Disturbed interaction of p21-rac with mutated p67-phox causes chronic granulomatous disease.

Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase

1988 • 6,107 citations

Activation of the NADPH oxidase involves the small GTP-binding protein p21rac1

1991 • 961 citations

Cloning the gene for an inherited human disorder—chronic granulomatous disease—on the basis of its chromosomal location

1986 • 839 citations

Regulation of Phagocyte Oxygen Radical Production by the GTP-Binding Protein Rac 2

1991 • 669 citations

Two cytosolic components of the human neutrophil respiratory burst oxidase translocate to the plasma membrane during cell activation.

1990 • 435 citations

Cloning of a 67-kD Neutrophil Oxidase Factor with Similarity to a Noncatalytic Region of p60 ^c-src

1990 • 393 citations

Interaction of Rac with p67 ^phox and Regulation pf Phagocytic NADPH Oxidase Activity

1994 • 384 citations

Cytochrome b-245 is a flavocytochrome containing FAD and the NADPH-binding site of the microbicidal oxidase of phagocytes

1992 • 351 citations

Recombinant 47-Kilodalton Cytosol Factor Restores NADPH Oxidase in Chronic Granulomatous Disease

1989 • 341 citations

Human neutrophil cytochrome b light chain (p22-phox). Gene structure, chromosomal location, and mutations in cytochrome-negative autosomal recessive chronic granulomatous disease.

1990 • 337 citations

Translocation of Rac correlates with NADPH oxidase activation. Evidence for equimolar translocation of oxidase components.

1993 • 316 citations

Cloning of the cDNA and functional expression of the 47-kilodalton cytosolic component of human neutrophil respiratory burst oxidase.

1989 • 310 citations

p40phox, a third cytosolic component of the activation complex of the NADPH oxidase to contain src homology 3 domains

1993 • 295 citations

Reconstitution of neutrophil NADPH oxidase activity in the cell-free system by four components: p67-phox, p47-phox, p21rac1, and cytochrome b-245.

1992 • 265 citations

Rac translocates independently of the neutrophil NADPH oxidase components p47phox and p67phox. Evidence for its interaction with flavocytochrome b558.

1994 • 260 citations

Cytosolic guanine nucleotide-binding protein Rac2 operates in vivo as a component of the neutrophil respiratory burst oxidase. Transfer of Rac2 and the cytosolic oxidase components p47phox and p67phox to the submembranous actin cytoskeleton during oxidase activation.

1994 • 186 citations

[8] Purification and cryopreservation of phagocytes from human blood

1986 • 174 citations

The Genetic Basis of Chronic Granulomatous Disease

1994 • 139 citations

Mechanisms of NADPH oxidase activation: translocation of p40phox, Rac1 and Rac2 from the cytosol to the membranes in human neutrophils lacking p47phox or p67phox

1996 • 138 citations

A structural model for the nucleotide binding domains of the flavocytochrome b_–245 β‐chain

1993 • 124 citations

Inhibition of superoxide production in B lymphocytes by rac antisense oligonucleotides.

1992 • 120 citations

Point mutations in the beta-subunit of cytochrome b558 leading to X- linked chronic granulomatous disease

1991 • 120 citations

A Novel Cytosolic Component, p40phox, of Respiratory Burst Oxidase Associates with p67phox and Is Absent in Patients with Chronic Granulomatous Disease Who Lack p67phox

1994 • 113 citations

The Rac Target NADPH Oxidase p67 Interacts Preferentially with Rac2 Rather Than Rac1

1996 • 110 citations

A point mutation in gp91-phox of cytochrome b558 of the human NADPH oxidase leading to defective translocation of the cytosolic proteins p47-phox and p67-phox.

1994 • 109 citations

Assembly and activation of the NADPH:O2 oxidoreductase in human neutrophils after stimulation with phorbol myristate acetate.

1990 • 108 citations

156Pro-->Gln substitution in the light chain of cytochrome b558 of the human NADPH oxidase (p22-phox) leads to defective translocation of the cytosolic proteins p47-phox and p67-phox.

1994 • 107 citations

Dissociation of Rac translocation from p47phox/p67phox movements in human neutrophils by tyrosine kinase inhibitors

1995 • 93 citations

Participation of the small molecular weight GTP-binding protein Rac1 in cell-free activation and assembly of the respiratory burst oxidase. Inhibition by a carboxyl-terminal Rac peptide.

1994 • 90 citations

The phagocyte 47-kilodalton cytosolic oxidase protein is an early reactant in activation of the respiratory burst.

1990 • 89 citations

A 68-kDa Kinase and NADPH Oxidase Component p67 Are Targets for Cdc42Hs and Rac1 in Neutrophils

1995 • 80 citations

Interactions between the Cytosolic Components p47 and p67 of the Human Neutrophil NADPH Oxidase That Are Not Required for Activation in the Cell-free System

1995 • 78 citations

The respiratory burst oxidase of human neutrophils. Guanine nucleotides and arachidonate regulate the assembly of a multicomponent complex in a semirecombinant cell-free system.

1993 • 67 citations

Heterogeneity in Chronic Granulomatous Disease Detected With an Improved Nitroblue Tetrazolium Slide Test

1986 • 49 citations

Autosomal recessive chronic granulomatous disease with absence of the 67-kD cytosolic NADPH oxidase component: identification of mutation and detection of carriers

1994 • 49 citations

Inhibition of neutrophil NADPH oxidase assembly by a myristoylated pseudosubstrate of protein kinase C.

1993 • 43 citations

Translocation of p21rac2 from Cytosol to Plasma Membrane Is Neither Necessary nor Sufficient for Neutrophil NADPH Oxidase Activity

1995 • 41 citations

A mutation located at the 5' splice junction sequence of intron 3 in the p67phox gene causes the lack of p67phox mRNA in a patient with chronic granulomatous disease

1995 • 34 citations

Combination of Arachidonic Acid and Guanosine 5′-O-(3-Thiotriphosphate) Induces Translocation of rac p21s to Membrane and Activation of NADPH Oxidase in a Cell-Free System

1993 • 31 citations

AG dinucleotide insertion in a patient with chronic granulomatous disease lacking cytosolic 67-kD protein

1995 • 25 citations

The Small GTP-Binding Protein rac Is Not Recruited to the Plasma Membrane upon NADPH Oxidase Activation in Human Neutrophils

1994 • 19 citations