Depletion of the mitochondrial electron transport abrogates the cytotoxic and gene-inductive effects of TNF.

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

[1] Role of free radicals and catalytic metal ions in human disease: An overview

1990 • 5,041 citations

Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1.

1991 • 3,819 citations

Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor

1987 • 3,057 citations

The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen

1973 • 2,608 citations

Prooxidant States and Tumor Promotion

1985 • 2,541 citations

IκB: a Specific Inhibitor of the NF-κB Transcription Factor

1988 • 2,203 citations

The Biology of Cachectin/TNF -- A Primary Mediator of the Host Response

1989 • 1,679 citations

NF-κB: A pleiotropic mediator of inducible and tissue-specific gene control

1989 • 1,622 citations

Generation of superoxide anion by the NADH dehydrogenase of bovine heart mitochondria

1980 • 1,609 citations

Redox Regulation of Fos and Jun DNA-Binding Activity in Vitro

1990 • 1,592 citations

Dithiocarbamates as potent inhibitors of nuclear factor kappa B activation in intact cells.

1992 • 1,524 citations

Human cells lacking mtDNA: repopulation with exogenous mitochondria by complementation

1990 • 1,390 citations

Activation of interleukin-6 gene expression through the NF-kappa B transcription factor.

1990 • 1,377 citations

Cytoplasmic dot hybridization. Simple analysis of relative mRNA levels in multiple small cell or tissue samples.

1982 • 1,333 citations

Activation in vitro of NF-κB" by phosphorylation of its inhibitor IκB"

1990 • 1,202 citations

Ubisemiquinone is the electron donor for superoxide formation by complex III of heart mitochondria

1985 • 1,201 citations

The inducible transcription activator NF-κB: regulation by distinct protein subunits

1991 • 1,079 citations

TNF activates NF-κB by phosphatidylcholine-specific phospholipase C-induced “Acidic” sphingomyelin breakdown

1992 • 1,058 citations

Intracellular thiols regulate activation of nuclear factor kappa B and transcription of human immunodeficiency virus.

1990 • 960 citations

Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions. Evidence for the involvement of mitochondrial radical generation.

1992 • 949 citations

Redox activation of Fos-Jun DNA binding activity is mediated by a DNA repair enzyme.

1992 • 920 citations

Transcriptional Regulator of Oxidative Stress-Inducible Genes: Direct Activation by Oxidation

1990 • 869 citations

An improved colorimetric assay for interleukin 2

1986 • 858 citations

Manganous superoxide dismutase is essential for cellular resistance to cytotoxicity of tumor necrosis factor

1989 • 821 citations

Tumor necrosis factor alpha activates human immunodeficiency virus type 1 through induction of nuclear factor binding to the NF-kappa B sites in the long terminal repeat.

1989 • 781 citations

Prolonged activation of jun and collagenase genes by tumour necrosis factor-α

1989 • 726 citations

Tumor necrosis factor Characterization at the molecular, cellular and in vivo level

1991 • 708 citations

Purification and NH2-terminal amino acid sequence of a T-cell-derived lymphokine with growth factor activity for B-cell hybridomas.

1986 • 701 citations

Rapid and preferential activation of the c-jun gene during the mammalian UV response.

1991 • 685 citations

Antioxidants in relation to lipid peroxidation

1987 • 684 citations

The O2−-forming NADPH oxidase of the phagocytes: nature, mechanisms of activation and function

1986 • 665 citations

Role of ubiquinone in the mitochondrial generation of hydrogen peroxide

1976 • 656 citations

Modulation of transcription factor NF-kappa B binding activity by oxidation-reduction in vitro.

1991 • 649 citations

Superoxide radicals as precursors of mitochondrial hydrogen peroxide

1974 • 627 citations

UV-induced DNA damage is an intermediate step in UV-induced expression of human immunodeficiency virus type 1, collagenase, c-fos, and metallothionein.

1989 • 549 citations

The complete nucleotide sequence of theRattus norvegicus mitochondrial genome: Cryptic signals revealed by comparative analysis between vertebrates

1989 • 523 citations

Six unidentified reading frames of human mitochondrial DNA encode components of the respiratory-chain NADH dehydrogenase

1985 • 517 citations

Familial mitochondrial encephalomyopathy (MERRF): Genetic, pathophysiological, and biochemical characterization of a mitochondrial DNA disease

1988 • 509 citations

Cytoplasmic activation of ISGF3, the positive regulator of interferon-alpha-stimulated transcription, reconstituted in vitro.

1989 • 484 citations

NF-κB and related proteins: Rel/dorsal homologies meet ankyrin-like repeats

1992 • 415 citations

Ionizing radiation induces expression and binding activity of the nuclear factor kappa B.

1991 • 410 citations

An octamer oligonucleotide upstream of a TATA motif is sufficient for lymphoid-specific promoter activity

1987 • 398 citations

In Vitro Activation and Nuclear Translocation of NF-κB Catalyzed by Cyclic AMP-Dependent Protein Kinase and Protein Kinase C

1989 • 389 citations

Involvement of a NF-kappa B-like transcription factor in the activation of the interleukin-6 gene by inflammatory lymphokines.

1990 • 384 citations

Activation of Interleukin-6 Gene Expression through the NF-κB Transcription Factor

1990 • 379 citations

DNA binding of purified transcription factor NF-kappa B. Affinity, specificity, Zn2+ dependence, and differential half-site recognition.

1991 • 349 citations

Tumor Necrosis Factor: The molecules and Their Emerging Role in Medicine

1992 • 330 citations

The Mitochondrial Genotype Can Influence Nuclear Gene Expression in Yeast

1987 • 318 citations

Enhancement of cAMP levels and of protein kinase activity by tumor necrosis factor and interleukin 1 in human fibroblasts: role in the induction of interleukin 6.

