Superoxide and hydrogen peroxide in relation to mammalian cell proliferation

Free radicals in biology and medicine

1991 • 17,840 citations

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

1993 • 6,009 citations

Free Radicals in Biology and Medicine

1990 • 4,962 citations

Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1.

1991 • 3,819 citations

Inositol trisphosphate and diacylglycerol as second messengers

1984 • 3,535 citations

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

1993 • 3,465 citations

Culture of Animal Cells

1983 • 3,334 citations

Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

1988 • 3,194 citations

Induction of apoptosis in fibroblasts by c-myc protein

1992 • 2,977 citations

p53 is required for radiation-induced apoptosis in mouse thymocytes

1993 • 2,911 citations

The stress-activated protein kinase subfamily of c-Jun kinases

1994 • 2,616 citations

Production of large amounts of hydrogen peroxide by human tumor cells.

1991 • 2,465 citations

Bcl-2 and the regulation of programmed cell death

1994 • 2,346 citations

Thymocyte apoptosis induced by p53-dependent and independent pathways

1993 • 2,322 citations

G ₁ Events and Regulation of Cell Proliferation

1989 • 2,203 citations

GROWTH FACTOR RECEPTOR TYROSINE KINASES

1988 • 1,841 citations

Tumor Suppressor Genes

1991 • 1,784 citations

Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species

1993 • 1,692 citations

Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

1993 • 1,638 citations

Redox Regulation of Fos and Jun DNA-Binding Activity in Vitro

1990 • 1,592 citations

Free-radical mechanisms in tissue injury

1984 • 1,518 citations

Cell death and control of cell survival in the oligodendrocyte lineage

1992 • 1,331 citations

Investigation of the subcellular distribution of the bcl-2 oncoprotein: residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes.

1993 • 1,044 citations

Apoptotic cell death induced by c-myc is inhibited by bcl-2

1992 • 981 citations

Intracellular thiols regulate activation of nuclear factor kappa B and transcription of human immunodeficiency virus.

1990 • 960 citations

Redox activation of Fos-Jun DNA binding activity is mediated by a DNA repair enzyme.

1992 • 920 citations

Identification of a protein-binding site that mediates transcriptional response of the c-fos gene to serum factors

1986 • 883 citations

Transcriptional Regulator of Oxidative Stress-Inducible Genes: Direct Activation by Oxidation

1990 • 869 citations

Constitutive c-myc expression in an IL-3-dependent myeloid cell line suppresses cell cycle arrest and accelerates apoptosis.

1991 • 861 citations

Dominoes and Clocks: the Union of Two Views of the Cell Cycle

1989 • 750 citations

Glutathione : chemical, biochemical, and medical aspects

1989 • 746 citations

Role for c-myc in Activation-Induced Apoptotic Cell Death in T Cell Hybridomas

1992 • 705 citations

Role of Cyclic Nucleotides in Growth Control

1975 • 692 citations

Human fibroblasts release reactive oxygen species in response to interleukin-1 or tumour necrosis factor-α

1989 • 660 citations

Signaling by the cytokine receptor superfamily: JAKs and STATs

1994 • 659 citations

Oxidative stress and heat shock induce a human gene encoding a protein-tyrosine phosphatase

1992 • 647 citations

Modulation of fibroblast proliferation by oxygen free radicals

1990 • 617 citations

Lipid activation of protein kinase C.

1991 • 566 citations

The pathway to signal achievement

1993 • 563 citations

Free radicals, lipids and protein degradation

1986 • 556 citations

Free Radicals, Lipid Peroxidation and Cancer

1982 • 530 citations

Molecular genetics of polyamine synthesis in eukaryotic cells

1990 • 519 citations

Inhibition of cell proliferation by alpha-tocopherol. Role of protein kinase C.

1991 • 510 citations

Increased manganese superoxide dismutase expression suppresses the malignant phenotype of human melanoma cells.

1993 • 479 citations

The role of sulfur-containing amino acids in superoxide production and modification of low density lipoprotein by arterial smooth muscle cells.

