Redox Regulation of Cell Adhesion Processes

Role of Oxidative Stress in Development of Complications in Diabetes

1991 • 3,774 citations

Cadherin Cell Adhesion Receptors as a Morphogenetic Regulator

1991 • 3,314 citations

Transcriptional regulation of endothelial cell adhesion molecules: NF‐κB and cytokine‐inducible enhancers

1995 • 1,715 citations

Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes

1989 • 1,715 citations

Identification of an inducible endothelial-leukocyte adhesion molecule.

1987 • 1,639 citations

pp125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions.

1992 • 1,456 citations

α4β7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1

1993 • 1,427 citations

Tyrosine phosphorylation of paxillin and pp125FAK accompanies cell adhesion to extracellular matrix: a role in cytoskeletal assembly.

1992 • 1,330 citations

Endothelial-Leukocyte Adhesion Molecules

1993 • 1,324 citations

Selectins: Interpreters of Cell-Specific Carbohydrate Information During Inflammation

1992 • 1,255 citations

Vascular cell adhesion molecule-1 (VCAM-1) gene transcription and expression are regulated through an antioxidant-sensitive mechanism in human vascular endothelial cells.

1993 • 1,079 citations

Efficacy of Oral N-Acetylcysteine in the Treatment of Acetaminophen Overdose

1988 • 1,064 citations

Adhesion molecules and inflammatory injury

1994 • 1,023 citations

Inactivation of the N-CAM gene in mice results in size reduction of the olfactory bulb and deficits in spatial learning

1994 • 1,010 citations

The selecting: vascular adhesion molecules

1995 • 954 citations

Cell adhesion or integrin clustering increases phosphorylation of a focal adhesion-associated tyrosine kinase.

1992 • 743 citations

Molecular and cellular properties of PECAM-1 (endoCAM/CD31): a novel vascular cell-cell adhesion molecule.

1991 • 719 citations

Paxillin: a new vinculin-binding protein present in focal adhesions.

1990 • 687 citations

Diabetes mellitus and free radicals

1993 • 666 citations

The neutrophil selectin LECAM-1 presents carbohydrate ligands to the vascular selectins ELAM-1 and GMP-140

1991 • 592 citations

Effects of Mechanical Forces on Signal Transduction and Gene Expression in Endothelial Cells

1998 • 582 citations

SELECTIN-CARBOHYDRATE INTERACTIONS AND THE INITIATION OF THE INFLAMMATORY RESPONSE

1995 • 574 citations

PADGEM (GMP140) is a component of Weibel-Palade bodies of human endothelial cells

1989 • 538 citations

Nitric oxide regulates vascular cell adhesion molecule 1 gene expression and redox-sensitive transcriptional events in human vascular endothelial cells.

1996 • 513 citations

Treatment of symptomatic diabetic peripheral neuropathy with the anti-oxidant ?-lipoic acid

1995 • 505 citations

Cloning of the human gene for intercellular adhesion molecule 1 and analysis of its 5'-regulatory region. Induction by cytokines and phorbol ester.

1991 • 419 citations

Regulation of interleukin 8 gene expression by oxidant stress.

1993 • 395 citations

Leukocyte-endothelial cell interactions: Molecular mechanisms and implications in gastrointestinal disease☆☆☆

1998 • 382 citations

Antioxidants inhibit monocyte adhesion by suppressing nuclear factor-kappa B mobilization and induction of vascular cell adhesion molecule-1 in endothelial cells stimulated to generate radicals.

1994 • 349 citations

The effects of alpha tocopherol supplementation on monocyte function. Decreased lipid oxidation, interleukin 1 beta secretion, and monocyte adhesion to endothelium.

1996 • 344 citations

Four molecular pathways of T cell adhesion to endothelial cells: roles of LFA-1, VCAM-1, and ELAM-1 and changes in pathway hierarchy under different activation conditions.

1991 • 343 citations

Clinical Pharmacokinetics of N-Acetylcysteine

1991 • 338 citations

Adhesion Molecules

1996 • 329 citations

Vascular Permeability Factor/Vascular Endothelial Cell Growth Factor-mediated Permeability Occurs through Disorganization of Endothelial Junctional Proteins

1998 • 320 citations

Reactivity of hydroxyl and hydroxyl-like radicals discriminated by release of thiobarbituric acid-reactive material from deoxy sugars, nucleosides and benzoate

1984 • 313 citations

Flavonoids inhibit cytokine-induced endothelial cell adhesion protein gene expression.

