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Helicobacter pyloriInfection and the Risk of Gastric Carcinoma

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Protein Oxidation and Aging

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Oxidative Stress Hypothesis in Alzheimer's Disease

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daf-2 , an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in Caenorhabditis elegans

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Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress

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Normal oxidative damage to mitochondrial and nuclear DNA is extensive.

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Positional Cloning of the Werner's Syndrome Gene

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The cellular production of hydrogen peroxide

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daf-16 : An HNF-3/forkhead Family Member That Can Function to Double the Life-Span of Caenorhabditis elegans

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1994 • 1,461 citations

Aging, energy, and oxidative stress in neurodegenerative diseases

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Oxidants as Stimulators of Signal Transduction

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The causes and prevention of cancer.

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Oxidative stress: the paradox of aerobic life

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The Receptor for Advanced Glycation End Products (RAGE) Is a Cellular Binding Site for Amphoterin

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Evolution of senescence: late survival sacrificed for reproduction

1991 • 1,066 citations

Chronic infections and inflammatory processes as cancer risk factors: possible role of nitric oxide in carcinogenesis

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The Retardation of Aging in Mice by Dietary Restriction: Longevity, Cancer, Immunity and Lifetime Energy Intake

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Oxidative Decay of DNA

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The oxidant stress hypothesis in Parkinson's disease: Evidence supporting it

1992 • 925 citations

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The Free Radical Theory of Aging

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Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age

1992 • 878 citations

Metal-catalyzed oxidation of proteins. Physiological consequences

1991 • 877 citations

Free radical theory of aging

1992 • 876 citations

A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans

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Thermotolerance and extended life-span conferred by single-gene mutations and induced by thermal stress.

1995 • 847 citations

Mutagenesis by 8-oxoguanine: an enemy within

1993 • 805 citations

Oxidative damage to brain proteins, loss of glutamine synthetase activity, and production of free radicals during ischemia/reperfusion-induced injury to gerbil brain.

1990 • 787 citations

Oxidative damage, mitochondrial oxidant generation and antioxidant defenses during aging and in response to food restriction in the mouse

1994 • 785 citations

Detection of a specific mitochondrial DNA deletion in tissues of older humans

1990 • 784 citations

LABORATORY EVOLUTION OF POSTPONED SENESCENCE INDROSOPHILA MELANOGASTER

1984 • 774 citations

Cytochrome c: Can't Live with It—Can't Live without It

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Nonenzymatic Browning in Vivo: Possible Process for Aging of Long-Lived Proteins

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Cell Biology of the Amyloid beta-Protein Precursor and the Mechanism of Alzheimer's Disease

1994 • 749 citations

Reactive oxygen species and programmed cell death

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Correlation Between Deoxyribonucleic Acid Excision-Repair and Life-Span in a Number of Mammalian Species

1974 • 738 citations

Caloric Intake and Aging

1997 • 736 citations

Reversal of age-related increase in brain protein oxidation, decrease in enzyme activity, and loss in temporal and spatial memory by chronic administration of the spin-trapping compound N-tert-butyl-alpha-phenylnitrone.

1991 • 734 citations

Urinary 8-hydroxy-2'-deoxyguanosine as a biological marker of in vivo oxidative DNA damage.

1989 • 733 citations

Nitric Oxide Inhibits Electron Transfer and Increases Superoxide Radical Production in Rat Heart Mitochondria and Submitochondrial Particles

1996 • 726 citations

Aging and resistance to oxidative damage in Caenorhabditis elegans.

1993 • 720 citations

Free Radicals in Biological Materials

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The Dawn of Darwinian Medicine

1991 • 707 citations

Oxidative DNA damage and senescence of human diploid fibroblast cells.

1995 • 697 citations

DNA oxidation matters: The HPLC–electrochemical detection assay of 8-oxo-deoxyguanosine and 8-oxo-guanine

1998 • 694 citations

The Rate of Living.

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8-oxoguanine (8-hydroxyguanine) DNA glycosylase and its substrate specificity.

1991 • 678 citations

Nuclear translocation of NF-κB is increased in dopaminergic neurons of patients with Parkinson disease

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Role of ubiquinone in the mitochondrial generation of hydrogen peroxide

1976 • 656 citations

Genetic analysis of ageing: role of oxidative damage and environmental stresses

1996 • 647 citations

Laboratory Evolution of Postponed Senescence in Drosophila melanogaster

1984 • 641 citations

A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues.

1992 • 633 citations

Cellular receptors for advanced glycation end products. Implications for induction of oxidant stress and cellular dysfunction in the pathogenesis of vascular lesions.

1994 • 632 citations

The inactivation of Fe-S cluster containing hydro-lyases by superoxide.

1993 • 628 citations

Superoxide radicals as precursors of mitochondrial hydrogen peroxide

1974 • 627 citations

Senescence-like growth arrest induced by hydrogen peroxide in human diploid fibroblast F65 cells.

