Modulation of Protein Kinase Activity and Gene Expression by Reactive Oxygen Species and Their Role in Vascular Physiology and Pathophysiology

NAD(P)H Oxidase

2000 • 2,902 citations

Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells.

1994 • 2,753 citations

Requirement for Generation of H ₂ O ₂ for Platelet-Derived Growth Factor Signal Transduction

1995 • 2,505 citations

Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques.

1994 • 2,497 citations

Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. Contribution to alterations of vasomotor tone.

1996 • 2,456 citations

Hypertension : pathophysiology, diagnosis, and management

1995 • 1,895 citations

Hypercholesterolemia increases endothelial superoxide anion production.

1993 • 1,799 citations

Nitric oxide decreases cytokine-induced endothelial activation. Nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines.

1995 • 1,762 citations

A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins

1994 • 1,684 citations

Mitogenic Signaling Mediated by Oxidants in Ras-Transformed Fibroblasts

1997 • 1,582 citations

Cell transformation by the superoxide-generating oxidase Mox1

1999 • 1,457 citations

Activation of Hypoxia-inducible Transcription Factor Depends Primarily upon Redox-sensitive Stabilization of Its α Subunit

1996 • 1,172 citations

Reactive oxygen species produced by macrophage-derived foam cells regulate the activity of vascular matrix metalloproteinases in vitro. Implications for atherosclerotic plaque stability.

1996 • 1,132 citations

REGULATION OF GENE EXPRESSION BY REACTIVE OXYGEN

1999 • 1,102 citations

Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation

1998 • 1,101 citations

Vascular cell adhesion molecule-1 (VCAM-1) gene transcription and expression are regulated through an antioxidant-sensitive mechanism in human vascular endothelial cells.

1993 • 1,079 citations

Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of hsp27

1994 • 866 citations

AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1

1997 • 836 citations

Role of Superoxide in Angiotensin II–Induced but Not Catecholamine-Induced Hypertension

1997 • 831 citations

Thiordoxin regulates the DNA binding activity of NF-χB by reduction of a disulphid bond involving cysteine 62

1992 • 825 citations

Identification of Renox, an NAD(P)H oxidase in kidney

2000 • 824 citations

Activation of the Receptor for Advanced Glycation End Products Triggers a p21 -dependent Mitogen-activated Protein Kinase Pathway Regulated by Oxidant Stress

1997 • 803 citations

p22 Is a Critical Component of the Superoxide-generating NADH/NADPH Oxidase System and Regulates Angiotensin IIinduced Hypertrophy in Vascular Smooth Muscle Cells

1996 • 768 citations

Human fibroblasts release reactive oxygen species in response to interleukin-1 or tumour necrosis factor-α

1989 • 660 citations

p38 Mitogen-activated Protein Kinase Is a Critical Component of the Redox-sensitive Signaling Pathways Activated by Angiotensin II

1998 • 657 citations

Cytokine-stimulated human vascular smooth muscle cells synthesize a complement of enzymes required for extracellular matrix digestion.

1994 • 644 citations

Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase‐1 and p70 S6 kinase

1996 • 631 citations

Role of NADH/NADPH Oxidase–Derived H ₂ O ₂ in Angiotensin II–Induced Vascular Hypertrophy

1998 • 616 citations

Oscillatory and Steady Laminar Shear Stress Differentially Affect Human Endothelial Redox State

1998 • 607 citations

A gp91phox Containing NADPH Oxidase Selectively Expressed in Endothelial Cells Is a Major Source of Oxygen Radical Generation in the Arterial Wall

2000 • 596 citations

Oxidative Stress-Induced Actin Reorganization Mediated by the p38 Mitogen-Activated Protein Kinase/Heat Shock Protein 27 Pathway in Vascular Endothelial Cells

1997 • 569 citations

Calcium-dependent Epidermal Growth Factor Receptor Transactivation Mediates the Angiotensin II-induced Mitogen-activated Protein Kinase Activation in Vascular Smooth Muscle Cells

1998 • 569 citations

Activation of the JAK-STAT pathway by reactive oxygen species

1998 • 566 citations

Reactive Oxygen Species Mediate the Activation of Akt/Protein Kinase B by Angiotensin II in Vascular Smooth Muscle Cells

1999 • 563 citations

p22phox mRNA Expression and NADPH Oxidase Activity Are Increased in Aortas From Hypertensive Rats

1997 • 555 citations

NADH oxidoreductase is a major source of superoxide anion in bovine coronary artery endothelium

1994 • 546 citations

Nitric oxide regulates vascular cell adhesion molecule 1 gene expression and redox-sensitive transcriptional events in human vascular endothelial cells.

