Insulin-induced Activation of NADPH-dependent H2O2 Generation in Human Adipocyte Plasma Membranes Is Mediated by Gαi2

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Metabolism of Isolated Fat Cells

1964 • 4,431 citations

Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

1985 • 2,257 citations

Heterotrimeric C proteins: Organizers of transmembrane signals

1995 • 1,388 citations

The subunit structures of two distinct receptors for insulin-like growth factors I and II and their relationship to the insulin receptor.

1982 • 709 citations

The biochemical basis of the NADPH oxidase of phagocytes

1993 • 631 citations

Inhibition of Adenylyl Cyclase by G _iα

1993 • 402 citations

Activation of Adenylate Cyclase by Choleragen

1979 • 394 citations

Signal transmission by the insulin-like growth factors

1989 • 380 citations

Distinct patterns of bidirectional regulation of mammalian adenylyl cyclases.

1994 • 351 citations

ADP-ribosylation of transducin by pertussis toxin blocks the light-stimulated hydrolysis of GTP and cGMP in retinal photoreceptors.

1984 • 327 citations

Activation of Exocytosis by the Heterotrimeric G Protein G _i3

1993 • 233 citations

Human fat cells possess a plasma membrane-bound H2O2-generating system that is activated by insulin via a mechanism bypassing the receptor kinase.

1992 • 232 citations

Abolition of the expression of inhibitory guanine nucleotide regulatory protein Gi activity in diabetes

1987 • 232 citations

Insulin action impaired by deficiency of the G-protein subunit Giα2

1996 • 210 citations

Gβγ Subunits Mediate Mitogen-activated Protein Kinase Activation by the Tyrosine Kinase Insulin-like Growth Factor 1 Receptor

1995 • 201 citations

Two distinct Gi-proteins mediate formyl peptide receptor signal transduction in human leukemia (HL-60) cells

1989 • 183 citations

G protein beta gamma subunits. Simplified purification and properties of novel isoforms.

1994 • 178 citations

Insulin inhibits pertussis toxin-catalyzed ADP-ribosylation of G-proteins. Evidence for a novel interaction between insulin receptors and G-proteins.

1988 • 156 citations

Activation of a G Protein Complex by Aggregation of β-1,4-Galactosyltransferase on the Surface of Sperm

1995 • 154 citations

Stimulation of insulin-like growth factor II receptor binding and insulin receptor kinase activity in rat adipocytes. Effects of vanadate and H2O2.

1987 • 148 citations

Antagonistic effects of different members of the fibroblast and platelet-derived growth factor families on adipose conversion and NADPH-dependent H2O2 generation in 3T3 L1-cells

1995 • 137 citations

Vasoactive intestinal peptide/pituitary adenylate cyclase-activating peptide-dependent activation of membrane-bound NO synthase in smooth muscle mediated by pertussis toxin-sensitive Gi1-2.

1994 • 112 citations

Pertussis toxin treatment attenuates some effects of insulin in BC3H-1 murine myocytes.

1988 • 107 citations

A pertussis toxin-sensitive G-protein mediates some aspects of insulin action in BC3H-1 murine myocytes.

1990 • 94 citations

Gs alpha mediates epidermal growth factor-elicited stimulation of rat cardiac adenylate cyclase.

1990 • 93 citations

Epidermal growth factor-mediated signaling of G(i)-protein to activation of phospholipases in rat-cultured hepatocytes.

1993 • 78 citations

Human fat cell lipolysis is primarily regulated by inhibitory modulators acting through distinct mechanisms.

1985 • 78 citations

In Vivo Coupling of Insulin-like Growth Factor II/Mannose 6-Phosphate Receptor to Heteromeric G Proteins

1995 • 75 citations

The stimulus-sensitive H2O2-generating system present in human fat-cell plasma membranes is multireceptor-linked and under antagonistic control by hormones and cytokines

1995 • 73 citations

Chemotactic Peptide Receptor-supported ADP-Ribosylation of a Pertussis Toxin Substrate GTP-binding Protein by Cholera Toxin in Neutrophil-type HL-60 Cells

1989 • 70 citations

Dual Mg²⁺ control of formyl‐peptide‐receptor–G‐protein interaction in HL 60 cells

1989 • 69 citations

The action of islet activating protein (pertussis toxin) on insulin's ability to inhibit adenylate cyclase and activate cyclic AMP phosphodiesterases in hepatocytes

1986 • 69 citations

Stimulation of a glycosyl-phosphatidylinositol-specific phospholipase by insulin and the sulfonylurea, glimepiride, in rat adipocytes depends on increased glucose transport.

