p53 and Human Cancer: The First Ten Thousand Mutations

A genetic model for colorectal tumorigenesis

1990 • 11,800 citations

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

p53 Mutations in Human Cancers

1991 • 8,133 citations

p53, the Cellular Gatekeeper for Growth and Division

1997 • 7,621 citations

Instability and decay of the primary structure of DNA

1993 • 5,370 citations

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1992 • 4,648 citations

Mdm2 promotes the rapid degradation of p53

1997 • 4,336 citations

Participation of p53 protein in the cellular response to DNA damage.

1991 • 3,818 citations

Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms

1990 • 3,720 citations

Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis.

1994 • 3,536 citations

Regulation of p53 stability by Mdm2

1997 • 3,238 citations

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1992 • 3,092 citations

p53 is required for radiation-induced apoptosis in mouse thymocytes

1993 • 2,911 citations

Mutations in the p53 gene occur in diverse human tumour types

1989 • 2,765 citations

Activation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal Domain

1997 • 2,510 citations

A model for p53-induced apoptosis

1997 • 2,502 citations

Crystal Structure of a p53 Tumor Suppressor-DNA Complex: Understanding Tumorigenic Mutations

1994 • 2,460 citations

Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

1998 • 2,427 citations

p53: puzzle and paradigm.

1996 • 2,363 citations

Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

1996 • 2,304 citations

Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo.

1994 • 2,141 citations

DNA Damage-Induced Phosphorylation of p53 Alleviates Inhibition by MDM2

1997 • 2,089 citations

Chromosome 17 Deletions and p53 Gene Mutations in Colorectal Carcinomas

1989 • 2,081 citations

WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis.

1994 • 2,025 citations

Amplification of a gene encoding a p53-associated protein in human sarcomas

1992 • 1,959 citations

Wild-type p53 is a cell cycle checkpoint determinant following irradiation.

1992 • 1,877 citations

An Adenovirus Mutant That Replicates Selectively in p53- Deficient Human Tumor Cells

1996 • 1,735 citations

Monoallelically Expressed Gene Related to p53 at 1p36, a Region Frequently Deleted in Neuroblastoma and Other Human Cancers

1997 • 1,636 citations

Preferential Formation of Benzo[ a ]pyrene Adducts at Lung Cancer Mutational Hotspots in P53

1996 • 1,636 citations

ARF Promotes MDM2 Degradation and Stabilizes p53: ARF-INK4a Locus Deletion Impairs Both the Rb and p53 Tumor Suppression Pathways

1998 • 1,584 citations

The Ink4a Tumor Suppressor Gene Product, p19Arf, Interacts with MDM2 and Neutralizes MDM2's Inhibition of p53

1998 • 1,538 citations

Mutational hot spot in the p53 gene in human hepatocellular carcinomas

1991 • 1,525 citations

Sunburn and p53 in the onset of skin cancer

1994 • 1,501 citations

Control of Angiogenesis in Fibroblasts by p53 Regulation of Thrombospondin-1

1994 • 1,460 citations

Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

1993 • 1,445 citations

Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa

1991 • 1,418 citations

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

1995 • 1,401 citations

Mitochondrial control of nuclear apoptosis.

1996 • 1,363 citations

Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53

1992 • 1,358 citations

Somatic Frameshift Mutations in the BAX Gene in Colon Cancers of the Microsatellite Mutator Phenotype

1997 • 1,329 citations

Mutator phenotype may be required for multistage carcinogenesis.

1991 • 1,327 citations

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

1995 • 1,263 citations

Is a p53-Regulated Inhibitor of G2/M Progression

1997 • 1,238 citations

Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li–Fraumeni syndrome

1990 • 1,228 citations

DNA Deaminating Ability and Genotoxicity of Nitric Oxide and its Progenitors

1991 • 1,223 citations

DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts.

