The nitric oxide and cGMP signal transduction system: regulation and mechanism of action

The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine

1980 • 12,033 citations

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

1987 • 10,774 citations

The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalytic Domains

1988 • 5,115 citations

Vascular endothelial cells synthesize nitric oxide from L-arginine

1988 • 4,800 citations

A novel multigene family may encode odorant receptors: A molecular basis for odor recognition

1991 • 4,793 citations

Nitric oxide as a secretory product of mammalian cells

1992 • 4,437 citations

Predicting Coiled Coils from Protein Sequences

1991 • 3,977 citations

Biochemistry of Nitric Oxide and Its Redox-Activated Forms

1992 • 2,725 citations

Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase

1991 • 2,371 citations

Cloning and Characterization of Inducible Nitric Oxide Synthase from Mouse Macrophages

1992 • 1,914 citations

Negative Inotropic Effects of Cytokines on the Heart Mediated by Nitric Oxide

1992 • 1,635 citations

Consensus sequences as substrate specificity determinants for protein kinases and protein phosphatases

1991 • 1,327 citations

A cyclic nucleotide-gated conductance in olfactory receptor cilia

1987 • 1,134 citations

Protein kinase recognition sequence motifs

1990 • 1,014 citations

Nitric Oxide: First in a New Class of Neurotransmitters

1992 • 1,001 citations

Vasorelaxant properties of the endothelium-derived relaxing factor more closely resemble S-nitrosocysteine than nitric oxide

1990 • 996 citations

A membrane form of guanylate cyclase is an atrial natriuretic peptide receptor

1989 • 996 citations

Molecular cloning and functional expression of an inducible nitric oxide synthase from a murine macrophage cell line.

1992 • 877 citations

Primary sequence of cyclic nucleotide phosphodiesterase isozymes and the design of selective inhibitors

1990 • 860 citations

Retinal degeneration in the rd mouse is caused by a defect in the β subunit of rod cGMP-phosphodiesterase

1990 • 841 citations

Cytoskeleton—Plasma Membrane Interactions

1992 • 792 citations

Generation of superoxide by purified brain nitric oxide synthase.

1992 • 765 citations

Macrophage Oxidation of L-Arginine to Nitric Oxide, Nitrite, and Nitrate

1989 • 681 citations

Primary structure and functional expression from complementary DNA of the rod photoreceptor cyclic GMP-gated channel

1989 • 663 citations

Intracellular cyclic GMP receptor proteins

1993 • 655 citations

Calmodulin is a subunit of nitric oxide synthase from macrophages.

1992 • 640 citations

Nitric oxide as a neuronal messenger

1991 • 638 citations

Induction and potential biological relevance of a Ca²⁺‐independent nitric oxide synthase in the myocardium

1992 • 623 citations

Mapping of neural nitric oxide synthase in the rat suggests frequent co-localization with NADPH diaphorase but not with soluble guanylyl cyclase, and novel paraneural functions for nitrinergic signal transduction.

1992 • 622 citations

Cloning and expression of a cDNA encoding human endothelium-derived relaxing factor/nitric oxide synthase.

1992 • 616 citations

Guanylyl cyclase is a heat-stable enterotoxin receptor

1990 • 600 citations

N omega-hydroxy-L-arginine is an intermediate in the biosynthesis of nitric oxide from L-arginine.

1991 • 572 citations

Reduced Biopterin as a Cofactor in the Generation of Nitrogen Oxides by Murine Macrophages

1989 • 571 citations

Recoverin: a Calcium Sensitive Activator of Retinal Rod Guanylate Cyclase

1991 • 569 citations

PROTEIN KINASES IN THE BRAIN

1985 • 559 citations

Cloned human brain nitric oxide synthase is highly expressed in skeletal muscle

1993 • 552 citations

Mammalian Nitric Oxide Synthases

1992 • 514 citations

Molecular cloning and characterization of human endothelial nitric oxide synthase

1992 • 494 citations

Molecular cloning and expression of a cDNA encoding endothelial cell nitric oxide synthase.

1992 • 477 citations

Inhibition of platelet aggregation by carbon monoxide is mediated by activation of guanylate cyclase.

1987 • 466 citations

Purification of the inducible murine macrophage nitric oxide synthase. Identification as a flavoprotein.

