oxygen Intermediates Mediate a Systemic Signal Network in the Establishment of Plant Immunity

1998 • 1,126 citations

REDOX REGULATION OF CELLULAR ACTIVATION

1997 • 1,121 citations

Regulation of JNK signaling by GSTp

1999 • 1,102 citations

REGULATION OF GENE EXPRESSION BY REACTIVE OXYGEN

1999 • 1,102 citations

Crystal structure of the tyrosine kinase domain of the human insulin receptor

1994 • 1,071 citations

Gene-expression profile of the ageing brain in mice

2000 • 1,057 citations

Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of I kappa B alpha: a mechanism for NF-kappa B activation.

1993 • 1,047 citations

MOLECULAR BIOLOGY OF THE LysR FAMILY OF TRANSCRIPTIONAL REGULATORS

1993 • 1,040 citations

Role of Oxidants in Ischemic Brain Damage

1996 • 1,037 citations

Biochemical Adaptations to Endurance Exercise in Muscle

1976 • 1,031 citations

Positive control of a regulon for defenses against oxidative stress and some heat-shock proteins in Salmonella typhimurium

1985 • 1,025 citations

Adhesion molecules and inflammatory injury

1994 • 1,023 citations

4‐Hydroxynonenal‐Derived Advanced Lipid Peroxidation End Products Are Increased in Alzheimer's Disease

1997 • 1,018 citations

Endothelial nitric oxide synthase: molecular cloning and characterization of a distinct constitutive enzyme isoform.

1992 • 1,004 citations

Inhibition of cyclin-dependent kinases by p21.

1995 • 999 citations

Cloning and Expression of a Plasma Membrane Cystine/Glutamate Exchange Transporter Composed of Two Distinct Proteins

1999 • 982 citations

Oxidative stress responses in Escherichia coli and Salmonella typhimurium

1991 • 981 citations

Acquired resistance in Arabidopsis.

1992 • 975 citations

The Retardation of Aging in Mice by Dietary Restriction: Longevity, Cancer, Immunity and Lifetime Energy Intake

1986 • 968 citations

Activation of the NADPH oxidase involves the small GTP-binding protein p21rac1

1991 • 961 citations

Intracellular thiols regulate activation of nuclear factor kappa B and transcription of human immunodeficiency virus.

1990 • 960 citations

Modulation of Protein Kinase Activity and Gene Expression by Reactive Oxygen Species and Their Role in Vascular Physiology and Pathophysiology

2000 • 959 citations

The Endocrinology of Aging

1997 • 957 citations

Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions. Evidence for the involvement of mitochondrial radical generation.

1992 • 949 citations

Specific and Reversible Inactivation of Protein Tyrosine Phosphatases by Hydrogen Peroxide: Evidence for a Sulfenic Acid Intermediate and Implications for Redox Regulation

1998 • 933 citations

JNK is involved in signal integration during costimulation of T lymphocytes

1994 • 929 citations

Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog

1997 • 929 citations

Reactive oxygen and reactive nitrogen intermediates in innate and specific immunity

2000 • 923 citations

Activation of human polymorphonuclear neutrophil functions by interferon-gamma and tumor necrosis factors.

1985 • 922 citations

Mouse model of X–linked chronic granulomatous disease, an inherited defect in phagocyte superoxide production

1995 • 920 citations

Redox activation of Fos-Jun DNA binding activity is mediated by a DNA repair enzyme.

1992 • 920 citations

Insulin Action, Diabetogenes, and the Cause of Type II Diabetes

1994 • 914 citations

Prion Protein Biology

1998 • 913 citations

Extension of Life-Span with Superoxide Dismutase/Catalase Mimetics

2000 • 909 citations

An essential role for free radicals and derived species in signal transduction

1997 • 909 citations

The DNA binding subunit of NF-κB is identical to factor KBF1 and homologous to the rel oncogene product

1990 • 900 citations

Nitric Oxide Inhibits Apoptosis by Preventing Increases in Caspase-3-like Activity via Two Distinct Mechanisms

1997 • 889 citations

Protein glycation and oxidative stress in diabetes mellitus and ageing

1991 • 882 citations

Cloning of the p50 DNA binding subunit of NF-κB: Homology to rel and dorsal

1990 • 870 citations

Transcriptional Regulator of Oxidative Stress-Inducible Genes: Direct Activation by Oxidation

1990 • 869 citations

Oxidative stress and nuclear factor-κB activation

2000 • 865 citations

Production of superoxide radicals and hydrogen peroxide by NADH-ubiquinone reductase and ubiquinol-cytochrome c reductase from beef-heart mitochondria

1977 • 854 citations

Extension of Drosophila lifespan by overexpression of human SOD1 in motorneurons

1998 • 852 citations

Redox Regulation of NF-kappa B Activation

1997 • 852 citations

Mild Hyperoxia Shortens Telomeres and Inhibits Proliferation of Fibroblasts: A Model for Senescence?

1995 • 849 citations

Stimulation of neutrophils by tumor necrosis factor.

1986 • 847 citations

Degradation of oxidized proteins in mammalian cells

1997 • 845 citations

Initiation of Runaway Cell Death in an Arabidopsis Mutant by Extracellular Superoxide

1996 • 845 citations

Protein damage and degradation by oxygen radicals. II. Modification of amino acids.

1987 • 840 citations

Role of oxygen free radicals in cancer development

1996 • 839 citations

Cloning of the mycobacterial epitope recognized by T lymphocytes in adjuvant arthritis

1988 • 838 citations

PML regulates p53 acetylation and premature senescence induced by oncogenic Ras

2000 • 826 citations

Thiordoxin regulates the DNA binding activity of NF-χB by reduction of a disulphid bond involving cysteine 62

1992 • 825 citations

Nitric oxide and cGMP cause vasorelaxation by activation of a charybdotoxin-sensitive K channel by cGMP-dependent protein kinase.

1994 • 819 citations

Extended Life-Span and Stress Resistance in the Drosophila Mutant methuselah

1998 • 815 citations

Oxidative Stress as a Regulator of Gene Expression in the Vasculature

1999 • 810 citations

Role of xanthine oxidase and granulocytes in ischemia-reperfusion injury

1988 • 794 citations

Is NF-kappaB the sensor of oxidative stress?

1999 • 786 citations

Oxidative damage, mitochondrial oxidant generation and antioxidant defenses during aging and in response to food restriction in the mouse

1994 • 785 citations

Development of “substrate-trapping” mutants to identify physiological substrates of protein tyrosine phosphatases

1997 • 774 citations

The nitric oxide and cGMP signal transduction system: regulation and mechanism of action

1993 • 761 citations

Hypertension and the Pathogenesis of Atherosclerosis

1995 • 760 citations

Acetylsalicylic acid (aspirin) induces resistance to tobacco mosaic virus in tobacco

1979 • 757 citations

Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro

1995 • 741 citations

Caloric Intake and Aging

1997 • 736 citations

Regulation of gamma-glutamyl-cysteine synthetase by nonallosteric feedback inhibition by glutathione.

1975 • 729 citations

A proteasome inhibitor prevents activation of NF-kappa B and stabilizes a newly phosphorylated form of I kappa B-alpha that is still bound to NF-kappa B.

1994 • 723 citations

Thedaf‐2gene network for longevity regulates oxidative stress resistance and Mn‐superoxide dismutase gene expression inCaenorhabditis elegans

1999 • 721 citations

Biochemistry of the SH group

1972 • 714 citations

Free Radicals in Biological Materials

1954 • 713 citations

Identification and characterization of Ref-1, a nuclear protein that facilitates AP-1 DNA-binding activity.

1992 • 702 citations

PATHOGENESIS OF TYPE 2 DIABETES: METABOLIC AND MOLECULAR IMPLICATIONS FOR IDENTIFYING DIABETES GENES

1997 • 701 citations

Role of redox potential and reactive oxygen species in stress signaling

1999 • 695 citations

Distinct effects of thioredoxin and antioxidants onthe activation of transcription factors NF-kappa B and AP-1.

1994 • 694 citations

The Pharmacological and Physiological Role of Cyclic GMP in Vascular Smooth Muscle Relaxation

1985 • 685 citations

Rapid and preferential activation of the c-jun gene during the mammalian UV response.

1991 • 685 citations

Oxidative stress activates extracellular signal-regulated kinases through Src and Ras in cultured cardiac myocytes of neonatal rats.