1994 • 1,165 citations

Role of poly(ADP-ribose) formation in DNA repair

1992 • 1,142 citations

Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles

1992 • 1,117 citations

Nibrin, a Novel DNA Double-Strand Break Repair Protein, Is Mutated in Nijmegen Breakage Syndrome

1998 • 1,071 citations

Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells

1997 • 1,034 citations

Role of a p53 polymorphism in the development of human papilloma-virus-associated cancer

1998 • 976 citations

The MDM2 gene amplification database

1998 • 958 citations

p73 is a human p53-related protein that can induce apoptosis

1997 • 951 citations

Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

1998 • 906 citations

Induction of the growth inhibitor IGF-binding protein 3 by p53

1995 • 884 citations

Gain of function mutations in p53

1993 • 876 citations

Database of p53 gene somatic mutations in human tumors and cell lines.

1994 • 866 citations

p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts.

1995 • 865 citations

p53-Dependent apoptosis in the absence of transcriptional activation of p53-target genes

1994 • 857 citations

DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways.

1994 • 850 citations

Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes.

1993 • 845 citations

DNA damage induces phosphorylation of the amino terminus of p53

1997 • 829 citations

Stabilization of wild-type p53 by hypoxia-inducible factor 1α

1998 • 818 citations

Abnormal Centrosome Amplification in the Absence of p53

1996 • 802 citations

Induction of nuclear accumulation of the tumor-suppressor protein p53 by DNA-damaging agents.

1993 • 770 citations

Molecular Assessment of Histopathological Staging in Squamous-Cell Carcinoma of the Head and Neck

1995 • 759 citations

5-Methylcytosine in Eukaryotic DNA

1981 • 744 citations

Wild-Type Human p53 and a Temperature-Sensitive Mutant Induce Fas/APO-1 Expression

1995 • 736 citations

Modulation of Activity of the Promoter of the Human MDR 1 Gene by Ras and p53

1992 • 735 citations

Specific P53 mutations are associated with de novo resistance to doxorubicin in breast cancer patients

1996 • 734 citations

The p53 Network

1998 • 731 citations

Effects of p21^Cip1/Waf1 at Both the G₁/S and the G₂/M Cell Cycle Transitions: pRb Is a Critical Determinant in Blocking DNA Replication and in Preventing Endoreduplication

1998 • 714 citations

Retrovirus–mediated wild–type P53 gene transfer to tumors of patients with lung cancer.

1996 • 708 citations

The multifaceted roles of nitric oxide in cancer

1998 • 686 citations

Frequent clones of p53-mutated keratinocytes in normal human skin

1996 • 678 citations

Recruitment of p300/CBP in p53-Dependent Signal Pathways

1997 • 671 citations

A p53-Dependent Mouse Spindle Checkpoint

1995 • 668 citations

Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity, and association with transcription factor ERCC3.

1994 • 666 citations

Structure and Function of the p53 Tumor Suppressor Gene: Clues for Rational Cancer Therapeutic Strategies

1996 • 666 citations

Mapping of the p53 and mdm-2 interaction domains.

1993 • 658 citations

Microsatellite alterations in plasma DNA of small cell lung cancer patients

1996 • 656 citations

Microsatellite alterations in serum DNA of head and neck cancer patients

1996 • 653 citations

Bax suppresses tumorigenesis and stimulates apoptosis in vivo

1997 • 648 citations

Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein.

1994 • 644 citations

5-Methylcytosine as an Endogenous Mutagen in the Human LDL Receptor and p53 Genes

1990 • 643 citations

In vivo ubiquitination and proteasome-mediated degradation of p53(1).

1996 • 643 citations

Nitric oxide synthase activity in human breast cancer

1995 • 637 citations

Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status.

1994 • 620 citations

Structural aspects of the p53 protein in relation to gene evolution.

