Caloric Intake and Aging

Aging: A Theory Based on Free Radical and Radiation Chemistry

1956 • 8,252 citations

Hydroperoxide metabolism in mammalian organs.

1979 • 5,821 citations

[1] Role of free radicals and catalytic metal ions in human disease: An overview

1990 • 5,041 citations

Oxidative Stress, Caloric Restriction, and Aging

1996 • 3,136 citations

Protein Oxidation and Aging

1992 • 2,687 citations

The Effect of Retarded Growth Upon the Length of Life Span and Upon the Ultimate Body Size

1935 • 2,189 citations

Comparative Animal Physiology

1951 • 2,152 citations

Body Weight and Mortality among Women

1995 • 2,018 citations

Antioxidant and redox regulation of gene transcription

1996 • 1,999 citations

The retardation of aging and disease by dietary restriction

1989 • 1,494 citations

Extension of Life-Span by Overexpression of Superoxide Dismutase and Catalase in Drosophila melanogaster

1994 • 1,461 citations

Oxidants as Stimulators of Signal Transduction

1997 • 1,380 citations

The Retardation of Aging in Mice by Dietary Restriction: Longevity, Cancer, Immunity and Lifetime Energy Intake

1986 • 968 citations

Oxidative damage, mitochondrial oxidant generation and antioxidant defenses during aging and in response to food restriction in the mouse

1994 • 785 citations

Dietary Restriction in Mice Beginning at 1 Year of Age: Effect on Life-Span and Spontaneous Cancer Incidence

1982 • 757 citations

The Biology of Senescence

1978 • 539 citations

The OB Protein (Leptin) Pathway - A Link Between Adipose Tissue Mass and Central Neural Networks

1996 • 517 citations

Age-related losses of cognitive function and motor skills in mice are associated with oxidative protein damage in the brain.

1996 • 493 citations

Relationship between mitochondrial superoxide and hydrogen peroxide production and longevity of mammalian species

1993 • 484 citations

Body Weight and Mortality

1993 • 436 citations

Mitochondria, free radicals, and neurodegeneration

1996 • 425 citations

Effect of age and caloric restriction on DNA oxidative damage in different tissues of C57BL/6 mice

1994 • 346 citations

Calorie restriction lowers body temperature in rhesus monkeys, consistent with a postulated anti-aging mechanism in rodents.

1996 • 305 citations

Effect of Age and Caloric Intake on Protein Oxidation in Different Brain Regions and on Behavioral Functions of the Mouse

1996 • 290 citations

Food restriction eliminates preneoplastic cells through apoptosis and antagonizes carcinogenesis in rat liver.

1994 • 274 citations

Influence of diet on survival of mice.

1976 • 261 citations

Das Problem der Lebensdauer und seine Beziehungen zu Wachstum und Ernährung

1908 • 256 citations

Dietary restriction increases insulin sensitivity and lowers blood glucose in rhesus monkeys

1994 • 235 citations

Comparison of mitochondrial pro-oxidant generation and anti-oxidant defenses between rat and pigeon: possible basis of variation in longevity and metabolic potential

1993 • 234 citations

Mitochondrial superoxide and hydrogen peroxide generation, protein oxidative damage, and longevity in different species of flies

1995 • 234 citations

Impact of westernization on the nutrition of Japanese: Changes in physique, cancer, longevity and centenarians

1978 • 232 citations

Dietary Restriction of Adult Male Rhesus Monkeys: Design, Methodology, and Preliminary Findings From the First Year of Study

1993 • 224 citations

The Influence of Dietary Protein Source on Longevity and Age-Related Disease Processes of Fischer Rats

1988 • 222 citations

Dietary Restriction and Aging: The Initiation of a Primate Study

1990 • 220 citations

Does food restriction retard aging by reducing the metabolic rate?

1985 • 212 citations

Effect of Dietary Restriction on the Age-Dependent Changes in the Expression of Antioxidant Enzymes in Rat Liver

1990 • 206 citations

Energy, nutrient intake and prostate cancer risk: a population-based case-control study in Sweden

1996 • 201 citations

Effects of food restriction on aging: separation of food intake and adiposity.

1984 • 191 citations

Oxidative DNA damage correlates with oxygen consumption in humans

1994 • 182 citations

Superoxide Radical: Controversies, Contradictions, and Paradoxes

1995 • 151 citations

Mortality rate and longevity of food-restricted exercising male rats: a reevaluation

1997 • 151 citations

Biological Effects of Dietary Restriction

1991 • 144 citations

Modulation of aging processes by dietary restriction

1994 • 140 citations

Total Food Consumption and Body Mass Index in Relation to Prostate Cancer Risk: A Case-Control Study in Sweden with Prospectively Collected Exposure Data

1996 • 129 citations

The rate of living : being an account of some experimental studies on the biology of life duration

1928 • 127 citations

Oxygen consumption, thermal conductance, and torpor in the California pocket mouse Perognathus californicus

1965 • 116 citations

Biochemical Correlates of Longevity in Two Closely Related Rodent Species

1993 • 115 citations

Restricted Feeding in Early and Late-Feathering Chickens.

1989 • 105 citations

Body weight and mortality. A 27-year follow-up of middle-aged men

1993 • 94 citations

Effect of Chronic Caloric Restriction on the Synchronization of Various Physiological Measures in Old Female Fischer 344 Rats

1990 • 90 citations

Relationship between susceptibility to protein oxidation, aging, and maximum life span potential of different species

1996 • 86 citations

Effect of dietary restriction on in vivo somatic mutation in mice

1993 • 85 citations

A Study of Caloric Restriction and Cardiovascular Aging in Cynomolgus Monkeys (Macacafascicularis): A Potential Model for Aging Research

1997 • 83 citations

Altered norepinephrine uptake in neuronal cultures from spontaneously hypertensive rat brain

1985 • 76 citations

Mitotic Activity in Mice is Suppressed by Energy Restriction-Induced Torpor

1992 • 67 citations

24 hour energy expenditure several months after weight loss in the underfed rat: evidence for a chronic increase in whole-body metabolic efficiency.

1993 • 67 citations

Impact of a moderately energy-restricted diet on energy metabolism and body composition in non-obese men.

1995 • 66 citations

Energy restriction, a useful intervention to retard human ageing? Results of a feasibility study.

1994 • 54 citations

Prevention of Obesity in Middle‐Aged Monkeys: Food Intake During Body Weight Clamp

1995 • 52 citations

Glucose transport with brief dietary restriction: heterogenous responses in muscles

1994 • 52 citations

Energy expenditure of adult male rhesus monkeys during the first 30 mo of dietary restriction

1997 • 49 citations

Energy balance, body size, and cancer

1990 • 45 citations

Cyclic nucleotide-gated cation channels mediate sodium absorption by IMCD (mIMCD-K2) cells

1997 • 39 citations

Dietary Calorie Restriction in Mice Induces Carbamyl Phosphate Synthetase I Gene Transcription Tissue Specifically

1996 • 38 citations

Acidification stimulates chloride and fluid absorption across frog retinal pigment epithelium

1994 • 38 citations

Energy restriction and oxidative DNA damage in humans.

1995 • 38 citations

Gaining on Fat

1996 • 34 citations

Beneficial effect of a moderately energy-restricted diet on fibrinolytic factors in non-obese men

1995 • 25 citations

Pi-class glutathione-S-transferase-positive hepatocytes in aging B6C3F1 mice undergo apoptosis induced by dietary restriction.

1996 • 25 citations

Issues in the measurement of energy intake for free-living human populations

1996 • 12 citations

Cardiomyopathies and oxidative stress

1996 • 10 citations