REGULATION OF GENE EXPRESSION BY REACTIVE OXYGEN

Oxidants, antioxidants, and the degenerative diseases of aging.

1993 • 6,011 citations

Hydroperoxide metabolism in mammalian organs.

1979 • 5,821 citations

Function and Activation of NF-kappaB in the Immune System

1994 • 4,698 citations

Inositol phosphates and cell signalling

1989 • 4,058 citations

Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1.

1991 • 3,819 citations

An Nrf2/Small Maf Heterodimer Mediates the Induction of Phase II Detoxifying Enzyme Genes through Antioxidant Response Elements

1997 • 3,743 citations

Bilirubin Is an Antioxidant of Possible Physiological Importance

1987 • 3,406 citations

The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation

1991 • 3,396 citations

The Biology of Oxygen Radicals

1978 • 3,361 citations

JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

1994 • 3,219 citations

Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor

1987 • 3,057 citations

The biochemical basis of zinc physiology

1993 • 2,967 citations

Protein kinases and phosphatases: The Yin and Yang of protein phosphorylation and signaling

1995 • 2,907 citations

The Regulation of AP-1 Activity by Mitogen-activated Protein Kinases

1995 • 2,441 citations

Purified transcription factor AP-1 interacts with TPA-inducible enhancer elements

1987 • 2,107 citations

Calcium signaling

1995 • 1,905 citations

Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain.

1993 • 1,902 citations

METALLOTHIONEIN

1986 • 1,606 citations

Redox Regulation of Fos and Jun DNA-Binding Activity in Vitro

1990 • 1,592 citations

The antioxidant responsive element. Activation by oxidative stress and identification of the DNA consensus sequence required for functional activity

1991 • 1,432 citations

Nuclear Factor Kb: An Oxidative Stress-Responsive Transcription Factor of Eukaryotic Cells (A Review)

1992 • 1,421 citations

Oxidants as Stimulators of Signal Transduction

1997 • 1,380 citations

Absorption, transport, and hepatic metabolism of copper and zinc: special reference to metallothionein and ceruloplasmin.

1985 • 1,331 citations

The regulation of transcription by phosphorylation

1992 • 1,316 citations

Transcriptional Regulation by Extracellular signals: Mechanisms and Specificity

1995 • 1,287 citations

Heme oxygenase is the major 32-kDa stress protein induced in human skin fibroblasts by UVA radiation, hydrogen peroxide, and sodium arsenite.

1989 • 1,273 citations

REDOX REGULATION OF CELLULAR ACTIVATION

1997 • 1,121 citations

Analysis of a form of oxidative DNA damage, 8-hydroxy-2′-deoxyguanosine, as a marker of cellular oxidative stress during carcinogenesis

1997 • 1,108 citations

Possible role for metallothionein in protection against radiation-induced oxidative stress. Kinetics and mechanism of its reaction with superoxide and hydroxyl radicals

1985 • 1,042 citations

Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:quinone oxidoreductase ₁ gene

1996 • 1,027 citations

Protein Kinase C Contains a Pseudosubstrate Prototope in Its Regulatory Domain

1987 • 1,020 citations

Phosphorylation of human I kappa B-alpha on serines 32 and 36 controls I kappa B-alpha proteolysis and NF-kappa B activation in response to diverse stimuli.

1995 • 1,010 citations

Site-Specific Phosphorylation of IκBα by a Novel Ubiquitination-Dependent Protein Kinase Activity

1996 • 960 citations

Intracellular thiols regulate activation of nuclear factor kappa B and transcription of human immunodeficiency virus.

1990 • 960 citations

Oncogene jun encodes a sequence-specific trans- activator similar to AP-1

1988 • 940 citations

Fatty acids and retinoids control lipid metabolism through activation of peroxisome proliferator-activated receptor-retinoid X receptor heterodimers.

1993 • 940 citations

Oxidative Decay of DNA

1997 • 938 citations

Redox activation of Fos-Jun DNA binding activity is mediated by a DNA repair enzyme.

1992 • 920 citations

Role of oxygen free radicals in carcinogenesis and brain ischemia

1990 • 885 citations

The mammalian ultraviolet response is triggered by activation of src tyrosine kinases

1992 • 874 citations

ROLE OF REVERSIBLE OXIDATION-REDUCTION OF ENZYME THIOLS-DISULFIDES IN METABOLIC REGULATION

1985 • 840 citations

Thiordoxin regulates the DNA binding activity of NF-χB by reduction of a disulphid bond involving cysteine 62

1992 • 825 citations

The I kappa B proteins: multifunctional regulators of Rel/NF-kappa B transcription factors.