1994 • 617 citations

Oxidative damage during aging targets mitochondrial aconitase

1997 • 612 citations

The respiratory burst oxidase.

1994 • 608 citations

The Werner syndrome protein is a DNA helicase

1997 • 597 citations

Naturally occurring carbonyl compounds are mutagens Salmonella tester strain TA104

1985 • 596 citations

Reactive oxygen species are downstream mediators of p53-dependent apoptosis.

1996 • 590 citations

The potential diagram for oxygen at pH 7

1988 • 590 citations

Oxidative damage to DNA: relation to species metabolic rate and life span.

1988 • 587 citations

Nitric oxide and oxygen radicals: a question of balance

1995 • 568 citations

Mitochondrial mutations may increase oxidative stress: Implications for carcinogenesis and aging?

1990 • 563 citations

Mice Deficient in Cellular Glutathione Peroxidase Develop Normally and Show No Increased Sensitivity to Hyperoxia

1997 • 558 citations

Oxidative and reductive metabolism by cytochrome P450 2E1

1992 • 557 citations

Oxidative damage to DNA in mammalian chromatin

1992 • 546 citations

Vitamin E Supplementation and In Vivo Immune Response in Healthy Elderly Subjects

1997 • 541 citations

Free radical damage to protein and DNA: Mechanisms involved and relevant observations on brain undergoing oxidative stress

1992 • 539 citations

Repair of Oxidative Damage to Nuclear and Mitochondrial DNA in Mammalian Cells

1997 • 508 citations

Superoxide sensitivity of the Escherichia coli aconitase.

1991 • 499 citations

Age-related losses of cognitive function and motor skills in mice are associated with oxidative protein damage in the brain.

1996 • 493 citations

Genetics of Aging

1997 • 493 citations

AN ATTEMPT AT A RATIONAL CLASSIFICATION OF THEORIES OF AGEING

1990 • 490 citations

Synthesis and characterization of the fluorescent products derived from malonaldehyde and amino acids

1969 • 487 citations

Relationship between mitochondrial superoxide and hydrogen peroxide production and longevity of mammalian species

1993 • 484 citations

Reactive oxygen species in tumorigenesis.

1994 • 479 citations

Cloning and characterization of a mammalian 8-oxoguanine DNA glycosylase

1997 • 477 citations

Superoxide Radical and Iron Modulate Aconitase Activity in Mammalian Cells

1995 • 467 citations

A gain-of-function of an amyotrophic lateral sclerosis-associated Cu,Zn-superoxide dismutase mutant: An enhancement of free radical formation due to a decrease in Km for hydrogen peroxide.

1996 • 464 citations

Radical AGEing in Alzheimer's disease

1995 • 464 citations

Aging and oxidative stress: Modulation by dietary restriction

1996 • 450 citations

Mitochondrial DNA Variants Observed in Alzheimer Disease and Parkinson Disease Patients

1993 • 449 citations

The age-1 and daf-2 genes function in a common pathway to control the lifespan of Caenorhabditis elegans.

1995 • 442 citations

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1997 • 432 citations

Mitochondrial decay in hepatocytes from old rats: Membrane potential declines, heterogeneity and oxidants increase

1997 • 427 citations

The role of O2.− in the production of HO.: in vitro and in vivo

1994 • 421 citations

Mosaicism for a specific somatic mitochondrial DNA mutation in adult human brain

1992 • 416 citations

Aconitase is a sensitive and critical target of oxygen poisoning in cultured mammalian cells and in rat lungs.

1994 • 415 citations

Protein, Lipid and DNA Repair Systems in Oxidative Stress: The Free-Radical Theory of Aging Revisited

1991 • 410 citations

Assay of metabolic superoxide production in Escherichia coli.

1991 • 405 citations

Mitochondrial production of superoxide anions and its relationship to the antimycin insensitive respiration

1975 • 403 citations

Protein oxidation and proteolysis during aging and oxidative stress

1989 • 396 citations

Low oxygen concentration extends the lifespan of cultured human diploid cells

1977 • 387 citations

Cloning and sequencing a human homolog (hMYH) of the Escherichia coli mutY gene whose function is required for the repair of oxidative DNA damage

1996 • 386 citations

Potential genotoxicity of chronically elevated nitric oxide: A review

1995 • 385 citations

Oxidative stress and ageing in Caenorhabditis elegans

1993 • 383 citations

Effects of alpha-tocopherol and beta-carotene supplements on cancer incidence in the Alpha-Tocopherol Beta-Carotene Cancer Prevention Study

1995 • 380 citations

Free radicals, reactive oxygen species and human disease: a critical evaluation with special reference to atherosclerosis.

1989 • 380 citations

Biochemical basis of lipofuscin, ceroid, and age pigment-like fluorophores

1996 • 377 citations

ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly(ADP-ribose) polymerase

1997 • 376 citations

Different prooxidant levels stimulate growth, trigger apoptosis, or produce necrosis of insulin-secreting RINm5F cells. The role of intracellular polyamines.