1997 • 683 citations

Is NF‐κB the sensor of oxidative stress?

1999 • 669 citations

Diabetes mellitus and free radicals

1993 • 666 citations

Ras Proteins Induce Senescence by Altering the Intracellular Levels of Reactive Oxygen Species

1999 • 661 citations

Human fibroblasts release reactive oxygen species in response to interleukin-1 or tumour necrosis factor-α

1989 • 660 citations

p38 Mitogen-activated Protein Kinase Is a Critical Component of the Redox-sensitive Signaling Pathways Activated by Angiotensin II

1998 • 657 citations

Role of ubiquinone in the mitochondrial generation of hydrogen peroxide

1976 • 656 citations

Molecular Analysis of Acute Promyelocytic Leukemia Breakpoint Cluster Region on Chromosome 17

1990 • 650 citations

Modulation of transcription factor NF-kappa B binding activity by oxidation-reduction in vitro.

1991 • 649 citations

Regulators of cell death

1995 • 647 citations

Superoxide radicals as precursors of mitochondrial hydrogen peroxide

1974 • 627 citations

Enhanced Release of Superoxide from Polymorphonuclear Neutrophils in Obstructive Sleep Apnea

2000 • 618 citations

Senescence-like growth arrest induced by hydrogen peroxide in human diploid fibroblast F65 cells.

1994 • 617 citations

Role of NADH/NADPH Oxidase–Derived H ₂ O ₂ in Angiotensin II–Induced Vascular Hypertrophy

1998 • 616 citations

Transcription factor NF-κB is activated in primary neurons by amyloid β peptides and in neurons surrounding early plaques from patients with Alzheimer disease

1997 • 611 citations

Activation of protein kinase C by tyrosine phosphorylation in response to H ₂ O ₂

1997 • 610 citations

Inhibition of NF-kappaB/Rel induces apoptosis of murine B cells.

1996 • 604 citations

Aconitase is readily inactivated by peroxynitrite, but not by its precursor, nitric oxide.

1994 • 596 citations

Alterations in Free Radical Tissue-Defense Mechanisms in Streptozocin-Induced Diabetes in Rat: Effects of Insulin Treatment

1987 • 592 citations

Reactive oxygen species are downstream mediators of p53-dependent apoptosis.

1996 • 590 citations

Copper Stimulates Endocytosis of the Prion Protein

1998 • 586 citations

Effects of Mechanical Forces on Signal Transduction and Gene Expression in Endothelial Cells

1998 • 582 citations

Depletion of the mitochondrial electron transport abrogates the cytotoxic and gene-inductive effects of TNF.

1993 • 581 citations

Overexpression of Manganese Superoxide Dismutase Suppresses Tumor Necrosis Factor-induced Apoptosis and Activation of Nuclear Transcription Factor-κB and Activated Protein-1

1998 • 580 citations

Reactions between nitric oxide and haemoglobin under physiological conditions

1998 • 577 citations

Structural Basis for Phosphotyrosine Peptide Recognition by Protein Tyrosine Phosphatase 1B

1995 • 575 citations

Mammalian lipoxygenases: molecular structures and functions

1992 • 571 citations

Deficiency of the Hematopoietic Cell-Specific Rho Family GTPase Rac2 Is Characterized by Abnormalities in Neutrophil Function and Host Defense

1999 • 568 citations

�ber den Stoffwechsel der Carcinomzelle

1924 • 566 citations

The H2O2 Stimulon in Saccharomyces cerevisiae

1998 • 564 citations

Regulation of the OxyR transcription factor by hydrogen peroxide and the cellular thiol—disulfide status

1999 • 561 citations

Programmed cell death and Bcl-2 protection in the absence of a nucleus.

1994 • 560 citations

Phosphorylation activates the insulin receptor tyrosine protein kinase.

1983 • 558 citations

Free radicals, lipids and protein degradation

1986 • 556 citations

UV-induced DNA damage is an intermediate step in UV-induced expression of human immunodeficiency virus type 1, collagenase, c-fos, and metallothionein.

1989 • 549 citations

NADH oxidoreductase is a major source of superoxide anion in bovine coronary artery endothelium

1994 • 546 citations

Respiratory chain linked H₂O₂ production in pigeon heart mitochondria

1971 • 544 citations

Regulation of gene expression by insulin

1996 • 543 citations

Involvement of Reactive Oxygen Species in Cytokine and Growth Factor Induction of c-fos Expression in Chondrocytes

1995 • 538 citations

Activation of Apoptosis Signal-Regulating Kinase 1 (ASK1) by Tumor Necrosis Factor Receptor-Associated Factor 2 Requires Prior Dissociation of the ASK1 Inhibitor Thioredoxin

2000 • 533 citations

Do Mitochondria Produce Oxygen Radicals in vivo?

1978 • 530 citations

Nitric Oxide Reversibly Inhibits Seven Members of the Caspase Family via S-Nitrosylation

1997 • 530 citations

Early Embryonic Lethality Caused by Targeted Disruption of the Mouse Thioredoxin Gene

1996 • 529 citations

Dephosphorylation of receptor tyrosine kinases as target of regulation by radiation, oxidants or alkylating agents.

1996 • 523 citations

Role of PML in Cell Growth and the Retinoic Acid Pathway

1998 • 522 citations

MEKK1/JNK signaling stabilizes and activates p53

1998 • 521 citations

Phenotype of Mice and Macrophages Deficient in Both Phagocyte Oxidase and Inducible Nitric Oxide Synthase

1999 • 512 citations

Inhibition of cell proliferation by alpha-tocopherol. Role of protein kinase C.

1991 • 510 citations

Protein kinase C zeta subspecies from rat brain: its structure, expression, and properties.

1989 • 508 citations

A Nonpeptidyl Mimic of Superoxide Dismutase with Therapeutic Activity in Rats

1999 • 502 citations

Reactive oxygen in skeletal muscle. I. Intracellular oxidant kinetics and fatigue in vitro

1992 • 496 citations

A role for oxygen radicals as second messengers

1991 • 494 citations

Regulation of PTP1B via Glutathionylation of the Active Site Cysteine 215

1999 • 492 citations

Reactive Oxygen Species Mediate Cytokine Activation of c-Jun NH2-terminal Kinases

1996 • 491 citations

Oxidoreductive regulation of nuclear factor kappa B. Involvement of a cellular reducing catalyst thioredoxin

1993 • 490 citations

A Molecular Redox Switch on p21

1997 • 488 citations

Hydrogen peroxide release from mouse peritoneal macrophages: dependence on sequential activation and triggering.

1977 • 488 citations

Biochemical Mechanisms for Oxygen Free Radical Formation During Exercise

1990 • 486 citations

Protein damage and degradation by oxygen radicals. IV. Degradation of denatured protein.

1987 • 482 citations

Structural basis for activation of human lymphocyte kinase Lck upon tyrosine phosphorylation

1996 • 479 citations

Involvement of reactive oxygen intermediates in cyclooxygenase-2 expression induced by interleukin-1, tumor necrosis factor-alpha, and lipopolysaccharide.

1995 • 477 citations

YAP1 dependent activation of TRX2 is essential for the response of Saccharomyces cerevisiae to oxidative stress by hydroperoxides.

1994 • 472 citations

A cascade of tyrosine autophosphorylation in the beta-subunit activates the phosphotransferase of the insulin receptor.

1988 • 467 citations

Respiratory Disturbance Index

2000 • 461 citations

Functions of glutathione and glutathione disulfide in immunology and immunopathology

1994 • 446 citations

Purification of a Novel Flavoprotein Involved in the Thyroid NADPH Oxidase

1999 • 445 citations

Big Mitogen-activated Protein Kinase 1 (BMK1) Is a Redox-sensitive Kinase

1996 • 445 citations

The insulinomimetic agents H2O2 and vanadate stimulate protein tyrosine phosphorylation in intact cells.

1990 • 440 citations

Regulation of yAP-1 nuclear localization in response to oxidative stress

1997 • 437 citations

Expression of phagocyte NADPH oxidase components in human endothelial cells

1996 • 432 citations

The Broad Spectrum of Responses to Oxidants in Proliferating Cells: A New Paradigm for Oxidative Stress

1999 • 432 citations

Activation of an H2O2-generating NADH Oxidase in Human Lung Fibroblasts by Transforming Growth Factor β1

1995 • 426 citations

Oxidative stress responses in Escherichia coli and Salmonella typhimurium.