1993 • 819 citations

[69] Overview of metallothionein

1991 • 793 citations

Transcriptional control by protein phosphorylation: signal transmission from the cell surface to the nucleus

1995 • 758 citations

Reversal of age-related increase in brain protein oxidation, decrease in enzyme activity, and loss in temporal and spatial memory by chronic administration of the spin-trapping compound N-tert-butyl-alpha-phenylnitrone.

1991 • 734 citations

Transcription factor NF-E2 is required for platelet formation independent of the actions of thrombopoeitin/MGDF in megakaryocyte development

1995 • 712 citations

Identification and characterization of Ref-1, a nuclear protein that facilitates AP-1 DNA-binding activity.

1992 • 702 citations

Functional antioxidant responsive elements

1997 • 702 citations

Distinct effects of thioredoxin and antioxidants onthe activation of transcription factors NF-kappa B and AP-1.

1994 • 694 citations

Rapid and preferential activation of the c-jun gene during the mammalian UV response.

1991 • 685 citations

Modulation of transcription factor NF-kappa B binding activity by oxidation-reduction in vitro.

1991 • 649 citations

NF-kappa B activation by ultraviolet light not dependent on a nuclear signal

1993 • 646 citations

NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development

1996 • 634 citations

Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain

1991 • 626 citations

Neural tube, skeletal and body wall defects in mice lacking transcription factor AP-2

1996 • 595 citations

Transcription factor AP-2 is expressed in neural crest cell lineages during mouse embryogenesis.

1991 • 593 citations

Depletion of the mitochondrial electron transport abrogates the cytotoxic and gene-inductive effects of TNF.

1993 • 581 citations

Cloning and expression of AP-2, a cell-type-specific transcription factor that activates inducible enhancer elements.

1988 • 578 citations

Thiolate ligands in metallothionein confer redox activity on zinc clusters

1998 • 566 citations

MT-III, a brain-specific member of the metallothionein gene family.

1992 • 558 citations

Iron Homeostasis, Oxidative Stress, and DNA Damage

1997 • 557 citations

Induction of a New Metallothionein Isoform (MT-IV) Occurs during Differentiation of Stratified Squamous Epithelia

1994 • 556 citations

UV-induced DNA damage is an intermediate step in UV-induced expression of human immunodeficiency virus type 1, collagenase, c-fos, and metallothionein.

1989 • 549 citations

[2] Thiol/disulfide exchange equilibria and disulfidebond stability

1995 • 535 citations

Induction of c-fos expression through JNK-mediated TCF/Elk-1 phosphorylation.

1995 • 535 citations

The voltage sensor of the mitochondrial permeability transition pore is tuned by the oxidation-reduction state of vicinal thiols. Increase of the gating potential by oxidants and its reversal by reducing agents

1994 • 527 citations

Modulation of the Mitochondrial Permeability Transition Pore by Pyridine Nucleotides and Dithiol Oxidation at Two Separate Sites

1996 • 522 citations

Analysis of the DNA-binding and activation properties of the human transcription factor AP-2.

1991 • 519 citations

Calcium-Mediated Mechanisms in Chemically Induced Cell Death

1992 • 518 citations

The role of oxidative stress in chemical carcinogenesis.

1998 • 517 citations

Cell and tissue responses to oxidative damage.

1993 • 492 citations

Oxidative mechanisms in carcinogenesis

1993 • 484 citations

Nuclear factor kappa B, a mediator of lipopolysaccharide effects

1993 • 476 citations

Xenobiotic-inducible expression of murine glutathione S-transferase Ya subunit gene is controlled by an electrophile-responsive element.

1990 • 472 citations

The roles of hydrogen peroxide and superoxide as messengers in the activation of transcription factor NF-κB

1995 • 460 citations

The serum response element

1992 • 458 citations

Role of Oxidants and Antioxidants in the Induction of AP-1, NF-κB, and Glutathione S-Transferase Gene Expression

1996 • 457 citations

Involvement of growth factor receptors in the mammalian UVC response

1994 • 456 citations

Ets-related protein Elk-1 is homologous to the c-fos regulatory factor p62TCF

1991 • 447 citations

Functions of glutathione and glutathione disulfide in immunology and immunopathology

1994 • 446 citations

Chemical and molecular regulation of enzymes that detoxify carcinogens.

1993 • 426 citations

Regulation of glutathione S-transferase Ya subunit gene expression: identification of a unique xenobiotic-responsive element controlling inducible expression by planar aromatic compounds.

