A phorbol ester binding domain of protein kinase C gamma. Deletion analysis of the Cys2 domain defines a minimal 43-amino acid peptide.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.

1982 • 4,786 citations

Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C

1992 • 4,480 citations

The molecular heterogeneity of protein kinase C and its implications for cellular regulation

1988 • 4,243 citations

A method for the quantitative recovery of protein in dilute solution in the presence of detergents and lipids

1984 • 3,959 citations

A rapid, sensitive, and specific method for the determination of protein in dilute solution

1973 • 2,518 citations

Calcium-dependent activation of a multifunctional protein kinase by membrane phospholipids.

1979 • 1,139 citations

Protein Kinase C Contains a Pseudosubstrate Prototope in Its Regulatory Domain

1987 • 1,020 citations

ZINC PROTEINS: Enzymes, Storage Proteins, Transcription Factors, and Replication Proteins

1992 • 966 citations

THE PROTEIN KINASE C FAMILY: HETEROGENEITY AND ITS IMPLICATIONS

1989 • 739 citations

The structure, expression, and properties of additional members of the protein kinase C family.

1988 • 706 citations

Cloning and expression of multiple protein kinase C cDNAs

1986 • 683 citations

Lipid activation of protein kinase C.

1991 • 566 citations

Phorbol ester binding to protein kinase C requires a cysteine-rich zinc-finger-like sequence.

1989 • 439 citations

A novel phorbol ester receptor/protein kinase, nPKC, distantly related to the protein kinase C family

1988 • 414 citations

Cooperative roles of various membrane phospholipids in the activation of calcium-activated, phospholipid-dependent protein kinase.

1981 • 367 citations

Altered growth regulation and enhanced tumorigenicity of NIH 3T3 fibroblasts transfected with protein kinase C-I cDNA

1988 • 285 citations

Purification and characterization of the zeta isoform of protein kinase C from bovine kidney.

1992 • 283 citations

A phorbol ester/diacylglycerol-binding protein encoded by the unc-13 gene of Caenorhabditis elegans.

1991 • 255 citations

Specificity and mechanism of protein kinase C activation by sn-1,2-diacylglycerols.

1986 • 254 citations

Diacylglycerols mimic phorbol diester induction of leukemic cell differentiation.

1985 • 234 citations

Protein kinase C contains two phorbol ester binding domains.

1991 • 234 citations

Expression, purification, and characterization of protein kinase C-epsilon.

1990 • 231 citations

Identification and Characterization of Zinc Binding Sites in Protein Kinase C

1991 • 193 citations

Reversible exposure of the pseudosubstrate domain of protein kinase C by phosphatidylserine and diacylglycerol.

1992 • 180 citations

Localization and differential expression of two isoforms of the tight junction protein ZO-1

1992 • 168 citations

Regulation of protein kinase C activity by lipids

1988 • 155 citations

Analysis of the phorbol ester pharmacophore on protein kinase C as a guide to the rational design of new classes of analogs.

1986 • 153 citations

Molecular Genetic Analysis of the Regulatory and Catalytic Domains of Protein Kinase C

1989 • 138 citations

Human brain n-chimaerin cDNA encodes a novel phorbol ester receptor

1990 • 136 citations

The regulatory domain of protein kinase C coordinates four atoms of zinc.

1992 • 129 citations

Phorbol ester binding and activation of protein kinase C on triton X-100 mixed micelles containing phosphatidylserine.

1986 • 127 citations

Expression of the alpha, beta II, and gamma protein kinase C isozymes in the baculovirus-insect cell expression system. Purification and characterization of the individual isoforms.

1990 • 120 citations

The cysteine-rich domain of human proteins, neuronal chimaerin, protein kinase C and diacylglycerol kinase binds zinc. Evidence for the involvement of a zinc-dependent structure in phorbol ester binding

1991 • 115 citations

Computer-assisted molecular modeling of tumor promoters: rationale for the activity of phorbol esters, teleocidin B, and aplysiatoxin.

1986 • 114 citations

Expression and properties of two distinct classes of the phorbol ester receptor family, four conventional protein kinase C types, and a novel protein kinase C.

1990 • 104 citations

Complete Activation of Protein Kinase C by an Antipeptide Antibody Directed against the Pseudosubstrate Prototope

1989 • 94 citations

Expression and characterization of protein kinase C‐δ

1991 • 94 citations

A Role of Membranes in the Activation of a New Multifunctional Protein Kinase System

1979 • 86 citations

A phorbol ester binding domain of protein kinase C gamma. High affinity binding to a glutathione-S-transferase/Cys2 fusion protein.

1994 • 77 citations

Mutations in a Protein Kinase C Homolog Confer Phorbol Ester Resistance on Caenorhabditis elegans

1989 • 76 citations

Protein kinase C: Current concepts and future perspectives

1993 • 24 citations