Tumour necrosis factor-α induces superoxide anion generation in mitochondria of L929 cells

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1983 • 52,849 citations

Hydroperoxide metabolism in mammalian organs.

1979 • 5,821 citations

An endotoxin-induced serum factor that causes necrosis of tumors.

1975 • 4,522 citations

Normal oxidative damage to mitochondrial and nuclear DNA is extensive.

1988 • 1,709 citations

Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions. Evidence for the involvement of mitochondrial radical generation.

1992 • 949 citations

Induction of Manganous Superoxide Dismutase by Tumor Necrosis Factor: Possible Protective Mechanism

1988 • 933 citations

Manganous superoxide dismutase is essential for cellular resistance to cytotoxicity of tumor necrosis factor

1989 • 821 citations

The oxidative inactivation of mitochondrial electron transport chain components and ATPase.

1990 • 718 citations

Human fibroblasts release reactive oxygen species in response to interleukin-1 or tumour necrosis factor-α

1989 • 660 citations

Sites of inhibition of mitochondrial electron transport in macrophage-injured neoplastic cells.

1982 • 349 citations

Oxidative stress in mitochondria: Its relationship to cellular Ca2+ homeostasis, cell death, proliferation, and differentiation

1991 • 307 citations

NADH- and NADPH-dependent formation of superoxide anions by bovine heart submitochondrial particles and NADH–ubiquinone reductase preparation

1979 • 293 citations

Ca2+ transport by mammalian mitochondria and its role in hormone action

1985 • 242 citations

Tumour cell killing by tumour necrosis factor: inhibition by anaerobic conditions, free-radical scavengers and inhibitors of arachidonate metabolism.

1987 • 206 citations

Preparations of lymphotoxin induce resistance to their own cytotoxic effect.

1984 • 168 citations

Inhibition of target cell mitochondrial electron transfer by tumor necrosis factor

1989 • 148 citations

Formation of Ion-Permeable Channels by Tumor Necrosis Factor-α

1992 • 143 citations

Mitochondrial regulation of superoxide by Ca2+: An alternate mechanism for the cardiotoxicity of doxorubicin

1991 • 133 citations

Tumor necrosis factor-mediated cytotoxicity involves ADP-ribosylation.

1988 • 113 citations

Superoxide generation by the respiratory chain of tumor mitochondria

1987 • 100 citations

Target cell DNA fragmentation is mediated by lymphotoxin and tumor necrosis factor.

1987 • 94 citations

Control of activity states of heart mitochondrial ATPase. Role of the proton-motive force and Ca2+

1980 • 49 citations

Mobilization of mitochondrial Ca2+ by hydroperoxy-eicosatetraenoic acid

1987 • 43 citations

The preparative isolation of mitochondria from Chinese hamster ovary cells

1987 • 41 citations

Evidence for superoxide dismutase and catalase in mollicutes and release of reactive oxygen species

1990 • 36 citations

A chemiluminescent assay for mycoplasmas in cell cultures

1985 • 13 citations