Oxygen sensing and signaling: impact on the regulation of physiologically important genes

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

1995 • 5,971 citations

Regulation of hypoxia-inducible factor 1α is mediated by an O ₂ -dependent degradation domain via the ubiquitin-proteasome pathway

1998 • 2,044 citations

Mitochondrial reactive oxygen species trigger hypoxia-induced transcription

1998 • 1,864 citations

Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1.

1994 • 1,821 citations

General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia.

1993 • 1,441 citations

Oxygen sensing and molecular adaptation to hypoxia

1996 • 1,187 citations

Activation of Hypoxia-inducible Transcription Factor Depends Primarily upon Redox-sensitive Stabilization of Its α Subunit

1996 • 1,172 citations

Erythropoietin: structure, control of production, and function

1992 • 1,158 citations

Regulation of the Erythropoietin Gene: Evidence That the Oxygen Sensor Is a Heme Protein

1988 • 1,042 citations

Desferrioxamine induces erythropoietin gene expression and hypoxia- inducible factor 1 DNA-binding activity: implications for models of hypoxia signal transduction

1993 • 740 citations

Intracellular Signaling by Reactive Oxygen Species during Hypoxia in Cardiomyocytes

1998 • 684 citations

Similarities between the oxygen-sensing mechanisms regulating the expression of vascular endothelial growth factor and erythropoietin.

1994 • 584 citations

Chemotransduction in the Carotid Body: K ⁺ Current Modulated by P O ₂ In Type I Chemoreceptor Cells

1988 • 543 citations

Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: similarities with the erythropoietin 3' enhancer.

1994 • 517 citations

The Hypoxic Response: Huffing and HIFing

1997 • 482 citations

A haemoprotein with kinase activity encoded by the oxygen sensor of Rhizobium meliloti

1991 • 477 citations

Oxygen sensing in airway chemoreceptors

1993 • 467 citations

Inhibition of macrophage and endothelial cell nitric oxide synthase by diphenyleneiodonium and its analogs ¹

1991 • 461 citations

Functional Interference between Hypoxia and Dioxin Signal Transduction Pathways: Competition for Recruitment of the Arnt Transcription Factor

1996 • 449 citations

Hypoxic stimulation of vascular endothelial growth factor expression in vitro and in vivo.

1994 • 433 citations

Inducible operation of the erythropoietin 3' enhancer in multiple cell lines: evidence for a widespread oxygen-sensing mechanism.

1993 • 411 citations

Activation of hypoxia-inducible factor 1α: Posttranscriptional regulation and conformational change by recruitment of the Arnt transcription factor

1997 • 406 citations

Endothelial cell expression of vasoconstrictors and growth factors is regulated by smooth muscle cell-derived carbon monoxide.

1995 • 355 citations

Inhibition of Hypoxia-inducible Factor 1 Activation by Carbon Monoxide and Nitric Oxide

1999 • 295 citations

The Role of the Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) in Hypoxic Induction of Gene Expression

1996 • 287 citations

Regulation of angiogenic growth factor expression by hypoxia, transition metals, and chelating agents

1995 • 274 citations

Relative mitochondrial membrane potential and [Ca2+]i in type I cells isolated from the rabbit carotid body.

1992 • 246 citations

Heme-Based Sensors, Exemplified by the Kinase FixL, Are a New Class of Heme Protein with Distinctive Ligand Binding and Autoxidation

1994 • 239 citations

Role of hydrogen peroxide in hypoxia-induced erythropoietin production

1994 • 233 citations

Inhibition of hypoxia-inducible factor 1 activity by nitric oxide donors in hypoxia

1998 • 230 citations

Carbon Monoxide and Nitric Oxide Suppress the Hypoxic Induction of Vascular Endothelial Growth Factor Gene via the 5′ Enhancer

1998 • 228 citations

Involvement of an NAD(P)H oxidase as a pO2 sensor protein in the rat carotid body

1990 • 199 citations

In vivo and in vitro regulation of erythropoietin mRNA: measurement by competitive polymerase chain reaction

1993 • 198 citations

Cellular Respiration during Hypoxia

1997 • 185 citations

Studies on Erythropoiesis

1958 • 166 citations

Single K+ channels in membrane patches of arterial chemoreceptor cells are modulated by O2 tension.

