The RxxRxRxxC motif conserved in all Rel/kappa B proteins is essential for the DNA-binding activity and redox regulation of the v-Rel oncoprotein.

[57] Sequencing end-labeled DNA with base-specific chemical cleavages

1980 • 15,302 citations

High-efficiency transformation of mammalian cells by plasmid DNA.

1987 • 5,377 citations

Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1.

1991 • 3,819 citations

Redox Regulation of Fos and Jun DNA-Binding Activity in Vitro

1990 • 1,592 citations

Activation of DNA-binding activity in an apparently cytoplasmic precursor of the NF-κB transcription factor

1988 • 1,200 citations

The inducible transcription activator NF-κB: regulation by distinct protein subunits

1991 • 1,079 citations

Intracellular thiols regulate activation of nuclear factor kappa B and transcription of human immunodeficiency virus.

1990 • 960 citations

The DNA binding subunit of NF-κB is identical to factor KBF1 and homologous to the rel oncogene product

1990 • 900 citations

Cloning of the p50 DNA binding subunit of NF-κB: Homology to rel and dorsal

1990 • 870 citations

High-Efficiency Transformation of Mammalian Cells by Plasmid DNA

1987 • 729 citations

Modulation of transcription factor NF-kappa B binding activity by oxidation-reduction in vitro.

1991 • 649 citations

DNA binding and IκB inhibition of the cloned p65 subunit of NF-κB, a rel-related polypeptide

1991 • 604 citations

Cytoplasmic activation of ISGF3, the positive regulator of interferon-alpha-stimulated transcription, reconstituted in vitro.

1989 • 484 citations

Isolation of a rel -related Human cDNAThat Potentially Encodes the 65-kD Subunit of NF-κB

1991 • 448 citations

Purified human IκB can rapidly dissociate the complex of the NF-κB transcription factor with its cognate DNA

1990 • 445 citations

Cloning of an NF-κB subunit which stimulates HIV transcription in synergy with p65

1991 • 410 citations

B cell lymphoma-associated chromosomal translocation involves candidate oncogene lyt-10, homologous to NF-κB p50

1991 • 403 citations

Cytokine-stimulated human immunodeficiency virus replication is inhibited by N-acetyl-L-cysteine.

1990 • 381 citations

RelB, a new Rel family transcription activator that can interact with p50-NF-kappa B.

1992 • 375 citations

Cloning of a mitogen-inducible gene encoding a κB DNA-binding protein with homology to the rel oncogene and to cell-cycle motifs

1990 • 330 citations

The v-rel oncogene encodes a κB enhancer binding protein that inhibits NF-κB function

1990 • 325 citations

TNF stimulates expression of mouse MHC class I genes by inducing an NF kappa B-like enhancer binding activity which displaces constitutive factors.

1989 • 275 citations

NF-κB, KBF1, dorsal, and related matters

1990 • 267 citations

Rel-Associated pp40: an Inhibitor of the Rel Family of Transcription Factors

1991 • 255 citations

Expression and purification of the leucine zipper and DNA-binding domains of Fos and Jun: both Fos and Jun contact DNA directly.

1990 • 245 citations

Redox redux: The control of oxidative stress responses

1991 • 242 citations

The dorsal morphogen is a sequence-specific DNA-binding protein that interacts with a long-range repression element in drosophila

1991 • 229 citations

The NF-kappa B binding sites in the human immunodeficiency virus type 1 long terminal repeat are not required for virus infectivity

1989 • 215 citations

Oncogenic conversion by regulatory changes in transcription factors

1991 • 215 citations

The rel-associated pp40 protein prevents DNA binding of Rel and NF-kappa B: relationship with I kappa B beta and regulation by phosphorylation.

1991 • 210 citations

Electrostatic influence of local cysteine environments on disulfide exchange kinetics

1981 • 167 citations

High mutation rate of a spleen necrosis virus-based retrovirus vector.

1986 • 157 citations

In vitro DNA binding activity of Fos/Jun and BZLF1 but not C/EBP is affected by redox changes.

1991 • 156 citations

c-rel activates but v-rel suppresses transcription from kappa B sites.

1991 • 146 citations

Different localization of the product of the v-rel oncogene in chicken fibroblasts and spleen cells correlates with transformation by REV-T

1986 • 142 citations

Biological Studies With RE Virus (Strain T) That Induces Reticuloendotheliosis in Turkeys, Chickens, and Japanese Quail<xref ref-type="fn" rid="FN2">2</xref>

1966 • 142 citations

Inhibition of transcription factors belonging to the rel/NF-kappa B family by a transdominant negative mutant.

1991 • 138 citations

v-rel oncoproteins in the nucleus and in the cytoplasm transform chicken spleen cells

1988 • 126 citations

Human transcription factor IIIC (TFIIIC)

1989 • 110 citations

RelB, a New Rel Family Transcription Activator That Can Interact with p50-NF-κB

1992 • 110 citations

vRel is an inactive member of the Rel family of transcriptional activating proteins

1991 • 100 citations

Oligonucleotide-Directed Site-Specific Mutagenesis Using Double-Stranded Plasmid DNA

1987 • 94 citations

Isolation and Characterization of Reticuloendotheliosis Virus Transformed Bone Marrow Cells

1974 • 87 citations

The physiology of the NF-κB transcription factor

1991 • 81 citations

Direct Evidence for Intra- and Intermolecular Disulfide Bond Formation in the Human Glucocorticoid Receptor

1989 • 80 citations

Synthesis and Applications of Dna and Rna

1987 • 78 citations

The v-rel oncogene encodes a cell-specific transcriptional activator of certain promoters.

1988 • 77 citations

A ubiquitous nuclear protein stimulates the DNA-binding activity of fos and jun indirectly.

1990 • 76 citations

High Mutation Rate of a Spleen Necrosis Virus-Based Retrovirus Vector

1986 • 74 citations

The functional domains of the Drosophila morphogen dorsal: evidence from the analysis of mutants.

1992 • 71 citations

p59v-rel, the transforming protein of reticuloendotheliosis virus, is complexed with at least four other proteins in transformed chicken lymphoid cells

1988 • 71 citations

Avian reticuloendotheliosis virus-transformed lymphoid cells contain multiple pp59v-rel complexes

1990 • 70 citations

Viral rel and cellular rel associate with cellular proteins in transformed and normal cells.

1989 • 51 citations

Expression of a mRNA related to c-rel and dorsal in early Xenopus laevis embryos.

1991 • 45 citations

The v-rel oncogene product is complexed with cellular proteins including its proto-oncogene product and heat shock protein 70

1990 • 44 citations

Kappa B-specific DNA binding proteins are differentially inhibited by enhancer mutations and biological oxidation.

1991 • 35 citations

Interaction of the v-rel protein with an NF-kappa B DNA binding site.

1991 • 33 citations

Transcriptional activity of rel family proteins.

1992 • 28 citations

Identification of protein complexes containing the c-rel proto-oncogene product in avian hematopoietic cells.

1990 • 28 citations

The v-rel oncogene product is complexed to a 40-kDa phosphoprotein in transformed lymphoid cells.

1988 • 27 citations

Differential sensitivity of chicken progesterone receptor forms to sulfhydryl reactive reagents

1989 • 27 citations

Mutational analysis of v-rel, the oncogene of reticuloendotheliosis virus strain T.

1990 • 18 citations

A member of the set of kappa B binding proteins, HIVEN86A, is a product of the human c-rel proto-oncogene.

1991 • 16 citations