1994 • 372 citations

Alterations in mitochondrial membrane fluidity by lipid peroxidation products

1994 • 367 citations

The potential of the hydrocarbon breath test as a measure of lipid peroxidation

1994 • 362 citations

Oxidative damage to mitochondrial DNA and its relationship to ageing

1995 • 350 citations

Protein oxidative damage is associated with life expectancy of houseflies.

1993 • 347 citations

RETRACTED: Mutations in mitochondrial cytochrome c oxidase genes segregate with late-onset Alzheimer disease

1997 • 345 citations

Peroxynitrite disables the tyrosine phosphorylation regulatory mechanism: Lymphocyte-specific tyrosine kinase fails to phosphorylate nitrated cdc2(6-20)NH2 peptide.

1996 • 341 citations

Inactivation-reactivation of aconitase in Escherichia coli. A sensitive measure of superoxide radical.

1992 • 336 citations

Superoxide Dismutases

1991 • 332 citations

Mitochondrial implication in accidental and programmed cell death: apoptosis and necrosis.

1997 • 326 citations

DNA damage and repair in telomeres: relation to aging.

1995 • 326 citations

Bacterial defenses against oxidative stress

1990 • 316 citations

A mammalian DNA repair enzyme that excises oxidatively damaged guanines maps to a locus frequently lost in lung cancer

1997 • 316 citations

Modification of glucose-6-phosphate dehydrogenase by 4-hydroxy-2-nonenal. Formation of cross-linked protein that inhibits the multicatalytic protease.

1994 • 311 citations

Genetic and functional changes in mitochondria associated with aging

1997 • 311 citations

Structural and Functional Conservation of the Caenorhabditis elegans Timing Gene clk-1

1997 • 309 citations

Marked Changes in Mitochondrial DNA Deletion Levels in Alzheimer Brains

1994 • 307 citations

Regulation of human mononuclear phagocyte migration by cell surface-binding proteins for advanced glycation end products.

1993 • 298 citations

The development of mitochondrial medicine.

1994 • 296 citations

Rage: A Novel Cellular Receptor for Advanced Glycation End Products

1996 • 296 citations

Antioxidants and immune response in aged persons: overview of present evidence

1995 • 296 citations

The role of intracellular oxidants in apoptosis

1995 • 294 citations

Hydrogen peroxide release by mitochondria increases during aging

1991 • 292 citations

Biomarkers of aging

1988 • 286 citations

Role of the Maillard Reaction in Diabetes Mellitus and Diseases of Aging

1996 • 283 citations

Inactivation of glucose-6-phosphate dehydrogenase by 4-hydroxy-2-nonenal. Selective modification of an active-site lysine.

1993 • 281 citations

Parkinson disease: A new link between monoamine oxidase and mitochondrial electron flow

1997 • 278 citations

Marked increase in the number and variety of mitochondrial DNA rearrangements in aging human skeletal muscle

1995 • 276 citations

Inhibitors of Lysosomal Enzymes: Accumulation of Lipofuscin-Like Dense Bodies in the Brain

1984 • 274 citations

Mitochondrial oxidative damage, hydrogen peroxide release, and aging

1994 • 273 citations

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1985 • 272 citations

Replicative senescence of human fibroblast-like cells in culture

1993 • 270 citations

A novel hypothesis of lipofuscinogenesis and cellular aging based on interactions between oxidative stress and autophagocytosis

1992 • 270 citations

The role of iron in the initiation of lipid peroxidation

1987 • 268 citations

Cardiac reperfusion injury: Aging, lipid peroxidation, and mitochondrial dysfunction

1998 • 260 citations

Low Mitochondrial Free Radical Production Per Unit O₂Consumption Can Explain the Simultaneous Presence of High Longevity and High Aerobic Metabolic Rate in Birds

1994 • 260 citations

Oxygen and Xenobiotic Reductase Activities of Cytochrome P450

1995 • 257 citations

Reactive species and their accumulation on radical-damaged proteins

1993 • 253 citations

Hydrophobicity as the signal for selective degradation of hydroxyl radical-modified hemoglobin by the multicatalytic proteinase complex, proteasome

1993 • 252 citations

Superoxide radicals and hydrogen peroxide formation in mitochondria from normal and neoplastic tissues

1975 • 250 citations

Rapid accumulation of genome rearrangements in liver but not in brain of old mice

1997 • 250 citations

Protein oxidation associated with aging is reduced by dietary restriction of protein or calories.

