Role of oxygen free radicals in cancer development

Oxidants, antioxidants, and the degenerative diseases of aging.

1993 • 6,011 citations

Instability and decay of the primary structure of DNA

1993 • 5,370 citations

Oxygen toxicity, oxygen radicals, transition metals and disease

1984 • 5,301 citations

The Effect of Vitamin E and Beta Carotene on the Incidence of Lung Cancer and Other Cancers in Male Smokers

1994 • 4,626 citations

Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1.

1991 • 3,819 citations

The Causes of Cancer: Quantitative Estimates of Avoidable Risks of Cancer in the United States Today

1981 • 3,794 citations

The Causes of Cancer: Quantitative Estimates of Avoidable Risks of Cancer in the United States Today

1983 • 3,602 citations

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

1993 • 3,465 citations

Biology of disease: free radicals and tissue injury.

1982 • 3,078 citations

Dietary Carcinogens and Anticarcinogens

1983 • 3,028 citations

Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: a hypothesis.

1981 • 2,777 citations

Prooxidant States and Tumor Promotion

1985 • 2,541 citations

Cellular defenses against damage from reactive oxygen species

1994 • 2,393 citations

Free radicals, antioxidants, and human disease: where are we now?

1992 • 2,223 citations

Oxidative stress as a mediator of apoptosis

1994 • 2,210 citations

DNA Damage and Oxygen Radical Toxicity

1988 • 1,964 citations

p53 function and dysfunction

1992 • 1,918 citations

Free Radicals in Biology

1976 • 1,879 citations

The chemical basis of radiation biology

1987 • 1,788 citations

Nutrition Intervention Trials in Linxian, China: Supplementation With Specific Vitamin/Mineral Combinations, Cancer Incidence, and Disease-Specific Mortality in the General Population

1993 • 1,783 citations

DNA damage by oxygen‐derived species Its mechanism and measurement in mammalian systems

1991 • 1,555 citations

Mutational hot spot in the p53 gene in human hepatocellular carcinomas

1991 • 1,525 citations

REPAIR OF OXIDATIVE DAMAGE TO DNA: Enzymology and Biology

1994 • 1,435 citations

Nitric oxide regulation of superoxide and peroxynitrite-dependent lipid peroxidation. Formation of novel nitrogen-containing oxidized lipid derivatives

1994 • 1,348 citations

Peroxynitrite, a cloaked oxidant formed by nitric oxide and superoxide

1992 • 1,319 citations

Persistent oxidative stress in cancer

1995 • 1,218 citations

p53: A Frequent Target for Genetic Abnormalities in Lung Cancer

1989 • 1,214 citations

Bcl-2 initiates a new category of oncogenes: regulators of cell death

1992 • 1,078 citations

Transcriptional Regulator of Oxidative Stress-Inducible Genes: Direct Activation by Oxidation

1990 • 869 citations

Bcl-2 initiates a new category of oncogenes: regulators of cell death

1992 • 860 citations

Role of Ca2+ in toxic cell killing

1989 • 856 citations

Bcl-2/Bax: a rheostat that regulates an anti-oxidant pathway and cell death.

1993 • 855 citations

Mutagenesis by 8-oxoguanine: an enemy within

1993 • 805 citations

The ras gene family and human carcinogenesis

1988 • 786 citations

A Clinical Trial of Antioxidant Vitamins to Prevent Colorectal Adenoma

1994 • 769 citations

Asbestos: Scientific Developments and Implications for Public Policy

1990 • 763 citations

Xeroderma Pigmentosum

1974 • 755 citations

Inflammation and cancer: role of phagocyte-generated oxidants in carcinogenesis

1990 • 741 citations

Supplemental ascorbate in the supportive treatment of cancer: Prolongation of survival times in terminal human cancer.

1976 • 686 citations

Modulation of transcription factor NF-kappa B binding activity by oxidation-reduction in vitro.

1991 • 649 citations

Oxy-radicals and cancer

1994 • 582 citations

Mechanisms of DNA Excision Repair

1994 • 560 citations

Serum Beta-Carotene, Vitamins a and E, Selenium, and the Risk of Lung Cancer

1986 • 542 citations

Uric acid-iron ion complexes. A new aspect of the antioxidant functions of uric acid

1986 • 538 citations

Cell and tissue responses to oxidative damage.

1993 • 492 citations

Gas phase oxidants of cigarette smoke induce lipid peroxidation and changes in lipoprotein properties in human blood plasma. Protective effects of ascorbic acid

1991 • 485 citations

Oxidative mechanisms in carcinogenesis

1993 • 484 citations

A Clinical Trial of Beta Carotene to Prevent Basal-Cell and Squamous-Cell Cancers of the Skin

1990 • 484 citations

Reactive oxygen species in tumorigenesis.

1994 • 479 citations

The Approaching Era of the Tumor Suppressor Genes

1987 • 468 citations

Mismatch Repair, Genetic Stability, and Cancer

1994 • 429 citations

Inflammation and Oxidative Stress in Carcinogenesis

1993 • 419 citations

Ca2+- and phospholipid-independent activation of protein kinase C by selective oxidative modification of the regulatory domain.

1989 • 409 citations

An overview of the relationship between oxidative stress and chemical carcinogenesis

1991 • 378 citations

p53-deficient mice are extremely susceptible to radiation-induced tumorigenesis

1994 • 366 citations

Iron Ion-dependent Modification of Bases in DNA by the Superoxide Radical-generating System Hypoxanthine/Xanthine Oxidase

1989 • 363 citations

Assays for 8-hydroxy-2′-deoxyguanosine: A biomarker of in vivo oxidative DNA damage

1991 • 363 citations

Colon Cancer, Dysplasia, and Surveillance in Patients with Ulcerative Colitis

1987 • 341 citations

Free radicals and the etiology of colon cancer

1990 • 329 citations

DNA base modifications in chromatin of human cancerous tissues

1992 • 278 citations

Increased formation of oxidative DNA damage, 8-hydroxydeoxyguanosine, in human livers with chronic hepatitis.

