Thiol-Mediated Redox Regulation of Intestinal Lamina Propria T Lymphocytes

Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine).

1979 • 1,680 citations

Determination of the in vivo redox status of cysteine, cysteinylglycine, homocysteine, and glutathione in human plasma

1992 • 503 citations

Enhanced production of interleukin 1-beta by mononuclear cells isolated from mucosa with active ulcerative colitis of Crohn's disease.

1989 • 430 citations

Isolation and functional characterization of human intestinal mucosal lymphoid cells.

1977 • 403 citations

Role of membrane transport in metabolism and function of glutathione in mammals

1986 • 376 citations

Increased macrophage subset in inflammatory bowel disease: apparent recruitment from peripheral blood monocytes.

1994 • 270 citations

Redox regulation of signal transduction: tyrosine phosphorylation and calcium influx.

1994 • 220 citations

Mechanism of growth stimulation of L1210 cells by 2-mercaptoethanol in vitro. Role of the mixed disulfide of 2-mercaptoethanol and cysteine.

1981 • 206 citations

Macrophages regulate intracellular glutathione levels of lymphocytes. Evidence for an immunoregulatory role of cysteine

1990 • 184 citations

Definition of a lamina propria T cell responsive state. Enhanced cytokine responsiveness of T cells stimulated through the CD2 pathway.

1995 • 182 citations

Severe generalized glutathione reductase deficiency after antitumor chemotherapy with BCNU" [1,3-bis(chloroethyl)-1-nitrosourea].

1977 • 176 citations

Cell cycle progression of glutathione-depleted human peripheral blood mononuclear cells is inhibited at S phase.

1989 • 164 citations

Induction of cystine transport activity in mouse peritoneal macrophages.

1987 • 163 citations

Regulation of glutathione levels in mouse spleen lymphocytes by transport of cysteine

1987 • 156 citations

In Situ Expression of Interleukin-10 in Noninflamed Human Gut and in Inflammatory Bowel Disease

1998 • 152 citations

Peripheral monocyte and naive T-cell recruitment and activation in Crohn's disease

1995 • 127 citations

Antigen-presenting Cells

2000 • 122 citations

Low membrane transport activity for cystine in resting and mitogenically stimulated human lymphocyte preparations and human T cell clones

1991 • 107 citations

Activation and signaling status of human lamina propria T lymphocytes

1991 • 102 citations

Continuous in vivo activation and transient hyporesponsiveness to TcR/CD3 triggering of human gut lamina propria lymphocytes

1993 • 78 citations

Cytokine messenger RNA expression and proliferation status of intestinal mononuclear cells in noninflamed gut and Crohn's disease

1995 • 58 citations

Human intestinal mucosa alters T-cell reactivities

1993 • 54 citations

Differential regulation of human T cell responsiveness by mucosal versus blood monocytes

1996 • 47 citations

Glutathione Reverses the Inhibition of T Cell Responses by Superoptimal Numbers of "Nonprofessional" Antigen Presenting Cells

1994 • 17 citations