1990 • 422 citations

Protein Sulfhydryls and Their Role in the Antioxidant Function of Protein S-Thiolation

1995 • 409 citations

p21 as a Common Signaling Target of Reactive Free Radicals and Cellular Redox Stress

1995 • 409 citations

UV-induced reactive oxygen species in photocarcinogenesis and photoaging.

1997 • 402 citations

Separation of oxidant-initiated and redox-regulated steps in the NF-kappa B signal transduction pathway.

1994 • 389 citations

Casein kinase II is a negative regulator of c-Jun DNA binding and AP-1 activity

1992 • 387 citations

Contribution of the mitochondrial permeability transition to lethal injury after exposure of hepatocytes to t-butylhydroperoxide

1995 • 384 citations

Cloned transcription factor MTF-1 activates the mouse metallothionein I promoter.

1993 • 382 citations

Targeting and germ-line transmission of a null mutation at the metallothionein I and II loci in mouse.

1993 • 381 citations

Control of transcription factors by signal transduction pathways: the beginning of the end

1992 • 360 citations

Identification of multiple metal regulatory elements in mouse metallothionein-I promoter by assaying synthetic sequences

1985 • 353 citations

Regulation of human NAD(P)H:quinone oxidoreductase gene. Role of AP1 binding site contained within human antioxidant response element.

1992 • 353 citations

The redox and DNA-repair activities of Ref-1 are encoded by nonoverlapping domains.

1994 • 351 citations

c-Fos transcriptional activity stimulated by H-Ras-activated protein kinase distinct from JNK and ERK

1994 • 350 citations

Oxidative metal release from metallothionein via zinc-thiol/disulfide interchange.

1994 • 334 citations

Enzymatic activation of chemicals to toxic metabolites

1985 • 331 citations

In vivo control of NF-kappa B activation by I kappa B alpha.

1993 • 326 citations

Glutathione disulfide formation and oxidant stress during acetaminophen-induced hepatotoxicity in mice in vivo: the protective effect of allopurinol.

1990 • 322 citations

Enhanced Sensitivity to Oxidative Stress in Cultured Embryonic Cells from Transgenic Mice Deficient in Metallothionein I and II Genes

1995 • 302 citations

Glutathione S-Transferases: Gene Structure and Regulation of Expression

1993 • 300 citations

Uva radiation-induced oxidative damage to lipids and proteins in vitro and in human skin fibroblasts is dependent on iron and singlet oxygen

1995 • 299 citations

Parallel Induction of Heme Oxygenase-1 and Chemoprotective Phase 2 Enzymes by Electrophiles and Antioxidants: Regulation by Upstream Antioxidant-Responsive Elements (ARE)

1995 • 298 citations

Protein synthesis inhibitors differentially superinduce c-fos and c-jun by three distinct mechanisms: lack of evidence for labile repressors.

1992 • 297 citations

Oxidative stress as a causal factor in differentiation and aging: a unifying hypothesis

1990 • 292 citations

The glutathione redox couple modulates zinc transfer from metallothionein to zinc-depleted sorbitol dehydrogenase

1998 • 291 citations

The world according to Maf

1997 • 285 citations

Antioxidant protection by haemopexin of haem-stimulated lipid peroxidation

1988 • 280 citations

Targeted disruption of the ubiquitous CNC-bZIP transcription factor, Nrf-1, results in anemia and embryonic lethality in mice

1998 • 278 citations

Oxidative Stress and Signal Transduction

1997 • 276 citations

Distinct effects of glutathione disulphide on the nuclear transcription factors κB and the activator protein‐1

1994 • 274 citations

The Maf transcription factors: regulators of differentiation

1997 • 272 citations

Activation of the c-fos gene by UV and phorbol ester: different signal transduction pathways converge to the same enhancer element.

1988 • 271 citations

v-maf, a viral oncogene that encodes a "leucine zipper" motif.

1989 • 266 citations

Transcriptional induction of the mouse metallothionein-I gene in hydrogen peroxide-treated Hepa cells involves a composite major late transcription factor/antioxidant response element and metal response promoter elements

1994 • 265 citations

UV-induced activation of AP-1 involves obligatory extranuclear steps including Raf-1 kinase.

1993 • 262 citations

Regulation of transcription factor AP-2 by the morphogen retinoic acid and by second messengers.

1989 • 260 citations

Redox signalling by transcription factors NF-κB and AP-1 in lymphocytes

1995 • 258 citations

Embryonic lethality and liver degeneration in mice lacking the metal-responsive transcriptional activator MTF-1

1998 • 257 citations

The Mechanism of the Eye

1857 • 253 citations

Cystamine induces toxicity in hepatocytes through the elevation of cytosolic Ca2+ and the stimulation of a nonlysosomal proteolytic system.