1990 • 618 citations

Cotranslation of activated mutant p53 with wild type drives the wild-type p53 protein into the mutant conformation

1991 • 617 citations

Synergistic activation of transcription by CBP and p53

1997 • 599 citations

Expression of inducible nitric oxide synthase and nitrotyrosine in colonic epithelium in inflammatory bowel disease

1996 • 588 citations

Two distinct mechanisms alter p53 in breast cancer: mutation and nuclear exclusion.

1992 • 587 citations

Restriction sites containing CpG show a higher frequency of polymorphism in human DNA

1984 • 586 citations

A subset of p53-deficient embryos exhibit exencephaly

1995 • 577 citations

Structure of the p53 Tumor Suppressor Bound to the Ankyrin and SH3 Domains of 53BP2

1996 • 569 citations

p53 modulation of TFIIH–associated nucleotide excision repair activity

1995 • 555 citations

A reversible, p53-dependent G0/G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage.

1996 • 544 citations

Cloning and expression of the cDNA for E6-AP, a protein that mediates the interaction of the human papillomavirus E6 oncoprotein with p53.

1993 • 537 citations

Cloning and functional analysis of human p51, which structurally and functionally resembles p53

1998 • 535 citations

Crystal Structure of the Tetramerization Domain of the p53 Tumor Suppressor at 1.7 Angstroms

1995 • 533 citations

Wild-type p53 binds to the TATA-binding protein and represses transcription.

1992 • 527 citations

The DNA-binding domain of p53 contains the four conserved regions and the major mutation hot spots.

1993 • 512 citations

Characterization of the p53-Dependent Postmitotic Checkpoint following Spindle Disruption

1998 • 498 citations

p53 in growth control and neoplasia

1996 • 488 citations

BRCA1 physically associates with p53 and stimulates its transcriptional activity

1998 • 484 citations

The gadd and MyD genes define a novel set of mammalian genes encoding acidic proteins that synergistically suppress cell growth.

1994 • 484 citations

Immediate early up-regulation of bax expression by p53 but not TGF beta 1: a paradigm for distinct apoptotic pathways.

1994 • 482 citations

Aflatoxin B1 induces the transversion of G-->T in codon 249 of the p53 tumor suppressor gene in human hepatocytes.

1993 • 482 citations

Interaction between ATM protein and c-Abl in response to DNA damage

1997 • 481 citations

Identification of redox/repair protein Ref-1 as a potent activator of p53.

1997 • 479 citations

Human DNA-Activated Protein Kinase Phosphorylates Serines 15 and 37 in the Amino-Terminal Transactivation Domain of Human p53

1992 • 473 citations

ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins

1998 • 471 citations

Primary structure polymorphism at amino acid residue 72 of human p53.

1987 • 466 citations

High-frequency developmental abnormalities in p53-deficient mice

1995 • 464 citations

Identification of a novel p53 functional domain that is necessary for efficient growth suppression

1996 • 459 citations

Nitric oxide-induced p53 accumulation and regulation of inducible nitric oxide synthase expression by wild-type p53.

1996 • 455 citations

Cyclin G is a transcriptional target of the p53 tumor suppressor protein.

1994 • 450 citations

IARC Database of p53 gene mutations in human tumors and cell lines: updated compilation, revised formats and new visualisation tools

1998 • 448 citations

p53 mutation in hepatocellular carcinoma after aflatoxin exposure

1991 • 448 citations

Detection of antibodies against the cellular protein p53 in sera from patients with breast cancer

1982 • 448 citations

A simple p53 functional assay for screening cell lines, blood, and tumors.

1995 • 447 citations

p53 Transcriptional Activation Mediated by Coactivators TAF _II 40 and TAF _II 60

1995 • 438 citations

A comparison of the biological activities of wild‐type and mutant p53

1993 • 423 citations

Wild-type p53 protein undergoes cytoplasmic sequestration in undifferentiated neuroblastomas but not in differentiated tumors.

1995 • 421 citations

Identification of BTG2, an antiproliferative p53–dependent component of the DNA damage cellular response pathway

1996 • 416 citations

Sequence-specific transcriptional activation is essential for growth suppression by p53.