1996 • 513 citations

Inhibitory Effects of Antioxidants on Neonatal Rat Cardiac Myocyte Hypertrophy Induced by Tumor Necrosis Factor-α and Angiotensin II

1998 • 509 citations

Akt Signaling--Linking Membrane Events to Life and Death Decisions

1997 • 504 citations

Identification of a Potential Role for the Adventitia in Vascular Lesion Formation After Balloon Overstretch Injury of Porcine Coronary Arteries

1996 • 502 citations

A Molecular Redox Switch on p21

1997 • 488 citations

Localization of a constitutively active, phagocyte-like NADPH oxidase in rabbit aortic adventitia: Enhancement by angiotensin II

1997 • 463 citations

Epidermal Growth Factor Receptor-dependent Akt Activation by Oxidative Stress Enhances Cell Survival

2000 • 455 citations

Big Mitogen-activated Protein Kinase 1 (BMK1) Is a Redox-sensitive Kinase

1996 • 445 citations

Purification of a Novel Flavoprotein Involved in the Thyroid NADPH Oxidase

1999 • 445 citations

Expression of phagocyte NADPH oxidase components in human endothelial cells

1996 • 432 citations

Differential Activation of Mitogen-Activated Protein Kinases by H ₂ O ₂ and O ₂ ⁻ in Vascular Smooth Muscle Cells

1995 • 416 citations

p21 as a Common Signaling Target of Reactive Free Radicals and Cellular Redox Stress

1995 • 409 citations

Cytokine-stimulated human vascular smooth muscle cells synthesize a complement of enzymes required for extracellular matrix digestion.

1994 • 408 citations

Chronic treatment with polyethylene-glycolated superoxide dismutase partially restores endothelium-dependent vascular relaxations in cholesterol-fed rabbits.

1991 • 403 citations

Angiotensin II Induces Monocyte Chemoattractant Protein-1 Gene Expression in Rat Vascular Smooth Muscle Cells

1998 • 388 citations

Angiotensin II Induces Vascular Cell Adhesion Molecule-1 Expression In Rat Vasculature

1999 • 376 citations

Intracellular Reactive Oxygen Species Mediate the Linkage of Na+/K+-ATPase to Hypertrophy and Its Marker Genes in Cardiac Myocytes

1999 • 334 citations

Stimulation of a Vascular Smooth Muscle Cell NAD(P)H Oxidase by Thrombin

1999 • 332 citations

Tumour necrosis factor α activates a p22phox-based NADH oxidase in vascular smooth muscle

1998 • 313 citations

SAPK2/p38-dependent F-Actin Reorganization Regulates Early Membrane Blebbing during Stress-induced Apoptosis

1998 • 303 citations

Angiotensin II-induced superoxide anion generation in human vascular endothelial cells Role of membrane-bound NADH-/NADPH-oxidases

1999 • 300 citations

Epidermal Growth Factor Receptor Transactivation by Angiotensin II Requires Reactive Oxygen Species in Vascular Smooth Muscle Cells

2001 • 285 citations

Involvement of the Transcription Factor NF-κB in Tubular Morphogenesis of Human Microvascular Endothelial Cells by Oxidative Stress

1996 • 278 citations

Vascular Superoxide Production and Vasomotor Function in Hypertension Induced by Deoxycorticosterone Acetate–Salt

2000 • 277 citations

Oxygen radicals as second messengers for expression of the monocyte chemoattractant protein, JE/MCP-1, and the monocyte colony-stimulating factor, CSF-1, in response to tumor necrosis factor-alpha and immunoglobulin G. Evidence for involvement of reduced nicotinamide adenine dinucleotide phosphate (NADPH)-dependent oxidase.

1993 • 275 citations

Activation of protein kinase B (Akt/RAC‐protein kinase) by cellular stress and its association with heat shock protein Hsp27

1997 • 270 citations

c-Src Is Required for Oxidative Stress-mediated Activation of Big Mitogen-activated Protein Kinase 1 (BMK1)

1997 • 270 citations

The activation of protein kinase B by H2O2 or heat shock is mediated by phosphoinositide 3-kinase and not by mitogen-activated protein kinase-activated protein kinase-2

1998 • 265 citations

Src and Cas Mediate JNK Activation but Not ERK1/2 and p38 Kinases by Reactive Oxygen Species

2000 • 257 citations

Platelet-Derived Growth Factor–Stimulated Superoxide Anion Production Modulates Activation of Transcription Factor NF-κB and Expression of Monocyte Chemoattractant Protein 1 in Human Aortic Smooth Muscle Cells

1997 • 257 citations

Expression of heme oxygenase-1 in atherosclerotic lesions.