1991 • 423 citations

Immunologic NO Synthase: Elevation in Severe AIDS Dementia and Induction by HIV-1 gp41

1996 • 422 citations

Function of the oxidative burst in hypersensitive disease resistance.

1995 • 417 citations

Differential Activation of Mitogen-Activated Protein Kinases by H ₂ O ₂ and O ₂ ⁻ in Vascular Smooth Muscle Cells

1995 • 416 citations

OxyR, a positive regulator of hydrogen peroxide-inducible genes in Escherichia coli and Salmonella typhimurium, is homologous to a family of bacterial regulatory proteins.

1989 • 415 citations

Inducible repair of oxidative DNA damage in Escherichia coli

1983 • 415 citations

Oxygen radicals stimulate intracellular proteolysis and lipid peroxidation by independent mechanisms in erythrocytes.

1987 • 414 citations

Differential regulation of antioxidant enzymes in response to oxidants.

1991 • 411 citations

Is atherosclerosis an immunologically mediated disease?

1995 • 411 citations

Increased F₂‐isoprostanes in Alzheimer's disease: evidence for enhanced lipid peroxidationin vivo

1998 • 411 citations

Ca2+- and phospholipid-independent activation of protein kinase C by selective oxidative modification of the regulatory domain.

1989 • 409 citations

Elevated 4-Hydroxynonenal in Ventricular Fluid in Alzheimer’s Disease

1997 • 403 citations

Human skin fibroblasts in vitro differentiate along a terminal cell lineage.

1988 • 400 citations

Redox state is a central modulator of the balance between self-renewal and differentiation in a dividing glial precursor cell

2000 • 400 citations

Uber den Stoffwechsel der Karzinomezellen

1924 • 399 citations

Regulation of the synthesis of superoxide dismutase in Escherichia coli. Induction by methyl viologen.

1977 • 396 citations

Role of Rac1 and Oxygen Radicals in Collagenase-1 Expression Induced by Cell Shape Change

1998 • 392 citations

Aerobic glycolysis by proliferating cells: a protective strategy against reactive oxygen species ¹

1997 • 392 citations

Low oxygen concentration extends the lifespan of cultured human diploid cells

1977 • 387 citations

Free radicals, reactive oxygen species and human disease: a critical evaluation with special reference to atherosclerosis.

1989 • 380 citations

Redox-dependent shift of OxyR-DNA contacts along an extended DNA-binding site: A mechanism for differential promoter selection

1994 • 379 citations

Somatic mutations in the p53 tumor suppressor gene in rheumatoid arthritis synovium

1997 • 378 citations

Structure of the FGF Receptor Tyrosine Kinase Domain Reveals a Novel Autoinhibitory Mechanism

1996 • 376 citations

EPR characterization of molecular targets for NO in mammalian cells and organelles

1993 • 373 citations

Negative feedback regulation of endothelial cell function by nitric oxide.

1993 • 371 citations

Absence of Respiratory Burst in X-linked Chronic Granulomatous Disease Mice Leads to Abnormalities in Both Host Defense and Inflammatory Response to Aspergillus fumigatus

1997 • 370 citations

Mitochondrial DNA deletion mutations colocalize with segmental electron transport system abnormalities, muscle fiber atrophy, fiber splitting, and oxidative damage in sarcopenia

2001 • 368 citations

Nitric Oxide-stimulated Guanine Nucleotide Exchange on p21ras

1995 • 367 citations

Control of transcription factors by signal transduction pathways: the beginning of the end

1992 • 360 citations

Novel homologs of gp91phox

2000 • 356 citations

Roles of Superoxide Radical Anion in Signal Transduction Mediated by Reversible Regulation of Protein-tyrosine Phosphatase 1B

1999 • 353 citations

Sequential acquisition of mitochondrial and plasma membrane alterations during early lymphocyte apoptosis.

1996 • 353 citations

Activation of human peripheral blood mononuclear cells by nitric oxide-generating compounds.

1993 • 353 citations

The influence of immobilization and stretch on protein turnover of rat skeletal muscle.

1977 • 352 citations

Reactive Oxygen Species- and Dimerization-induced Activation of Apoptosis Signal-regulating Kinase 1 in Tumor Necrosis Factor-α Signal Transduction

1998 • 351 citations

A novel mechanism for the insulin-like effect of vanadate on glycogen synthase in rat adipocytes.

1984 • 351 citations

Low Concentrations of Acid-Soluble Thiol (Cysteine) in the Blood Plasma of HIV-1-Infected Patients

1989 • 349 citations

Caspase-1 and -3 are sequentially activated in motor neuron death in Cu,Zn superoxide dismutase-mediated familial amyotrophic lateral sclerosis

2000 • 346 citations

soxR, a locus governing a superoxide response regulon in Escherichia coli K-12

1990 • 341 citations

rac1 Regulates a Cytokine-Stimulated, Redox-Dependent Pathway Necessary for NF-κB Activation

1996 • 337 citations

Degradation of Oxidized Proteins in K562 Human Hematopoietic Cells by Proteasome

1996 • 333 citations

Differential Activation of Mitogen-activated Protein Kinases by Nitric Oxide-related Species

1996 • 332 citations

HYPERTENSION, CARDIAC ARRHYTHMIAS, MYOCARDIAL INFARCTION, AND STROKE IN RELATION TO OBSTRUCTIVE SLEEP APNEA

1992 • 329 citations

Adhesion Molecules

1996 • 329 citations

Soluble guanylate cyclase purified from bovine lung contains heme and copper

1981 • 328 citations

Protein oxidation in response to increased transcriptional or translational errors

2000 • 328 citations

Overproduction of human Cu/Zn-superoxide dismutase in transfected cells: extenuation of paraquat-mediated cytotoxicity and enhancement of lipid peroxidation.

1986 • 322 citations

Stimulation of “Stress-regulated” Mitogen-activated Protein Kinases (Stress-activated Protein Kinases/c-Jun N-terminal Kinases and p38-Mitogen-activated Protein Kinases) in Perfused Rat Hearts by Oxidative and Other Stresses

1998 • 320 citations

Hydrogen peroxide-induced apoptosis is CD95-independent, requires the release of mitochondria-derived reactive oxygen species and the activation of NF-κB

1999 • 319 citations

N-acetylcysteine inhibits muscle fatigue in humans.

1994 • 317 citations

Aerobic glycolysis during lymphocyte proliferation

1976 • 317 citations

Pervanadate [peroxide(s) of vanadate] mimics insulin action in rat adipocytes via activation of the insulin receptor tyrosine kinase

1989 • 317 citations

Tumour necrosis factor α activates a p22phox-based NADH oxidase in vascular smooth muscle

1998 • 313 citations

SYNOVIAL FLUID T CELL REACTIVITY AGAINST 65 kD HEAT SHOCK PROTEIN OF MYCOBACTERIA IN EARLY CHRONIC ARTHRITIS

1988 • 311 citations

Platelet-derived Growth Factor-induced H2O2 Production Requires the Activation of Phosphatidylinositol 3-Kinase

2000 • 309 citations

Superoxide production from nonenzymatically glycated protein

1988 • 309 citations

Oxidative Stress Disrupts Insulin-induced Cellular Redistribution of Insulin Receptor Substrate-1 and Phosphatidylinositol 3-Kinase in 3T3-L1 Adipocytes

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Signalling mechanisms and oxidative stress in apoptosis

1995 • 306 citations

IL-2 gene expression and NF-kappa B activation through CD28 requires reactive oxygen production by 5-lipoxygenase.

1995 • 304 citations

Proteasome inhibition by lipofuscin/ceroid during postmitotic aging of fibroblasts

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Transcriptional activation of early‐response genes by hydrogen peroxide in a mouse osteoblastic cell line

1991 • 298 citations

Glucose is essential for proliferation and the glycolytic enzyme induction that provokes a transition to glycolytic energy production.