1994 • 412 citations

Tumors associated with p53 germline mutations: a synopsis of 91 families.

1997 • 409 citations

Redox modulation of p53 conformation and sequence-specific DNA binding in vitro.

1993 • 406 citations

Frequent mutation of the p53 gene in human esophageal cancer.

1990 • 393 citations

Absence of WAF1 mutations in a variety of human malignancies

1994 • 390 citations

Sensitivity and selectivity of the DNA damage sensor responsible for activating p53-dependent G1 arrest.

1996 • 385 citations

Inhibition of DNA replication factor RPA by p53

1993 • 380 citations

Mismatch amplification mutation assay (MAMA): application to the c-H-ras gene.

1992 • 379 citations

Localization of the E6-AP regions that direct human papillomavirus E6 binding, association with p53, and ubiquitination of associated proteins.

1993 • 377 citations

Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo

1997 • 370 citations

Wild-type and mutant p53 differentially regulate transcription of the insulin-like growth factor I receptor gene.

1996 • 365 citations

Functional inactivation but not structural mutation of p53 causes liver cancer

1995 • 364 citations

p53-dependent and -independent regulation of the death receptor KILLER/DR5 gene expression in response to genotoxic stress and tumor necrosis factor alpha.

1998 • 363 citations

Is p53 Polymorphism Maintained by Natural Selection?

1994 • 361 citations

Activation of p53 sequence-specific DNA bindingby short single strands of DNA requires the p53 C-terminus

1995 • 347 citations

Restoration of the growth suppression function of mutant p53 by a synthetic peptide derived from the p53 C-terminal domain

1997 • 346 citations

Proliferation of mutators in A cell population

1997 • 342 citations

Ki-ras mutation and p53 overexpression predict the clinical behavior of colorectal cancer: a Southwest Oncology Group study.

1998 • 338 citations

Positional cloning of the gene for Nijmegen breakage syndrome

1998 • 336 citations

Cytosine methylation determines hot spots of DNA damage in the human P 53 gene

1997 • 335 citations

Increased and altered DNA binding of human p53 by S and G2/M but not Gl cyclin-dependent kinases

1995 • 334 citations

Wild type p53 can mediate sequence-specific transactivation of an internal promoter within the mdm2 gene.

1993 • 332 citations

Widely dispersed p53 mutation in respiratory epithelium. A novel mechanism for field carcinogenesis.

1997 • 329 citations

UV and skin cancer: specific p53 gene mutation in normal skin as a biologically relevant exposure measurement.

1994 • 324 citations

The polyproline region of p53 is required to activate apoptosis but not growth arrest

1997 • 318 citations

The XPB and XPD DNA helicases are components of the p53-mediated apoptosis pathway.

1996 • 318 citations

High mobility group protein-1 (HMG-1) is a unique activator of p53

1998 • 316 citations

DNA-dependent protein kinase acts upstream of p53 in response to DNA damage

1998 • 313 citations

Evidence for a second cell cycle block at G2/M by p53.

1995 • 306 citations

Misalignment-mediated DNA synthesis errors

1990 • 306 citations

Allosteric activation of latent p53 tetramers

1994 • 302 citations

Slow Repair of Pyrimidine Dimers at p53 Mutation Hotspots in Skin Cancer

1994 • 301 citations

Serum p53 antibodies as early markers of lung cancer

1995 • 301 citations

Role of Cysteine Residues in Regulation of p53 Function

1995 • 301 citations

High-Resolution Structure of the Oligomerization Domain of p53 by Multidimensional NMR

1994 • 300 citations

Foundations in Cancer Research p53 and ATM: Cell Cycle, Cell Death, and Cancer

1997 • 300 citations

Specific loss of apoptotic but not cell-cycle arrest function in a human tumor derived p53 mutant.