1987 • 465 citations

The cyclic AMP-mediated stimulation of cell proliferation

1989 • 464 citations

Cyclins and cyclin-dependent kinases: take your partners

1993 • 441 citations

Superoxide dismutase and catalase conjugated to polyethylene glycol increases endothelial enzyme activity and oxidant resistance.

1988 • 425 citations

4‐Hydroxyalk‐2‐enals are substrates for glutathione transferase

1985 • 422 citations

Ca2+- and phospholipid-independent activation of protein kinase C by selective oxidative modification of the regulatory domain.

1989 • 409 citations

Redox modulation of p53 conformation and sequence-specific DNA binding in vitro.

1993 • 406 citations

Aldehyde Dehydrogenases and Their Role in Carcinogenesis

1992 • 400 citations

G proteins control diverse pathways of transmembrane signaling ¹

1989 • 399 citations

Targeting of Bcl-2 to the mitochondrial outer membrane by a COOH-terminal signal anchor sequence.

1993 • 390 citations

Cytokine-stimulated human immunodeficiency virus replication is inhibited by N-acetyl-L-cysteine.

1990 • 381 citations

S Phase of the Cell Cycle

1989 • 366 citations

Increased superoxide anion release from human endothelial cells in response to cytokines.

1986 • 365 citations

Separation and characterization of the aldehydic products of lipid peroxidation stimulated by carbon tetrachloride or ADP-iron in isolated rat hepatocytes and rat liver microsomal suspensions

1985 • 362 citations

Low Concentrations of Acid-Soluble Thiol (Cysteine) in the Blood Plasma of HIV-1-Infected Patients

1989 • 349 citations

Free radicals in liver injury

1987 • 338 citations

Perspectives on mammalian cell death

1988 • 334 citations

Cell killing and DNA damage by hydrogen peroxide are mediated by intracellular iron

1984 • 334 citations

An iron-sulfur center essential for transcriptional activation by the redox-sensing SoxR protein.

1994 • 331 citations

Suppression of human immunodeficiency virus expression in chronically infected monocytic cells by glutathione, glutathione ester, and N-acetylcysteine.

1991 • 330 citations

Cell Cycle Regulation in the Yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe

1991 • 326 citations

Free Radicals, Lipid Peroxidation and Cancer

1982 • 320 citations

Transcriptional activation of early‐response genes by hydrogen peroxide in a mouse osteoblastic cell line

1991 • 298 citations

Distinct effects of glutathione disulphide on the nuclear transcription factors κB and the activator protein‐1

1994 • 274 citations

Tumour necrosis factor-α induces superoxide anion generation in mitochondria of L929 cells

1993 • 272 citations

Quantitative and temporal characterization of the extracellular H2O2 pool generated by human neutrophils.

1984 • 264 citations

Dynamics of Biological Membranes

1983 • 255 citations

HIV-induced cysteine deficiency and T-cell dysfunction — a rationale for treatment with N-acetylcysteine

1992 • 254 citations

Promotion of cystine uptake and its utilization for glutathione biosynthesis induced by cysteamine and N-acetylcysteine

1988 • 234 citations

Effect of N-acetylcysteine on plasma cysteine and glutathione following paracetamol administration

1989 • 234 citations

Identification of a superoxide-generating NADPH oxidase system in human fibroblasts

1991 • 233 citations

Mechanism of c-fos induction by active oxygen.

1992 • 224 citations

Free Radicals and the Regulation of Mammalian Cell Proliferation

1989 • 195 citations

Protein kinase C in transmembrane signalling

1990 • 194 citations

Production of hydrogen peroxide by rabbit articular chondrocytes. Enhancement by cytokines.

1990 • 187 citations

Perspectives on mammalian cell death.

1987 • 183 citations

G1-specific cyclins: in search of an S-phase-promoting factor

1991 • 181 citations

The ras superfamily of small GTP-binding proteins

1990 • 180 citations

Oxidative Stress and Tumour Cell Proliferation

1990 • 179 citations

Free radicals: From basic science to medicine

1994 • 175 citations

The RxxRxRxxC motif conserved in all Rel/kappa B proteins is essential for the DNA-binding activity and redox regulation of the v-Rel oncoprotein.