1994 • 277 citations

Mutation Caused by Human Phagocytes

1981 • 264 citations

Oxy-radicals in molecular biology and pathology

1989 • 262 citations

Cigarette smoke induces DNA single-strand breaks in human cells

1985 • 248 citations

Nitric Oxide Regulation of Superoxide and Peroxynitrite-dependent Lipid Peroxidation

1994 • 244 citations

Oxidative DNA base damage and antioxidant enzyme activities in human lung cancer

1994 • 243 citations

Inflammation, chromosomal instability, and cancer: the schistosomiasis model.

1994 • 229 citations

p53: the ultimate tumor suppressor gene?

1992 • 209 citations

Characterization of a Mammalian Homolog of the Escherichia coli MutY Mismatch Repair Protein

1995 • 194 citations

Dietary iron and colorectal cancer risk

1992 • 192 citations

Mutation spectrum of copper-induced DNA damage.

1991 • 190 citations

Reverse chemical mutagenesis: identification of the mutagenic lesions resulting from reactive oxygen species-mediated damage to DNA.

1994 • 189 citations

DNA excision-repair defect of xeroderma pigmentosum prevents removal of a class of oxygen free radical-induced base lesions.

1993 • 183 citations

It was a very good year for DNA repair

1994 • 181 citations

The antioxidant efficiency of vitamin C is concentration-dependent

1986 • 175 citations

Evidence for reactive oxygen species inducing mutations in mammalian cells.

1986 • 175 citations

Role of [Ca ²⁺ ] _i in induction of c‐ fos , c‐ jun and c‐ myc mRNA in rat PTE after oxidative stress

1992 • 168 citations

Metabolism of Polycyclic Aromatic Hydrocarbon Derivatives to Ultimate Carcinogens During Lipid Peroxidation

1983 • 162 citations

Calcium chelator Quin 2 prevents hydrogen‐peroxide‐induced DNA breakage and cytotoxicity

1989 • 157 citations

Histone shuttling by poly(ADP-ribosylation).

1992 • 152 citations

Immunocompetence and oxidant defense during ascorbate depletion of healthy men

1991 • 144 citations

The Fenton oxidation mechanism: reactivities of biologically relevant substrates with two oxidizing intermediates differ from those predicted for the hydroxyl radical.

1994 • 137 citations

Translocation and enhancement of phosphotransferase activity of protein kinase C following exposure in mouse epidermal cells to oxidants.

1989 • 132 citations

Protein modification by oxidants and the role of proteolytic enzymes

1993 • 129 citations

Oxy-radical induced mutagenesis of hotspot codons 248 and 249 of the human p53 gene.

1994 • 127 citations

Mutagenesis by hydrogen peroxide treatment of mammalian cells: a molecular analysis

1990 • 120 citations

Differential effects of superoxide, hydrogen peroxide, and hydroxyl radical on intracellular calcium in human endothelial cells

1995 • 118 citations

Antioxidant enzyme activities and oxidative stress in human breast cancer

1994 • 116 citations

Oxidants stress induces the proto-oncogenes, C-fos and C-myc in mouse epidermal cells.

1990 • 109 citations

The metal-mediated formation of hydroxyl radical by aqueous extracts of cigarette tar

1985 • 108 citations

Effects of ionizing radiation on deoxyribonucleic acid and related systems. Part 1. The rôle of oxygen

1984 • 99 citations

Recognition of oxidized abasic sites by repair endonucleases

1994 • 99 citations

Malignant transformation by mutant Rel proteins

1991 • 96 citations

Oxidants induce phosphorylation of ribosomal protein S6.

1988 • 91 citations

Importance of various antioxidant enzymes for cell stability. Confrontation between theoretical and experimental data

1992 • 90 citations

Early superoxide dismutase-sensitive event promotes neoplastic transformation in mouse epidermal JB6 cells

1988 • 88 citations

Cholesterol and cholesterol epoxides in nipple aspirates of human breast fluid.

1981 • 80 citations

Intracellular Ca2+ and the regulation of early response gene expression in HL-60 myeloid leukemia cells

1993 • 73 citations

Coming to terms with death: apoptosis in cancer and immune development

1994 • 56 citations

Application of Radiation Chemistry to Biology

1977 • 46 citations

The permissive role of oxygen‐derived free radicals in the development of colonic cancer in the rat. A new theory for carcinogenesis

1993 • 43 citations

DNA Repair Works Its Way to the Top

1994 • 41 citations

HEPATITIS B, HEPATOCELLULAR CARCINOMA, AND STRATEGIES FOR PREVENTION

1984 • 37 citations

Electron Spin Resonance Studies Of Carcinogenesis

1972 • 32 citations

Formamidopyrimidine DNA glycosylase in the yeastSaccharomyces cerevisiae

1994 • 32 citations

Alcohol acts to promote incidence of tumors.

1992 • 29 citations

[53] Radical-mediated DNA damage in presence of oxygen

1990 • 29 citations

Constitutive and phorbol‐myristate‐acetate regulated antioxidant defense of mouse epidermal JB6 cells

1989 • 25 citations

Superoxide-dependent production of hydroxyl radicals in the presence of iron salts

1982 • 25 citations

Case 33-1994

1994 • 22 citations

DNA repair: Looking back and peering forward

1994 • 17 citations

Projecting international lung cancer mortality rates: first approximations with tobacco-consumption data.

1992 • 16 citations

Cigarettes: then and now.

1994 • 5 citations

Lipids and Cancer

1987 • 2 citations