The 55-kDa Tumor Necrosis Factor Receptor Induces Clustering of Mitochondria through Its Membrane-proximal Region

Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c

1996 • 5,133 citations

Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked

1997 • 4,921 citations

The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis

1997 • 4,728 citations

FADD, a novel death domain-containing protein, interacts with the death domain of fas and initiates apoptosis

1995 • 2,436 citations

The TNF receptor 1-associated protein TRADD signals cell death and NF-κB activation

1995 • 1,979 citations

Identification of a novel force-generating protein, kinesin, involved in microtubule-based motility

1985 • 1,930 citations

A novel domain within the 55 kd TNF receptor signals cell death

1993 • 1,302 citations

Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo.

1995 • 1,179 citations

Bcl-2 inhibits the mitochondrial release of an apoptogenic protease.

1996 • 1,143 citations

Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis

1996 • 980 citations

RIP: A novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death

1995 • 964 citations

Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions. Evidence for the involvement of mitochondrial radical generation.

1992 • 949 citations

Mitochondrial permeability transition is a central coordinating event of apoptosis.

1996 • 857 citations

FADD/MORT1 Is a Common Mediator of CD95 (Fas/APO-1) and Tumor Necrosis Factor Receptor-induced Apoptosis

1996 • 780 citations

Functional dichotomy of neutral and acidic sphingomyelinases in tumor necrosis factor signaling

1994 • 726 citations

Purification and NH2-terminal amino acid sequence of a T-cell-derived lymphokine with growth factor activity for B-cell hybridomas.

1986 • 701 citations

The p38/RK mitogen-activated protein kinase pathway regulates interleukin-6 synthesis response to tumor necrosis factor.

1996 • 650 citations

A novel brain ATPase with properties expected for the fast axonal transport motor

1985 • 604 citations

Direct evidence for tumor necrosis factor-induced mitochondrial reactive oxygen intermediates and their involvement in cytotoxicity.

1995 • 599 citations

Depletion of the mitochondrial electron transport abrogates the cytotoxic and gene-inductive effects of TNF.

1993 • 581 citations

Cloning and expression of cDNAs for two distinct murine tumor necrosis factor receptors demonstrate one receptor is species specific.

1991 • 576 citations

Role for Bcl-x_Las an inhibitor of cytosolic cytochrome C accumulation in DNA damage-induced apoptosis

1997 • 397 citations

FAN, a Novel WD-Repeat Protein, Couples the p55 TNF-Receptor to Neutral Sphingomyelinase

1996 • 390 citations

Self-association of the “Death Domains” of the p55 Tumor Necrosis Factor (TNF) Receptor and Fas/APO1 Prompts Signaling for TNF and Fas/APO1 Effects

1995 • 383 citations

Cytoplasmic dynein is a minus end-directed motor for membranous organelles

1989 • 313 citations

Molecular mechanisms of tumor necrosis factor‐induced cytotoxicity

1994 • 238 citations

Cell death induction by receptors of the TNF family: towards a molecular understanding

1997 • 237 citations

Inhibition of kinesin-driven microtubule motility by monoclonal antibodies to kinesin heavy chains.

1988 • 180 citations

Chloromethyl-X-rosamine is an aldehyde-fixable potential-sensitive fluorochrome for the detection of early apoptosis

1996 • 178 citations

Microtubule-dependent control of cell shape and pseudopodial activity is inhibited by the antibody to kinesin motor domain.

1993 • 160 citations

The phosphorylation of kinesin regulates its binding to synaptic vesicles.

1992 • 156 citations

A potential mechanism of "cross-talk" between the p55 tumor necrosis factor receptor and Fas/APO1: proteins binding to the death domains of the two receptors also bind to each other.

1996 • 134 citations

Downregulation of tumor necrosis factor receptors on macrophages and endothelial cells by microtubule depolymerizing agents.

1990 • 126 citations

Syringe loading introduces macromolecules into living mammalian cell cytosol

1992 • 121 citations

Sequential activation of three distinct ICE‐like activities in Fas‐ligated Jurkat cells

1996 • 120 citations

Phosphorylation of Kinesin inVivo Correlates with Organelle Association and Neurite Outgrowth

1995 • 112 citations

Steric inhibition of cytoplasmic dynein and kinesin motility by MAP2

1993 • 111 citations

Calmodulin binding to and cAMP-dependent phosphorylation of kinesin light chains modulate kinesin ATPase activity

1993 • 106 citations

A Novel Interaction between the Juxtamembrane Region of the p55 Tumor Necrosis Factor Receptor and Phosphatidylinositol-4-phosphate 5-Kinase

1997 • 101 citations

Cell membrane permeabilization and cellular collapse, followed by loss of dehydrogenase activity: Early events in tumour necrosis factor-induced cytotoxicity

1993 • 97 citations

Tumor necrosis factor (TNF)-alpha activates c-raf-1 kinase via the p55 TNF receptor engaging neutral sphingomyelinase.

1995 • 96 citations

Regulation of kinesin activity by phosphorylation of kinesin-associated proteins.

1994 • 90 citations

Overexpression of MAP4 inhibits organelle motility and trafficking in vivo

1997 • 85 citations

Increased activity and sensitivity of mitochondrial respiratory enzymes to tumor necrosis factor alpha-mediated inhibition is associated with increased cytotoxicity in drug-resistant leukemic cell lines

1996 • 73 citations

Induced Expression of Trimerized Intracellular Domains of the Human Tumor Necrosis Factor (TNF) p55 Receptor Elicits TNF Effects

1997 • 68 citations

Two discrete types of tumor necrosis factor-resistant cells derived from the same cell line.

1991 • 51 citations

Phosphotransferases Associated with the Regulation of Kinesin Motor Activity

1997 • 45 citations

A Microtubule-associated Protein (MAP2) Kinase Restores Microtubule Motility in Embryonic Brain

1995 • 39 citations

Involvement of the mitochondrion respiratory chain in the synergy achieved by treatment of human ovarian carcinoma cell lines with both tumor necrosis factor-alpha and cis-diamminedichloroplatinum.

1996 • 37 citations

Involvement of the mitochondrion respiratory chain in the synergy achieved by treatment of human ovarian carcinoma cell lines with both tumor necrosis factor-α and cis-diamminedichloroplatinum

1996 • 23 citations

Activation of the nuclear factor κB is not sufficient for regulation of tumor necrosis factor-induced interleukin-6 gene expression

1993 • 19 citations