1998 • 256 citations

Inhibition of Endothelial Vascular Cell Adhesion Molecule-1 Expression by Nitric Oxide Involves the Induction and Nuclear Translocation of IκBα

1997 • 250 citations

Increased NAD(P)H oxidase-mediated superoxide production in renovascular hypertension: Evidence for an involvement of protein kinase C

1999 • 249 citations

Redox signaling and gene control in the Escherichia coli soxRS oxidative stress regulon — a review

1996 • 239 citations

Hydrogen peroxide induces complex formation of SHC-Grb2-SOS with receptor tyrosine kinase and activates Ras and extracellular signal-regulated protein kinases group of mitogen-activated protein kinases.

1996 • 238 citations

Differential regulation of endothelial cell adhesion molecule expression by nitric oxide donors and antioxidants

1998 • 233 citations

Angiotensin II Induces p67 ^phox mRNA Expression and NADPH Oxidase Superoxide Generation in Rabbit Aortic Adventitial Fibroblasts

1998 • 228 citations

Monocyte Chemoattractant Protein-1 Expression in Aortic Tissues of Hypertensive Rats

1997 • 220 citations

Upregulation of vascular endothelial growth factor by H2O2 in rat heart endothelial cells

1998 • 218 citations

Differential Activation of Mitogen-Activated Protein Kinases in Smooth Muscle Cells by Angiotensin II

2000 • 218 citations

Overexpression of Human Catalase Inhibits Proliferation and Promotes Apoptosis in Vascular Smooth Muscle Cells

1999 • 214 citations

Activation of endothelial cell phospholipase D by hydrogen peroxide and fatty acid hydroperoxide.

1993 • 213 citations

Fyn and JAK2 Mediate Ras Activation by Reactive Oxygen Species

1999 • 206 citations

Dietary probucol preserves endothelial function in cholesterol-fed rabbits by limiting vascular oxidative stress and superoxide generation.

1995 • 202 citations

Ang II–Stimulated Superoxide Production Is Mediated via Phospholipase D in Human Vascular Smooth Muscle Cells

1999 • 202 citations

Angiotensin II Type 1 Receptor–Induced Extracellular Signal–Regulated Protein Kinase Activation Is Mediated by Ca ²⁺ /Calmodulin-Dependent Transactivation of Epidermal Growth Factor Receptor

1998 • 196 citations

Modulation of Extracellular Superoxide Dismutase Expression by Angiotensin II and Hypertension

1999 • 196 citations

Determinants of Vascular Smooth Muscle Cell Apoptosis After Balloon Angioplasty Injury

1999 • 188 citations

Expression of a functional neutrophil-type NADPH oxidase in cultured rat coronary microvascular endothelial cells

1998 • 188 citations

Molecular adaptation of vascular endothelial cells to oxidative stress

1993 • 182 citations

Stimulation of multiple mitogen-activated protein kinase sub-families by oxidative stress and phosphorylation of the small heat shock protein, HSP25/27, in neonatal ventricular myocytes

1998 • 182 citations

A Redox-triggered Ras-Effector Interaction

1998 • 182 citations

Nitric Oxide Inhibits Macrophage-Colony Stimulating Factor Gene Transcription in Vascular Endothelial Cells

1995 • 180 citations

Cyclic strain induces an oxidative stress in endothelial cells

1997 • 179 citations

Electroporation of pp60c− Antibodies Inhibits the Angiotensin II Activation of Phospholipase C-γ1 in Rat Aortic Smooth Muscle Cells

1995 • 175 citations

Angiotensin II Induces Transactivation of Two Different Populations of the Platelet-derived Growth Factor β Receptor

2000 • 162 citations

Agonist-stimulated cytoskeletal reorganization and signal transduction at focal adhesions in vascular smooth muscle cells require c-Src

1999 • 161 citations

N-Acetyl-Cysteine Decreases the Matrix-Degrading Capacity of Macrophage-Derived Foam Cells

1998 • 160 citations

Induction of Vascular Endothelial Growth Factor in Balloon-Injured Baboon Arteries

1997 • 158 citations

Vitamins C and E Inhibit O ₂ ⁻ Production in the Pig Coronary Artery

1997 • 151 citations

Shear-induced tyrosine phosphorylation in endothelial cells requires Rac1-dependent production of ROS

1999 • 150 citations

Linoleic acid and its metabolites, hydroperoxyoctadecadienoic acids, stimulate c-Fos, c-Jun, and c-Myc mRNA expression, mitogen-activated protein kinase activation, and growth in rat aortic smooth muscle cells.

1995 • 143 citations

Elevation of Manganese Superoxide Dismutase Gene Expression by Thioredoxin

1997 • 143 citations

Combination of Vitamins C and E Alters the Response to Coronary Balloon Injury in the Pig

1995 • 142 citations

Antioxidants Inhibit Interleukin-1-induced Cyclooxygenase and Nitric-oxide Synthase Expression in Rat Mesangial Cells

1996 • 130 citations

Role of reactive oxygen species in the signalling cascade of cyclosporine A‐mediated up‐regulation of eNOS in vascular endothelial cells

1998 • 126 citations

Inactivation of a redox-sensitive protein phosphatase during the early events of tumor necrosis factor/interleukin-1 signal transduction.