1992 • 174 citations

Elevation of intracellular glutathione content associated with mitogenic stimulation of quiescent fibroblasts

1986 • 167 citations

Involvement of reactive oxygen intermediates in the induction of c-jun gene transcription by ionizing radiation

1992 • 161 citations

Role of reactive oxygen in bile salt stimulation of colonic epithelial proliferation.

1986 • 159 citations

Transmembrane Receptors and Intracellular Pathways that Control Cell Proliferation

1992 • 151 citations

Cyclin-dependent kinases: a new cell cycle motif?

1991 • 148 citations

Nuclear targets for transcription regulation by oncogenes

1991 • 147 citations

Oncogenes and the molecular origins of cancer

1991 • 142 citations

Role of cysteine₆₂in DNA recognition by the P50 subunit of NF-_xB

1993 • 142 citations

Stimulation by hydrogen peroxide of DNA synthesis, competence family gene expression and phosphorylation of a specific protein in quiescent Balb/3T3 cells.

1990 • 139 citations

The control of apoptosis in mammalian cells

1993 • 139 citations

OxyR: A Regulator of Antioxidant Genes

1992 • 137 citations

Hydrogen peroxide-induced c-fos expression is mediated by arachidonic acid release: role of protein kinase C

1993 • 137 citations

Activation of hepatocyte protein kinase C by redox-cycling quinones

1989 • 136 citations

Translocation and enhancement of phosphotransferase activity of protein kinase C following exposure in mouse epidermal cells to oxidants.

1989 • 132 citations

Reduction of a conserved Cys is essential for Myb DNA-binding

1992 • 129 citations

Oxygen Radicals Acting as Chemical Messengers: A Hypothesis

1989 • 129 citations

Animal Cell Biotechnology

1994 • 124 citations

Cell Proliferation and Oxidative Stress

1989 • 124 citations

PRODUCTION OF ACTIVE OXYGEN SPECIES BY ISOLATED HUMAN CHONDROCYTES

1993 • 122 citations

Tumour suppressor genes

1992 • 117 citations

Effects of 4-hydroxynonenal on adenylate cyclase and 5′-nucleotidase activities in rat liver plasma membranes

1985 • 114 citations

Hydrogen peroxide‐induced oxidative stress to the mammalian heart‐muscle cell (cardiomyocyte): Lethal peroxidative membrane injury

1991 • 108 citations

Superoxide anion increases intracellular pH, intracellular free calcium, and arachidonate release in human amnion cells

1991 • 106 citations

In vivo lipid peroxidation: measurement via exhaled pentane and protection by vitamin E.

1981 • 106 citations

Membrane-stabilizing effect of vitamin E: Effect of α-tocopherol and its model compounds on fluidity of lecithin liposomes

1988 • 105 citations

Growth-related lipid peroxidation in tumour microsomal membranes and mitochondria

1979 • 102 citations

Radical-induced inactivation of kidney Na+,K+-ATPase: Sensitivity to membrane lipid peroxidation and the protective effect of vitamin E

1990 • 99 citations

Endocytosis of superoxide dismutase is required in order for the enzyme to protect hepatocytes from the cytotoxicity of hydrogen peroxide.

1988 • 98 citations

Antioxidants inhibit proliferation and cell surface expression of receptors for interleukin-2 and transferrin in T lymphocytes stimulated with phorbol myristate acetate and ionomycin

1988 • 97 citations

Mitogens and Ion Fluxes

1988 • 94 citations

Induction of differentiation in human HL-60 cells by 4-hydroxynonenal, a product of lipid peroxidation

1991 • 93 citations

Oxidative Stress, Cell Activation and Viral Infection

1994 • 91 citations

4-Hydroxynonenal, a product of cellular lipid peroxidation, which modulates c-myc and globin gene expression in K562 erythroleukemic cells.