1991 • 458 citations

Purification of a Ca²⁺/calmodulin‐dependent nitric oxide synthase from porcine cerebellum

1990 • 433 citations

Brain nitric oxide synthase is a biopterin‐ and flavin‐containing multi‐functional oxido‐reductase

1991 • 422 citations

Insulin Secretion from Pancreatic B Cells Caused by L-Arginine-Derived Nitrogen Oxides

1992 • 415 citations

Arginine is a physiological precursor of endothelium-derived nitric oxide

1988 • 392 citations

NITRERGIC TRANSMISSION: NITRIC OXIDE AS A MEDIATOR OF NON‐ADRENERGIC, NON‐CHOLINERGIC NEURO‐EFFECTOR TRANSMISSION

1992 • 378 citations

The 46/50 kDa phosphoprotein VASP purified from human platelets is a novel protein associated with actin filaments and focal contacts.

1992 • 374 citations

Human atrial natriuretic peptide receptor defines a new paradigm for second messenger signal transduction.

1989 • 370 citations

Role of cyclic GMP in the action of heat-stable enterotoxin of Escherichia coli

1978 • 363 citations

Why nitric oxide?

1992 • 350 citations

cGMP-dependent protein kinase mediates the reduction of Ca2+ by cAMP in vascular smooth muscle cells

1990 • 347 citations

Guanylyl cyclase receptors and their endocrine, paracrine, and autocrine ligands

1992 • 346 citations

Opposite effects of cyclic GMP and cyclic AMP on Ca2+ current in single heart cells

1986 • 338 citations

Molecular identification of the gene responsible for congenital nephrogenic diabetes insipidus

1992 • 331 citations

Soluble guanylate cyclase purified from bovine lung contains heme and copper

1981 • 328 citations

Regulation of Intracellular Ca2+ Levels in Cultured Vascular Smooth Muscle Cells

1989 • 318 citations

Interleukin-lβ-Induced Nitric Oxide Production in Isolated Rat Pancreatic Islets Requires Gene Transcription and May Lead to Inhibition of the Krebs Cycle Enzyme Aconitase*

1991 • 317 citations

Cloning and expression of odorant receptors

1993 • 277 citations

Phosphorylation by calcium calmodulin-dependent protein kinase II and protein kinase C modulates the activity of nitric oxide synthase

1991 • 275 citations

Direct evidence for cross-activation of cGMP-dependent protein kinase by cAMP in pig coronary arteries.

1992 • 269 citations

Stimulation of intestinal Cl- transport by heat-stable enterotoxin: activation of cAMP-dependent protein kinase by cGMP

1992 • 265 citations

Potassium channel stimulation by natriuretic peptides through cGMP-dependent dephosphorylation

1993 • 258 citations

The Isolation and Characterization of Dihydropteridine Reductase from Sheep Liver

1972 • 256 citations

Characterization of free radical generation by xanthine oxidase

1989 • 256 citations

Regulation and subcellular location of nitrogen oxide synthases in RAW264.7 macrophages.

1992 • 248 citations

Regulation of the cystic fibrosis transmembrane conductance regulator Cl- channel by specific protein kinases and protein phosphatases.

1993 • 246 citations

Implications of the NO/cGMP system for olfaction

1993 • 245 citations

Characterization of a purified bovine lung cGMP-binding cGMP phosphodiesterase.

1990 • 232 citations

Rod and cone photoreceptor cells express distinct genes for cGMP-gated channels

1993 • 229 citations

Soluble guanylate cyclase from rat lung exists as a heterodimer.

1986 • 227 citations

Regulation of sarcoplasmic reticulum protein phosphorylation by localized cyclic GMP-dependent protein kinase in vascular smooth muscle cells.

1991 • 226 citations

The cyclic nucleotide-gated channels of vertebrate photoreceptors and olfactory epithelium

1991 • 224 citations

Molecular cloning of a retina-specific membrane guanylyl cyclase

1992 • 220 citations

High concentrations of a cGMP-stimulated phosphodiesterase mediate ANP-induced decreases in cAMP and steroidogenesis in adrenal glomerulosa cells.

1991 • 218 citations

Anatomy of cerebellar Purkinje cells in the rat determined by a specific immunohistochemical marker

1984 • 218 citations

Reduced Triphosphopyridine Nucleotide Oxidase-catalyzed Alterations of Membrane Phospholipids

1968 • 213 citations

Ca2+/calmodulin-dependent cytochrome c reductase activity of brain nitric oxide synthase.

1992 • 210 citations

Dual ion-channel regulation by cyclic GMP and cyclic GMP-dependent protein kinase

1990 • 210 citations

Mechanism of cyclic GMP inhibition of inositol phosphate formation in rat aorta segments and cultured bovine aortic smooth muscle cells.