1992 • 248 citations

Commentary the Measurement of Oxidative Damage to DNA by HPLC and GC/MS Techniques

1992 • 242 citations

Cellular injury induced by oxidative stress is mediated through lysosomal damage

1995 • 240 citations

Simultaneous Overexpression of Copper- and Zinc-containing Superoxide Dismutase and Catalase Retards Age-related Oxidative Damage and Increases Metabolic Potential in Drosophila melanogaster

1995 • 239 citations

Redox signaling and gene control in the Escherichia coli soxRS oxidative stress regulon — a review

1996 • 239 citations

alpha, beta-Dihydroxyisovalerate dehydratase. A superoxide-sensitive enzyme.

1987 • 239 citations

Protein hydroperoxides can give rise to reactive free radicals

1995 • 238 citations

Longevity and the genetic determination of collagen glycoxidation kinetics in mammalian senescence.

1996 • 237 citations

Antioxidants and Aging

2012 • 235 citations

Mitochondrial superoxide and hydrogen peroxide generation, protein oxidative damage, and longevity in different species of flies

1995 • 234 citations

Superoxide dismutase, aging, and degenerative disease

1994 • 234 citations

Comparison of mitochondrial pro-oxidant generation and anti-oxidant defenses between rat and pigeon: possible basis of variation in longevity and metabolic potential

1993 • 234 citations

Reactive oxygen and DNA damage in mitochondria

1992 • 234 citations

Formation of 8-hydroxydeoxyguanosine in liver DNA of rats following long-term exposure to a peroxisome proliferator.

1989 • 233 citations

Superoxide and the production of oxidative DNA damage

1995 • 231 citations

Free Radical Involvement in Aging

1993 • 226 citations

Mitochondrial DNA mutations in human degenerative diseases and aging

1995 • 224 citations

A network theory of ageing: the interactions of defective mitochondria, aberrant proteins, free radicals and scavengers in the ageing process

1996 • 220 citations

Ancient mtDNA sequences in the human nuclear genome: A potential source of errors in identifying pathogenic mutations

1997 • 218 citations

Alteration of antioxidant enzymes with aging in rat skeletal muscle and liver

1990 • 215 citations

Age-Related Decline of Rat Liver Multicatalytic Proteinase Activity and Protection from Oxidative Inactivation by Heat-Shock Protein 90

1996 • 214 citations

Deleterious mitochondrial DNA mutations accumulate in aging human tissues

1992 • 212 citations

A Ginkgo Biloba Extract (EGb 761) Prevents Mitochondrial Aging by Protecting Against Oxidative Stress

1998 • 212 citations

A methyl viologen-sensitive mutant of the nematode Caenorhabditis elegans

1990 • 212 citations

Involvement of Hydrogen Peroxide in Collagen Cross-linking by High Glucose in Vitro and in Vivo

1996 • 209 citations

Sites and mechanisms responsible for the low rate of free radical production of heart mitochondria in the long-lived pigeon

1997 • 209 citations

Effect of Dietary Restriction on the Age-Dependent Changes in the Expression of Antioxidant Enzymes in Rat Liver

1990 • 206 citations

Susceptibility of cloned K+ channels to reactive oxygen species.

1995 • 197 citations

Senescence as a mode of tumor suppression.

1991 • 195 citations

Age-related changes in antioxidant enzymes and prooxidant generation in tissues of the rat with special reference to parameters in two insect species

1990 • 193 citations

Protein-bound 3,4-dihydroxyphenylalanine is a major reductant formed during hydroxyl radical damage to proteins

1993 • 191 citations

Problems in the measurement of 8-oxoguanine in human DNA. Report of a workshop, DNA oxidation, held in Aberdeen, UK, 19-21 January, 1997

1997 • 189 citations

Effect of age on the expression of antioxidant enzymes in male Fischer F344 rats

1990 • 189 citations

Chronic antioxidant treatment improves the cognitive performance of aged rats

1995 • 186 citations

Non-linear accumulation of 8-hydroxy-2′-deoxyguanosine, a marker of oxidized DNA damage, during aging

1996 • 184 citations

Oxidative DNA damage correlates with oxygen consumption in humans

1994 • 182 citations

The COQ7 Gene Encodes a Protein in Saccharomyces cerevisiae Necessary for Ubiquinone Biosynthesis

1996 • 180 citations

Effect of age on superoxide dismutase, catalase, glutathione reductase, inorganic peroxides, TBA-reactive material, GSH/GSSG, NADPH/NADP+ and NADH/NAD+ in Drosophila melanogaster

1990 • 180 citations

DNA damage, mutation and fine structure DNA repair in aging

1995 • 176 citations

Relationship between antioxidant defenses and longevity in different mammalian species

1990 • 175 citations

Involvement of free radicals in ageing: a consequence or cause of senescence

1993 • 173 citations

Hydrogen peroxide production by liver mitochondria in different species

1990 • 173 citations

Susceptibility of Glucose-6-Phosphate Dehydrogenase Modified by 4-Hydroxy-2-nonenal and Metal-Catalyzed Oxidation to Proteolysis by the Multicatalytic Protease

