Ras Proteins Induce Senescence by Altering the Intracellular Levels of Reactive Oxygen Species

Aging: A Theory Based on Free Radical and Radiation Chemistry

1956 • 8,252 citations

A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

1995 • 6,950 citations

Hydroperoxide metabolism in mammalian organs.

1979 • 5,821 citations

Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a

1997 • 4,870 citations

The Free Radical Theory of Aging Matures

1998 • 3,846 citations

Oxidative Stress, Caloric Restriction, and Aging

1996 • 3,136 citations

Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells.

1994 • 2,753 citations

Requirement for Generation of H ₂ O ₂ for Platelet-Derived Growth Factor Signal Transduction

1995 • 2,505 citations

A model for p53-induced apoptosis

1997 • 2,502 citations

Functions of Ceramide in Coordinating Cellular Responses to Stress

1996 • 1,620 citations

Mitogenic Signaling Mediated by Oxidants in Ras-Transformed Fibroblasts

1997 • 1,582 citations

Epidermal Growth Factor (EGF)-induced Generation of Hydrogen Peroxide

1997 • 1,208 citations

Oxygen radicals and signaling

1998 • 1,163 citations

Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts

1996 • 944 citations

Direct Effect of Ceramide on the Mitochondrial Electron Transport Chain Leads to Generation of Reactive Oxygen Species

1997 • 801 citations

Bypass of Senescence After Disruption of p21 ^CIP1/WAF1 Gene in Normal Diploid Human Fibroblasts

1997 • 797 citations

Isolation of adenovirus type 5 host range deletion mutants defective for transformation of rat embryo cells

1979 • 785 citations

Superoxide in Apoptosis

1998 • 773 citations

Oxidative DNA damage and senescence of human diploid fibroblast cells.

1995 • 697 citations

Human fibroblasts release reactive oxygen species in response to interleukin-1 or tumour necrosis factor-α

1989 • 660 citations

Genetic analysis of ageing: role of oxidative damage and environmental stresses

1996 • 647 citations

Senescence-like growth arrest induced by hydrogen peroxide in human diploid fibroblast F65 cells.

1994 • 617 citations

Reactive oxygen species are downstream mediators of p53-dependent apoptosis.

1996 • 590 citations

Involvement of Reactive Oxygen Species in Cytokine and Growth Factor Induction of c-fos Expression in Chondrocytes

1995 • 538 citations

A novel neurological phenotype in mice lacking mitochondrial manganese superoxide dismutase

1998 • 497 citations

Regulation of reactive-oxygen-species generation in fibroblasts by Rac 1

1996 • 488 citations

Production of hydrogen peroxide by transforming growth factor-beta 1 and its involvement in induction of egr-1 in mouse osteoblastic cells.

1994 • 478 citations

Signals from Ras and Rho GTPases interact to regulate expression of p21Waf1/Cip1

1998 • 468 citations

Role of Ceramide in Cellular Senescence

1995 • 453 citations

Molecular analysis of H2O2-induced senescent-like growth arrest in normal human fibroblasts: p53 and Rb control G1 arrest but not cell replication

1998 • 436 citations

Mitochondrial decay in hepatocytes from old rats: Membrane potential declines, heterogeneity and oxidants increase

1997 • 427 citations

Role of Rac1 and Oxygen Radicals in Collagenase-1 Expression Induced by Cell Shape Change

1998 • 392 citations

Wild-type p53 triggers a rapid senescence program in human tumor cells lacking functional p53

1997 • 295 citations

Human fat cells possess a plasma membrane-bound H2O2-generating system that is activated by insulin via a mechanism bypassing the receptor kinase.

1992 • 232 citations

Ras-mediated cell cycle arrest is altered by nuclear oncogenes to induce Schwann cell transformation.

1988 • 220 citations

WAF1 Retards S-Phase Progression Primarily by Inhibition of Cyclin-Dependent Kinases

1997 • 189 citations

A Rac1 Effector Site Controlling Mitogenesis through Superoxide Production

1998 • 187 citations

In vivo suppression of injury-induced vascular smooth muscle cell accumulation using adenovirus-mediated transfer of the herpes simplex virus thymidine kinase gene.

1994 • 184 citations

Response of a primary human fibroblast cell line to H2O2: senescence-like growth arrest or apoptosis?

1997 • 171 citations

A requirement for the rac1 GTPase in the signal transduction pathway leading to cardiac myocyte hypertrophy.

1998 • 142 citations

Origins of G₁ arrest in senescent human fibroblasts

1995 • 134 citations

Superoxide-mediated Actin Response in Post-hypoxic Endothelial Cells

1996 • 93 citations

Role of c-myc in the transformation of REF52 cells by viral and cellular oncogenes.

1987 • 52 citations

Relevance of oxidative stress to the limited replicative capacity of cultured human diploid cells: the limit of cumulative population doublings increases under low concentrations of oxygen and decreases in response to aminotriazole

1995 • 32 citations