1988 • 288 citations

A study of the kinetics of the oxidation of cytochrome c by cytochrome c oxidase

1956 • 286 citations

Enhancement of hydrogen peroxide formation by protophores and ionophores in antimycin-supplemented mitochondria

1980 • 273 citations

Molecular cloning of mouse tumour necrosis factor cDNA and its eukaryotic expression

1985 • 266 citations

Synthesis of interleukin 6 (interferon-beta 2/B cell stimulatory factor 2) in human fibroblasts is triggered by an increase in intracellular cyclic AMP.

1988 • 261 citations

Inhibition of HIV-1 replication and NF-x B activity by cysteine and cysteine derivatives

1991 • 256 citations

Redox status of cells influences constitutive or induced NF-kappa B translocation and HIV long terminal repeat activity in human T and monocytic cell lines.

1992 • 242 citations

Redox regulation of a protein tyrosine kinase in the endoplasmic reticulum

1991 • 242 citations

Redox redux: The control of oxidative stress responses

1991 • 242 citations

Mechanism of c-fos induction by active oxygen.

1992 • 224 citations

Intramitochondrial functions regulate nonmitochondrial citrate synthase (CIT2) expression in Saccharomyces cerevisiae.

1991 • 220 citations

Nucleo‐mitochondrial interactions in yeast mitochondrial biogenesis

1989 • 216 citations

Intracellular hydroxyl radical production induced by recombinant human tumor necrosis factor and its implication in the killing of tumor cells in vitro.

1989 • 199 citations

Response to adversity: molecular control of gene activation following genotoxic stress.

1991 • 189 citations

Ethidium Bromide-Induced Loss of Mitochondrial DNA from Primary Chicken Embryo Fibroblasts

1985 • 183 citations

A Multiple Cytokine- and Second Messenger-Responsive Element in the Enhancer of the Human Interleukin-6 Gene: Similarities with c-fosGene Regulation

1989 • 178 citations

Oxidative damage in murine tumor cells treated in vitro by recombinant human tumor necrosis factor.

1989 • 171 citations

Ca2+ release from mitochondria induced by prooxidants

1988 • 166 citations

Generation of hydrogen peroxide by brain mitochondria: The effect of reoxygenation following postdecapitative ischemia

1989 • 145 citations

Differential effects of ethidium bromide on mitochondrial and nuclear DNA synthesis in vivo in cultured mammalian cells

1972 • 139 citations

Reduction of a conserved Cys is essential for Myb DNA-binding

1992 • 129 citations

DNA fragmentation and cytotoxicity caused by tumor necrosis factor is enhanced by interferon‐γ

1987 • 127 citations

Rapid and Preferential Activation of the c-jun Gene during the Mammalian UV Response

1991 • 120 citations

Human transcription factor IIIC (TFIIIC)

1989 • 110 citations

Superoxide generation by the respiratory chain of tumor mitochondria

1987 • 100 citations

Induction and regulation of mRNA encoding 26-kDa protein in human cell lines treated with recombinant human tumor necrosis factor.

1987 • 97 citations

RESPIRATORY ENZYMES AND MITOCHONDRIAL MORPHOLOGY OF H<scp>E</scp>L<scp>A</scp> AND L CELLS TREATED WITH CHLORAMPHENICOL AND ETHIDIUM BROMIDE

1972 • 90 citations

Reversible tenfod reduction in mitochondrial DNA content of human cells treated with ethidium bromide

1978 • 81 citations

Stimulation of RNA Synthesis in L-929 Cells by Rabbit Tumor Necrosis Factor

1979 • 81 citations

Tumour‐necrosis‐factor‐mediated cytotoxicity is correlated with phospholipase‐A₂ activity, but not with arachidonic acid release per se

1991 • 80 citations

Direct Evidence for Intra- and Intermolecular Disulfide Bond Formation in the Human Glucocorticoid Receptor

1989 • 80 citations

Chloramphenicol‐resistant mutants of human HeLa cells

1972 • 79 citations

Interaction and identification of ubiquinone-binding proteins in ubiquinol-cytochrome c reductase by azido-ubiquinone derivatives.

1985 • 77 citations

Protection from tumor necrosis factor cytotoxicity by protease inhibitors

1987 • 75 citations

Involvement of a NF-κB-Like Transcription Factor in the Activation of the Interleukin-6 Gene by Inflammatory Lymphokines

1990 • 72 citations

Suppressive effects of intracellular glutathione on hydroxyl radical production induced by tumor necrosis factor

1990 • 70 citations

Evidence that interleukin-1 and phorbol esters activate NF-kappa B by different pathways: role of protein kinase C.

1991 • 68 citations

Involvement of a serine protease in tumour‐necrosis‐factor‐mediated cytotoxicity

1988 • 65 citations

Intramitochondrial Functions Regulate Nonmitochondrial Citrate Synthase (CIT2) Expression in Saccharomyces cerevisiae

1991 • 63 citations

Development and characterization of continuous avian cell lines depleted of mitochondrial DNA

1988 • 59 citations

Phosphorylation of cytochrome b6 by the LHC II kinase associated with the cytochrome complex

1992 • 35 citations

Lithium chloride potentiates tumor necrosis factor-induced and interleukin 1-induced cytokine and cytokine receptor expression

1991 • 30 citations

Cyclic AMP-Independent Activation of Transcription Factor NF-κB in HL60 Cells by Tumor Necrosis Factors α and β

1991 • 26 citations

TNF‐mediated IL6 gene expression and cytotoxicity are co‐inducible in TNF‐resistant L929 cells

1992 • 19 citations

Tumor necrosis factor-induced interleukin-6 expression and cytotoxicity follow a common signal transduction pathway in L929 cells

1991 • 16 citations