Free Radicals and Their Involvement During Long-Term Myocardial Ischemia and Reperfusion

Oxygen-Derived Free Radicals in Postischemic Tissue Injury

1985 • 5,488 citations

Factors Influencing Infarct Size Following Experimental Coronary Artery Occlusions

1971 • 1,500 citations

Myocardial reperfusion: a double-edged sword?

1985 • 1,355 citations

Early phase acute myocardial infarct size quantification: Validation of the triphenyl tetrazolium chloride tissue enzyme staining technique

1981 • 925 citations

Canine myocardial reperfusion injury. Its reduction by the combined administration of superoxide dismutase and catalase.

1984 • 915 citations

Myocardial necrosis induced by temporary occlusion of a coronary artery in the dog.

1960 • 762 citations

Demonstration of free radical generation in "stunned" myocardium of intact dogs with the use of the spin trap alpha-phenyl N-tert-butyl nitrone.

1988 • 691 citations

Direct detection of free radicals in the reperfused rat heart using electron spin resonance spectroscopy.

1987 • 628 citations

Species variation in the coronary collateral circulation during regional myocardial ischaemia: a critical determinant of the rate of evolution and extent of myocardial infarction

1987 • 508 citations

Lethal myocardial ischemic injury.

1981 • 451 citations

Abrupt reoxygenation of the anoxic potassium-arrested perfused rat heart: A study of myocardial enzyme release

1973 • 443 citations

Reperfusion-induced arrhythmias and oxygen-derived free radicals. Studies with "anti-free radical" interventions and a free radical-generating system in the isolated perfused rat heart.

1986 • 396 citations

Oxygen-derived free radicals and postischemic myocardial dysfunction (“stunned myocardium”)

1988 • 349 citations

Reduction in experimental infarct size by recombinant human superoxide dismutase: insights into the pathophysiology of reperfusion injury.

1986 • 344 citations

Factors involved in salvaging ischemic myocardium: effect of reperfusion of arterial blood.

1983 • 318 citations

Free radicals and myocardial ischemia and reperfusion injury.

1987 • 307 citations

Appearance of superoxide anion radical in cerebral extracellular space during increased prostaglandin synthesis in cats.

1985 • 296 citations

Role of oxygen radicals in cardiac injury due to reoxygenation*

1984 • 276 citations

The independent effects of oxygen radical scavengers on canine infarct size. Reduction by superoxide dismutase but not catalase.

1985 • 234 citations

The mechanism of the tetrazolium reaction in identifying experimental myocardial infarction

1981 • 232 citations

Ultrastructural damage associated with reoxygenation of the anoxic myocardium

1975 • 202 citations

Myocardial ischemia and reperfusion: direct evidence for free radical generation by electron spin resonance spectroscopy.

1988 • 200 citations

Free radical-producing enzyme, xanthine oxidase, is undetectable in human hearts

1987 • 199 citations

Reduction of myocardial ischemic injury with oxygen-derived free radical scavengers.

1983 • 195 citations

Failure of superoxide dismutase and catalase to alter size of infarction in conscious dogs after 3 hours of occlusion followed by reperfusion.

1986 • 189 citations

Attenuation of dysfunction in the postischemic 'stunned' myocardium by dimethylthiourea.

1987 • 168 citations

Free radicals and myocardial ischemia. The role of xanthine oxidase.

1985 • 153 citations

Superoxide dismutase reduces reperfusion arrhythmias but fails to salvage regional function or myocardium at risk in conscious dogs.

1989 • 129 citations

Calcium uptake during post-ischemic reperfusion in the isolated rat heart: Influence of extracellular sodium

1982 • 127 citations

Xanthine oxidase is not a source of free radicals in the ischemic rabbit heart

1987 • 127 citations

Effect of α-tocopherol on hypoxic-perfused and reoxygenated rabbit heart muscle

1978 • 106 citations

Mitochondrial hydrogen peroxide generation and activities of glutathione peroxidase and superoxide dismutase following global ischemia

1987 • 105 citations

Infarct size limitation by the xanthine oxidase inhibitor, allopurinol, in closed-chest dogs with small infarcts

1985 • 97 citations

Evidence for a pathogenetic role of xanthine oxidase in the "stunned" myocardium

1987 • 93 citations

Effect of superoxide dismutase on myocardial infarct size in the canine heart after 6 hours of regional ischemia and reperfusion: a demonstration of myocardial salvage.

1989 • 79 citations

Oxypurinol limits myocardial stunning but does not reduce infarct size after reperfusion.

1987 • 77 citations

The rapid evolution of a myocardial infarction in an end-artery coronary preparation.

1987 • 69 citations

Effects of the free radical scavenger DMTU and mannitol on the oxygen paradox in perfused rat hearts*

1987 • 66 citations

Xanthine Oxidase is Not Responsible for Reoxygenation Injury in Isolated-Perfused Rat Heart

1987 • 59 citations

Evidence for a role of iron-catalyzed oxidants in functional and metabolic stunning in the canine heart.

1988 • 55 citations

Oxygen free radicals and reperfusion injury; the effect of ischaemia and reperfusion on the cellular ability to neutralise oxygen toxicity

1986 • 53 citations

Myocyte and endothelial injury with ischemia reperfusion in isolated rat hearts

1987 • 52 citations

Effects of flurbiprofen in altering the size of myocardial infarcts in dogs: Reduction or delay?

1983 • 48 citations

Intracoronary superoxide dismutase for the treatment of “reperfusion injury” A blind randomized placebo-controlled trial in ischemic, reperfused porcine hearts

1988 • 33 citations

The xanthine oxidase inhibitor oxypurinol does not limit infarct size in a canine model of 40 minutes of ischemia with reperfusion

1988 • 25 citations

No evidence for reactive oxygen damage in ischemia-reflow injury.

1987 • 16 citations

Myocardial salvage with allopurinol during 24 h of permanent coronary occlusion: importance of pretreatment.

1988 • 7 citations