Structure of the FGF Receptor Tyrosine Kinase Domain Reveals a Novel Autoinhibitory Mechanism

PROCHECK: a program to check the stereochemical quality of protein structures

1993 • 23,689 citations

Dictionary of protein secondary structure: Pattern recognition of hydrogen‐bonded and geometrical features

1983 • 14,802 citations

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1991 • 14,222 citations

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

Protein folding and association: Insights from the interfacial and thermodynamic properties of hydrocarbons

1991 • 5,267 citations

AMoRe: an automated package for molecular replacement

1994 • 4,990 citations

Oncogenes and signal transduction

1991 • 2,816 citations

Active and Inactive Protein Kinases: Structural Basis for Regulation

1996 • 1,361 citations

SETOR: Hardware-lighted three-dimensional solid model representations of macromolecules

1993 • 1,295 citations

The Fgf Family of Growth Factors and Oncogenes

1992 • 1,164 citations

Replacement of insulin receptor tyrosine residues 1162 and 1163 compromises insulin-stimulated kinase activity and uptake of 2-deoxyglucose

1986 • 1,100 citations

Crystal structure of the tyrosine kinase domain of the human insulin receptor

1994 • 1,071 citations

The structure of protein-protein recognition sites.

1990 • 825 citations

RIBBONS 2.0

1991 • 814 citations

SH2 and SH3 domains

1993 • 697 citations

Fibroblast growth factor receptor tyrosine kinases: molecular analysis and signal transduction

1992 • 625 citations

Thanatophoric dysplasia (types I and II) caused by distinct mutations in fibroblast growth factor receptor 3

1995 • 602 citations

Crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with magnesium-ATP and peptide inhibitor

1993 • 593 citations

Atomic structure of the MAP kinase ERK2 at 2.3 Å resolution

1994 • 591 citations

An Alternative to SH2 Domains for Binding Tyrosine-Phosphorylated Proteins

1994 • 501 citations

Graded activation of fibroblast growth factor receptor 3 by mutations causing achondroplasia and thanatophoric dysplasia

1996 • 500 citations

Regulation of growth factor activation by proteoglycans: What is the role of the low affinity receptors?

1995 • 478 citations

A recurrent mutation in the tyrosine kinase domain of fibroblast growth factor receptor 3 causes hypochondroplasia

1995 • 464 citations

Point mutation in FGF receptor eliminates phosphatidylinositol hydrolysis without affecting mitogenesis

1992 • 438 citations

breathless, a Drosophila FGF receptor homolog, is essential for migration of tracheal and specific midline glial cells.

1992 • 419 citations

Point mutation of an FGF receptor abolishes phosphatidylinositol turnover and Ca2+ flux but not mitogenesis

1992 • 414 citations

Phosphotransferase and substrate binding mechanism of the cAMP-dependent protein kinase catalytic subunit from porcine heart as deduced from the 2.0 A structure of the complex with Mn2+ adenylyl imidodiphosphate and inhibitor peptide PKI(5-24).

1993 • 399 citations

Identification of Six Novel Autophosphorylation Sites on Fibroblast Growth Factor Receptor 1 and Elucidation of Their Importance in Receptor Activation and Signal Transduction

1996 • 385 citations

How do protein kinases discriminate between serine/threonine and tyrosine? Structural insights from the insulin receptor protein‐tyrosine kinase

1995 • 187 citations

An FGF receptor signaling pathway is required for the normal cell migrations of the sex myoblasts in C. elegans hermaphrodites

1995 • 183 citations

Transformations to optimize the superposition of similar structures

1979 • 62 citations

Diffraction methods for biological macromolecules

1985 • 58 citations