1995 • 311 citations

Platelet-derived growth factor modulation of focal adhesion kinase (p125FAK) and paxillin tyrosine phosphorylation in Swiss 3T3 cells. Bell-shaped dose response and cross-talk with bombesin.

1994 • 305 citations

Bombesin, vasopressin, and endothelin stimulation of tyrosine phosphorylation in Swiss 3T3 cells. Identification of a novel tyrosine kinase as a major substrate.

1992 • 296 citations

d-alpha-tocopherol inhibition of vascular smooth muscle cell proliferation occurs at physiological concentrations, correlates with protein kinase C inhibition, and is independent of its antioxidant properties.

1995 • 290 citations

Leukocyte adhesion: CD11/CD18 integrins and intercellular adhesion molecules

1997 • 282 citations

Effects of vitamin E and C supplementation on oxidative stress and viral load in HIV-infected subjects

1998 • 279 citations

Bombesin stimulation of p125 focal adhesion kinase tyrosine phosphorylation. Role of protein kinase C, Ca2+ mobilization, and the actin cytoskeleton

1993 • 277 citations

Lysophosphatidic acid stimulates tyrosine phosphorylation of focal adhesion kinase, paxillin, and p130. Signaling pathways and cross-talk with platelet-derived growth factor.

1994 • 264 citations

Cell spreading on extracellular matrix proteins induces tyrosine phosphorylation of tensin

1993 • 253 citations

Oxidative stress and plasma antioxidant micronutrients in humans with HIV infection

1998 • 250 citations

Oxidants and Antioxidants in Viral Diseases: Disease Mechanisms and Metabolic Regulation

1997 • 234 citations

Oxygen radical scavengers selectively inhibit interleukin 8 production in human whole blood.

1992 • 232 citations

Hypoxia, oxidative stress and rheumatoid arthritis

1995 • 229 citations

Activation of transcription factor AP-2 mediates UVA radiation- and singlet oxygen-induced expression of the human intercellular adhesion molecule 1 gene

1996 • 217 citations

Alpha-tocopherol inhibits agonist-induced monocytic cell adhesion to cultured human endothelial cells.

1994 • 213 citations

Bombesin, vasopressin, and endothelin rapidly stimulate tyrosine phosphorylation of the focal adhesion-associated protein paxillin in Swiss 3T3 cells.

1993 • 209 citations

Increased Adhesiveness of Isolated Monocytes to Endothelium Is Prevented by Vitamin C Intake in Smokers

1996 • 200 citations

Quercetin inhibits inducible ICAM-1 expression in human endothelial cells through the JNK pathway

1999 • 197 citations

Copper-dependent Inflammation and Nuclear Factor- κ B Activation by Particulate Air Pollution

1998 • 180 citations

Intercellular adhesion molecule 1 knockout abrogates radiation induced pulmonary inflammation

1997 • 170 citations

Vitamin C prevents cigarette smoke-induced leukocyte aggregation and adhesion to endothelium in vivo.

1994 • 167 citations

Reactive oxygen species rapidly increase endothelial ICAM-1 ability to bind neutrophils without detectable upregulation

1994 • 165 citations

Cigarette smoke condensate-induced adhesion molecule expression and transendothelial migration of monocytes

1996 • 164 citations

Systemic endothelial activation occurs in both mild and severe malaria. Correlating dermal microvascular endothelial cell phenotype and soluble cell adhesion molecules with disease severity.

1998 • 158 citations

P- and E-selectin use common sites for carbohydrate ligand recognition and cell adhesion.

1993 • 150 citations

Intercellular adhesion molecule-1 and CD36 synergize to mediate adherence of Plasmodium falciparum-infected erythrocytes to cultured human microvascular endothelial cells.

1997 • 149 citations

Cadherins and catenins: interactions and functions in embryonic development

1994 • 146 citations

The Role of Leukocyte and Endothelial Adhesion Molecules in Ischemia – Reperfusion Injury

1997 • 144 citations

Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1) Homophilic Adhesion Is Mediated by Immunoglobulin-like Domains 1 and 2 and Depends on the Cytoplasmic Domain and the Level of Surface Expression

1996 • 142 citations

HIV-1-Tat modulates the function of monocytes and alters their interactions with microvessel endothelial cells. A mechanism of HIV pathogenesis.

1996 • 141 citations

Pathomechanisms of Photosensitive Lupus Erythematosus

1993 • 141 citations

Inhibitors of protein tyrosine kinase suppress TNF-stimulated induction of endothelial cell adhesion molecules.