1986 • 249 citations

X-irradiation, phorbol esters, and H2O2 stimulate mitogen-activated protein kinase activity in NIH-3T3 cells through the formation of reactive oxygen intermediates.

1994 • 247 citations

Receptor-mediated activation of phospholipase A2 and arachidonic acid release in signal transduction

1990 • 247 citations

Antioxidant response element

1994 • 245 citations

Oxygen and the control of gene expression

1994 • 245 citations

Activation of mammalian gene expression by the UV component of sunlight – from models to reality

1996 • 243 citations

Redox status of cells influences constitutive or induced NF-kappa B translocation and HIV long terminal repeat activity in human T and monocytic cell lines.

1992 • 242 citations

Endotoxin induction of murine metallothionein gene expression.

1990 • 239 citations

Oxidative Stress Activates Metal-responsive Transcription Factor-1 Binding Activity

1996 • 237 citations

Phagocytosis and H2O2 induce catalase and metallothionein gene expression in human retinal pigment epithelial cells.

1995 • 236 citations

Contribution of hepatic cytochrome P450 systems to the generation of reactive oxygen species

1994 • 235 citations

Characterization of a Dimerization Motif in AP-2 and Its Function in Heterologous DNA-Binding Proteins

1991 • 234 citations

The Mitochondrial Permeability Transition Pore is Modulated by Oxidative Agents Through Both Pyridine Nucleotides and Glutathione at Two Separate Sites

1996 • 233 citations

Increase in metallothionein produced by chemicals that induce oxidative stress

1991 • 232 citations

[26] Low-level chemiluminescence as an indicator of singlet molecular oxygen in biological systems

1984 • 231 citations

Yeast and mammalian metallothioneins functionally substitute for yeast copper-zinc superoxide dismutase.

1993 • 230 citations

Electrophile and antioxidant regulation of enzymes that detoxify carcinogens.

1995 • 230 citations

Two adjacent AP-1-like binding sites form the electrophile-responsive element of the murine glutathione S-transferase Ya subunit gene.

1992 • 230 citations

Toxic and signaling effects of photochemically or chemically generated singlet oxygen in biological systems.

1997 • 227 citations

Oxidant stress leads to transcriptional activation of the human heme oxygenase gene in cultured skin fibroblasts.

1990 • 226 citations

The Level of Intracellular Glutathione Is a Key Regulator for the Induction of Stress-Activated Signal Transduction Pathways Including Jun N-Terminal Protein Kinases and p38 Kinase by Alkylating Agents

1997 • 226 citations

Loss of Function of Cytochrome c in Jurkat Cells Undergoing Fas-mediated Apoptosis

1996 • 225 citations

Mechanism of c-fos induction by active oxygen.

1992 • 224 citations

Antitumor promotion by phenolic antioxidants: inhibition of AP-1 activity through induction of Fra expression.

1995 • 222 citations

A role for the human DNA repair enzyme HAP1 in cellular protection against DNA damaging agents and hypoxic stress

1994 • 221 citations

Inhibition of hydroxyl-radical-generated DNA degradation by metallothionein

1989 • 218 citations

Activation of transcription factor AP-2 mediates UVA radiation- and singlet oxygen-induced expression of the human intercellular adhesion molecule 1 gene

1996 • 217 citations

Multiple redox regulation in NF-kappaB transcription factor activation.

1997 • 215 citations

Chemoprevention by inducers of carcinogen detoxication enzymes.

1997 • 215 citations

Molecular Biology of Metallothionein Gene Expression

1987 • 214 citations

Oxygen toxicity and iron accumulation in the lungs of mice lacking heme oxygenase-2.

1998 • 213 citations

Activation of the mitogen-activated protein kinase signaling pathway in neutrophils. Role of oxidants.

1994 • 212 citations

The participation of coenzyme Q in free radical production and antioxidation

1990 • 210 citations

Erythropoiesis and globin gene expression in mice lacking the transcription factor NF-E2.

1995 • 210 citations

Induction of fos RNA by DNA-damaging agents.

1989 • 209 citations

Persistent induction of c-fos and c-jun expression by asbestos.

1993 • 208 citations

Fos and Jun repress transcription activation by NF-IL6 through association at the basic zipper region.