1994 • 172 citations

Oxidative stress and aging in the Mongolian gerbil (Meriones unguiculatus)

1995 • 170 citations

An investigation of antioxidant status, DNA repair capacity and mutation as a function of age in humans

1995 • 170 citations

The free radical hypothesis of aging: An appraisal of the current status

1993 • 166 citations

Mechanisms of Hepatocarcinogenicity of Peroxisome-Proliferating Drugs and Chemicals

1995 • 166 citations

Critical Evaluation of the Free Radical Theory of Aging

1996 • 165 citations

Mitochondrial DNA alterations as ageing-associated molecular events

1992 • 163 citations

The Mechanism of Collagen Cross-Linking in Diabetes: A Puzzle Nearing Resolution

1996 • 163 citations

Mammalian telomere dynamics: healing, fragmentation shortening and stabilization

1994 • 161 citations

Multiple Deletions Are Detectable in Mitochondrial DNA of Aging Mice

1995 • 159 citations

Neuroprotective strategies for treatment of lesions produced by mitochondrial toxins: Implications for neurodegenerative diseases

1996 • 157 citations

Mechanism of somatic mitochondrial DNA mutations associated with age and diseases

1995 • 156 citations

Preferential mitochondrial DNA injury caused by glucose oxidase as a steady generator of hydrogen peroxide in human fibroblasts

1997 • 154 citations

Exposure of Hydrophobic Moieties Promotes the Selective Degradation of Hydrogen Peroxide-Modified Hemoglobin by the Multicatalytic Proteinase Complex, Proteasome

1994 • 153 citations

DNA damage metabolism and aging

1990 • 152 citations

Brain synaptosomal aging: Free radicals and membrane fluidity

1995 • 147 citations

Determination of steady-state levels of oxidative DNA base modifications in mammalian cells by means of repair endonucleases

1997 • 143 citations

Protein Oxidation and Aging 1. Difficulties in Measuring Reactive Protein Carbonyls in Tissues Using 2,4-Dinitrophenylhydrazine

1995 • 138 citations

Artifacts associated with the measurement of oxidized DNA bases.

1997 • 138 citations

Apparent mtDNA heteroplasmy in Alzheimer’s disease patients and in normals due to PCR amplification of nucleus-embedded mtDNA pseudogenes

1997 • 137 citations

Comparison of the Effects of Ozone on the Modification of Amino Acid Residues in Glutamine Synthetase and Bovine Serum Albumin

1996 • 137 citations

Oxidative and other DNA damages as the basis of aging: a review

1992 • 135 citations

An update on the mitochondrial-DNA mutation hypothesis of cell aging

1992 • 135 citations

Oxygen-Dependent Perturbation of Life Span and Aging Rate in the Nematode

1993 • 134 citations

Relationship between Antioxidants, Prooxidants, and the Aging Processa

1992 • 124 citations

Modelling the effects of age-related mtDNA mutation accumulation; Complex I deficiency, superoxide and cell death

1995 • 124 citations

High levels of mitochondrial DNA deletions in skeletal muscle of old rhesus monkeys

1995 • 123 citations

There is substantial agreement among interspecies estimates of DNA repair activity

1996 • 120 citations

Protein hydroperoxides as new reactive oxygen species

1997 • 120 citations

Increased frequency of deletions in the mitochondrial genome with age ofCaenorhabditis elegans

1995 • 119 citations

Mitochondrial Ubiquinone Homologues, Superoxide Radical Generation, and Longevity in Different Mammalian Species

1997 • 119 citations

Aging and protein oxidative damage

1994 • 119 citations

Fatty-acid metabolism and the pathogenesis of hepatocellular carcinoma: Review and hypothesis

1993 • 119 citations

Role of superoxide radical in mitochondrial dehydrogenase reactions

1974 • 118 citations

Role of oxidative stress in Drosophila aging

1992 • 117 citations

Reactive Oxygen Species as Causal Agents in the Neurotoxicity of the Alzheimer's Disease‐Associated Amyloid Beta Peptidea

1996 • 116 citations

Correlation Between Mitochondrial DNA 4977-bp Deletion and Respiratory Chain Enzyme Activities in Aging Human Skeletal Muscles

1994 • 115 citations

Biochemical Correlates of Longevity in Two Closely Related Rodent Species

1993 • 115 citations

Multiple Mitochondrial DNA Deletions Associated With Age in Skeletal Muscle of Rhesus Monkeys

1993 • 114 citations

Exposure of cells to nonlethal concentrations of hydrogen peroxide induces degeneration-repair mechanisms involving lysosomal destabilization

1995 • 114 citations

[25] Role of oxidized amino acids in protein breakdown and stability

1995 • 110 citations

The Spin-Trap N-tert-α-Phenylbutylnitrone Prolongs the Life Span of the Senescence-Accelerated Mouse

1995 • 110 citations

Marked increase in mitochondrial DNA deletion levels in the cerebral cortex of Huntington's disease patients