1990 • 205 citations

A 26 kd calcium binding protein from bovine rod outer segments as modulator of photoreceptor guanylate cyclase.

1991 • 198 citations

Role of cGMP and Ca2+ in Vertebrate Photoreceptor Excitation and Adaptation

1992 • 198 citations

The cDNA of the two isoforms of bovine cGMP‐dependent protein kinase

1989 • 195 citations

Ca2+calmodulin-regulated nitric oxide synthases

1992 • 194 citations

Interaction of pp60c-src, phospholipase C, inositol-lipid, and diacyglycerol kinases with the cytoskeletons of thrombin-stimulated platelets

1991 • 193 citations

Signal transduction by cGMP in heart

1991 • 181 citations

A new form of guanylyl cyclase is preferentially expressed in rat kidney

1990 • 178 citations

Cyclic nucleotide phosphodiesterases: Structure, regulation and drug action

1991 • 176 citations

Cyclic GMP phosphodiesterase from cattle retina

1986 • 167 citations

Potentiation by cyclic GMP of beta‐adrenergic effect on Ca2+ current in guinea‐pig ventricular cells.

1991 • 167 citations

Expression of soluble guanylyl cyclase

1990 • 167 citations

Endothelium-derived relaxing factor inhibits renin release

1988 • 165 citations

Role of the endothelium-dependent relaxing factor nitric oxide on renal function.

1992 • 163 citations

Expression of soluble guanylate cyclase activity requires both enzyme subunits

1991 • 162 citations

Substrate- and kinase-directed regulation of phosphorylation of a cGMP-binding phosphodiesterase by cGMP.

1990 • 161 citations

Molecular cloning and expression of a new α‐subunit of soluble guanylyl cyclase Interchangeability of the α‐subunits of the enzyme

1991 • 160 citations

Characterization of a novel isozyme of cGMP-dependent protein kinase from bovine aorta

1989 • 158 citations

cGMP-dependent protein kinase enhances Ca2+ current and potentiates the serotonin-induced Ca2+ current increase in snail neurones

1986 • 154 citations

Intrasteric regulation of protein kinases and phosphatases

1991 • 151 citations

Calcium/calmodulin-dependent nitric oxide synthase type I: a biopteroflavoprotein with calcium/calmodulin-independent diaphorase and reductase activities

1992 • 151 citations

Human rod photoreceptor cGMP-gated channel: amino acid sequence, gene structure, and functional expression

1992 • 150 citations

A cyclic GMP-activated channel in dissociated cells of the chick pineal gland

1991 • 149 citations

Regulation of cytosolic calcium by cAMP and cGMP in freshly isolated smooth muscle cells from bovine trachea.

1988 • 147 citations

Molecular cloning and predicted full‐length amino acid sequence of the type Iβ isozyme of cGMP‐dependent protein kinase from human placenta

1989 • 147 citations

Analysis of the functional role of cGMP-dependent protein kinase in intact human platelets using a specific activator 8-para-chlorophenylthio-cGMP

1992 • 145 citations

The cGMP-dependent protein kinase-gene, protein, and function

1993 • 143 citations

Differential distribution of nitric oxide synthase between cell fractions isolated from the rat gastric mucosa

1992 • 140 citations

Studies of cGMP analog specificity and function of the two intrasubunit binding sites of cGMP-dependent protein kinase.

1986 • 137 citations

Cyclic GMP stimulates Na+/Ca2+ exchange in vascular smooth muscle cells in primary culture

1991 • 136 citations

Endothelium‐derived relaxing factor is a nitrosyl iron complex with thiol ligands

1991 • 132 citations

Site‐specific phosphorylation of the purified receptor for calcium‐channel blockers by cAMP‐ and cGMP‐dependent protein kinases, protein kinase C, calmodulin‐dependent protein kinase II and casein kinase II

1988 • 131 citations

Inhibition of cGMP‐dependent protein kinase by (Rp)‐guanosine 3',5'‐monophosphorothioates

1990 • 130 citations

Structure and physiological role of cGMP-dependent protein kinase

1992 • 130 citations

Noncatalytic cGMP-binding sites of amphibian rod cGMP phosphodiesterase control interaction with its inhibitory gamma-subunits. A putative regulatory mechanism of the rod photoresponse.

1992 • 129 citations

cGMP-dependent Protein Kinase Genes in Drosophila

1989 • 129 citations

Detection of cGMP dependent protein kinase isozymes by specific antibodies

1992 • 127 citations

Cloning and expression of guanylin. Its existence in various mammalian tissues.

