A proteasome inhibitor prevents activation of NF-kappa B and stabilizes a newly phosphorylated form of I kappa B-alpha that is still bound to NF-kappa B.

Function and Activation of NF-kappaB in the Immune System

1994 • 4,698 citations

Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1.

1991 • 3,819 citations

Inducibility of κ immunoglobulin enhancer-binding protein NF-κB by a posttranslational mechanism

1986 • 2,043 citations

Dithiocarbamates as potent inhibitors of nuclear factor kappa B activation in intact cells.

1992 • 1,524 citations

Nuclear Factor Kb: An Oxidative Stress-Responsive Transcription Factor of Eukaryotic Cells (A Review)

1992 • 1,421 citations

Okadaic acid: a new probe for the study of cellular regulation

1990 • 1,396 citations

Activation in vitro of NF-κB" by phosphorylation of its inhibitor IκB"

1990 • 1,202 citations

Activation of DNA-binding activity in an apparently cytoplasmic precursor of the NF-κB transcription factor

1988 • 1,200 citations

NF-κB Controls Expression of Inhibitor IκBα: Evidence for an Inducible Autoregulatory Pathway

1993 • 1,141 citations

Rapid proteolysis of IκB-α is necessary for activation of transcription factor NF-κB

1993 • 1,129 citations

Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of I kappa B alpha: a mechanism for NF-kappa B activation.

1993 • 1,047 citations

IMF-κB and Rel: Participants in a Multiform Transcriptional Regulatory System

1993 • 967 citations

Intracellular thiols regulate activation of nuclear factor kappa B and transcription of human immunodeficiency virus.

1990 • 960 citations

Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions. Evidence for the involvement of mitochondrial radical generation.

1992 • 949 citations

Ornithine decarboxylase is degraded by the 26S proteasome without ubiquitination

1992 • 780 citations

Distinct effects of thioredoxin and antioxidants onthe activation of transcription factors NF-kappa B and AP-1.

1994 • 694 citations

Signaling by the cytokine receptor superfamily: JAKs and STATs

1994 • 659 citations

NF-kappa B activation by ultraviolet light not dependent on a nuclear signal

1993 • 646 citations

Mutual regulation of the transcriptional activator NF-kappa B and its inhibitor, I kappa B-alpha.

1993 • 639 citations

Depletion of the mitochondrial electron transport abrogates the cytotoxic and gene-inductive effects of TNF.

1993 • 581 citations

The oncoprotein Bcl-3 directly transactivates through κB motifs via association with DNA-binding p50B homodimers

1993 • 506 citations

Polypeptide signalling to the nucleus through tyrosine phosphorylation of Jak and Stat proteins

1993 • 504 citations

A role for oxygen radicals as second messengers

1991 • 494 citations

The multicatalytic proteinase complex, a major extralysosomal proteolytic system

1990 • 464 citations

Purified human IκB can rapidly dissociate the complex of the NF-κB transcription factor with its cognate DNA

1990 • 445 citations

The inducible transcription factor NF-κB: structure-function relationship of its protein subunits

1993 • 429 citations

NF-κB and related proteins: Rel/dorsal homologies meet ankyrin-like repeats

1992 • 415 citations

In Vitro Activation and Nuclear Translocation of NF-κB Catalyzed by Cyclic AMP-Dependent Protein Kinase and Protein Kinase C

1989 • 389 citations

DNA binding of purified transcription factor NF-kappa B. Affinity, specificity, Zn2+ dependence, and differential half-site recognition.

1991 • 349 citations

Nuclear uptake control of NF-kappa B by MAD-3, an I kappa B protein present in the nucleus.

1993 • 330 citations

Lipopolysaccharide induces phosphorylation of MAD3 and activation of c-Rel and related NF-kappa B proteins in human monocytic THP-1 cells

1993 • 239 citations

zeta PKC induces phosphorylation and inactivation of I kappa B-alpha in vitro.

1994 • 231 citations

Cloning of the DNA-binding subunit of human nuclear factor kappa B: the level of its mRNA is strongly regulated by phorbol ester or tumor necrosis factor alpha.

1991 • 230 citations

Distinct NF-κB/Rel transcription factors are responsible for tissue-specific and inducible gene activation

1993 • 225 citations

Tumor Necrosis Factor and Interleukin-1 Lead to Phosphorylation and Loss of IκBα: a Mechanism for NF-κB Activation

1993 • 223 citations

A Dominant Negative Protein Kinase C ζ Subspecies Blocks NF-κ B Activation

1993 • 223 citations

The rel-associated pp40 protein prevents DNA binding of Rel and NF-kappa B: relationship with I kappa B beta and regulation by phosphorylation.

1991 • 210 citations

The glucocorticoid receptor

1991 • 208 citations

Kappa B site-dependent induction of gene expression by diverse inducers of nuclear factor kappa B requires Raf-1.

1993 • 189 citations

Autoregulation of the NF-kappa B transactivator RelA(p65) by multiple cytoplasmic inhibitors containing ankyrinmotifs.

1994 • 187 citations

The IκB proteins: members of a multifunctional family

1993 • 169 citations

A brain-specific transcription activator

1989 • 141 citations

Direct association of pp40/I kappa B beta with rel/NF-kappa B transcription factors: role of ankyrin repeats in the inhibition of DNA binding activity.

1992 • 140 citations

Pituitary multicatalytic proteinase complex. Specificity of components and aspects of proteolytic activity

1989 • 139 citations

Inhibition of Protein Kinase C ζ Subspecies Blocks the Activation of an NF-Kappa B-Like Activity in Xenopus laevis Oocytes

1993 • 131 citations

A methyl jasmonate-induced shift in the length of the 5′ untranslated region impairs translation of the plastid rbcL transcript in barley.

1993 • 129 citations

Qualitative changes in the subunit composition of kappa B-binding complexes during murine B-cell differentiation.

1994 • 125 citations

Proteins controlling the nuclear uptake of NF-κB, Rel and dorsal

1991 • 105 citations

Common structural constituents confer I kappa B activity to NF-kappa B p105 and I kappa B/MAD-3.

1993 • 92 citations

Differential induction of nuclear NF-kappa B by protein phosphatase inhibitors in primary and transformed human cells. Requirement for both oxidation and phosphorylation in nuclear translocation.

1993 • 89 citations

Comparison of the Effect of Calpain Inhibitors on Two Extralysosomal Proteinases: The Multicatalytic Proteinase Complex and m‐Calpain

1994 • 89 citations

Induction of nuclear factor-kappa B and the human immunodeficiency virus long terminal repeat by okadaic acid, a specific inhibitor of phosphatases 1 and 2A.

1990 • 67 citations

Bcl-3-mediated nuclear regulation of the NF-кB trans-activating factor

1994 • 58 citations

Expression of v-src in T cells correlates with nuclear expression of NF-kappa B.

1994 • 34 citations