1993 • 125 citations

Modulation of Ras/Raf/Extracellular Signal–Regulated Kinase Pathway by Reactive Oxygen Species Is Involved in Cyclic Strain–Induced Early Growth Response-1 Gene Expression in Endothelial Cells

1999 • 123 citations

Oxidant-sensitive and phosphorylation-dependent activation of NF-kappa B and AP-1 in endothelial cells

1995 • 113 citations

Cytochrome b-558 α-subunit cloning and expression in rat aortic smooth muscle cells

1995 • 110 citations

Lactosylceramide Mediates Tumor Necrosis Factor-α-induced Intercellular Adhesion Molecule-1 (ICAM-1) Expression and the Adhesion of Neutrophil in Human Umbilical Vein Endothelial Cells

1998 • 107 citations

Selective Induction of Heparin-binding Epidermal Growth Factor-like Growth Factor by Methylglyoxal and 3-Deoxyglucosone in Rat Aortic Smooth Muscle Cells

1997 • 105 citations

The involvement of reactive oxygen species and arachidonic acid in α₁‐adrenoceptor‐induced smooth muscle cell proliferation and migration

1997 • 101 citations

Role for NADPH/NADH Oxidase in the Modulation of Vascular Tone^a

1999 • 99 citations

Hydrogen Peroxide Stimulates Extracellular Signal-regulated Protein Kinases in Pulmonary Arterial Smooth Muscle Cells

1998 • 96 citations

Transcriptional regulation of the heme oxygenase 1 gene by pyrrolidine dithiocarbamate

1998 • 96 citations

Convergence of Redox-Sensitive and Mitogen-Activated Protein Kinase Signaling Pathways in Tumor Necrosis Factor-α–Mediated Monocyte Chemoattractant Protein-1 Induction in Vascular Smooth Muscle Cells

2000 • 86 citations

Coronary Microvascular Endothelial Cell Redox State in Left Ventricular Hypertrophy

2000 • 83 citations

Arachidonic Acid Metabolites Mediate Angiotensin II-Induced NADH/NADPH Oxidase Activity and Hypertrophy in Vascular Smooth Muscle Cells

1999 • 80 citations

Hydrogen peroxide-mediated transcriptional induction of macrophage colony-stimulating factor by TGF-beta1.

1997 • 78 citations

Regulation of manganese superoxide dismutase: IL-1 and TNF induction in pulmonary artery and microvascular endothelial cells

1992 • 74 citations

Endothelial function as an end-point in interventional trials: concepts, methods and current data

1996 • 73 citations

Modulation of glutathione peroxidase activity in human vascular endothelial cells by fatty acids and the cytokine interleukin-1 β

1996 • 72 citations

Distinct Effects of N-Acetylcysteine and Nitric Oxide on Angiotensin II-induced Epidermal Growth Factor Receptor Phosphorylation and Intracellular Ca2+ Levels

2000 • 70 citations

PYK2/CAKβ Represents a Redox-Sensitive Tyrosine Kinase in Vascular Smooth Muscle Cells

2000 • 53 citations

Arachidonic acid induces the activation of the stress‐activated protein kinase, membrane ruffling and H₂O₂ production via a small GTPase Rac1

1999 • 52 citations

Ambient but not incremental oxidant generation effects intercellular adhesion molecule 1 induction by tumour necrosis factor α in endothelium

1998 • 51 citations

Expression of bovine and mouse endothelial cell antioxidant enzymes following TNF-α exposure

1990 • 51 citations

Transcriptional Activation of Scavenger Receptor Expression in Human Smooth Muscle Cells Requires AP-1/c-Jun and C/EBPβ

1998 • 47 citations

Vascular Thrombin Receptor Regulation in Hypertensive Rats

1997 • 46 citations

The Y-box Motif Mediates Redox-dependent Transcriptional Activation in Mouse Cells

1995 • 45 citations

Effect of NADPH oxidase inhibition on endothelial cell ELAM-1 mRNA expression

1992 • 43 citations

The Angiotensin II–Dependent Association of Jak2 and c-Src Requires the N-Terminus of Jak2 and the SH2 Domain of c-Src

1999 • 40 citations

The Requirement of both Intracellular Reactive Oxygen Species and Intracellular Calcium Elevation for the Induction of Heparin-Binding EGF-like Growth Factor in Vascular Endothelial Cells and Smooth Muscle Cells

1999 • 39 citations

Oxidative injury of coronary venular endothelial cells depletes intracellular glutathione and induces HSP 70 mRNA

1995 • 25 citations

Regulation of the Superoxide Releasing System in Human Fibroblasts

1996 • 10 citations