Epidermal Growth Factor Receptor Transactivation by Angiotensin II Requires Reactive Oxygen Species in Vascular Smooth Muscle Cells

NAD(P)H Oxidase

2000 • 2,902 citations

Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells.

1994 • 2,753 citations

Epidermal Growth Factor (EGF)-induced Generation of Hydrogen Peroxide

1997 • 1,208 citations

Modulation of Protein Kinase Activity and Gene Expression by Reactive Oxygen Species and Their Role in Vascular Physiology and Pathophysiology

2000 • 959 citations

p22 Is a Critical Component of the Superoxide-generating NADH/NADPH Oxidase System and Regulates Angiotensin IIinduced Hypertrophy in Vascular Smooth Muscle Cells

1996 • 768 citations

Autophosphorylation sites on the epidermal growth factor receptor

1984 • 730 citations

p38 Mitogen-activated Protein Kinase Is a Critical Component of the Redox-sensitive Signaling Pathways Activated by Angiotensin II

1998 • 657 citations

Calcium-dependent Epidermal Growth Factor Receptor Transactivation Mediates the Angiotensin II-induced Mitogen-activated Protein Kinase Activation in Vascular Smooth Muscle Cells

1998 • 569 citations

Reactive Oxygen Species Mediate the Activation of Akt/Protein Kinase B by Angiotensin II in Vascular Smooth Muscle Cells

1999 • 563 citations

Gβγ Subunits Mediate Src-dependent Phosphorylation of the Epidermal Growth Factor Receptor

1997 • 456 citations

Differential Activation of Mitogen-Activated Protein Kinases by H ₂ O ₂ and O ₂ ⁻ in Vascular Smooth Muscle Cells

1995 • 416 citations

The tyrosine phosphorylated carboxyterminus of the EGF receptor is a binding site for GAP and PLC-gamma.

1990 • 314 citations

Tyrosine phosphorylation of the EGF receptor by the kinase Jak2 is induced by growth hormone

1997 • 286 citations

Pleiotropic Coupling of G Protein-coupled Receptors to the Mitogen-activated Protein Kinase Cascade

1999 • 259 citations

Hydrogen peroxide induces complex formation of SHC-Grb2-SOS with receptor tyrosine kinase and activates Ras and extracellular signal-regulated protein kinases group of mitogen-activated protein kinases.

1996 • 238 citations

Role of Janus Kinase/Signal Transducer and Activator of Transcription and Mitogen-activated Protein Kinase Cascades in Angiotensin II- and Platelet-derived Growth Factor-induced Vascular Smooth Muscle Cell Proliferation

1997 • 226 citations

Analysis of deletions of the carboxyl terminus of the epidermal growth factor receptor reveals self-phosphorylation at tyrosine 992 and enhanced in vivo tyrosine phosphorylation of cell substrates.

1990 • 193 citations

Hydrogen peroxide preferentially enhances the tyrosine phosphorylation of epidermal growth factor receptor

1995 • 187 citations

Redox Regulation of Signal Transduction in Cardiac and Smooth Muscle

1999 • 173 citations

Involvement of PYK2 in Angiotensin II Signaling of Vascular Smooth Muscle Cells

1999 • 168 citations

Phosphotyrosine 1173 Mediates Binding of the Protein-tyrosine Phosphatase SHP-1 to the Epidermal Growth Factor Receptor and Attenuation of Receptor Signaling

1998 • 156 citations

Role of Tyrosine Kinase Activity of Epidermal Growth Factor Receptor in the Lysophosphatidic Acid-stimulated Mitogen-activated Protein Kinase Pathway

1998 • 149 citations

Signal transduction of angiotensin II type 1 receptor through receptor tyrosine kinase

2000 • 142 citations

Shear Stress Stimulation of p130 Tyrosine Phosphorylation Requires Calcium-dependent c-Src Activation

1999 • 112 citations

Characterization of phosphatidylinositol-specific phospholipase C from cultured vascular smooth muscle cells

1991 • 97 citations

Angiotensin II Receptor Coupling to Phospholipase D Is Mediated by the βγ Subunits of Heterotrimeric G Proteins in Vascular Smooth Muscle Cells

1999 • 92 citations

Modulation of the SH2 Binding Specificity and Kinase Activity of Src by Tyrosine Phosphorylation within Its SH2 Domain

1996 • 91 citations

Shc Regulates Epidermal Growth Factor-induced Activation of the JNK Signaling Pathway

1999 • 68 citations

PYK2/CAKβ Represents a Redox-Sensitive Tyrosine Kinase in Vascular Smooth Muscle Cells

2000 • 53 citations

The SH3 and SH2 domains are capable of directing specificity in protein interactions between the non-receptor tyrosine kinases cSrc and cYes

2000 • 28 citations

Cyclic ADP-ribose-gated Ca2+ Release in Sea Urchin Eggs Requires an Elevated [Ca2+]

1997 • 24 citations