1992 • 126 citations

Predicted structures of the cGMP binding domains of the cGMP-dependent protein kinase: a key alanine/threonine difference in evolutionary divergence of cAMP and cGMP binding sites

1989 • 124 citations

Modulation of calcium movements by nitroprusside in isolated vascular smooth muscle cells

1991 • 123 citations

Endothelium-derived relaxing factors

1995 • 119 citations

Phosphorylation of nitric oxide synthase by protein kinase A

1991 • 114 citations

Nitric oxide synthase immunoreactivity and NADPH-diaphorase activity in a subpopulation of intrinsic neurones of the guinea-pig heart

1992 • 111 citations

Molecular cloning of a cyclic GMP-stimulated cyclic nucleotide phosphodiesterase cDNA. Identification and distribution of isozyme variants.

1991 • 111 citations

Cyclic nucleotide-dependent regulation of Mn2+ influx, [Ca2+]i, and arterial smooth muscle relaxation

1992 • 110 citations

Hydroxyl radical mediates the endothelium-dependent relaxation produced by bradykinin in mouse cerebral arterioles.

1987 • 110 citations

Beta-subunit of bovine rod photoreceptor cGMP phosphodiesterase. Comparison with the phosphodiesterase family.

1990 • 108 citations

Guanylyl Cyclase-Linked Receptors

1992 • 106 citations

Synthesis of nitric oxide in the bovine retina

1991 • 102 citations

Molecular cloning of the cDNAs coding for the two subunits of soluble guanylyl cyclase from human brain

1992 • 100 citations

The activation of expressed cGMP‐dependent protein kinase isozymes Iα and Iβ is determined by the different amino‐termini

1991 • 99 citations

Developmental and tissue-specific expression of the rod photoreceptor cGMP-gated ion channel gene

1990 • 99 citations

Cyclic GMP-dependent protein kinase stimulates the plasma membrane Ca2+ pump ATPase of vascular smooth muscle via phosphorylation of a 240-kDa protein.

1991 • 96 citations

Relaxation of pig coronary arteries by new and potent cGMP analogs that selectively activate type I alpha, compared with type I beta, cGMP-dependent protein kinase.

1992 • 96 citations

cGMP‐dependent protein kinase

1985 • 95 citations

Cyclic GMP phosphodiesterase from cattle retina

1986 • 94 citations

Endothelial nitric oxide synthase is myristylated

1992 • 93 citations

One amino acid change produces a high affinity cGMP-binding site in cAMP-dependent protein kinase.

1990 • 90 citations

Cyclic GMP phosphodiesterase from bovine retina Amino acid sequence of the α‐subunit and nucleotide sequence of the corresponding cDNA

1987 • 89 citations

Purification and characterization of two forms of cyclic GMP-dependent protein kinase from bovine aorta.

1988 • 86 citations

Phosphorylation of cGMP-dependent protein kinase increases the affinity for cyclic AMP

1986 • 82 citations

A phenylalanine in peptide substrates provides for selectivity between cGMP- and cAMP-dependent protein kinases.

1992 • 80 citations

Regulation and function of cyclic nucleotides

1992 • 78 citations

Defective nitrovasodilator-stimulated protein phosphorylation and calcium regulation in cGMP-dependent protein kinase-deficient human platelets of chronic myelocytic leukemia

1993 • 78 citations

The catalytic subunit of protein kinase A triggers activation of the type V cyclic GMP-specific phosphodiesterase from guinea-pig lung

1992 • 78 citations

Glomeruli synthesize nitrite in active Heymann nephritis; the source is infiltrating macrophages

1991 • 76 citations

Studies on the mechanism of carbon monoxide-induced vasodilation in the isolated perfused rat heart

1987 • 75 citations

Molecular cloning of cDNA encoding a “63”-kDa calmodulin-stimulated phosphodiesterase from bovine brain.

1992 • 72 citations

Activation of a small-conductance Ca2+-dependent K+ channel contributes to bradykinin-induced stimulation of nitric oxide synthesis in pig aortic endothelial cells

1992 • 72 citations

Proton NMR and circular dichroism studies of the N-terminal domain of cyclic GMP dependent protein kinase: a leucine/isoleucine zipper

1991 • 68 citations

Identification of the residues on cyclic GMP-dependent protein kinase that are autophosphorylated in the presence of cyclic AMP and cyclic GMP

1984 • 67 citations

Is arginine a physiological precursor of endothelium-derived nitric oxide?