1994 • 293 citations

Oxidation of proteins by mixed-function oxidation systems: implication in protein turnover, ageing and neutrophil function

1986 • 290 citations

Electron spin resonance studies of intact mammalian skeletal muscle

1985 • 289 citations

Epidermal Growth Factor Receptor Transactivation by Angiotensin II Requires Reactive Oxygen Species in Vascular Smooth Muscle Cells

2001 • 285 citations

The Skn7 response regulator controls gene expression in the oxidative stress response of the budding yeast Saccharomyces cerevisiae

1997 • 284 citations

Crystal structures of the myristylated catalytic subunit of cAMP‐dependent protein kinase reveal open and closed conformations

1993 • 284 citations

Inhibition of I kappa B-alpha phosphorylation and degradation and subsequent NF-kappa B activation by glutathione peroxidase overexpression.

1996 • 283 citations

Structure of a Voltage-Dependent K+ Channel β Subunit

1999 • 281 citations

Targeting Nitric Oxide (NO) Deliveryin Vivo. Design of a Liver-Selective NO Donor Prodrug That Blocks Tumor Necrosis Factor-α-Induced Apoptosis and Toxicity in the Liver

1997 • 279 citations

Oxygen sensing by the carotid body chemoreceptors

2000 • 276 citations

Activation of Host Defense Mechanisms by Elevated Production of H2O2 in Transgenic Plants

1997 • 275 citations

Distinct effects of glutathione disulphide on the nuclear transcription factors κB and the activator protein‐1

1994 • 274 citations

Mitochondrial oxidative damage, hydrogen peroxide release, and aging

1994 • 273 citations

Selective inhibition of protein tyrosine phosphatase activities by H2O2 and vanadate In vitro

1992 • 273 citations

Tumour necrosis factor-α induces superoxide anion generation in mitochondria of L929 cells

1993 • 272 citations

Rheumatoid arthritis and p53: how oxidative stress might alter the course of inflammatory diseases

2000 • 271 citations

Secretion of pyruvate. An antioxidant defense of mammalian cells.

1987 • 271 citations

Elevation of Mitochondrial Transmembrane Potential and Reactive Oxygen Intermediate Levels Are Early Events and Occur Independently from Activation of Caspases in Fas Signaling

1999 • 270 citations

c-Src Is Required for Oxidative Stress-mediated Activation of Big Mitogen-activated Protein Kinase 1 (BMK1)

1997 • 270 citations

Prion protein expression and superoxide dismutase activity

1998 • 269 citations

Kinetics of glucose disposal in whole body and across the forearm in man.

1987 • 268 citations

Increased levels of circulating ICAM-1, VCAM-1, and L-selectin in obstructive sleep apnea syndrome

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Chronic Granulomatous Disease

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Hydrogen peroxide elicits pulmonary arterial relaxation and guanylate cyclase activation

1987 • 265 citations

Redox sensing by prokaryotic transcription factors

2000 • 264 citations

Reactive oxygen intermediates activate NF-kappa B in a tyrosine kinase- dependent mechanism and in combination with vanadate activate the p56lck and p59fyn tyrosine kinases in human lymphocytes

1993 • 260 citations

Free Radicals and Their Involvement During Long-Term Myocardial Ischemia and Reperfusion

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転写因子NF‐κBとAP‐1の活性化に及ぼすチオレドキシンと抗酸化剤の異なった効果

1994 • 259 citations

Blood antioxidant status and erythrocyte lipid peroxidation following distance running

1990 • 258 citations

Src and Cas Mediate JNK Activation but Not ERK1/2 and p38 Kinases by Reactive Oxygen Species

2000 • 257 citations

Blood glutathione oxidation during human exercise

1988 • 257 citations

Induction of heme oxygenase-1 gene expression by lipopolysaccharide is mediated by AP-1 activation.

1995 • 256 citations

Inhibition of HIV-1 replication and NF-x B activity by cysteine and cysteine derivatives

1991 • 256 citations

Mechanism of Sodium Arsenite-mediated Induction of Heme Oxygenase-1 in Hepatoma Cells

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Effect of muscle glycogen depletion on in vivo insulin action in man.

1983 • 252 citations

Adult T cell leukemia-derived factor/human thioredoxin protects endothelial F-2 cell injury caused by activated neutrophils or hydrogen peroxide

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Crucial Role of the Amino-Terminal Tyrosine Residue 42 and the Carboxyl-Terminal PEST Domain of IκBα in NF-κB Activation by an Oxidative Stress

2000 • 251 citations

Determination of the mechanism of free radical generation in human aortic endothelial cells exposed to anoxia and reoxygenation.

1994 • 251 citations

The 2.35 å crystal structure of the inactivated form of chicken src: a dynamic molecule with multiple regulatory interactions

1997 • 251 citations

A20 Blocks Endothelial Cell Activation through a NF-κB-dependent Mechanism

1996 • 248 citations

Mitochondrial enzymes increase in muscle in response to 7-10 days of cycle exercise

1996 • 248 citations

Nerve Growth Factor-induced Neuronal Differentiation Requires Generation of Rac1-regulated Reactive Oxygen Species

2000 • 248 citations

Exhaustive physical exercise causes oxidation of glutathione status in blood: prevention by antioxidant administration

1992 • 245 citations

A cytosolic catalase is needed to extend adult lifespan in C. elegans daf-C and clk-1 mutants

1999 • 244 citations

Inhibition of NF-κB Activation by Vitamin E Derivatives

1993 • 243 citations

Redox modulation of tyrosine phosphorylation-dependent signal transduction pathways

1996 • 242 citations

Insulin-stimulated intracellular hydrogen peroxide production in rat epididymal fat cells

1979 • 239 citations

Activation of guanylate cyclase by superoxide dismutase and hydroxyl radical: a physiological regulator of guanosine 3',5'-monophosphate formation.

1977 • 238 citations

Hydrogen peroxide induces complex formation of SHC-Grb2-SOS with receptor tyrosine kinase and activates Ras and extracellular signal-regulated protein kinases group of mitogen-activated protein kinases.

1996 • 238 citations

Increased atherosclerosis in hyperlipidemic mice deficient in α-tocopherol transfer protein and vitamin E

2000 • 235 citations

Protein kinase C contains two phorbol ester binding domains.

1991 • 234 citations

Elevation in the Ratio of Cu/Zn-Superoxide Dismutase to Glutathione Peroxidase Activity Induces Features of Cellular Senescence and This Effect Is Mediated by Hydrogen Peroxide

1996 • 234 citations

Role of hydrogen peroxide in hypoxia-induced erythropoietin production

1994 • 233 citations

Mitogen‐activated protein kinase (p38‐, JNK‐, ERK‐) activation pattern induced by extracellular and intracellular singlet oxygen and UVA

1999 • 232 citations

An essential role of NFκB in tyrosine kinase signaling of p38 MAP kinase regulation of myocardial adaptation to ischemia

1998 • 232 citations

Superoxide anion participation in human monocyte-mediated oxidation of low-density lipoprotein and conversion of low-density lipoprotein to a cytotoxin.

1989 • 231 citations

Mechanisms for Redox Control of Gene Expression

1999 • 231 citations

Hypoxia, oxidative stress and rheumatoid arthritis

1995 • 229 citations

Reactive oxygen species and Alzheimer's disease

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Fas mediates apoptosis in human monocytes by a reactive oxygen intermediate dependent pathway.

1996 • 228 citations

Ischemic Stroke and Incomplete Infarction

1996 • 227 citations

The Level of Intracellular Glutathione Is a Key Regulator for the Induction of Stress-Activated Signal Transduction Pathways Including Jun N-Terminal Protein Kinases and p38 Kinase by Alkylating Agents

1997 • 226 citations

Exercise-induced oxidative stress: glutathione supplementation and deficiency

1994 • 226 citations

CD28 Mediates Transcriptional Upregulation of the Interleukin-2 (IL-2) Promoter through a Composite Element Containing the CD28RE and NF-IL-2B AP-1 Sites

1997 • 224 citations

Solution structure of human thioredoxin in a mixed disulfide intermediate complex with its target peptide from the transcription factor NFκB

1995 • 224 citations

SoxR, a [2Fe-2S] transcription factor, is active only in its oxidized form.

1996 • 224 citations

Superoxide dismutase, glutathione peroxidase and lipoperoxidation in Oown's syndrome fetal brain

1984 • 224 citations

Mediator‐induced activation of xanthine oxidase in endothelial cells

1989 • 223 citations

Down's syndrome: Abnormal neuromuscular junction in tongue of transgenic mice with elevated levels of human Cu/Zn-superoxide dismutase

1988 • 220 citations

Redox regulation of signal transduction: tyrosine phosphorylation and calcium influx.