1995 • 109 citations

Oxidative damage to DNA induced by areca nut extract

1996 • 109 citations

Lipofuscin and lipofuscin-like substances

1987 • 108 citations

Detection of DNA damage after hyperbaric oxygen (HBO) therapy

1996 • 107 citations

A decrease of free radical production near critical targets as a cause of maximum longevity in animals

1994 • 107 citations

Maximum life span in vertebrates: Relationship with liver antioxidant enzymes, glutathione system, ascorbate, urate, sensitivity to peroxidation, true malondialdehyde, in vivo H2O2, and basal and maximum aerobic capacity

1993 • 106 citations

Transgenic Mice and Knockout Mutants in the Study of Oxidative Stress in Brain Injury

1995 • 106 citations

Rapid accumulation of fluorescent material with aging in an oxygen-sensitive mutant mev-1 of Caenorhabditis elegans

1994 • 103 citations

Mitochondria and Ageing

1992 • 103 citations

Conditions allowing redox-cycling ubisemiquinone in mitochondria to establish a direct redox couple with molecular oxygen

1996 • 103 citations

Age-associated changes in superoxide dismutase activity, thiobarbituric acid reactivity and reduced glutathione level in the brain and liver in senescence accelerated mice (SAM): a comparison with ddY mice

1993 • 102 citations

Artifacts Associated with the Measurement of Oxidized DNA Bases

1997 • 100 citations

Pentane and isoprene in expired air from humans: gas-chromatographic analysis of single breath

1994 • 99 citations

Homeostasis between lipid peroxidation and antioxidant enzyme activities in healthy human aging

1992 • 97 citations

Decreases in protective enzymes correlates with increased oxidative damage in the aging mouse brain

1995 • 97 citations

Aging processes, DNA damage, and repair ¹

1997 • 97 citations

Purification of All Forms of HeLa Cell Mitochondrial DNA and Assessment of Damage to It Caused by Hydrogen Peroxide Treatment of Mitochondria or Cells

1995 • 94 citations

The effects of hydrogen peroxide on DNA repair activities

1995 • 94 citations

Melatonin in the Context of the Free Radical Theory of Aginga

1996 • 94 citations

DNA damage profiles induced by oxidizing agents

1995 • 93 citations

Evidence that specific mtDNA point mutations may not accumulate in skeletal muscle during normal human aging.

1996 • 92 citations

Advances in age pigment research

1991 • 90 citations

Measurement of Radiation-induced Damage to DNA at the Molecular Level

1992 • 90 citations

LIPOFUSCIN ACCUMULATION AND AGEING OF FIBROBLASTS

1995 • 89 citations

Effect of ambient oxygen concentration on lipofuscin accumulation in cultured rat heart myocytes—A novel in vitro model of lipofuscinogenesis

1989 • 88 citations

Oxidative stress in Parkinson's disease

1995 • 87 citations

N-Acetylcysteine protects against age-related decline of oxidative phosphorylation in liver mitochondria

1995 • 86 citations

Mutations and epimutations in mammalian cells

1991 • 86 citations

The effect of oxygen and vitamin E on the lifespan of human diploid cells in vitro.

1977 • 86 citations

Caloric restriction, aging, and antioxidant enzymes

1993 • 86 citations

The beneficial effects of dietary restriction: reduced oxidative damage and enhanced apoptosis

1996 • 86 citations

Adaptation to oxidative stress in young, but not in mature or old, caenorhabditis elegans

1995 • 85 citations

Myocardial aging: antioxidant enzyme systems and related biochemical properties

1991 • 83 citations

Transcription and activity of antioxidant enzymes after ionizing irradiation in radiation-resistant and radiation-sensitive mice

1997 • 82 citations

Reactive Oxygen Species in Normal Physiology, Cell Injury and Phagocytosis

1994 • 80 citations

Formation of dityrosine and other fluorescent amino acids by reaction of amino acids with lipid hydroperoxides

1991 • 80 citations

Aging‐ and Oxygen‐induced Modifications in Brain Biochemistry and Behavior^a

1994 • 79 citations

Age-Associated Alterations of the Mitochondrial Genome

1997 • 77 citations

Detection and quantitation by competitive PCR of an age-associated increase in a 4.8-kb deletion in rat mitochondrial DNA

1994 • 77 citations

Aging and Caloric Restriction Affect Mitochondrial Respiration and Lipid Membrane Status: An Electron Paramagnetic Resonance Investigation

1997 • 76 citations

[38] Detection and quantification of oxidative adducts of mitochondrial DNA

1996 • 75 citations

DNA repair comes of age

1995 • 74 citations

8-Hydroxyguanine Levels in Nuclear DNA and Its Repair Activity in Rat Organs Associated With Age

1996 • 72 citations

Multiple age-associated mitochondrial DNA deletions in skeletal muscle of mice

1994 • 69 citations

In vivo antioxidant status, DNA damage, mutation and DNA repair capacity in cultured lymphocytes from healthy 75- to 80-year-old humans

1997 • 68 citations

Glutathione, oxidative stress and aging

1996 • 67 citations

Pitfalls in the use of breath pentane measurements to assess lipid peroxidation.

