Lipid Peroxidation Is Involved in the Activation of NF-κB by Tumor Necrosis Factor but Not Interleukin-1 in the Human Endothelial Cell Line ECV304

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1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

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Function and Activation of NF-kappaB in the Immune System

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1990 • 4,022 citations

Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1.

1991 • 3,819 citations

NF-κB: Ten Years After

1996 • 3,008 citations

TRADD–TRAF2 and TRADD–FADD Interactions Define Two Distinct TNF Receptor 1 Signal Transduction Pathways

1996 • 1,976 citations

Transcriptional regulation of endothelial cell adhesion molecules: NF‐κB and cytokine‐inducible enhancers

1995 • 1,715 citations

Tumor necrosis factor alpha and interleukin 1 stimulate the human immunodeficiency virus enhancer by activation of the nuclear factor kappa B.

1989 • 1,660 citations

Dithiocarbamates as potent inhibitors of nuclear factor kappa B activation in intact cells.

1992 • 1,524 citations

H2O2 and antioxidants have opposite effects on activation of NF-kappa B and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor.

1993 • 1,330 citations

MAP3K-related kinase involved in NF-KB induction by TNF, CD95 and IL-1

1997 • 1,294 citations

TRAF6 is a signal transducer for interleukin-1

1996 • 1,287 citations

Vascular cell adhesion molecule-1 (VCAM-1) gene transcription and expression are regulated through an antioxidant-sensitive mechanism in human vascular endothelial cells.

1993 • 1,079 citations

Site-Specific Phosphorylation of IκBα by a Novel Ubiquitination-Dependent Protein Kinase Activity

1996 • 960 citations

Activated transcription factor nuclear factor-kappa B is present in the atherosclerotic lesion.

1996 • 795 citations

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1993 • 541 citations

Endothelial nuclear factor-kappa B and the initiation of the atherosclerotic lesion.

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The roles of hydrogen peroxide and superoxide as messengers in the activation of transcription factor NF-κB

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[33] Overview of methods used for detecting lipid peroxidation

1984 • 450 citations

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1990 • 428 citations

Biologically active metal-independent superoxide dismutase mimics

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1984 • 412 citations

Antioxidants inhibit monocyte adhesion by suppressing nuclear factor-kappa B mobilization and induction of vascular cell adhesion molecule-1 in endothelial cells stimulated to generate radicals.

1994 • 349 citations

IL-2 gene expression and NF-kappa B activation through CD28 requires reactive oxygen production by 5-lipoxygenase.

1995 • 304 citations

Genetic control of inflammatory gene induction and NF-kappa B-like transcription factor activation in response to an atherogenic diet in mice.

1993 • 291 citations

Dithiocarbamates Induce Apoptosis in Thymocytes by Raising the Intracellular Level of Redox-active Copper

1995 • 280 citations

Reactive oxygen intermediates activate NF-kappa B in a tyrosine kinase- dependent mechanism and in combination with vanadate activate the p56lck and p59fyn tyrosine kinases in human lymphocytes

1993 • 260 citations

Inhibition of HIV-1 replication and NF-x B activity by cysteine and cysteine derivatives

1991 • 256 citations

Redox status of cells influences constitutive or induced NF-kappa B translocation and HIV long terminal repeat activity in human T and monocytic cell lines.

1992 • 242 citations

Genetic evidence for a common pathway mediating oxidative stress, inflammatory gene induction, and aortic fatty streak formation in mice.

1994 • 228 citations

Effects of oxidants and antioxidants on nuclear factor ϰB activation in three different cell lines: evidence against a universal hypothesis involving oxygen radicals

1995 • 206 citations

Effect of Inorganic Phosphate Concentration on the Nature of Inner Mitochondrial Membrane Alterations Mediated by Ca2+ Ions

1996 • 177 citations

Apoptosis and altered redox state induced by caffeic acid phenethyl ester (CAPE) in transformed rat fibroblast cells.

1995 • 175 citations

Inhibition of Lipid Peroxidation by Spin Labels

1989 • 173 citations

Modulation of transcription factor NFχB activity by intracellular glutathione levels and by variations of the extracellular cysteine supply

1995 • 168 citations

Involvement of oxidants and oxidant-generating enzyme(s) in tumour-necrosis-factor-α-mediated apoptosis: role for lipoxygenase pathway but not mitochondrial respiratory chain

1995 • 160 citations

Signal transduction for nuclear factor-kappa B activation. Proposed location of antioxidant-inhibitable step.

1994 • 158 citations

A semi-automated micro-assay for H2O2 release by human blood monocytes and mouse peritoneal macrophages

1985 • 152 citations

Activation of the NF-κB transcription factor in a T-lymphocytic cell line by hypochlorous acid

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Endothelial activation by hydrogen peroxide. Selective increases of intercellular adhesion molecule-1 and major histocompatibility complex class I.

1993 • 142 citations

2-mercaptoethanol restores the ability of nuclear factor κB (NF κB) to bind DNA in nuclear extracts from interleukin 1-treated cells incubated with pyrollidine dithiocarbamate (PDTC). Evidence for oxidation of glutathione in the mechanism of inhibition of NFκB by PDTC

1996 • 136 citations

Antioxidants Inhibit Interleukin-1-induced Cyclooxygenase and Nitric-oxide Synthase Expression in Rat Mesangial Cells

1996 • 130 citations

Mechanism of the Tumor Necrosis Factor α-mediated Induction of Endothelial Tissue Factor

1995 • 125 citations

Studies into the Effect of the Tyrosine Kinase Inhibitor Herbimycin A on NF-κB Activation in T Lymphocytes EVIDENCE FOR COVALENT MODIFICATION OF THE p50 SUBUNIT

1995 • 118 citations

Linoleic acid activates nuclear transcription factor-κB (NF-κB) and induces NF-κB-dependent transcription in cultured endothelial cells

1996 • 108 citations

Activation of NF-kappa B and induction of vascular cell adhesion molecule-1 and intracellular adhesion molecule-1 expression in human glial cells by IL-1. Modulation by antioxidants.

1994 • 105 citations

Involvement of intracellular Ca²⁺ in oxidant‐induced NF‐κB activation

1996 • 105 citations

Posttranscriptional regulation of macrophage tissue factor expression by antioxidants

1995 • 80 citations

Interleukin‐1β Induces Nuclear Factor κ B in Epithelial Cells Independently of the Production of Reactive Oxygen Intermediates

1996 • 69 citations

Inhibition of NF-κB Activation in Human T-Cell Lines by Anetholdithiolthione

1996 • 61 citations

Antioxidant effect of diethyldithiocarbamate on microsomal lipid peroxidation assessed by low‐level chemiluminescence and alkane production

1983 • 60 citations

An electron paramagnetic resonance study of the antioxidant properties of the nitroxide free radical tempo

1993 • 58 citations

Iron chelators inhibit human platelet aggregation, thromboxane A₂ synthesis and lipoxygenase activity

1989 • 54 citations

Pyrrolidine dithiocarbamate abrogates tissue factor (TF) expression by endothelial cells: evidence implicating nuclear factor-kappa B in TF induction by diverse agonists

1995 • 50 citations

Responses of vascular endothelial oxidant metabolism to lipopolysaccharide and tumor necrosis factor-α

1992 • 50 citations

Transient Overexpression of Catalase Does Not Inhibit TNF- or PMA-Induced NF-κB Activation

1995 • 47 citations

Therapeutic properties of sodium diethyldithiocarbamate: its role as an inhibitor in the progression of AIDS.

1991 • 42 citations

Covalent cross-linking of proteins by carbon disulfide

1992 • 28 citations