Redox regulation of signal transduction in mammalian cells

Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors

1996 • 1,473 citations

MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo

1993 • 1,169 citations

Hypoxia-inducible factor 1: master regulator of O2 homeostasis

1998 • 1,066 citations

Ultraviolet Light and Osmotic Stress: Activation of the JNK Cascade Through Multiple Growth Factor and Cytokine Receptors

1996 • 1,046 citations

Intracellular thiols regulate activation of nuclear factor kappa B and transcription of human immunodeficiency virus.

1990 • 960 citations

Specific and Reversible Inactivation of Protein Tyrosine Phosphatases by Hydrogen Peroxide: Evidence for a Sulfenic Acid Intermediate and Implications for Redox Regulation

1998 • 933 citations

Redox activation of Fos-Jun DNA binding activity is mediated by a DNA repair enzyme.

1992 • 920 citations

Aryl-hydrocarbon Receptor-Deficient Mice Are Resistant to 2,3,7,8-Tetrachlorodibenzo-p-dioxin-Induced Toxicity

1996 • 820 citations

Development of “substrate-trapping” mutants to identify physiological substrates of protein tyrosine phosphatases

1997 • 774 citations

A family of proteins that inhibit signalling through tyrosine kinase receptors

1997 • 648 citations

Epidermal growth factor receptors: critical mediators of multiple receptor pathways

1999 • 610 citations

Structural Basis for Phosphotyrosine Peptide Recognition by Protein Tyrosine Phosphatase 1B

1995 • 575 citations

From Form to Function: Signaling by Protein Tyrosine Phosphatases

1996 • 526 citations

Dephosphorylation of receptor tyrosine kinases as target of regulation by radiation, oxidants or alkylating agents.

1996 • 523 citations

Identification of redox/repair protein Ref-1 as a potent activator of p53.

1997 • 479 citations

Ultraviolet Light Induces Apoptosis via Direct Activation of CD95 (Fas/APO-1) Independently of Its Ligand CD95L

1998 • 472 citations

The roles of hydrogen peroxide and superoxide as messengers in the activation of transcription factor NF-κB

1995 • 460 citations

Involvement of growth factor receptors in the mammalian UVC response

1994 • 456 citations

Role of the Ah Receptor and the Dioxin‐Inducible [Ah] Gene Battery in Toxicity, Cancer, and Signal Transductiona

1993 • 425 citations

The tumor promoter arsenite stimulates AP-1 activity by inhibiting a JNK phosphatase.

1996 • 419 citations

Dimerization of B-type Platelet-derived Growth Factor Receptors Occurs After Ligand Binding and Is Closely Associated with Receptor Kinase Activation

1989 • 366 citations

Epidermal growth factor receptors

1981 • 352 citations

p27Kip1 induction and inhibition of proliferation by the intracellular Ah receptor in developing thymus and hepatoma cells

1999 • 352 citations

Multiple positive and negative regulators of signaling by the EGF-receptor

1999 • 330 citations

Ultraviolet Radiation-induced Apoptosis Is Mediated by Activation of CD-95 (Fas/APO-1)

1997 • 298 citations

Bridge over Troubled Waters

1999 • 294 citations

IKAP is a scaffold protein of the IκB kinase complex

1998 • 294 citations

Crystal Structure of the Catalytic Domain of the Human Cell Cycle Control Phosphatase, Cdc25A

1998 • 282 citations

Heparan Sulfate-modified CD44 Promotes Hepatocyte Growth Factor/Scatter Factor-induced Signal Transduction through the Receptor Tyrosine Kinase c-Met

1999 • 231 citations

Singlet oxygen: a primary effector in the ultraviolet A/near-visible light induction of the human heme oxygenase gene.

1993 • 204 citations

Nuclear and cell membrane effects contribute independently to the induction of apoptosis in human cells exposed to UVB radiation

1999 • 190 citations

Protein tyrosine phosphatases take off

1995 • 174 citations

A splice variant of CD44 expressed in the apical ectodermal ridge presents fibroblast growth factors to limb mesenchyme and is required for limb outgrowth

1998 • 167 citations

Inactivation of Protein-tyrosine Phosphatases as Mechanism of UV-induced Signal Transduction

1999 • 166 citations

UV activation of receptor tyrosine kinase activity.

1995 • 164 citations

Specific interaction of the CD45 protein-tyrosine phosphatase with tyrosine-phosphorylated CD3 zeta chain.

1994 • 163 citations

Ligand-independent activation of platelet-derived growth factor receptor is a necessary intermediate in lysophosphatidic, acid-stimulated mitogenic activity in L cells

1998 • 154 citations

ZAP-70 tyrosine kinase, CD45, and T cell receptor involvement in UV- and H2O2-induced T cell signal transduction.

1994 • 150 citations

ahr null alleles: distinctive or different?

1998 • 147 citations

Hypoxia-Inducible Factor 1

1998 • 131 citations

Ultraviolet-irradiation-induced apoptosis is mediated via ligand independent activation of tumor necrosis factor receptor 1

1998 • 123 citations

Genetic evidence that Shp-2 tyrosine phosphatase is a signal enhancer of the epidermal growth factor receptor in mammals

1999 • 104 citations

Molecular Biology Of The Toxic Response

1999 • 91 citations

Regulation of T-cell activation and T-cell growth factor (TCGF) production by hydrogen peroxide

1987 • 89 citations

Review

1997 • 69 citations

Transcriptional and post-transcriptional responses to DNA-damaging agents

1994 • 51 citations

Oxidant, Antioxidant Status and Photocarcinogenesis: The Role of Gene Activation

1996 • 48 citations

Use of Selective Tyrosine Kinase Blockers to Monitor Growth Factor Receptor Dephosphorylation in Intact Cells

1995 • 28 citations

The dephosphorylation characteristics of the receptors for epidermal growth factor and platelet‐derived growth factor in Swiss 3T3 cell membranes suggest differential regulation of receptor signalling by endogenous protein‐tyrosine phosphatases

1993 • 15 citations

DNA-damage-inducible genes in mammalian cells.

1990 • 14 citations

Signal transduction induced by adverse agents: 'activation by inhibition'. The UV response 1997

1999 • 2 citations