1994 • 220 citations

Identification of a Second Region Upstream of the Mouse Heme Oxygenase-1 Gene That Functions as a Basal Level and Inducer-dependent Transcription Enhancer

1995 • 219 citations

Hydrogen peroxide as a potent activator of T lymphocyte functions

1995 • 217 citations

Protein oxidation and degradation during cellular senescence of human BJ fibroblasts: part I— effects of proliferative senescence

2000 • 216 citations

Multiple redox regulation in NF-kappaB transcription factor activation.

1997 • 215 citations

Caloric restriction of rhesus monkeys lowers oxidative damage in skeletal muscle

2000 • 215 citations

Alteration of antioxidant enzymes with aging in rat skeletal muscle and liver

1990 • 215 citations

Increased expression of heat shock protein 65 coincides with a population of infiltrating T lymphocytes in atherosclerotic lesions of rabbits specifically responding to heat shock protein 65.

1993 • 215 citations

Prion infection impairs the cellular response to oxidative stress

2000 • 213 citations

Theories of biological aging

1985 • 212 citations

T Lymphocyte Activation Signals for Interleukin-2 Production Involve Activation of MKK6-p38 and MKK7-SAPK/JNK Signaling Pathways Sensitive to Cyclosporin A

1998 • 209 citations

Evidence for the Involvement of Sulfhydryl Oxidation in the Regulation of Fat Cell Hexose Transport by Insulin

1974 • 209 citations

The PAR1 (YAP1/SNQ3) gene of Saccharomyces cerevisiae, ac-jun homologue, is involved in oxygen metabolism

1992 • 209 citations

Mechanism of Free Radical Production in Exhaustive Exercise in Humans and Rats; Role of Xanthine Oxidase and Protection by Allopurinol

2000 • 207 citations

Fyn and JAK2 Mediate Ras Activation by Reactive Oxygen Species

1999 • 206 citations

Binuclear [2Fe-2S] Clusters in the Escherichia coli SoxR Protein and Role of the Metal Centers in Transcription

1995 • 206 citations

Immunocytochemical Characterization of the Expression of Inducible and Constitutive Isoforms of Nitric Oxide Synthase in Demyelinating Multiple Sclerosis Lesions

1997 • 205 citations

Xanthine oxidase is involved in exercise-induced oxidative stress in chronic obstructive pulmonary disease

1999 • 203 citations

Redox regulation of a src family protein tyrosine kinase p56lck in T cells.

1993 • 201 citations

Impact of HIV-1 infection and highly active antiretroviral therapy on the kinetics of CD4 ⁺ and CD8 ⁺ T cell turnover in HIV-infected patients

2000 • 199 citations

Atherosclerosis, autoimmunity, and vascular‐associated lymphoid tissue

1997 • 199 citations

Nitric oxide inhibits neuronal nitric oxide synthase by interacting with the heme prosthetic group. Role of tetrahydrobiopterin in modulating the inhibitory action of nitric oxide.

1994 • 199 citations

Neuronal Nitric Oxide Synthase Self-inactivates by Forming a Ferrous-Nitrosyl Complex during Aerobic Catalysis

1995 • 195 citations

A review of cancer cachexia and abnormal glucose metabolism in humans with cancer.

1992 • 195 citations

Changes in the glutathione status of plasma, liver and muscle following exhaustive exercise in rats

1985 • 193 citations

Lipid Peroxidation Is Involved in the Activation of NF-κB by Tumor Necrosis Factor but Not Interleukin-1 in the Human Endothelial Cell Line ECV304

1997 • 190 citations

Vitamin E Decreases the Occurrence of Malformations in the Offspring of Diabetic Rats

1997 • 188 citations

Transcription factor AP-1 activity is required for initiation of DNA synthesis and is lost during cellular aging.

1992 • 187 citations

Altered inflammatory responses in leukotriene-deficient mice.

1994 • 186 citations

Anti-oxidant treatment prevents the development of peripheral nerve dysfunction in streptozotocin-diabetic rats

1993 • 185 citations

Intracellular Signaling by 14-hydroxy-4,14- Retro -Retinol

1991 • 184 citations

Macrophages regulate intracellular glutathione levels of lymphocytes. Evidence for an immunoregulatory role of cysteine

1990 • 184 citations

Oxidative damage to mitochondrial DNA and glutathione oxidation in apoptosis: studiesin vivoandin vitro

1999 • 180 citations

Role of nitric oxide in mediation of macrophage cytotoxicity and apoptosis.

1998 • 180 citations

Activation of the Lck tyrosine protein kinase by hydrogen peroxide requires the phosphorylation of Tyr-394.

1995 • 179 citations

Regulation of heme oxygenase-1 gene expression in vascular smooth muscle cells by nitric oxide

1997 • 175 citations

Trisomie 21 et superoxyde dismutase-1 (IPO-A)

1976 • 175 citations

Oxidative stress after human exercise: effect of N-acetylcysteine supplementation

1994 • 174 citations

Protein tyrosine phosphatases take off

1995 • 174 citations

The RxxRxRxxC motif conserved in all Rel/kappa B proteins is essential for the DNA-binding activity and redox regulation of the v-Rel oncoprotein.

1992 • 174 citations

Insulin Signaling Is Inhibited by Micromolar Concentrations of H2O2

1999 • 174 citations

Redox Regulation of Signal Transduction in Cardiac and Smooth Muscle

1999 • 173 citations

The role of oxidative stress in neuropathy and other diabetic complications

1995 • 171 citations

Response of a primary human fibroblast cell line to H2O2: senescence-like growth arrest or apoptosis?

1997 • 171 citations

Evidence for the role of an altered redox state in hyporesponsiveness of synovial T cells in rheumatoid arthritis.

1997 • 170 citations

Oxygen sensing and signaling: impact on the regulation of physiologically important genes

1999 • 170 citations

Role of [Ca ²⁺ ] _i in induction of c‐ fos , c‐ jun and c‐ myc mRNA in rat PTE after oxidative stress

1992 • 168 citations

p72syk tyrosine kinase is activated by oxidizing conditions that induce lymphocyte tyrosine phosphorylation and Ca2+ signals

1993 • 167 citations

The 55-kDa Tumor Necrosis Factor Receptor Induces Clustering of Mitochondria through Its Membrane-proximal Region

1998 • 167 citations

Role of cysteine and glutathione in HIV infection and other diseases associated with muscle wasting and immunological dysfunction

1997 • 166 citations

The expression of NADPH oxidase components in human glomerular mesangial cells

1995 • 166 citations

Inactivation of Protein-tyrosine Phosphatases as Mechanism of UV-induced Signal Transduction

1999 • 166 citations

Accelerated Telomere Shortening in Fibroblasts After Extended Periods of Confluency

1998 • 165 citations

Nitric Oxide Controls Src Kinase Activity through a Sulfhydryl Group Modification-mediated Tyr-527-independent and Tyr-416-linked Mechanism

1999 • 165 citations

Reactive oxygen species rapidly increase endothelial ICAM-1 ability to bind neutrophils without detectable upregulation

1994 • 165 citations

Effect of hydrogen peroxide on calcium homeostasis in smooth muscle cells

1992 • 164 citations

Effect of electron transfer inhibitors on superoxide generation in the cytochrome bc₁ site of the mitochondrial respiratory chain

1983 • 164 citations

Specific interaction of the CD45 protein-tyrosine phosphatase with tyrosine-phosphorylated CD3 zeta chain.

1994 • 163 citations

Angiotensin II Induces Transactivation of Two Different Populations of the Platelet-derived Growth Factor β Receptor

2000 • 162 citations

Oxygen Free Radical Effects in Sciatic Nerve in Experimental Diabetes

1991 • 161 citations

Involvement of reactive oxygen intermediates in the induction of c-jun gene transcription by ionizing radiation

1992 • 161 citations

Enhancement of T Cell Receptor Signaling by a Mild Oxidative Shift in the Intracellular Thiol Pool

2000 • 160 citations

Involvement of oxidants and oxidant-generating enzyme(s) in tumour-necrosis-factor-α-mediated apoptosis: role for lipoxygenase pathway but not mitochondrial respiratory chain

1995 • 160 citations

Protein oxidation and degradation during cellular senescence of human BJ fibroblasts: part II—aging of nondividing cells

2000 • 160 citations

Redox regulation of signal transduction in mammalian cells

2000 • 159 citations

Cell type-specific role for reactive oxygen species in nuclear factor-kappaB activation by Interleukin-1

2000 • 158 citations

Extracellular production of singlet oxygen by stimulated macrophages quantified using 9,10-diphenylanthracene and perylene in a polystyrene film

1993 • 157 citations

Role of insulin receptor phosphorylation in the insulinomimetic effects of hydrogen peroxide.