1988 • 66 citations

Phosphodiesterase II, the cGMP-activatable cyclic nucleotide phosphodiesterase, regulates cyclic AMP metabolism in PC12 cells.

1991 • 65 citations

A polymerase chain reaction strategy to identify and clone cyclic nucleotide phosphodiesterase cDNAs. Molecular cloning of the cDNA encoding the 63-kDa calmodulin-dependent phosphodiesterase.

1992 • 65 citations

Inhibition of Macromolecular Synthesis in Escherichia coli by Protease Inhibitors

1974 • 64 citations

Endothelial cell-dependent phosphorylation of a platelet protein mediated by cAMP- and cGMP-elevating factors

1991 • 64 citations

Metabolism of vinyl chloride: destruction of the heme of highly purified liver Microsomal cytochrome P-450 by a metabolite.

1977 • 62 citations

Cyclic AMP-dependent protein kinase activation of cystic fibrosis transmembrane conductance regulator chloride channels in planar lipid bilayers.

1992 • 61 citations

Structural analysis of cGMP-dependent protein kinase using limited proteolysis.

1980 • 60 citations

Amino acid sequence of the cyclic GMP stimulated cyclic nucleotide phosphodiesterase from bovine heart

1990 • 60 citations

Autophosphorylation of cGMP-dependent protein kinase.

1981 • 60 citations

Signals from focal adhesions

1992 • 55 citations

Reversible activation of soluble guanylate cyclase by oxidizing agents

1992 • 55 citations

Glomerular nitrite synthesis in in situ immune complex glomerulonephritis in the rat.

1991 • 54 citations

Properties of a cGMP-dependent Monomeric Protein Kinase from Bovine Aorta

1989 • 54 citations

cGMP-dependent protein kinase regulation of a chloride channel in T84 cells

1992 • 52 citations

Molecular Pathogenesis of Gastrointestinal Infections

1991 • 52 citations

Isolation and characterization of dihydropteridine reductase from human liver

1981 • 51 citations

Regulation of calcium current by low-Km cyclic AMP phosphodiesterases in cardiac cells.

1990 • 49 citations

Effects of cyclic GMP on the secondary structure of cyclic GMP dependent protein kinase and an analysis of the enzymes and amino-terminal domain by far-ultraviolet circular dichroism

1990 • 48 citations

Nitric Oxide Synthase-Catalyzed Activation of Oxygen and Reduction of Cytochromes: Reaction Mechanisms and Possible Physiological Implications

1992 • 47 citations

Rat homologs of the Drosophila dunce gene code for cyclic AMP phosphodiesterases sensitive to rolipram and RO 20-1724.

1990 • 43 citations

Inhibitory effects of mepacrine and eicosatetraynoic acid on cyclic GMP elevations caused by calcium and hormonal factors in rat ductus deferens

1980 • 43 citations

Investigation of the existence and biological role of <scp>l</scp>‐arginine/nitric oxide pathway in human platelets by spin‐trapping/EPR studies

1991 • 42 citations

Loss of haem from cytochrome P-450 caused by lipid peroxidation and 2-allyl-2-isoprophylacetamide. An abnormal pathway not involving production of carbon monoxide

1977 • 40 citations

Segment-specific effects of the heat-stable enterotoxin of E. coli on electrolyte transport in the rat coton

1991 • 39 citations

Interferon‐γ/lipolysaccharide‐treated mouse embryonic fibroblasts are killed by a glycolysis/<scp>l</scp>‐arginine‐dependent process accompanied by depression of mitochondrial respiration

1991 • 36 citations

Nitroprusside-sensitive and insensitive guanylate cyclases in retinal rod outer segments

1992 • 33 citations

Histamine H3 receptor-mediated inhibition of gastric acid secretion in conscious dogs

1993 • 33 citations

Regulation of a potassium-selective current in rabbit corneal epithelium by cyclic GMP, carbachol and diltiazem

1992 • 31 citations

Sequence homologies between guanylyl cyclases and structural analogies to other signal‐transducing proteins

1991 • 21 citations

Cyclic GMP-Dependent Protein Kinase and Smooth Muscle Relaxation

1992 • 16 citations

The effect of TLCK on transcription and its role in modifying cell growth

1977 • 14 citations

The effect of phenobarbital and 3-methylcholanthrene treatment on carbon tetrachloride-stimulated heme degradation and carbon monoxide expiration in vivo

1978 • 11 citations