1992 • 91 citations

Superoxide as a signal for increase in intracellular pH

1988 • 87 citations

The export of glutathione from human diploid cells in culture.

1979 • 81 citations

The generation of oxygen radicals: A positive signal for lymphocyte activation

1988 • 80 citations

Wound therapy: growth factors as agents to promote healing

1993 • 80 citations

Reduction of a Tetrazolium Salt and Superoxide Generation in Human Tumor Cells (HeLa)

1993 • 79 citations

Manganese superoxide dismutase in normal and transformed human embryonic lung fibroblasts

1989 • 78 citations

Free radicals, lipoproteins and cardiovascular dysfunction

1992 • 75 citations

Translocation of glutathione from lymphoid cells that have markedly different gamma-glutamyl transpeptidase activities.

1979 • 73 citations

Effects of a biomimetic superoxide dismutase on complete and multistage carcinogenesis in mouse skin

1985 • 67 citations

Cellularly Generated Active Oxygen Species and Hela Cell Proliferation

1993 • 66 citations

Correlation between the loss of the transformed phenotype and an increase in superoxide dismutase activity in a revertant subclone of sarcoma virus-infected mammalian cells.

1982 • 65 citations

Endogenously Generated Active Oxygen Species and Cellular Glutathione Levels in Relation to BHK-21 Cell Proliferation

1994 • 65 citations

Production of hydrogen peroxide by murine epidermal keratinocytes following treatment with the tumor promoter 12-O-tetradecanoylphorbol-13-acetate.

1990 • 64 citations

Formation of sulfhydryl groups in the culture medium by human diploid fibroblasts

1980 • 57 citations

Protein kinase C subspecies in adult rat hippocampal synaptosomes Activation by diacylglycerol and arachidonic acid

1991 • 56 citations

Effect of 4-Hydroxynonenal on c-myc Expression

1987 • 55 citations

Effects of 4-Hydroxynonenal, A Product of Lipid Peroxidation, on Cell Proliferation and Ornithine Decarboxylase Activity

1991 • 55 citations

Oncogenic conversion of Ets affects redox regulationin-vivoandin-vitro

1993 • 54 citations

Role of protein kinase C in cellular regulation.

1990 • 51 citations

Lipid peroxidation in hepatomas of different degrees of deviation

1983 • 40 citations

New Data on Kinetics of Lipid Peroxidation in Experimental Hepatomas and Preneoplastic Nodules

1986 • 35 citations

Effect of cis-unsaturated fatty acids on aortic protein kinase C activity

1989 • 29 citations

α-Tocopherol Uptake and Its Influence on Cell Proliferation and Lipid Peroxidation in Transformed and Nontransformed Baby Hamster Kidney Cells

1993 • 26 citations

Stimulation by xanthine oxidase of 3T3 Swiss fibroblasts and human lymphocytes

1991 • 25 citations

Endocytosis of superoxide dismutase by rat liver

1992 • 19 citations

Role of oxygen-derived free radicals in gastric mucosal injury induced by ischemia-reperfusion in rats

1989 • 19 citations

Hydrogen peroxide generation in whole rat pancreatic islets: Synergistic regulation by cytoplasmic free calcium and protein kinase-C

1988 • 15 citations

Effect of oxidants on vascular smooth muscle proliferation

1993 • 15 citations

Cell proliferation and oxidative stress: basis for anticancer drugs

1992 • 12 citations

Increased glutathione levels in quiescent, serum‐stimulated NRK‐49F cells are associated not with a response to growth factors but with nutrient repletion

1991 • 11 citations

Involvement of hydrogen peroxide in the actions of TGFβ1

1994 • 10 citations

Oxidative Stress in Cultured Animal Cells

1994 • 10 citations

Glutathione status of rat thymocytes and splenocytes during the early events of their ConA proliferative responses

1987 • 7 citations

Oxidative Stress and Growth Factor-Mediated Signal Transduction

1994 • 4 citations

The effect of reactive oxygen species (ROS) on human T and B lymphoid cells

1994 • 2 citations