1987 • 156 citations

Insulin-induced Activation of NADPH-dependent H2O2 Generation in Human Adipocyte Plasma Membranes Is Mediated by Gαi2

1997 • 156 citations

4-Hydroxy-2-Nonenal Pyrrole Adducts in Human Neurodegenerative Disease

1997 • 155 citations

Oxidative stress in skeletal muscle atrophied by immobiIization

1991 • 152 citations

Nitric Oxide–Induced Apoptosis in Human Leukemic Lines Requires Mitochondrial Lipid Degradation and Cytochrome C Release

1999 • 152 citations

Ultrastructural studies of young and old mouse neuromuscular junctions

1982 • 151 citations

ZAP-70 tyrosine kinase, CD45, and T cell receptor involvement in UV- and H2O2-induced T cell signal transduction.

1994 • 150 citations

New perspectives on the biochemistry of superoxide anion and the efficiency of superoxide dismutases

1990 • 149 citations

Activation of soluble guanylate cyclase from rat lung by incubation or by hydrogen peroxide.

1976 • 147 citations

Ras‐dependent and ‐independent regulation of reactive oxygen species by mitogenic growth factors and TGF‐β1

2000 • 147 citations

A Novel Promoter Sequence Is Involved in the Oxidative Stress-Induced Expression of the Adult T-Cell Leukemia-Derived Factor (ADF)/Human Thioredoxin (Trx) Gene

1996 • 145 citations

CD4 and CD8 T cells with high intracellular glutathione levels are selectively lost as the HIV infection progresses

1991 • 145 citations

Assessment of alanine, urea, and glucose interrelationships in normal subjects and in patients with sepsis with stable isotopic tracers.

1985 • 144 citations

The Role of Leukocyte and Endothelial Adhesion Molecules in Ischemia – Reperfusion Injury

1997 • 144 citations

Activation of the NF-κB transcription factor in a T-lymphocytic cell line by hypochlorous acid

1997 • 143 citations

Hydrogen peroxide activates agonist-sensitive Ca2+-flux pathways in canine venous endothelial cells

1994 • 142 citations

Endogenous Reactive Oxygen Intermediates Activate Tyrosine Kinases in Human Neutrophils

1996 • 142 citations

Vitamin E: a sensor and an information transducer of the cell oxidation state

1995 • 142 citations

Biochemie des oxidativen Stress

1986 • 142 citations

L-2-Oxothiazolidine-4-carboxylic acid reverses endothelial dysfunction in patients with coronary artery disease.

1998 • 141 citations

Selective enrichment and biochemical characterization of seven human skin fibroblasts cell types in vitro

1989 • 141 citations

Tumor necrosis factor mediates endotoxic effects in mice

1987 • 140 citations

Displacement of Linker for Activation of T Cells from the Plasma Membrane Due to Redox Balance Alterations Results in Hyporesponsiveness of Synovial Fluid T Lymphocytes in Rheumatoid Arthritis

2000 • 139 citations

Comparison of the Effects of Ozone on the Modification of Amino Acid Residues in Glutamine Synthetase and Bovine Serum Albumin

1996 • 137 citations

Dosage effects for superoxide dismutase-1 in nucleated cells aneuploid for chromosome 21.

1977 • 137 citations

Cu/Zn-superoxide dismutase and glutathione peroxidase during aging.

1995 • 137 citations

Apoptosis caused by oxidized LDL is manganese superoxide dismutase and p53 dependent

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The Metal-Insulator Transition in Correlated Disordered Systems

1996 • 136 citations

Inhibition of the Rac1 GTPase protects against nonlethal ischemia/reperfusion‐induced necrosis and apoptosisin vivo

2000 • 135 citations

Prospects for an ageing population

1985 • 135 citations

Translocation and enhancement of phosphotransferase activity of protein kinase C following exposure in mouse epidermal cells to oxidants.

1989 • 132 citations

Substrate Phosphorylation Catalyzed by the Insulin Receptor Tyrosine Kinase

1989 • 132 citations

Complexities of the Protein Kinase C Pathway

1991 • 131 citations

Retinoids are important cofactors in T cell activation.

1992 • 131 citations

Listeriosis in p47phox−/− and TRp55−/− Mice: Protection Despite Absence of ROI and Susceptibility Despite Presence of RNI

1997 • 130 citations

Nitrosyl Complexes of Iron-Sulfur Clusters

1988 • 129 citations

Cloning and characterization of rac-like cDNAs from Arabidopsis thaliana.

1997 • 128 citations

Mechanisms and meaning of cellular oxygen sensing in the organism

1994 • 128 citations

Oxy-radical induced mutagenesis of hotspot codons 248 and 249 of the human p53 gene.

1994 • 127 citations

Transcriptional Activation of the HO-1 Gene by Lipopolysaccharide Is Mediated by 5 ′ Distal Enhancers: Role of Reactive Oxygen Intermediates and AP-1

1998 • 127 citations

Exercise‐induced overexpression of key regulatory proteins involved in glucose uptake and metabolism in tetraplegic persons: molecular mechanism for improved glucose homeostasis

1998 • 126 citations

Expression, Characterization, and Crystallization of the Catalytic Core of the Human Insulin Receptor Protein-tyrosine Kinase Domain

1995 • 126 citations

In vivo kinetics of a redox-regulated transcriptional switch

1997 • 125 citations

Somatic mutation in the tumore suppressor gene in erosive rheumatoid arthritis synovium

1997 • 124 citations

Antigen-presenting Cells

2000 • 122 citations

Effects of H2O2 on protein tyrosine phosphatase activity in HER14 cells

1994 • 121 citations

Superoxide Formation and Macrophage Resistance to Nitric Oxide-mediated Apoptosis

1997 • 121 citations

Conformation-dependent phosphorylation of p53

1997 • 120 citations

Tissue components of weight loss in cancer patients. A new method of study and preliminary observations

1985 • 119 citations

Differential effects of superoxide, hydrogen peroxide, and hydroxyl radical on intracellular calcium in human endothelial cells

1995 • 118 citations

Cytosolic NADH/NAD + , free radicals, and vascular dysfunction in early diabetes mellitus

1997 • 117 citations

Improvement of immune functions in HIV infection by sulfur supplementation: Two randomized trials

2000 • 116 citations

Induction of ADF/TRX by oxidative stress in keratinocytes and lymphoid cells

1995 • 115 citations

Oxidative stress-inducible proteins in macrophages

1999 • 114 citations

Oxidative stress, mutant SOD1, and neurofilament pathology in transgenic mouse models of human motor neuron disease.

1997 • 113 citations

Longitudinal exposure of human T lymphocytes to weak oxidative stress suppresses transmembrane and nuclear signal transduction.

1994 • 113 citations

Retinol is essential for growth of activated human B cells.

1990 • 112 citations

Redox mechanism as alternative to ligand binding for receptor activation delivering disregulated cellular signals.

1994 • 112 citations

Metabolic Control May Influence the Increased Superoxide Generation in Diabetic Serum

1991 • 111 citations

Effect of glutathione depletion and oral N‐acetyl‐cysteine treatment on CD4 ⁺ and CD8 ⁺ cells

1994 • 110 citations

Influences of Age and Dietary Restriction on Gastrocnemius Electron Transport System Activities in Mice

1996 • 110 citations

The Glucose Metabolism of Patients with Malignant Disease and of Normal Subjects as Studied by Means of an Intravenous Glucose Tolerance Test12

1957 • 108 citations

Restoration of Prostacyclin/Thromboxane A2 Balance in the Diabetic Rat: Influence of Dietary Vitamin E

1982 • 108 citations

Differential induction of c-fos, c-jun, and apoptosis in lung epithelial cells exposed to ROS or RNS

1997 • 107 citations

No requirement of reactive oxygen intermediates in Fas‐mediated apoptosis

1994 • 107 citations

Induction of mitochondrial manganese superoxide dismutase in macrophages by oxidized LDL: its relevance in atherosclerosis of humans and heritable hyperlipidemic rabbits

1997 • 106 citations

Reperfusion injury, antioxidants and hemodynamics during orthotopic liver transplantation

1994 • 105 citations

A phorbol ester binding domain of protein kinase C gamma. Deletion analysis of the Cys2 domain defines a minimal 43-amino acid peptide.