1994 • 207 citations

Effects of oxidants and antioxidants on nuclear factor ϰB activation in three different cell lines: evidence against a universal hypothesis involving oxygen radicals

1995 • 206 citations

Function of the iron-sulfur protein of the cytochrome b-c1 segment in electron-transfer and energy-conserving reactions of the mitochondrial respiratory chain

1981 • 206 citations

Detoxication Enzymes and Chemoprevention

1997 • 204 citations

Fos is an essential component of the mammalian UV response.

1995 • 200 citations

Host Biochemical Defense Mechanisms Against Prooxidants

1988 • 200 citations

The Heme-Responsive Element of the Mouse Heme Oxygenase-1 Gene Is an Extended AP-1 Binding Site That Resembles the Recognition Sequences for MAF and NF-E2 Transcription Factors

1996 • 197 citations

Ca(2+)-induced mitochondrial membrane permeabilization: role of coenzyme Q redox state

1995 • 187 citations

The DNA Binding Activity of Metal Response Element-binding Transcription Factor-1 Is Activated in vivo and in Vitro by Zinc, but Not by Other Transition Metals

1998 • 186 citations

Fine Mapping of a Mouse Metallothionein Gene Metal Response Element

1989 • 185 citations

Heme Oxygenase-2 Is a Hemoprotein and Binds Heme through Heme Regulatory Motifs That Are Not Involved in Heme Catalysis

1997 • 182 citations

Sublethal Levels of Oxidant Stress Stimulate Multiple Serine/Threonine Kinases and Suppress Protein Phosphatases in Jurkat T Cells

1995 • 181 citations

Dioxin Induces Expression of c-fosand c-junProto-Oncogenes and a Large Increase in Transcription Factor AP-1

1992 • 179 citations

Effect of Inorganic Phosphate Concentration on the Nature of Inner Mitochondrial Membrane Alterations Mediated by Ca2+ Ions

1996 • 177 citations

Constitutive and metal-inducible protein:DNA interactions at the mouse metallothionein I promoter examined by in vivo and in vitro footprinting.

1988 • 176 citations

Oxidative stress by acute acetaminophen administration in mouse liver

1995 • 175 citations

Transcriptional regulation by Fos and Jun in vitro: interaction among multiple activator and regulatory domains.

1991 • 175 citations

In vivo indices of oxidative stress in lead-exposed C57BL/6 mice are reduced by treatment with meso-2,3-Dimercaptosuccinic Acid or N-acetylcysteine

1996 • 170 citations

Epidermal Changes in Human Skin Following Irradiation With Either UVB or UVA

1987 • 169 citations

Role of [Ca ²⁺ ] _i in induction of c‐ fos , c‐ jun and c‐ myc mRNA in rat PTE after oxidative stress

1992 • 168 citations

Inhibition of hepatocyte plasma membrane Ca²⁺‐ATPase activity by menadione metabolism and its restoration by thiols

1985 • 168 citations

Cytoplasmic metallothionein overexpression protects NIH 3T3 cells from tert-butyl hydroperoxide toxicity.

1994 • 166 citations

Involvement of reactive oxygen intermediates in the induction of c-jun gene transcription by ionizing radiation

1992 • 161 citations

Cytochrome P450 _cam : crystallography, oxygen activation, and electron transfer ¹

1992 • 160 citations

TNF induces c-fos via a novel pathway requiring conversion of arachidonic acid to a lipoxygenase metabolite.

1991 • 159 citations

Functional domains of the heavy metal-responsive transcription regulator MTF-1

1995 • 155 citations

Structural and functional analysis of an enhancer GPEI having a phorbol 12-O-tetradecanoate 13-acetate responsive element-like sequence found in the rat glutathione transferase P gene

1989 • 154 citations

A conserved region adjacent to the basic domain is required for recognition of an extended DNA binding site by Maf/Nrl family proteins.

1994 • 153 citations

Transcriptional regulation of a rat liver glutathione S-transferase Ya subunit gene. Analysis of the antioxidant response element and its activation by the phorbol ester 12-O-tetradecanoylphorbol-13-acetate.

