Transcription factor NF-κB is activated in primary neurons by amyloid β peptides and in neurons surrounding early plaques from patients with Alzheimer disease

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

1984 • 5,166 citations

Function and Activation of NF-kappaB in the Immune System

1994 • 4,698 citations

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

1987 • 4,544 citations

Amyloid plaque core protein in Alzheimer disease and Down syndrome.

1985 • 4,276 citations

Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1.

1991 • 3,819 citations

Oxidative Stress, Glutamate, and Neurodegenerative Disorders

1993 • 3,746 citations

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

1995 • 2,456 citations

Hydrogen peroxide mediates amyloid β protein toxicity

1994 • 2,065 citations

Neurotrophic and Neurotoxic Effects of Amyloid β Protein: Reversal by Tachykinin Neuropeptides

1990 • 1,975 citations

Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB

1995 • 1,849 citations

Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation.

1995 • 1,739 citations

H2O2 and antioxidants have opposite effects on activation of NF-kappa B and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor.

1993 • 1,330 citations

NF-κB Controls Expression of Inhibitor IκBα: Evidence for an Inducible Autoregulatory Pathway

1993 • 1,141 citations

Rapid proteolysis of IκB-α is necessary for activation of transcription factor NF-κB

1993 • 1,129 citations

A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease.

1994 • 1,085 citations

Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6.

1993 • 1,009 citations

Intracellular thiols regulate activation of nuclear factor kappa B and transcription of human immunodeficiency virus.

1990 • 960 citations

β-amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity

1995 • 686 citations

Tumor necrosis factors alpha and beta protect neurons against amyloid beta-peptide toxicity: evidence for involvement of a kappa B-binding factor and attenuation of peroxide and Ca2+ accumulation.

1995 • 632 citations

β-Amyloid protein increases the vulnerability of cultured cortical neurons to excitotoxic damage

1990 • 620 citations

Vitamin E protects nerve cells from amyloid βprotein toxicity

1992 • 583 citations

Interleukin-1 Expression in Different Plaque Types in Alzheimerʼs Disease

1995 • 538 citations

The roles of hydrogen peroxide and superoxide as messengers in the activation of transcription factor NF-κB

1995 • 460 citations

Cell death in Alzheimer's disease evaluated by DNA fragmentation in situ

1995 • 450 citations

Induction of MHC Class I Genes in Neurons

1995 • 446 citations

Glial cytokines in Alzheimer's disease: Review and pathogenic implications

1995 • 412 citations

Constitutive NF-kB Activity in Neurons

1994 • 400 citations

Detection of interleukin-6 and alpha 2-macroglobulin immunoreactivity in cortex and hippocampus of Alzheimer's disease patients.

1992 • 329 citations

Inflammatory mechanisms in Alzheimer's disease: implications for therapy

1994 • 321 citations

Stimulation of ionotropic glutamate receptors activates transcription factor NF-kappa B in primary neurons.

1995 • 312 citations

Behavioral and anatomical deficits in mice homozygous for a modified ?-amyloid precursor protein gene

1994 • 307 citations

Synaptic activation of NF-kappa B by glutamate in cerebellar granule neurons in vitro.

1995 • 289 citations

Sequential Induction of NF-κB/Rel Family Proteins during B-Cell Terminal Differentiation

1994 • 275 citations

Is amyloidogenesis during Alzheimer's disease due to an IL-1-/IL-6-mediated ‘acute phase response’ in the brain?

1991 • 267 citations

Localization of Alzheimer βA4 amyloid precursor protein at central and peripheral synaptic sites

1991 • 259 citations

Brain synapses contain inducible forms of the transcription factor NF-κB

1993 • 225 citations

Reciprocal control of inflammatory cytokines, IL-1 and IL-6, and β-amyloid production in cultures

1995 • 202 citations

Induction of Oxidative Stress by Okadaic Acid Is Required for Activation of Transcription Factor NF-κB

1995 • 170 citations

Expression of inducible nitric oxide synthase by neurones following exposure to endotoxin and cytokine

1994 • 157 citations

Cytokine regulation of interleukin-6 gene expression in astrocytes involves activation of an NF-κ B-like nuclear protein

1992 • 147 citations

Generation of mice with a 200-kb amyloid precursor protein gene deletion by Cre recombinase-mediated site-specific recombination in embryonic stem cells.

1996 • 145 citations

Transcription factor NF-κB is activated in microglia during experimental autoimmune encephalomyelitis

1994 • 133 citations

Accumulation of intercellular adhesion molecule-1 in senile plaques in brain tissue of patients with Alzheimer's disease.

1994 • 104 citations

Selective Recognition of the Activated Form of Transcription Factor NF-χB by a Monoclonal Anfibody

1995 • 98 citations

Identification and Characterization of a κB/Rel Binding Site in the Regulatory Region of the Amyloid Precursor Protein Gene

1995 • 98 citations

The NF-kappa B p65 promoter.

1993 • 55 citations

Amyloid beta-protein activates tachykinin receptors and inositol trisphosphate accumulation by synergy with glutamate.

1993 • 55 citations

TrkA Activation Is Sufficient to Rescue Axotomized Cholinergic Neurons

1996 • 54 citations