1996 • 299 citations

Genetic alterations in esophageal cancer and their relevance to etiology and pathogenesis: A review

1996 • 299 citations

Wild-type p53 triggers a rapid senescence program in human tumor cells lacking functional p53

1997 • 295 citations

Characterization of the tumor suppressor protein p53 as a protein kinase C substrate and a S100b-binding protein.

1992 • 289 citations

A variation in the structure of the protein-coding region of the human p53 gene

1988 • 286 citations

The requirement for the p53 proline-rich functional domain for mediation of apoptosis is correlated with specific PIG3 gene transactivation and with transcriptional repression

1998 • 286 citations

COMMENTARY: p⁵³ Tumor suppressor gene: from the basic research laboratory to the clinic—an abridged historical perspective

1996 • 284 citations

Geographic Variation of p53 Mutational Profile in Nonmalignant Human Liver

1994 • 282 citations

A novel protein with strong homology to the tumor suppressor p53

1997 • 282 citations

Specific UV-induced mutation spectrum in the p53 gene of skin tumors from DNA-repair-deficient xeroderma pigmentosum patients.

1993 • 278 citations

Cytoplasmic Sequestration of Wild-Type p53 Protein Impairs the G₁ Checkpoint after DNA Damage

1996 • 274 citations

Differential Activation of Target Cellular Promoters by p53 Mutants with Impaired Apoptotic Function

1996 • 271 citations

Mdm2: keeping p53 under control

1997 • 267 citations

Hepatocellular Carcinoma: From Gene to Public Health

1997 • 267 citations

Selective targeting of p53 gene mutational hotspots in human cancers by etiologically defined carcinogens.

1991 • 262 citations

Solution structure of the tetrameric minimum transforming domain of p53

1994 • 260 citations

Simian virus-40 large-T antigen binds p53 in human mesotheliomas

1997 • 259 citations

Identification of a human ubiquitin-conjugating enzyme that mediates the E6-AP-dependent ubiquitination of p53.

1994 • 259 citations

p53 Is Phosphorylated in Vitro and in Vivo by an Ultraviolet Radiation-induced Protein Kinase Characteristic of the c-Jun Kinase, JNK1

1995 • 256 citations

The p53-deficient mouse: a model for basic and applied cancer studies

1996 • 256 citations

Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53.

1992 • 255 citations

Cloning and Expression of Human G/T Mismatch-specific Thymine-DNA Glycosylase

1996 • 255 citations

Functional interaction between DNA-PK and c-Abl in response to DNA damage

1997 • 254 citations

p53 Protein Exhibits 3′-to-5′ Exonuclease Activity

1996 • 248 citations

The Role of E6AP in the Regulation of p53 Protein Levels in Human Papillomavirus (HPV)-positive and HPV-negative Cells

1998 • 247 citations

Cancer Cells Exhibit a Mutator Phenotype

1997 • 243 citations

An oncogenic form of p53 confers a dominant, gain-of-function phenotype that disrupts spindle checkpoint control

1998 • 241 citations

p53 point mutation and survival in colorectal cancer patients.

1995 • 240 citations

Molecular detection of genetic alterations in the serum of colorectal cancer patients.

1998 • 240 citations

FRAMESHIFT MUTATION: DETERMINANTS OF SPECIFICITY

1990 • 238 citations

A mutant p53 transgene accelerates tumour development in heterozygous but not nullizygous p53–deficient mice

1995 • 233 citations

Analysis of the most representative tumour-derived p53 mutants reveals that changes in protein conformation are not correlated with loss of transactivation or inhibition of cell proliferation.

1994 • 231 citations

Role for c-Abl tyrosine kinase in growth arrest response to DNA damage

1996 • 220 citations

P53 tumor suppressor gene therapy for cancer.