1994 • 67 citations

Mutagenesis by metal-induced oxygen radicals.

1994 • 67 citations

The Search for the Genetic Basis of Aging: The Identification of Gerontogenes in the Nematode Caenorhabditis elegans

1992 • 67 citations

Chemical Effects of Ionizing Radiations

1948 • 66 citations

Mitochondrial damage as a source of diseases and aging: a strategy of how to fight these

1996 • 64 citations

Oxidative modification of DNA bases in rat liver and lung during chemical carcinogenesis and aging

1995 • 64 citations

Inherited Enhancement of Hydroxyl Radical Generation and Lipid Peroxidation in the S Strain Rats Results in DNA Rearrangements, Degenerative Diseases, and Premature Aging

1994 • 63 citations

Lysosomes, membranes and aging

1971 • 63 citations

Comparing mutants, selective breeding, and transgenics in the dissection of aging processes ofCaenorhabditis elegans

1993 • 62 citations

Effect of vitamin-antioxidant micronutrients on the frequency of spontaneous and in vitro γ-ray-induced micronuclei in lymphocytes of donors: the age factor

1996 • 61 citations

Relationship between Aging and Susceptibility to Protein Oxidative Damage

1993 • 61 citations

Studies of Human and Rat Blood under Oxidative Stress: Changes in Plasma Thiol Level, Antioxidant Enzyme Activity, Protein Carbonyl Content, and Fluidity of Erythrocyte Membrane

1996 • 61 citations

The effect of superoxide dismutase alleles on aging inDrosophila

1993 • 60 citations

The somatic mutation theory of ageing

1995 • 60 citations

Mitochondrial function in neurodegeneration and ageing

1992 • 59 citations

Ponce d'elegans: Genetic Quest for the Fountain of Youth

1996 • 59 citations

Aging and Disease: Extending Functional Life Span

1996 • 57 citations

Comparative life spans of species: why do species have the life spans they do?

1992 • 56 citations

Effect of dietary restriction on DNA repair and DNA damage

1993 • 55 citations

Effect of the Spin-Trapping CompoundN-tert-Butyl-α-phenylnitrone on Protein Oxidation and Life Span

1995 • 55 citations

Oxidative Status in Senescence-Accelerated Mice

1996 • 55 citations

Longevity and antioxidant enzymes, non-enzymatic antioxidants and oxidative stress in the vertebrate lung: a comparative study

1994 • 53 citations

Aging of the Liver: Proteolysis of Oxidatively Modified Glutamine Synthetase

1995 • 53 citations

The process and theories of aging.

1995 • 52 citations

Extension of the lifespan of cultured normal human diploid cells by vitamin E: a reevaluation.

1977 • 51 citations

Effect of ferric iron and desferrioxamine on lipofuscin accumulation in cultured rat heart myocytes

1988 • 49 citations

An age-related increase in the basal level of DNA damage and DNA vulnerability to oxygen radicals in the individual hepatocytes of male F344 rats

1994 • 49 citations

Mitochondrial DNA Mutation Associated with Aging and Degenerative Disease^a

1992 • 49 citations

Antioxidant enzymes of the human retina: effect of age on enzyme activity of macula and periphery

1996 • 48 citations

Clastogenicity of lanthanides: induction of chromosomal aberration in bone marrow cells of mice in vivo

1995 • 48 citations

Hydrogen peroxide metabolism during peroxisome proliferation by fenofibrate

1995 • 48 citations

Oxidants and antioxidants in proliferative senescence

1991 • 48 citations

Age-associated, oxidatively modified proteins: A critical evaluation

1997 • 47 citations

Production of active oxygen species by phagocytic leukocytes.

1994 • 47 citations

Hypothesis: A damaging role in aging for reactive protein oxidation products?

1992 • 44 citations

Somatic mutations in the brain: relationship to aging?

1995 • 43 citations

Metabolic Rate and Life Span

2015 • 43 citations

Mechanisms of lipofuscinogenesis: Effect of the inhibition of lysosomal proteinases and lipases under varying concentrations of ambient oxygen in cultured rat neonatal myocardial cells

1991 • 41 citations

Pulmonary pentane excretion increases with age in healthy subjects

1993 • 41 citations

Genomic Heterogeneity of DNA Repair

1992 • 40 citations

Impairment of Respiratory Functions in Mitochondria of Rats with an Inherited Hyperproduction of Free Radicals

1994 • 39 citations

Accumulation of Cardiac Lipofuscin Depends on Metabolic Rate of Mammals

1992 • 38 citations

Dietary· supplements of antioxidants reduce hprt mutant frequency in splenocytes of aging mice

1995 • 38 citations

Shortening of the in vitro lifespan of human diploid fibroblasts exposed to hyperbaric oxygen☆

1983 • 37 citations

Centenarians: Human Longevity Outliers

1997 • 37 citations

Scavenging activity of "beta catechin" on reactive oxygen species generated by photosensitization of riboflavin.

