Comparisons of ESR and HPLC methods for the detection of OH. radicals in ischemic/reperfused hearts

Some statistical methods useful in circulation research.

1980 • 3,978 citations

Direct measurement of free radical generation following reperfusion of ischemic myocardium.

1987 • 1,185 citations

The Lambeth Conventions: guidelines for the study of arrhythmias in ischaemia, infarction, and reperfusion

1988 • 1,099 citations

Spin trapping of superoxide and hydroxyl radical: Practical aspects

1980 • 861 citations

Demonstration of free radical generation in "stunned" myocardium of intact dogs with the use of the spin trap alpha-phenyl N-tert-butyl nitrone.

1988 • 691 citations

Measurement of superoxide-derived free radicals in the reperfused heart. Evidence for a free radical mechanism of reperfusion injury.

1988 • 629 citations

Direct detection of free radicals in the reperfused rat heart using electron spin resonance spectroscopy.

1987 • 628 citations

Molecular oxygen: Friend and foe*The role of the oxygen free radical system in the calcium paradox, the oxygen paradox and ischemia/reperfusion injury

1984 • 543 citations

Reperfusion injury and its pharmacologic modification.

1989 • 509 citations

Aromatic hydroxylation as a potential measure of hydroxyl-radical formation in vivo. Identification of hydroxylated derivatives of salicylate in human body fluids

1986 • 374 citations

Survival after Resuscitation from Out-of-Hospital Ventricular Fibrillation

1974 • 369 citations

Superoxide dismutase plus catalase improve contractile function in the canine model of the "stunned myocardium".

1986 • 360 citations

Oxygen-derived free radicals and myocardial reperfusion injury: An overview

1991 • 303 citations

Spin-trapping evidence that graded myocardial ischemia alters post-ischemic superoxide production

1987 • 205 citations

Reduction of myocardial ischemic injury with oxygen-derived free radical scavengers.

1983 • 195 citations

Failure of superoxide dismutase and catalase to alter size of infarction in conscious dogs after 3 hours of occlusion followed by reperfusion.

1986 • 189 citations

Failure of the xanthine oxidase inhibitor allopurinol to limit infarct size after ischemia and reperfusion in dogs.

1985 • 180 citations

Free radicals and reperfusion-induced arrhythmias: protection by spin trap agent PBN in the rat heart.

1987 • 179 citations

Free radicals : chemistry, pathology and medicine

1988 • 147 citations

Hydroxylation of salicylate by microsomal fractions and cytochrome P-450. Lack of production of 2,3-dihydroxybenzoate unless hydroxyl radical formation is permitted

1991 • 133 citations

Superoxide dismutase reduces reperfusion arrhythmias but fails to salvage regional function or myocardium at risk in conscious dogs.

1989 • 129 citations

Detection of hydroxyl radical in the mitochondria of ischemic-reperfused myocardium by trapping with salicylate

1989 • 123 citations

Pathophysiology of superoxide radical as potential mediator of reperfusion injury in pig heart

1986 • 117 citations

Cardiac electrophysiologic alterations during myocardial ischemia

1977 • 109 citations

Use of salicylate as a probe for ·OH formation in isolated ischemic rat hearts

1990 • 95 citations

Heart protection and radical trapping by DMPO during reperfusion in isolated working rat hearts

1990 • 78 citations

Use of Spin Traps in Intact Animals Undergoing Myocardial Ischemia/Reperfusion: A New Approach to Assessing the Role of Oxygen Radicals in Myocardial “Stunning”

1990 • 76 citations

Effects of superoxide dismutase on reperfusion arrhythmias and left ventricular function in patients undergoing thrombolysis for anterior wall acute myocardial infarction

1991 • 72 citations

Enhanced prostaglandin synthesis due to phospholipid breakdown in ischemic-reperfused myocardium†Control of its production by a phospholipase inhibitor of free radical scavengers

1986 • 72 citations

Reperfusion-Induced Arrhythmias and Free Radicals

1987 • 71 citations

Detection of hydroxyl radicals in the post-ischemic reperfused heart using salicylate as a trapping agent

1991 • 69 citations

Postischemic free radical production in the venous blood of the regionally ischemic swine heart. Effect of deferoxamine.

1991 • 69 citations

Detection of oxygen-derived free radical generation in the canine postischemic heart during late phase of reperfusion.

1990 • 63 citations

Quantification of hydroxyl radical and its lack of relevance to myocardial injury during early reperfusion after graded ischemia in rat hearts.

1992 • 63 citations

Protection Against Postischemic Myocardial Dysfunction in Anesthetized Rabbits with Scavengers of Oxygen-Derived Free Radicals

1991 • 54 citations

Ischemia‐induced changes in myocardial paramagnetic metabolites: Implications for intracellular oxy‐radical generation

1989 • 51 citations

High-performance liquid chromatographic detection of hydroxylated benzoic acids as an indirect measure of hydroxyl radical in heart: its possible link with the myocardial reperusion injury

1991 • 50 citations

Use of high-performance liquid chromatography to detect hydroxyl and superoxide radicals generated from mitomycin C

1985 • 48 citations

DMPO and reperfusion injury: Arrhythmia, heart function, electron spin resonance, and nuclear magnetic resonance studies in isolated working guinea pig hearts

1990 • 46 citations

[27] High-pressure liquid chromatography-electrochemical detection of oxygen free radicals

1984 • 41 citations

Inverse relationship between ESR spin trapping of oxyradicals and degree of functional recovery during myocardial reperfusion in isolated working rat heart

1990 • 41 citations

Protective activity of the spin trap tert-bytyl-α-phenyl nitrone (PBN) in reperfused rat heart

1992 • 40 citations

Detection of oxygen-derived free radical generation in the canine postischemic heart during late phase of reperfusion.

1990 • 31 citations

4 Mechanism of Free Radical Generation during Reperfusion of Ischemic Myocardium

2015 • 22 citations

Lack of significant effects of superoxide dismutase and catalase on development of reperfusion arrhythmias

1991 • 19 citations

Reappraisal of the e.p.r. signals in (post)-ischaemic cardiac tissue

1989 • 16 citations

Oxygen radicals: systemic events and disease processes

1990 • 16 citations

Salicylate Reduces Ventricular Dysfunction and Arrhythmias During Reperfusion in Isolated Rat Hearts

1992 • 10 citations