1998 • 220 citations

Refined solution structure of the oligomerization domain of the tumour suppressor p53

1995 • 217 citations

Poly(ADP-ribose) Binds to Specific Domains of p53 and Alters Its DNA Binding Functions

1998 • 216 citations

Computer program for the analysis of mutational spectra: application to p53 mutations

1994 • 216 citations

Prevalence of serum antibodies against the p53 tumor suppressor gene protein in various cancers

1994 • 213 citations

Functional activation of p53 via phosphorylation following DNA damage by UV but not γ radiation

1998 • 210 citations

p53: the ultimate tumor suppressor gene?

1992 • 209 citations

A functionally inactive p53 protein interatocarcinoma cells is activated by either DNA damage or cellular differentiation

1996 • 209 citations

Direct interaction between the transcriptional activation domain of human p53 and the TATA box-binding protein.

1993 • 209 citations

Conformational shifts propagate from the oligomerization domain of p53 to its tetrameric DNA binding domain and restore DNA binding to select p53 mutants.

1993 • 206 citations

Structural Aspects of the p53 Protein in Relation to Gene Evolution: A Second Look

1996 • 205 citations

Regulation of specific DNA binding by p53: evidence for a role for O-glycosylation and charged residues at the carboxy-terminus.

1996 • 203 citations

CLINICAL IMPLICATIONS OF THE p53 GENE

1996 • 200 citations

Germ line polymorphisms of p53 and CYP1A1 genes involved in human lung cancer

1993 • 199 citations

Regulation of the Sequence-specific DNA Binding Function of p53 by Protein Kinase C and Protein Phosphatases

1995 • 199 citations

Wild-type p53 adopts a ‘mutant’-like conformation when bound to DNA.

1993 • 199 citations

DNA rereplication in the presence of mitotic spindle inhibitors in human and mouse fibroblasts lacking either p53 or pRb function.

1997 • 198 citations

Genomic instability and apoptosis are frequent in p53 deficient young mice

1997 • 197 citations

Cancer therapy and p53

1995 • 194 citations

p53 codon 72 polymorphism and risk of cervical cancer in UK

1998 • 191 citations

Nuclear localization is essential for the activity of p53 protein.

1991 • 190 citations

p53 gene mutation: software and database

1996 • 189 citations

Nitric oxide induces conformational and functional modifications of wild-type p53 tumor suppressor protein.

1997 • 188 citations

Characterization of Structural p53 Mutants Which Show Selective Defects in Apoptosis but Not Cell Cycle Arrest

1998 • 186 citations

Multisite Phosphorylation and the Integration of Stress Signals at p53

1998 • 185 citations

CREB-binding protein and p300/CBP-associated factor are transcriptional coactivators of the p53 tumor suppressor protein.

1997 • 183 citations

A structural role for metal ions in the "wild-type" conformation of the tumor suppressor protein p53.

1993 • 182 citations

Field cancerisation and polyclonal p53 mutation in the upper aero- digestive tract

1997 • 180 citations

Mice with reduced levels of p53 protein exhibit the testicular giant-cell degenerative syndrome.

1993 • 179 citations

p53 tagged sites from human genomic DNA

1994 • 178 citations

In vivo evidence for endogenous DNA alkylation damage as a source of spontaneous mutation in eukaryotic cells.

1993 • 177 citations

Inhibition of presenilin 1 expression is promoted by p53 and p21WAF-1and results in apoptosis and tumor suppression

1998 • 175 citations

Mdm-2: “big brother” of p53

1997 • 175 citations

Compilation of somatic mutations of theCDKN2 gene in human cancers: Non-random distribution of base substitutions

1996 • 174 citations

Analysis of p53 antibodies in patients with various cancers define B-cell epitopes of human p53: distribution on primary structure and exposure on protein surface.