1994 • 105 citations

Redox regulation and oxidant activation of heme oxygenase-1

1999 • 104 citations

Genetic evidence that Shp-2 tyrosine phosphatase is a signal enhancer of the epidermal growth factor receptor in mammals

1999 • 104 citations

Conditions allowing redox-cycling ubisemiquinone in mitochondria to establish a direct redox couple with molecular oxygen

1996 • 103 citations

Stimulation of Immediate Early Gene Expression in Striatal Neurons by Nitric Oxide

1995 • 103 citations

Regulation of purified soluble guanylate cyclase by porphyrins and metalloporphyrins: a unifying concept.

1984 • 102 citations

Overproduction and Physical Characterization of SoxR, a [2Fe-2S] Protein That Governs an Oxidative Response Regulon in Escherichia coli

1995 • 102 citations

Biochemistry of exercise VI

1986 • 101 citations

Influence of reduced glutathione infusion on glucose metabolism in patients with non—insulin-dependent diabetes mellitus

1998 • 99 citations

Singlet oxygen mediates the activation of JNK by UVA radiation in human skin fibroblasts

1997 • 99 citations

Glycogen synthase and phosphofructokinase protein and mRNA levels in skeletal muscle from insulin-resistant patients with non-insulin-dependent diabetes mellitus.

1993 • 98 citations

Role of hsp60 during Autoimmune and Bacterial Inflammation

1991 • 98 citations

Macrophages, synovial tissue and rheumatoid arthritis.

1993 • 97 citations

The Redox State as a Correlate of Senescence and Wasting and as a Target for Therapeutic Intervention

1998 • 97 citations

Role of oxygen in the zonation of carbohydrate metabolism and gene expression in liver

1997 • 96 citations

The functional expression of p47‐phox and p67‐phox may contribute to the generation of superoxide by an NADPH oxidase‐like system in human fibroblasts

1994 • 93 citations

Ischemic preconditioning attenuates apoptotic cell death associated with ischemia/reperfusion.

1998 • 91 citations

Abnormal Amino-Acid Concentrations in the Blood of Patients with Acquired Immunodeficiency Syndrome (AIDS) May Contribute to the Immunological Defect

1988 • 90 citations

ZAP-70-dependent and -independent Activation of Erk in Jurkat T Cells

1998 • 89 citations

LIPOFUSCIN ACCUMULATION AND AGEING OF FIBROBLASTS

1995 • 89 citations

Regulation of T-cell activation and T-cell growth factor (TCGF) production by hydrogen peroxide

1987 • 89 citations

Early superoxide dismutase-sensitive event promotes neoplastic transformation in mouse epidermal JB6 cells

1988 • 88 citations

Disturbed interaction of p21-rac with mutated p67-phox causes chronic granulomatous disease.

1996 • 87 citations

Enzymatic characteristics of the c-Raf-1 proteinkinase.

1994 • 87 citations

The Roles of Dopamine Oxidative Stress and Dopamine Receptor Signaling in Aging and Age-Related Neurodegeneration

2000 • 86 citations

N-Acetylcysteine protects against age-related decline of oxidative phosphorylation in liver mitochondria

1995 • 86 citations

Mice lacking reduced nicotinamide adenine dinucleotide phosphate oxidase activity show increased susceptibility to early infection with Listeria monocytogenes.

1997 • 86 citations

Hypoxic damage generates reactive oxygen species in isolated perfused rat liver

1988 • 86 citations

Retinoids as ligands and coactivators of protein kinase C alpha

2000 • 86 citations

Oxidative derangement in rat synaptosomes induced by hyperglycaemia: restorative effect of dehydroepiandrosterone treatment

2000 • 85 citations

Cardiac performance during reperfusion improved by pretreatment with oxygen free-radical scavengers

1986 • 85 citations

Phosphorylation of the insulin receptor kinase by phosphocreatine in combination with hydrogen peroxide: the structural basis of redox priming

1999 • 83 citations

Indications to an NADPH oxidase as a possible pO₂ sensor in the rat carotid body

1989 • 83 citations

The autoxidation of glyceraldehyde and other simple monosaccharides

1984 • 83 citations

Reactive Oxygen Species and Their Contribution to Pathology in Down Syndrome

1996 • 83 citations

Glucose and urea kinetics in patients with early and advanced gastrointestinal cancer: the response to glucose infusion, parenteral feeding, and surgical resection.

1987 • 83 citations

Down's syndrome: morphological remodelling and increased complexity in the neuromuscular junction of transgenic CuZn-superoxide dismutase mice

1991 • 81 citations

Regulation of mitogen-activated protein kinase cascade in adult rat heart preparations in vitro.

1994 • 80 citations

The Cysteine-Rich Regions of the Regulatory Domains of Raf and Protein Kinase C as Retinoid Receptors

2000 • 80 citations

Role of reactive oxygen intermediates in TCR-induced death of T cell blasts and hybridomas.

1996 • 80 citations

Cobalt chloride and desferrioxamine antagonize the inhibition of erythropoietin production by reactive oxygen species

1997 • 79 citations

Free radical activity following contraction-induced injury to the extensor digitorum longus muscles of rats

1999 • 77 citations

Telomerase expression prevents replicative senescence but does not fully reset mRNA expression patterns in Werner syndrome cell strains

2001 • 77 citations

Ultrastructural evidence of continued reorganization at the aging (11–26 months) rat soleus neuromuscular junction

1983 • 75 citations

Analysis of the pathways of nitric oxide utilization in mitochondria

2000 • 75 citations

Comparisons of ESR and HPLC methods for the detection of OH. radicals in ischemic/reperfused hearts

1993 • 74 citations

Biochemical determinants of adriamycin® toxicity in mouse liver, heart and intestine

1992 • 74 citations

Redox priming of the insulin receptor β‐chain associated with altered tyrosine kinase activity and insulin responsiveness in the absence of tyrosine autophosphorylation

1998 • 73 citations

Cytotoxicity of oxidized low‐density lipoprotein to mouse peritoneal macrophages: An ultrastructural study

1993 • 73 citations

Structural basis of protein kinase C activation by diacylglycerols and tumor promoters

1992 • 72 citations

Enhanced prostaglandin synthesis due to phospholipid breakdown in ischemic-reperfused myocardium†Control of its production by a phospholipase inhibitor of free radical scavengers

1986 • 72 citations

K+ and Ca2+ channel activity and cytosolic [Ca2+] in oxygen-sensing tissues

1999 • 71 citations

Thiol-Mediated Redox Regulation of Intestinal Lamina Propria T Lymphocytes

2000 • 70 citations

Distinct Effects of N-Acetylcysteine and Nitric Oxide on Angiotensin II-induced Epidermal Growth Factor Receptor Phosphorylation and Intracellular Ca2+ Levels

2000 • 70 citations

Cystine levels, cystine flux, and protein catabolism in cancer cachexia, HIV/SIV infection, and senescence

1997 • 69 citations

Rapid and Delayed p42/p44 Mitogen-Activated Protein Kinase Activation by Nitric Oxide: The Role of Cyclic GMP and Tyrosine Phosphatase Inhibition

1998 • 69 citations

Evidence of a novel redox-linked activation mechanism for the Src kinase which is independent of tyrosine 527-mediated regulation.

1996 • 69 citations

Cyclic guanosine 3′,5′-monophosphate-mediated neuroprotection by nitric oxide in dissociated cultures of rat dorsal root ganglion neurones

1997 • 68 citations

Protein synthesis rates in atrophied gastrocnemius muscles after limb immobilization

1981 • 67 citations

Effect of age on lymphocyte proliferation

1987 • 67 citations

Oxidative stress and aging inCaenorhabditis elegans

2000 • 67 citations

Roles for NAD(P)H oxidases and reactive oxygen species in vascular oxygen sensing mechanisms

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Effect of in vitro generation of oxygen free radicals on T cell function in young and old rats

1998 • 65 citations

Lipid Peroxidation and Superoxide Dismutase-1 and Glutathione Peroxidase Activities in Trisomy 16 Fetal Mice and Human Trisomy 21 Fibroblasts

1987 • 64 citations

Hydroxyl radical generation in skeletal muscle atrophied by immobilization

1994 • 64 citations

Endothelial-leukocyte adhesive interactions in inflammatory diseases.