1991 • 162 citations

Isoenzyme-specific regulation of genes involved in energy metabolism by hypoxia: similarities with the regulation of erythropoietin

1996 • 151 citations

Carotid body O2 chemoreception and mitochondrial oxidative phosphorylation

1981 • 143 citations

Effects of Transition Metals on the Expression of the Erythropoietin Gene: Further Evidence That the Oxygen Sensor Is a Heme Protein

1996 • 134 citations

Mechanisms and meaning of cellular oxygen sensing in the organism

1994 • 128 citations

The primary oxygen sensor of the cat carotid body is cytochrome a₃ of the mitochondrial respiratory chain

1994 • 125 citations

Photometric characteristics of haem proteins in erythropoietin-producing hepatoma cells (HepG2)

1993 • 93 citations

Diphenylene Iodonium Inhibits the Induction of Erythropoietin and Other Mammalian Genes by Hypoxia

1995 • 91 citations

Immunohistochemical demonstration of four subunits of neutrophil NAD(P)H oxidase in type I cells of carotid body

1995 • 90 citations

Hypoxic induction of gene expression in chronic granulomatous disease- derived B-cell lines: oxygen sensing is independent of the cytochrome b558-containing nicotinamide adenine dinucleotide phosphate oxidase

1996 • 77 citations

CO reveals dual mechanisms of O2 chemoreception in the cat carotid body

1993 • 77 citations

Time course of K⁺ current inhibition by low oxygen in chemoreceptor cells of adult rabbit carotid body Effects of carbon monoxide

1992 • 76 citations

Hypoxia-inducible Factor 1α (HIF-1α) Is a Non-heme Iron Protein

1998 • 71 citations

Metal specificity of the iron-protoporphyrin chelating enzyme from rat liver

1961 • 68 citations

Formation of cobalt protoporphyrin in the liver of rats. A mechanism for the inhibition of liver haem biosynthesis by inorganic cobalt

1979 • 68 citations

Regulation of tyrosine hydroxylase gene expression during hypoxia: Role of Ca2+ and PKC

1997 • 58 citations

Cellular Oxygen Sensors

1994 • 57 citations

A Ferro-Heme Protein Senses Oxygen Levels, Which Modulate the Glucagon-Dependent Activation of the Phosphoenolpyruvate Carboxykinase Gene in Rat Hepatocyte Cultures

1993 • 55 citations

Characterization of Ferrous FixL−Nitric Oxide Adducts by Resonance Raman Spectroscopy

1997 • 52 citations

Structural Basis for Ligand Discrimination and Response Initiation in the Heme-Based Oxygen Sensor FixL

1996 • 49 citations

EFFECTS OF TESTOSTERONE, COBALT AND HYPOXIA ON ERYTHROPOIETIN PRODUCTION IN THE ISOLATED PERFUSED DOG KIDNEY*

1968 • 42 citations

Reciprocal photolabile O2 consumption and chemoreceptor excitation by carbon monoxide in the cat carotid body: evidence for cytochrome a3 as the primary O2 sensor

1995 • 40 citations

Correlation between adenosine triphosphate levels, dopamine release and electrical activity in the carotid body: Support for the metabolic hypothesis of chemoreception

1985 • 39 citations

Effects of cobalt on haem proteins of erythropoietin‐producing HepG2 cells in multicellular spheroid culture

1994 • 38 citations

Diphenylene iodonium blocks K+ and Ca2+ currents in type I cells isolated from the neonatal rat carotid body

1994 • 36 citations

Cobalt Stimulates the Expression of Vascular Endothelial Growth Factor mRNA in Rat Cardiac Cells

1994 • 34 citations

Regulation of erythropoietin production.

1993 • 32 citations

Formation of cobalt protoporphyrin by chicken hepatocytes in culture

1982 • 26 citations

Polycythemia Induced in Rats by Intrarenal Injection of Nickel Sulfide Ni3S2

1975 • 25 citations

Differential Inhibition by Iodonium Compounds of Induced Erythropoietin Expression

1995 • 20 citations

Dose-response and time-response study of erythrocytosis in rats after intrarenal injection of nickel subsulfide.

1977 • 18 citations