1993 • 173 citations

p53 Is Phosphorylated by CDK7-Cyclin H in a p36^MAT1-Dependent Manner

1997 • 173 citations

Regulation of p53 by Metal Ions and by Antioxidants: Dithiocarbamate Down-Regulates p53 DNA-Binding Activity by Increasing the Intracellular Level of Copper

1997 • 169 citations

Slow repair of bulky DNA adducts along the nontranscribed strand of the human p53 gene may explain the strand bias of transversion mutations in cancers

1998 • 167 citations

p53 is phosphorylated in vitro and in vivo by the delta and epsilon isoforms of casein kinase 1 and enhances the level of casein kinase 1 delta in response to topoisomerase-directed drugs

1997 • 167 citations

Molecular basis for heterogeneity of the human p53 protein.

1986 • 167 citations

No significant predictive value of c- erbB-2 or p53 expression regarding sensitivity to primary chemotherapy or radiotherapy in breast cancer

1998 • 167 citations

Up-regulation of inducible nitric oxide synthase expression in cancer-prone p53 knockout mice

1998 • 166 citations

Further characterisation of the p53 responsive element – identification of new candidate genes for trans-activation by p53

1997 • 160 citations

Responses to DNA damage and regulation of cell cycle checkpoints by the ATM protein kinase family

1997 • 160 citations

TP53 DNA contact mutations are selectively associated with allelic loss and have a strong clinical impact in head and neck cancer

1998 • 156 citations

Human epidermal cancer and accompanying precursors have identical p53 mutations different from p53 mutations in adjacent areas of clonally expanded non-neoplastic keratinocytes.

1996 • 156 citations

Phosphorylation of the tumor suppressor protein p53 by mitogen-activated protein kinases.

1994 • 154 citations

Involvement of p85 in p53-dependent apoptotic response to oxidative stress

1998 • 154 citations

The origin of point mutations in human tumor cells.

1992 • 154 citations

Tumor Suppressor p53 Can Participate in Transcriptional Induction of the GADD45 Promoter in the Absence of Direct DNA Binding

1998 • 152 citations

The distribution of UV photoproducts along the human p53 gene and its relation to mutations in skin cancer.

1993 • 152 citations

The CDK₇-cycH-p36 Complex of Transcription Factor IIH Phosphorylates p53, Enhancing Its Sequence-Specific DNA Binding Activity In Vitro

1997 • 152 citations

p53 Regulates Insulin-Like Growth Factor-I (IGF-I) Receptor Expression and IGF-I-Induced Tyrosine Phosphorylation in an Osteosarcoma Cell Line: Interaction between p53 and Sp1

1998 • 151 citations

Involvement of NAD-poly(ADP-ribose) metabolism in p53 regulation and its consequences.

1995 • 148 citations

p53 involvement in control of G2 exit of the cell cycle: role in DNA damage-induced apoptosis.

1995 • 147 citations

Higher lung cancer risk for younger African-Americans with the Pro/Pro p53 genotype

1995 • 144 citations

p53 gene mutation: software and database

1998 • 144 citations

p53 mediates permanent arrest over multiple cell cycles in response to gamma-irradiation.

1997 • 143 citations

Analyses of p53 antibodies in sera of patients with lung carcinoma define immunodominant regions in the p53 protein

1994 • 143 citations

Interaction of heat-shock protein 70 with p53 translated in vitro: evidence for interaction with dimeric p53 and for a role in the regulation of p53 conformation.

1992 • 142 citations

Mutation of the serine 15 phosphorylation site of human p53 reduces the ability of p53 to inhibit cell cycle progression.

1993 • 140 citations

Anti-p53 Antibodies in Sera of Workers Occupationally Exposed to Vinyl Chloride

1995 • 138 citations

Polymorphism at codon 213 within the p53 gene.

1991 • 137 citations

p53 dependent growth suppression by the c-Abl nuclear tyrosine kinase.

1995 • 133 citations

A temperature-sensitive mutant of human p53.

1994 • 128 citations

MDM2-arbiter of p53's destruction

1997 • 127 citations

TP53 and long-term prognosis in colorectal cancer: mutations in the L3 zinc-binding domain predict poor survival.

1998 • 126 citations

Mutant p53 can induce tumorigenic conversion of human bronchial epithelial cells and reduce their responsiveness to a negative growth factor, transforming growth factor beta 1.