1995 • 132 citations

Oxidative Stress in Cancer, AIDS, and Neurodegenerative Diseases

1997 • 131 citations

Vascular Activation of Adhesion Molecule mRNA and Cell Surface Expression by Ionizing Radiation

1998 • 130 citations

HIV-1-Tat protein promotes chemotaxis and invasive behavior by monocytes.

1996 • 122 citations

Involvement of Cytokines, DNA Damage, and Reactive Oxygen Intermediates in Ultraviolet Radiation-Induced Modulation of Intercellular Adhesion Molecule-1 Expression

1995 • 119 citations

Adhesion molecules and tumor metastasis: an update.

1994 • 116 citations

Chronic Blockade of NO Synthase Activity Induces a Proinflammatory Phenotype in the Arterial Wall

1998 • 115 citations

Elevated Levels of Circulating Adhesion Molecules in IDDM Patients and in Subjects at Risk for IDDM

1992 • 115 citations

Sphingosine induces p125FAK and paxillin tyrosine phosphorylation, actin stress fiber formation, and focal contact assembly in Swiss 3T3 cells.

1994 • 113 citations

Molecular Ordering in HIV-induced Apoptosis

1998 • 113 citations

The effects of alpha‐tocopherol on critical cells in atherogenesis

1998 • 112 citations

Elevated Circulating P-Selectin in Insulin Dependent Diabetes Mellitus

1996 • 111 citations

Antioxidants inhibit tumor necrosis factor-alpha mediated stimulation of interleukin-8, monocyte chemoattractant protein-1, and collagenase expression in cultured human synovial cells.

1996 • 109 citations

Activation of NF-kappa B and induction of vascular cell adhesion molecule-1 and intracellular adhesion molecule-1 expression in human glial cells by IL-1. Modulation by antioxidants.

1994 • 105 citations

Sphingosylphosphorylcholine Rapidly Induces Tyrosine Phosphorylation of p125 and Paxillin, Rearrangement of the Actin Cytoskeleton and Focal Contact Assembly

1995 • 103 citations

Macrophages, synovial tissue and rheumatoid arthritis.

1993 • 97 citations

Soluble forms of intercellular adhesion molecule-1 in insulin-dependent diabetes mellitus

1994 • 90 citations

alpha-Tocopheryl succinate inhibits monocytic cell adhesion to endothelial cells by suppressing NF-kappa B mobilization

1997 • 83 citations

Pasteurella multocida Toxin, a Potent Intracellularly Acting Mitogen, Induces p125FAK@ and Paxillin Tyrosine Phosphorylation, Actin Stress Fiber Formation, and Focal Contact Assembly in Swiss 3T3 Cells

1996 • 81 citations

Lipoxygenase metabolites induced expression of adhesion molecules and transendothelial migration of monocyte-like HL-60 cells is linked to protein kinase C activation

1996 • 77 citations

Antioxidant Regulation of Phorbol Ester-Induced Adhesion of Human Jurkat T-Cells to Endothelial Cells

1998 • 76 citations

Apigenin Inhibits Tumor Necrosis Factor‐Induced Intercellular Adhesion Molecule‐1 Upregulation In Vivo

1996 • 75 citations

Pyrrolidine dithiocarbamate inhibits intercellular adhesion molecule-1 biosynthesis induced by cytokines in human fibroblasts.

1995 • 74 citations

Guanosine 5′-3-O-(Thio)triphosphate Stimulates Tyrosine Phosphorylation of p125FAK and Paxillin in Permeabilized Swiss 3T3 Cells

1995 • 72 citations

Oxidant stress-induced transendothelial migration of monocytes is linked to phosphorylation of PECAM-1.

1997 • 68 citations

Nitric Oxide Reduces Endothelial Expression of Intercellular Adhesion Molecule (ICAM)-1

1996 • 66 citations

Endothelial-leukocyte adhesive interactions in inflammatory diseases.

1993 • 64 citations

Regulation of ICAM‐1 and IL‐6 in Myocardial Ischemia: Effect of Reperfusion a

1994 • 63 citations

Selective Inhibition of Tumor Necrosis Factor–Induced Vascular Cell Adhesion Molecule-1 Gene Expression by a Novel Flavonoid

1996 • 62 citations

Hypoxia induces PECAM-1 phosphorylation and transendothelial migration of monocytes

1996 • 62 citations

Ionizing Radiation Induces, via Generation of Reactive Oxygen Intermediates, Intercellular Adhesion Molecule-1 (ICAM-1) Gene Transcription and NFκB-like Binding Activity in the ICAM-1 Transcriptional Regulatory Region

1997 • 56 citations

Immunological mechanisms in atherosclerosis

1995 • 54 citations

Rheumatoid Arthritis: Current Clinical and Research Directions

1997 • 46 citations

Thiol-Mediated Regulation of ICAM-1 Expression in Endotoxin-Induced Acute Lung Injury

1998 • 46 citations

Kupffer cell iron overload induces intercellular adhesion molecule-1 expression on hepatocytes in genetic hemochromatosis

1995 • 43 citations

Superoxide and hydrogen peroxide induce CD18-mediated adhesion in the postischemic heart

1996 • 42 citations

The role of ICAM expression in immunity and disease.