1996 • 37 citations

Use of transgenic mouse models for studying somatic mutations in aging

1995 • 35 citations

Relevance of oxidative stress to the limited replicative capacity of cultured human diploid cells: the limit of cumulative population doublings increases under low concentrations of oxygen and decreases in response to aminotriazole

1995 • 32 citations

Protein Oxidation and Aging II. Difficulties in Measuring Alkaline Protease Activity in Tissues Using the Fluorescamine Procedure

1995 • 31 citations

Depletion of cytosolic GSH decreases the ATP levels and viability of synaptosomes from aged mice but not from young mice

1995 • 31 citations

Biochemical changes associated with the mechanism controlling superoxide radical formation in the aging rotifer

1990 • 29 citations

Somatic mutagenesis and antimutagenesis in aging research

1996 • 28 citations

Mechanisms of cellular senescence

1997 • 28 citations

Age-Associated Change of 8-Hydroxyguanine Repair Activity in Cultured Human Fibroblasts

1995 • 28 citations

Free radical theory of aging: Effects of antioxidants on mitochondrial function

1987 • 27 citations

Are clinical trials really the answer?

1995 • 26 citations

Somatic mutations and cellular aging

1993 • 26 citations

β-Carotene and the role of intervention studies

1997 • 25 citations

Practical Aspects of Radiation Injury

1953 • 25 citations

Genotypic selection of mitochondrial and oncogenic mutations in human tissue suggests mechanisms of age-related pathophysiology

1995 • 24 citations

Increased Sensitivity to Oxidative Stress and the Loss of Muscarinic Receptor Responsiveness in Senescence

1996 • 23 citations

Dietary modulation of experimental neoplastic development: role of fat and fiber content and calorie intake

1991 • 23 citations

Effect of alpha-tocopherol and some metal chelators on lipofuscin accumulation in cultured neonatal rat cardiac myocytes.

1990 • 22 citations

Intracellular protein degradation.

1990 • 22 citations

Evidence for and against the causal involvement of mitochondrial DNA mutation in mammalian ageing

1992 • 22 citations

Genetics and Evolution of Aging

1994 • 22 citations

Effect of “βCATECHIN” on the life span of senescence accelerated mice (SAM‐P8 strain)

1997 • 20 citations

Accumulation of cardiac lipofuscin in crab-eating monkeys (Macaca fasicularis): The same rate of lipofuscin accumulation in several species of primates

1993 • 20 citations

Altered Protein Metabolism in Aging

1991 • 19 citations

Catalase-negative peroxisomes: transient appearance in rat hepatocytes during liver regeneration after partial hepatectomy.

1995 • 19 citations

Age-related accumulation of lipofuscin in myocardium of Japanese monkey (Macaca fuscata)

1989 • 17 citations

Mutagenic activity of ambient oxygen and mitomycin C in Fanconi's anaemia cells

1997 • 17 citations

The sensitivity to hyperbaric oxygen of human diploid fibroblasts during ageing in vitro

1980 • 16 citations

Age changes in visceral content of glutathione in the senescence accelerated mouse (SAM)

1993 • 16 citations

THE ROLE OF COENZYME Q-10 IN AGING: A FOLLOW-UP STUDY ON LIFELONG ORAL SUPPLEMENTATION Q-10 IN RATS

1995 • 16 citations

Chinese hamster cells expressing antisense to metallothionein become spontaneous mutators

1997 • 15 citations

The search for the gene

1992 • 15 citations

Degeneration of human oncogenes and mitochondrial genes occurs in cells that exhibit age-related pathology

1996 • 15 citations

The relevance of bacterial mutators to understanding human cancer.

1996 • 13 citations

Lack of recovery from oxygen-induced damage to colony formation and DNA synthesis in senescent human diploid fibroblasts

1987 • 13 citations

Oxygen dependency of life-span in the nematode

1993 • 12 citations

Lung glutathione reductase induction in aging catalase-depleted frogs correlates with early survival throughout the life span

1993 • 12 citations

Oxidative stress and human ageing

1995 • 12 citations

Genetics of aging: Current animal models

1996 • 12 citations

Is increased tissue ferritin a risk factor for atherosclerosis and ischaemic heart disease?

1995 • 10 citations

Indenoindole depresses lipofuscin formation in cultured neonatal rat myocardial cells

1995 • 9 citations

Atherogenic change in the thoracic aorta of the senescence-accelerated mouse

1995 • 9 citations

Deleted Work

1955 • 0 citations