1994 • 68 citations

Action of insulin modulated by pertussis toxin in rat adipocytes

1985 • 61 citations

The pathway mediating insulin's effects on pyruvate dehydrogenase bypasses the insulin receptor tyrosine kinase

1991 • 58 citations

Interaction between G Proteins and Tyrosine Kinases upon T Cell Receptor·CD3-mediated Signaling

1995 • 55 citations

Mechanism of IGF-I-Stimulated Glucose Transport in Human Adipocytes: Demonstration of Specific IGF-I Receptors Not Involved in Stimulation of Glucose Transport

1989 • 45 citations

Opioid peptides promote cholera-toxin-catalysed ADP-ribosylation of the inhibitory guanine-nucleotide-binding protein (Gi) in membranes of neuroblastoma x glioma hybrid cells

1988 • 44 citations

The interaction of nucleotides with pertussis toxin. Direct evidence for a nucleotide binding site on the toxin regulating the rate of ADP-ribosylation of Ni, the inhibitory regulatory component of adenylyl cyclase.

1986 • 39 citations

Mn2(+)-binding properties of a recombinant protein-tyrosine kinase derived from the human insulin receptor.

1990 • 38 citations

GTP‐binding protein‐activator sequences in the insulin receptor

1993 • 31 citations

Insulin activates GTP binding to a 40 kDa protein in fat cells

1991 • 30 citations

Islet‐activating protein discriminates the antilipolytic mechanism of insulin from that of other antilipolytic compounds

1983 • 27 citations

Guanine nucleotide binding regulatory proteins in liver from obese humans with and without type II diabetes: Evidence for altered “cross‐talk” between the insulin receptor and G_i‐proteins

1994 • 26 citations

A GTP-binding protein inhibits a gastric housekeeping chloride channel via intracellular production of superoxide.

1994 • 26 citations

Identification, partial purification, and characterization of two guanosine triphosphate-binding proteins associated with insulin receptors.

1992 • 25 citations

Insulin receptor function is inhibited by guanosine 5′-[γ-thio]triphosphate (GTP[S])

1990 • 24 citations

An insulin receptor peptide (1135-1156) stimulates guanosine 5′-[γ-thio]triphosphate binding to the 67 kDa G-protein associated with the insulin receptor

1993 • 19 citations

A role for inositol-glycan mediators and G-proteins in insulin action

1993 • 16 citations

Pertussis toxin catalyzed ADP‐ribosylation of a 41 kDa G‐protein impairs insulin‐stimulated glucose metabolism in Bc3H‐1 myocytes

1990 • 14 citations

Stimulation of high-affinity GTPase activity and cholera toxin-catalysed [32P]ADP-ribosylation of Gi by lysophosphatidic acid (LPA) in wild-type and α2C10 adrenoceptor-transfected Rat 1 fibroblasts

1994 • 14 citations

Quantitation of inhibitory G-proteins in fat cells of obese and normal-weight human subjects

1994 • 13 citations

Photoaffinity labelling of cardiac membrane GTP‐binding proteins in response to insulin

1994 • 12 citations

Insulin inhibits the phosphorylation of α-Gi-2 in intact hepatocytes

1995 • 9 citations

Guanosine 5'‐(γ‐thio) triphosphate (GTPγS) inhibits phosphorylation of insulin receptor and a novel GTP‐binding protein, G_ir, from human placenta

1994 • 8 citations

Regulation of cardiac insulin receptor function by guanosine nucleotides

1992 • 6 citations

Insulin stimulates GDP release from G proteins in the rat and human liver plasma membranes

1993 • 5 citations