Role of Oxidants in Ischemic Brain Damage

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

1990 • 7,068 citations

The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen

1973 • 2,608 citations

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme

1993 • 2,484 citations

A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds

1993 • 2,423 citations

Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells

1987 • 2,368 citations

The Reaction of no With Superoxide

1993 • 2,133 citations

Hypertension in mice lacking the gene for endothelial nitric oxide synthase

1995 • 2,075 citations

Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase

1995 • 1,761 citations

Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species

1993 • 1,692 citations

Effects of Cerebral Ischemia in Mice Deficient in Neuronal Nitric Oxide Synthase

1994 • 1,578 citations

Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase

1995 • 1,454 citations

Genetic transformation of mouse embryos by microinjection of purified DNA.

1980 • 1,428 citations

Targeted disruption of the neuronal nitric oxide synthase gene

1993 • 1,300 citations

NMDA-dependent superoxide production and neurotoxicity

1993 • 1,188 citations

Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia

1994 • 1,106 citations

Mechanisms of nitric oxide-mediated neurotoxicity in primary brain cultures

1993 • 1,024 citations

Superoxide production in rat hippocampal neurons: selective imaging with hydroethidine

1996 • 868 citations

A novel neuronal messenger molecule in brain: The free radical, nitric oxide

1992 • 837 citations

Oxidative damage to brain proteins, loss of glutamine synthetase activity, and production of free radicals during ischemia/reperfusion-induced injury to gerbil brain.

1990 • 787 citations

Mitochondrial production of reactive oxygen species in cortical neurons following exposure to N-methyl-D-aspartate

1995 • 779 citations

Human copper-containing superoxide dismutase of high molecular weight.

1982 • 751 citations

Nitric Oxide Measured by a Porphyrinic Micro Sensor in Rat Brain after Transient Middle Cerebral Artery Occlusion

1993 • 632 citations

bcl-2 inhibits death of central neural cells induced by multiple agents.

1993 • 631 citations

Neurotrophic Factors Attenuate Glutamate‐Induced Accumulation of Peroxides, Elevation of Intracellular Ca²⁺ Concentration, and Neurotoxicity and Increase Antioxidant Enzyme Activities in Hippocampal Neurons

1995 • 616 citations

Attenuation of focal cerebral ischemic injury in transgenic mice overexpressing CuZn superoxide dismutase.

1991 • 591 citations

Human copper-zinc superoxide dismutase transgenic mice are highly resistant to reperfusion injury after focal cerebral ischemia.

1994 • 571 citations

Free Radicals and Brain Damage

1993 • 527 citations

Regulation of the cerebral microcirculation during neural activity: is nitric oxide the missing link?

1993 • 474 citations

Transgenic mice with increased Cu/Zn-superoxide dismutase activity: animal model of dosage effects in Down syndrome.

1987 • 461 citations

Requirement for Superoxide in Excitotoxic Cell Death

1996 • 437 citations

George E. Brown memorial lecture. Oxygen radicals in cerebral vascular injury.

1985 • 393 citations

Loss of the p53 tumor suppressor gene protects neurons from kainate- induced cell death

1996 • 378 citations

Attenuation of p53 Expression Protects against Focal Ischemic Damage in Transgenic Mice

1994 • 317 citations

Overexpression of Bcl-2 with herpes simplex virus vectors protects CNS neurons against neurological insults in vitro and in vivo

1996 • 311 citations

Protective effects of liposome‐entrapped superoxide dismutase on posttraumatic brain edema

1987 • 283 citations

Downregulation of Cu/Zn superoxide dismutase leads to cell death via the nitric oxide-peroxynitrite pathway

1996 • 267 citations

Liposome-entrapped superoxide dismutase reduces cerebral infarction in cerebral ischemia in rats.

1990 • 266 citations

Oxygen Radicals in Focal Cerebral Ischemia

1994 • 263 citations

Marked Induction of Calcium-Independent Nitric Oxide Synthase Activity after Focal Cerebral Ischemia

1995 • 220 citations

Role of BCL-2 in the survival and function of developing and mature sympathetic neurons

1995 • 193 citations

bcl-2 is expressed in neurons that survive focal ischemia in the rat

1995 • 169 citations

Basic fibroblast growth factor protects striatal neurons in vitro from NMDA-receptor mediated excitotoxicity

1992 • 148 citations

Brain infarction is not reduced in SOD-1 transgenic mice after a permanent focal cerebral ischemia

1993 • 126 citations

Potentiation of nitric oxide formation following bilateral carotid occlusion and focal cerebral ischemia in the rat: in vivo detection of the nitric oxide radical by electron paramagnetic resonance spin trapping

1993 • 114 citations

Polyethylene glycol-conjugated superoxide dismutase in focal cerebral ischemia-reperfusion

1993 • 98 citations

Human cytoplasmic superoxide dismutase cDNA clone: a probe for studying the molecular biology of Down syndrome.

1982 • 95 citations

Cerebral Ischemia and Resuscitation

1990 • 93 citations

Chapter 6 Role of superoxide dismutase in ischemic brain injury: reduction of edema and infarction in transgenic mice following focal cerebral ischemia

1993 • 73 citations

Thermosensitive phenotype of transgenic mice overproducing human glutathione peroxidases.

1995 • 69 citations

Mice expressing a bovine basic fibroblast growth factor transgene in the brain show increased resistance to hypoxemic-ischemic cerebral damage.

1993 • 66 citations