1993 • 64 citations

Detection of Oxidative DNA Damage to Ischemic Reperfused Rat Hearts by 8-Hydroxydeoxyguanosine Formation

1998 • 64 citations

Metabolic disorder as early consequence of simian immunodeficiency virus infection in rhesus macaques

1991 • 64 citations

Regulation of ICAM‐1 and IL‐6 in Myocardial Ischemia: Effect of Reperfusion a

1994 • 63 citations

Changes in plasma amino acid concentrations in response to HIV-1 infection

1994 • 63 citations

The proximal promoter region of the human heme oxygenase gene contains elements involved in stimulation of transcriptional activity by a variety of agents including oxidants

1993 • 62 citations

The Oxidative Burst and Related Phenomena in Mouse Macrophages Elicited by Different Sterile Inflammatory Stimuli

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Nitric oxide stimulates stress‐activated protein kinases in glomerular endothelial and mesangial cells

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13,14-Dihydroxy-retinol, a New Bioactive Retinol Metabolite

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Psoralen photoactivation promotes morphological and functional changes in fibroblasts in vitro reminiscent of cellular senescence

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Cysteine-to-Alanine Replacements in the Escherichia Coli SoxR Protein and the Role of the [2Fe-2S] Centers in Transcriptional Activation

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Sublethal levels of oxidative stress stimulate transcriptional activation of c-jun and suppress IL-2 promoter activation in Jurkat T cells.

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N-Acetylcysteine suppression of the proliferative index in the colon of patients with previous adenomatous colonic polyps

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Long-Term in vitro Growth of Human T Cell Clones: Can Postmitotic ‘Senescent’ Cell Populations Be Defined?

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Antioxidant enzyme activities in heart and skeletal muscle of rats of different ages

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SUGAR TOLERANCE IN CANCER

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Exercise-enhanced activation of glycogen synthase in human skeletal muscle

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Amino Acid Analogs Activate NF-κB through Redox-dependent IκB-α Degradation by the Proteasome without Apparent IκB-α Phosphorylation

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Effects of Pro- and Antioxidative Compounds on Renal Production of Erythropoietin*

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Nitric oxide induces c-fos gene expression via cyclic AMP response element binding protein (CREB) phosphorylation in rat retinal pigment epithelium

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Evidence for in vitro senescence of T-lymphocytes cultured from normal human peripheral blood

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Hydroperoxide metabolism in rat liver

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Mechanisms of O2 Sensing in the Carotid Body in Comparison With Other O2-Sensing Cells

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Novel Mechanisms Involved in Superoxide Anion Radical-Triggered Ca²⁺Release from Cardiac Sarcoplasmic Reticulum Linked to Cyclic ADP-Ribose Stimulation

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Premature aging changes in neuromuscular junctions of transgenic mice with an extra human CuZnSOD gene: A model for tongue pathology in Down's syndrome

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Characterization of apoptotic macrophages in atheromatous tissue of humans and heritable hyperlipidemic rabbits

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Regulation of interleukin 2 production, interleukin 2 mRNA expression and intracellular glutathione levels in ex vivo derived T lymphocytes by lactate

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Massive Loss of Sulfur in HIV Infection

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Transient Overexpression of Catalase Does Not Inhibit TNF- or PMA-Induced NF-κB Activation

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Glutathione is a factor of resistance of Jurkat leukemia cells to nitric oxide-mediated apoptosis

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Functional biochemistry of the macrophage.

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Insulin action on glucose and branched-chain amino acid metabolism in cancer cachexia: differential effects of insulin.

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The permissive role of oxygen‐derived free radicals in the development of colonic cancer in the rat. A new theory for carcinogenesis

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Requirement of nitric oxide and calcium mobilization for the induction of apoptosis in adrenal vascular endothelial cells

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Glucose‐enriched medium enhances cell‐mediated low density lipoprotein peroxidation

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Superoxide and hydrogen peroxide induce CD18-mediated adhesion in the postischemic heart

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Molecular mechanism of blood monocyte adhesion to vascular endothelial cells.

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Reactions of glutathione with the catechol, the ortho-quinone and the semi-quinone free radical of etoposide Consequences for DNA inactivation

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Differential sensitivity of the insulin-receptor kinase to thiol and oxidizing agents in the absence and presence of insulin

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Oxidant—antioxidant imbalance in blood of children with juvenile rheumatoid arthritis

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Myofibers in tongues of Down's syndrome

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[13] Effect of reactive oxygen intermediates and antioxidants on proliferation and function of T lymphocytes

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Reactive oxygen species are critical for the growth and differentiation of medullary thyroid carcinoma cells.

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Toward a Biological Understanding of the Ageing Process

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Cell Adhesion Molecules in Rheumatoid Arthritis

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Study of causes underlying the low atherosclerotic response to dietary hypercholesterolemia in a selected strain of rabbits

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Effects of modulators of the production and degradation of hydrogen peroxide on erythropoietin synthesis

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Novel intracellular signaling function of prostaglandin H synthase-1 in NF-kappa B activation.

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Mechanism of joint destruction in rheumatoid arthritis.

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Local Potentiation of Bradykinin-Induced Vasodilation by Converting-Enzyme Inhibition in Isolated Coronary Arteries

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Early Metastasis of Human Solid Tumours: Expression of Cell Adhesion Molecules

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Pre- and posttranslational upregulation of muscle-specific glycogen synthase in athletes

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N-acetyl-cysteine in the therapy of HIV-positive patients

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Calmodulin and free oxygen radicals interaction with steady-state calcium accumulation and passive calcium permeability of cardiac sarcoplasmic reticulum.

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The effect of insulin on glucose and protein metabolism in the forearm of cancer patients

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Adhesion molecules in rheumatoid arthritis

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Expression of Oxidant Stress-Related Genes in Tumor Promotion of Mouse Epidermal Cells JB6

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Effects of tert-butyl hydroperoxide on promotable and non-promotable JB6 mouse epidermal cells

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Elevated concentrations of elements and abnormalities of neuromuscular junctions in tongue muscles of Down's syndrome

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Serotonergic Neuronal Properties in C-Cell Lines

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Analysis of the order of autophosphorylation of human insulin receptor tyrosines 1158, 1162 and 1163

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Current issues in reperfusion therapy

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Regulation of intracellular glutathione levels and lymphocyte functions by lactate

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Weight Loss in Cancer Patients

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Short Communication: Elevated Hepatic γ-Glutamylcysteine Synthetase Activity and Abnormal Sulfate Levels in Liver and Muscle Tissue May Explain Abnormal Cysteine and Glutathione Levels in SIV-Infected Rhesus Macaques

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Determination of cell-cell adhesion in response to oxidants and antioxidants

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A nonpeptidyl mimic of superoxide dismutase with therapeutic activity in rats

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Strategies to assess oxidative stress

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Glutathione Reverses the Inhibition of T Cell Responses by Superoptimal Numbers of "Nonprofessional" Antigen Presenting Cells

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Cell aging in vitro: A historical perspective

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Calmodulin participation in oxygen radical-induced cardiac sarcoplasmic reticulum calcium uptake reduction

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Effect of alterations of blood cholesterol levels on macrophages in the myocardium of New Zealand White rabbits

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Redox regulation of a src family protein tyrosine kinase p56[lck] in T cells

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Intracellular interactions under oxidative stress and aging: a hypothesis.

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Redox state as a correlate of senescence and wasting and as a target for therapeutic intervention

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The Rheumatoid Joint: Redox-Paradox?

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Regulation of Signal Transduction and Gene Expression by Reactive Nitrogen Species

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Aging: a non-regulated process

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Inhibition of the Insulin Receptor Kinase Phosphorylation by Nitric Oxide: Functional and Structural Aspects

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Redox Regulation of Cell Adhesion Processes

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Antioxidant Genes and Reactive Oxygen Species in Down's Syndrome

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