1994 • 152 citations

v-Crk Modulation of Growth Factor-induced PC12 Cell Differentiation Involves the Src Homology 2 Domain of v-Crk and Sustained Activation of the Ras/Mitogen-activated Protein Kinase Pathway

1995 • 151 citations

The DNA Binding Activity of C/EBP Transcription Factors Is Regulated in the G1 Phase of the Hepatocyte Cell Cycle

1995 • 151 citations

New perspectives on the biochemistry of superoxide anion and the efficiency of superoxide dismutases

1990 • 149 citations

On the effects of paraquat on isolated mitochondria. Evidence that paraquat causes opening of the cyclosporin A-sensitive permeability transition pore synergistically with nitric oxide

1995 • 146 citations

Role of cysteine₆₂in DNA recognition by the P50 subunit of NF-_xB

1993 • 142 citations

ARE- and TRE-mediated Regulation of Gene Expression

1995 • 140 citations

DNA methylation and the association between genetic and epigenetic changes: relation to carcinogenesis

1997 • 140 citations

Hydrogen peroxide-induced c-fos expression is mediated by arachidonic acid release: role of protein kinase C

1993 • 137 citations

Dioxin induces transcription of fos and jun genes by ah receptor-dependent and -independent pathways

1996 • 134 citations

Induction of Nuclear Factor κB after Low-Dose Ionizing Radiation Involves a Reactive Oxygen Intermediate Signaling Pathway

1994 • 131 citations

Identification of a cis-acting element that is responsible for cadmium-mediated induction of the human heme oxygenase gene.

1994 • 130 citations

Oxygen Radicals Acting as Chemical Messengers: A Hypothesis

1989 • 129 citations

Reversible Activation of Mouse Metal Response Element-Binding Transcription Factor 1 DNA Binding Involves Zinc Interaction with the Zinc Finger Domain

1997 • 127 citations

Mitochondria-Mediated Cell Injury,

1997 • 127 citations

Fine mapping of a mouse metallothionein gene metal response element.

1989 • 126 citations

Identification of oxygen responsive elements in the 5'-flanking region of the human glutathione peroxidase gene.

1993 • 125 citations

Hydrogen peroxide stimulates transcription of c-jun in vascular smooth muscle cells: role of arachidonic acid.

1993 • 123 citations

Endogenous non-cyclooxygenase metabolites of arachidonic acid modulate growth and mRNA levels of immediate-early response genes in rat mesangial cells

1991 • 122 citations

Mitochondria-Mediated Cell Injury

1997 • 121 citations

Escape from redox regulation enhances the transforming activity of Fos.

1993 • 119 citations

Involvement of Cytokines, DNA Damage, and Reactive Oxygen Intermediates in Ultraviolet Radiation-Induced Modulation of Intercellular Adhesion Molecule-1 Expression

1995 • 119 citations

Induction of metallothionein as an adaptive mechanism affecting the magnitude and progression of toxicological injury.

1998 • 118 citations

Studies into the Effect of the Tyrosine Kinase Inhibitor Herbimycin A on NF-κB Activation in T Lymphocytes EVIDENCE FOR COVALENT MODIFICATION OF THE p50 SUBUNIT

1995 • 118 citations

Metallothionein is a component of exocrine pancreas secretion: implications for zinc homeostasis

1996 • 117 citations

Interaction of the CNC-bZIP factor TCF11/LCR-F1/Nrf1 with MafG: Binding-site selection and regulation of transcription

1998 • 115 citations

Butylated Hydroxyanisole and Its Metabolitetert-Butylhydroquinone Differentially Regulate Mitogen-activated Protein Kinases

1997 • 115 citations

Transgenic Mice That Overexpress Metallothionein-I Resist Dietary Zinc Deficiency

1996 • 115 citations

The bZIP transcription factor LCR-F1 is essential for mesoderm formation in mouse development.

1997 • 113 citations

Coordination dynamics of biological zinc “clusters” in metallothioneins and in the DNA-binding domain of the transcription factor Gal4

1997 • 112 citations

Oxidative Damage to Behavior During Aging

1991 • 112 citations

Redox‐Mediated Regulation of p21^Waf1/Cip1 Expression Involves a Post‐Transcriptional Mechanism and Activation of the Mitogen‐Activated Protein Kinase Pathway

1997 • 112 citations

Influence of metabolic inhibitors on mitochondrial permeability transition and glutathione status

1995 • 109 citations

Control of Drosophila head segment identity by the bZIP homeotic gene cnc

1995 • 109 citations

c-Jun is phosphorylated by the DNA-dependent protein kinasein vitro; definition of the minimal kinase recognition motif

1993 • 104 citations

Conditions allowing redox-cycling ubisemiquinone in mitochondria to establish a direct redox couple with molecular oxygen

1996 • 103 citations

Optimal NFκB Mediated Transcriptional Responses in Jurkat T Cells Exposed to Oxidative Stress Are Dependent on Intracellular Glutathione and Costimulatory Signals

1996 • 102 citations

Metallothionein Knockout and Transgenic Mice Exhibit Altered Intestinal Processing of Zinc with Uniform Zinc-Dependent Zinc Transporter-1 Expression ,

1998 • 101 citations

The Role of Oxidative Stress in Chemical Carcinogenesis

1998 • 101 citations

Transcriptional regulation of the rat NAD(P)H:quinone reductase gene. Characterization of a DNA-protein interaction at the antioxidant responsive element and induction by 12-O-tetradecanoylphorbol 13-acetate.

