Neuronal Nitric Oxide Synthase Self-inactivates by Forming a Ferrous-Nitrosyl Complex during Aerobic Catalysis

Nitric oxide: physiology, pathophysiology, and pharmacology.

1991 • 15,563 citations

Hemoglobin and myoglobin in their reactions with ligands

1971 • 2,698 citations

NITRIC OXIDE: A Physiologic Messenger Molecule

1994 • 2,299 citations

Biosynthesis and Metabolism of Endothelium-Derived Nitric Oxide

1990 • 1,284 citations

Nitric Oxide Synthases: Properties and Catalytic Mechanism

1995 • 1,275 citations

Generation of superoxide by purified brain nitric oxide synthase.

1992 • 765 citations

Biological Roles of Nitric Oxide

1992 • 731 citations

Simulation of the diffusion and reaction of endogenously produced nitric oxide.

1994 • 699 citations

Oxidation of nitrogen oxides by bound dioxygen in hemoproteins

1981 • 633 citations

Nitric oxide synthase is a cytochrome P-450 type hemoprotein

1992 • 617 citations

Reactions of the bioregulatory agent nitric oxide in oxygenated aqueous media: Determination of the kinetics for oxidation and nitrosation by intermediates generated in the nitric oxide/oxygen reaction

1993 • 474 citations

Nitric oxide synthases reveal a role for calmodulin in controlling electron transfer.

1993 • 411 citations

Feedback inhibition of nitric oxide synthase activity by nitric oxide

1993 • 396 citations

Negative feedback regulation of endothelial cell function by nitric oxide.

1993 • 371 citations

Cloned, expressed rat cerebellar nitric oxide synthase contains stoichiometric amounts of heme, which binds carbon monoxide.

1992 • 368 citations

Inhibition of Cytochromes P450 by Nitric Oxide and a Nitric Oxide-Releasing Agent

1993 • 358 citations

Why nitric oxide?

1992 • 350 citations

Spectral characterization of brain and macrophage nitric oxide synthases. Cytochrome P-450-like hemeproteins that contain a flavin semiquinone radical.

1992 • 344 citations

Quantitative and kinetic characterization of nitric oxide and EDRF released from cultured endothelial cells

1988 • 342 citations

The surprising life of NITRIC OXIDE

1993 • 316 citations

Multiple catalytic functions of brain nitric oxide synthase. Biochemical characterization, cofactor-requirement, and the role of N omega-hydroxy-L-arginine as an intermediate

1993 • 260 citations

Constitutive nitric oxide synthase from cerebellum is reversibly inhibited by nitric oxide formed from L-arginine

1992 • 254 citations

Calmodulin controls neuronal nitric-oxide synthase by a dual mechanism. Activation of intra- and interdomain electron transfer.

1994 • 247 citations

Inducible nitric oxide synthase from a rat alveolar macrophage cell line is inhibited by nitric oxide.

1993 • 225 citations

Spectroscopic and Kinetic Studies on Reaction of Cytochrome P450nor with Nitric Oxide

1995 • 202 citations

Nitric oxide inhibits neuronal nitric oxide synthase by interacting with the heme prosthetic group. Role of tetrahydrobiopterin in modulating the inhibitory action of nitric oxide.

1994 • 199 citations

Regulation of nitric oxide synthase by nitric oxide.

1993 • 197 citations

Studies of the oxygen binding site of cytochrome P-450. Nitric oxide as a spin-label probe.

1978 • 134 citations

Irreversible inactivation of macrophage and brain nitric oxide synthase by L-NG-methylarginine requires NADPH-dependent hydroxylation

1993 • 130 citations

Studies of the primary oxygen intermediate in the reaction of fully reduced cytochrome oxidase.

1991 • 122 citations

Heme coordination of NO in NO synthase.

1994 • 112 citations

L-arginine and calmodulin regulation of the heme iron reactivity in neuronal nitric oxide synthase.

1994 • 100 citations

Heme coordination and structure of the catalytic site in nitric oxide synthase.

1993 • 99 citations

NITRIC OXIDE SYNTHASES: WHY SO COMPLEX?

1994 • 84 citations

Ligand diffusion in the distal heme pocket of myoglobin. A primary determinant of geminate rebinding.

1993 • 54 citations

Electron paramagnetic resonance study of ferrous cytochrome P-450scc-nitric oxide complexes: effects of cholesterol and its analogs

1987 • 33 citations