1995 • 42 citations

Molecular mechanism of blood monocyte adhesion to vascular endothelial cells.

1992 • 41 citations

Role of adhesion molecules in cutaneous inflammation and neoplasia

1992 • 40 citations

Oxidant—antioxidant imbalance in blood of children with juvenile rheumatoid arthritis

1998 • 40 citations

Leukocyte—Endothelial Cell Interactions in Ischemia‐Reperfusion Injury

1997 • 39 citations

Kupffer cell iron overload induces intercellular adhesion molecule-1 expression on hepatocytes in genetic hemochromatosis*1

1995 • 38 citations

Short-term ozone exposure upregulates P-selectin in normal human airways.

1997 • 38 citations

Suppressive Effect of Antioxidants on Intercellular Adhesion Molecule-1 (ICAM-1) Expression in Human Epidermal Keratinocytes

1994 • 38 citations

The cell biology of atherosclerosis ‐ new developments

1997 • 37 citations

Study of causes underlying the low atherosclerotic response to dietary hypercholesterolemia in a selected strain of rabbits

1996 • 36 citations

Cell Adhesion Molecules in Rheumatoid Arthritis

1996 • 36 citations

Putative Role of Adhesion Molecules in Metabolic Disorders

1997 • 35 citations

Mechanism of joint destruction in rheumatoid arthritis.

1998 • 33 citations

Early Metastasis of Human Solid Tumours: Expression of Cell Adhesion Molecules

2007 • 31 citations

Endothelial and leukocyte adhesion molecules in inflammation and disease.

1998 • 28 citations

Heavy-metal modulation of the human intercellular adhesion molecule (ICAM-1) gene expression

1995 • 28 citations

Effects of the natural flavonoid delphinidin on diabetic microangiopathy.

1995 • 28 citations

Modulation of Ca²⁺‐dependent intercellular adhesion in bovine aortic and human umbilical vein endothelial cells by heparin‐binding growth factors

1990 • 26 citations

Antioxidant-Sensitive Regulation of Inflammatory-Response Genes in Kaposi's Sarcoma Cells

1996 • 26 citations

Modulation of ICAM-1 expression by extracellular glutathione in hyperoxia-exposed human pulmonary artery endothelial cells.

1996 • 26 citations

Nitric oxide inhibits intracellular adhesion molecule-1 expression in rat mesangial cells.

1996 • 25 citations

In situ analysis of adhesion molecule expression in kidneys infected with murine malaria

1998 • 25 citations

The effect of radiation on the expression of intercellular adhesion molecule-1 of human adenocarcinoma cells

1998 • 24 citations

Transgenic Mice With Elevated Level of CuZnSOD Are Highly Susceptible to Malaria Infection

1998 • 23 citations

In vitro models of lymphocyte transendothelial migration.

1992 • 22 citations

Leukocyte-endothelial cell adhesive receptors.

1994 • 22 citations

Beta2 integrin/ICAM-1 adhesion molecule interactions in cutaneous inflammation and tumor promotion

1998 • 22 citations

Gamma and Pulse Radiolysis Study of Pentoxifylline, a Methylxanthine

1991 • 21 citations

Flavonoid-lnduced Gastroprotection in Rats: Role of Blood Flow and Leukocyte Adherence

1997 • 17 citations

Treatment of Inflammatory Diseases with a Monoclonal Antibody to Intercellular Adhesion Molecule 1

2007 • 17 citations

Determination of cell-cell adhesion in response to oxidants and antioxidants

1999 • 17 citations

Modulation of the expression of intercellular adhesion molecule-1 (ICAM-1) in human keratinocytes by ultraviolet (UV) radiation

1992 • 15 citations

Intercellular adhesion molecule-1 (ICAM-1; CD54) expression in human hepatocytic cells depends on protein kinase C

1996 • 11 citations

The role of integrins in the immune response.

1992 • 9 citations

The Rheumatoid Joint: Redox-Paradox?

1997 • 8 citations

Glutathione Depletion Prevents Lipopolysaccharide-Induced Local Skin Inflammation

1997 • 7 citations