1993 • 100 citations

Ultraviolet‐A induces activation of AP‐1 in cultured human keratinocytes

1996 • 100 citations

Review of the current status of calcium and thiols in cellular injury

1990 • 98 citations

Induction of AP-1 (Fos/Jun) by chemical agents mediates activation of glutathione S-transferase and quinone reductase gene expression.

1994 • 97 citations

Transient Ca2+ changes in endothelial cells induced by low doses of reactive oxygen species: role of hydrogen peroxide.

1997 • 97 citations

Regulation of rat glutathione S-transferase Ya subunit gene expression. DNA-protein interaction at the antioxidant responsive element.

1992 • 96 citations

Role of the Mitochondrial Permeability Transition in Salicylate Toxicity to Cultured Rat Hepatocytes: Implications for the Pathogenesis of Reye's Syndrome

1997 • 95 citations

Free radicals and lung disease

1993 • 95 citations

Oxidant-induced mobilization of zinc from metallothionein

1992 • 87 citations

Regulation of c-fos and c-jun protooncogene expression by the Ca(2+)-ATPase inhibitor thapsigargin.

1991 • 83 citations

Fos and jun cooperate in transcriptional regulation via heterologous activation domains.

1990 • 82 citations

Alterations to glutathione and nicotinamide nucleotides during the mitochondrial permeability transition induced by peroxynitrite

1996 • 82 citations

Elevation of AP1 activity during F9 cell differentiation is due to increased c-jun transcription.

1990 • 82 citations

Deletion in Human Chromosome Region 12q13-15 by Integration of Human Papillomavirus DNA in a Cervical Carcinoma Cell Line

1995 • 80 citations

Ca2+ depletion prevents anoxic death of hepatocytes by inhibiting mitochondrial permeability transition

1995 • 79 citations

Role of Hydroperoxyeicosatetraenoic Acids in Oxidative Stress-induced Activating Protein 1 (AP-1) Activity

1996 • 79 citations

Hydroperoxide-induced Increases in Intracellular Calcium Due to Annexin VI Translocation and Inactivation of Plasma Membrane Ca2+-ATPase

1996 • 78 citations

Induction of hepatic metallothionein by nonmetallic compounds associated with acute-phase response in inflammation

1991 • 74 citations

Ultraviolet A radiation-induced expression of human genes: molecular and photobiological mechanisms.

1997 • 73 citations

Induction of c-fos and c-jun gene expression by phenolic antioxidants.

1993 • 72 citations

Inhibition of NF-kappa B DNA binding activity by alpha-tocopheryl succinate.

1993 • 72 citations

Oxidative damage of mitochondria induced by Fe(II)citrate or t-butyl hydroperoxide in the presence of Ca2+: Effect of coenzyme Q redox state

1995 • 71 citations

Oxidant Carcinogenesis and Antioxidant Defensea

1992 • 69 citations

Purification and characterization of a protein that binds to metal responsive elements of the human metallothionein IIA gene.

1994 • 68 citations

A New Principle of Regulation of Enzymic Activity

1981 • 67 citations

What's new with calcium?

1992 • 65 citations

Comprehensive Analysis of Proteins Which Interact with the Antioxidant Responsive Element: Correlation of ARE-BP-1 with the Chemoprotective Induction Response

1997 • 63 citations

Furan-Induced Cytolethality in Isolated Rat Hepatocytes: Correspondence with in Vivo Dosimetry

1993 • 62 citations

The Consequences of Lipid Peroxidation in Isolated Hepatocytes

1975 • 61 citations

Rapid Loss in the Mitochondrial Membrane Potential during Geranylgeranoic Acid-Induced Apoptosis

1997 • 61 citations

Activation of the complete mouse metallothionein gene locus in the maternal deciduum

1996 • 61 citations

Adaptation to oxidative stress: Quinone-mediated protection of signaling in rat lung epithelial L2 cells

1997 • 60 citations

Damage to DNA by UV light and activation of transcription factors

1994 • 56 citations

Oxidative stress induces the levels of a MAFG homolog in hamster HA-1 cells

1996 • 56 citations

Overxpression of Bcl-2 inhibits UVA-mediated immediate apoptosiinrat 6 fibroblasts: evidence for the involvement of Bcl-2 as an antioxidant.

