Inactivation of Protein-tyrosine Phosphatases as Mechanism of UV-induced Signal Transduction

Rapid and efficient site-specific mutagenesis without phenotypic selection.

1985 • 7,573 citations

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

Protein Oxidation in Aging, Disease, and Oxidative Stress

1997 • 3,299 citations

Dimerization of cell surface receptors in signal transduction

1995 • 1,631 citations

Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors

1996 • 1,473 citations

Growth factor signaling by receptor tyrosine kinases

1992 • 1,450 citations

Ultraviolet Light and Osmotic Stress: Activation of the JNK Cascade Through Multiple Growth Factor and Cytokine Receptors

1996 • 1,046 citations

Specific and Reversible Inactivation of Protein Tyrosine Phosphatases by Hydrogen Peroxide: Evidence for a Sulfenic Acid Intermediate and Implications for Redox Regulation

1998 • 933 citations

Development of “substrate-trapping” mutants to identify physiological substrates of protein tyrosine phosphatases

1997 • 774 citations

Signal characteristics of G protein-transactivated EGF receptor

1997 • 669 citations

Heparin-induced oligomerization of FGF molecules is responsible for FGF receptor dimerization, activation, and cell proliferation

1994 • 665 citations

Phospholipase C-γ1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal

1993 • 658 citations

Autophosphorylation of the PDGF receptor in the kinase insert region regulates interactions with cell proteins

1989 • 524 citations

Dephosphorylation of receptor tyrosine kinases as target of regulation by radiation, oxidants or alkylating agents.

1996 • 523 citations

Regulation of signal transduction and signal diversity by receptor oligomerization

1994 • 485 citations

Involvement of growth factor receptors in the mammalian UVC response

1994 • 456 citations

A protein-tyrosine phosphatase with sequence similarity to the SH2 domain of the protein-tyrosine kinases

1991 • 401 citations

Dimerization of B-type Platelet-derived Growth Factor Receptors Occurs After Ligand Binding and Is Closely Associated with Receptor Kinase Activation

1989 • 366 citations

Identification of two juxtamembrane autophosphorylation sites in the PDGF beta-receptor; involvement in the interaction with Src family tyrosine kinases.

1993 • 354 citations

Autoregulatory Mechanisms in Protein-tyrosine Kinases

1998 • 319 citations

Crystal Structure of the Catalytic Domain of the Human Cell Cycle Control Phosphatase, Cdc25A

1998 • 282 citations

UV activates growth factor receptors via reactive oxygen intermediates.

1996 • 281 citations

Selective platelet-derived growth factor receptor kinase blockers reverse sis-transformation.

1994 • 272 citations

UV-induced activation of AP-1 involves obligatory extranuclear steps including Raf-1 kinase.

1993 • 262 citations

Expression of DEP-1, a receptor-like protein-tyrosine-phosphatase, is enhanced with increasing cell density.

1994 • 222 citations

CREB is activated by UVC through a p38/HOG-1-dependent protein kinase

1997 • 217 citations

Daughter of Sevenless Is a Substrate of the Phosphotyrosine Phosphatase Corkscrew and Functions during Sevenless Signaling

1996 • 210 citations

‘Zip codes’ direct intracellular protein tyrosine phosphatases to the correct cellular ‘address’

1994 • 201 citations

Sublethal Levels of Oxidant Stress Stimulate Multiple Serine/Threonine Kinases and Suppress Protein Phosphatases in Jurkat T Cells

1995 • 181 citations

Protein Tyrosine Phosphatase Substrate Specificity: Size and Phosphotyrosine Positioning Requirements in Peptide Substrates

1994 • 171 citations

UV activation of receptor tyrosine kinase activity.

1995 • 164 citations

Identification of a Putative Syp Substrate, the PDGFβ Receptor

1995 • 158 citations

Differential activities of protein tyrosine phosphatases in intact cells.

1993 • 155 citations

Ligand-independent activation of platelet-derived growth factor receptor is a necessary intermediate in lysophosphatidic, acid-stimulated mitogenic activity in L cells

1998 • 154 citations

Identification of an additional member of the protein-tyrosine-phosphatase family: evidence for alternative splicing in the tyrosine phosphatase domain.

1990 • 149 citations

Selective Down-regulation of the Insulin Receptor Signal by Protein-tyrosine Phosphatases α and ∊

1995 • 147 citations

Association of SH2 Domain Protein Tyrosine Phosphatases with the Epidermal Growth Factor Receptor in Human Tumor Cells

1995 • 145 citations

Novel mechanisms of RTK signal generation

1997 • 137 citations

Phosphorylation Site-Specific Inhibition of Platelet-Derived Growth Factor β-Receptor Autophosphorylation by the Receptor Blocking Tyrphostin AG1296

1997 • 132 citations

The Transmembrane Protein-tyrosine Phosphatase LAR Modulates Signaling by Multiple Receptor Tyrosine Kinases

1996 • 130 citations

Mutation of a Src phosphorylation site in the PDGF beta-receptor leads to increased PDGF-stimulated chemotaxis but decreased mitogenesis.

1996 • 123 citations

A Dual Inhibitor of Platelet-Derived Growth Factor β-Receptor and Src Kinase Activity Potently Interferes With Motogenic and Mitogenic Responses to PDGF in Vascular Smooth Muscle Cells

1999 • 112 citations

Both SH2 Domains Are Involved in Interaction of SHP-1 with the Epidermal Growth Factor Receptor but Cannot Confer Receptor-directed Activity to SHP-1/SHP-2 Chimera

1997 • 106 citations

SHP-1 Associates with Both Platelet-derived Growth Factor Receptor and the p85 Subunit of Phosphatidylinositol 3-Kinase

1998 • 95 citations

Mutations of the Platelet-Derived Growth Factor Receptor That Cause a Loss of Ligand-Induced Conformational Change, Subtle Changes in Kinase Activity, and Impaired Ability To Stimulate DNA Synthesis

1989 • 89 citations

The transmembrane protein tyrosine phosphatase RPTPσ modulates signaling of the epidermal growth factor receptor in A431 cells

1999 • 84 citations

Direct Binding and Activation of Receptor Tyrosine Kinases by Collagen

1997 • 84 citations

Review

1997 • 69 citations

Erythrocyte thiol status regulates band 3 phosphotyrosine level via oxidation/reduction of band 3-associated phosphotyrosine phosphatase

1997 • 68 citations

The transmembrane protein tyrosine phosphatase α dephosphorylates the insulin receptor in intact cells

1997 • 60 citations

Mutations of the platelet-derived growth factor receptor that cause a loss of ligand-induced conformational change, subtle changes in kinase activity, and impaired ability to stimulate DNA synthesis.

1989 • 54 citations

The Transmembrane Protein-tyrosine Phosphatase CD45 Is Associated with Decreased Insulin Receptor Signaling

1996 • 44 citations

Ligand-Induced Homo-and Hetero-Dimerization of Platelet-Derived Growth Factor α- and β-Receptors in Intact Cells

1992 • 43 citations

Developmentally regulated expression of a murine receptor-type protein tyrosine phosphatase in the thymus.

1994 • 27 citations

Suppression of platelet-derived growth factor receptor tyrosine kinase activity by unsaturated fatty acids.

1993 • 18 citations

Radiation-induced signal transduction. Mechanisms and consequences

1999 • 15 citations