1997 • 56 citations

Chemoprevention by Inducers of Carcinogen Detoxication Enzymes

1997 • 56 citations

Several nongenotoxic carcinogens uncouple mitochondrial oxidative phosphorylation

1992 • 55 citations

Induction of hepatic metallothionein by paraquat

1992 • 55 citations

Furan-Mediated Uncoupling of Hepatic Oxidative Phosphorylation in Fischer-344 Rats: An Early Event in Cell Death

1997 • 53 citations

Transactivation activity of Maf nuclear oncoprotein is modulated by Jun, Fos and small Maf proteins.

1996 • 49 citations

Differential Mechanisms of Induction of the Mitochondrial Permeability Transition by Quinones of Varying Chemical Reactivities

1995 • 49 citations

Jun and Fos regulation of NAD(P)H

1994 • 49 citations

Detection of a nuclear protein which binds specifically to the antioxidant responsive element (ARE) of the human NAD(P)H:quinone oxidoreductase gene

1994 • 48 citations

Manganese superoxide dismutase expression inhibits soft agar growth in JB6 clone41 mouse epidermal cells

1997 • 47 citations

Transient Overexpression of Catalase Does Not Inhibit TNF- or PMA-Induced NF-κB Activation

1995 • 47 citations

[39] Glucocorticoid receptor thiols andsteroid-binding activity

1995 • 46 citations

The Rat Liver Glutathione S-Transferase Ya Subunit Gene: Characterization of the Binding Properties of a Nuclear Protein from HepG2 Cells That Has High Affinity for the Antioxidant Response Element

1996 • 43 citations

Induction of metallothionein by diethyl maleate

1992 • 41 citations

Induction of c-fos and c-jun gene expression by phenolic antioxidants

1993 • 40 citations

Inhibition of arachidonic acid release by nordihydroguaiaretic acid and its antioxidant action in rat alveolar macrophages and chinese hamster lung fibroblasts

1990 • 39 citations

Analysis of the heavy metal-responsive transcription factor MTF-1 from human and mouse

1995 • 31 citations

Irreversible Inactivation of Protein Kinase C by a Peptide-Substrate Analog

1995 • 31 citations

Crossed signals: oncogenic transcription factors

1992 • 31 citations

Involvement of Cytokines, DNA Damage, and Reactive Oxygen Intermediates in Ultraviolet Radiation-Induced Modulation of Intercellular Adhesion Molecule-1 Expression.

1995 • 30 citations

Acrylic Acid Induces the Glutathione-Independent Mitochondrial Permeability Transitionin Vitro

1998 • 30 citations

Fos and Jun. Oncogenic Transcription Factors.

1992 • 29 citations

Mn and Cu/Zn SOD expression in cells from LPS-sensitive and LPS-resistant mice☆

1992 • 29 citations

Activation of the Chicken Metallothionein Promoter by Metals and Oxidative Stress in Cultured Cells and Transgenic Mice

1997 • 28 citations

Glutathione oxidation during peroxidase catalysed drug metabolism

1987 • 28 citations

Differential roles for Fos and Jun in DNA-binding: redoxdependent and independent functions

1993 • 27 citations

Prevention of Cancer-by Agents that Suppress Oxygen Radical Formation

1991 • 26 citations

Induction of Metallothionein as an Adaptive Mechanism Affecting the Magnitude and Progression of Toxicological Injury

1998 • 25 citations

Metallothionein, glutathione, and cystine transport in pulmonary artery endothelial cells and NIH/3T3 cells

1998 • 24 citations

Protection against carbon tetrachloride hepatotoxicity by 5,10-dihydroindeno[1,2-b]indole, a potent inhibitor of lipid peroxidation

1988 • 24 citations

Oxidative damage by ozone and nitrogen dioxide: synergistic toxicity in vivo but no evidence of synergistic oxidative damage in an extracellular fluid

1995 • 21 citations

On the Mechanism of Action of H₂O₂in the Cellular Stress

1991 • 20 citations

Mechanisms of oxidant carcinogenesis.

1990 • 19 citations

Protection from N-nitrosodimethylamine-mediated liver damage by indole-3-carbinol

1987 • 18 citations

Importance of protein thiols during N-methyl-N′-nitro-N-nitrosoguanidine toxicity in primary rat hepatocytes

1990 • 17 citations

Oncogenes, oncogenesis, and oxygen radicals.

1990 • 16 citations

Dioxin Induces Transcription ofandGenes byReceptor-Dependent and -Independent Pathways

1996 • 6 citations