1992 • 126 citations

Cooperative DNA binding of p53 with TFIID (TBP): a possible mechanism for transcriptional activation.

1993 • 124 citations

Modulation of the human interleukin-6 promoter (IL-6) and transcription factor C/EBP beta (NF-IL6) activity by p53 species

1993 • 123 citations

Casein kinase II and the tumor suppressor protein P53 associate in a molecular complex that is negatively regulated upon P53 phosphorylation.

1992 • 122 citations

Phosphorylation of the p53 tumour-suppressor protein at three N-terminal sites by a novel casein kinase I-like enzyme.

1992 • 121 citations

Clinical significance of p53 mutations in relapsed T-cell acute lymphoblastic leukemia

1994 • 121 citations

p53: A Cell Cycle Regulator Activated by DNA Damage

1995 • 121 citations

A specific spectrum of p53 mutations in lung cancer from smokers: review of mutations compiled in the IARC p53 database.

1998 • 120 citations

Wild-Type Human p53 Transactivates the Human Proliferating Cell Nuclear Antigen Promoter

1995 • 120 citations

Nijmegen Breakage Syndrome Cells Fail To Induce the p53-Mediated DNA Damage Response following Exposure to Ionizing Radiation

1997 • 119 citations

A rapid PCR fidelity assay

1994 • 118 citations

Deletions and insertions in the p53 tumor suppressor gene in human cancers: confirmation of the DNA polymerase slippage/misalignment model.

1996 • 117 citations

P53 polymorphisms and haplotypes in lung cancer

1995 • 117 citations

Susceptibility to radiation-carcinogenesis and accumulation of chromosomal breakage in p53 deficient mice.

1994 • 117 citations

Identification of a novel class of genomic DNA-binding sites suggests a mechanism for selectivity in target gene activation by the tumor suppressor protein p53

1998 • 116 citations

Mutations in the p53 gene in schistosomal bladder cancer: a study of 92 tumours from Egyptian patients and a comparison between mutational spectra from schistosomal and non-schistosomal urothelial tumours

1995 • 116 citations

Both viral (adenovirus E1B) and cellular (hsp 70, p53) components interact with centrosomes

1994 • 116 citations

Analysis of a germ line polymorphism of the p53 gene in lung cancer patients; discrete results with smoking history

1996 • 115 citations

Molecular pathology in basal cell cancer with p53 as a genetic marker

1997 • 113 citations

p53 binds to the TATA-binding protein-TATA complex

1993 • 113 citations

Functional interplay between p53 and E2F through co-activator p300

1998 • 112 citations

Functional Interaction between p53, the TATA-Binding Protein (TBP), and TBP-Associated Factors In Vivo

1996 • 112 citations

The 1995 Walter Hubert Lecture - molecular epidemiology of human cancer: insights from the mutational analysis of the p53 tumour-suppressor gene

1996 • 111 citations

Modulation of p53 protein conformation and DNA-binding activity by intracellular chelation of zinc

1998 • 109 citations

Anti-apoptotic activity of low levels of wild-type p53.

1996 • 109 citations

The p53 activation domain binds the TATA box-binding polypeptide in Holo-TFIID, and a neighboring p53 domain inhibits transcription.

1993 • 108 citations

P53 activity is essential for normal development in Xenopus

1997 • 108 citations

Role of p53 in Apoptosis

1997 • 107 citations

Stranded in an active gene

1993 • 105 citations

Mutation of the casein kinase II phosphorylation site abolishes the anti-proliferative activity of p53

1992 • 105 citations

An Alu polymorphism intragenic to the TP53 gene

1991 • 104 citations

p⁵³Protein expression is correlated with benzo[a]pyrene-DNA adducts in carcinoma cell lines

1995 • 104 citations

Modulation of DNA Topoisomerase I Activity by p53

1996 • 103 citations

Effects of p53 mutants on wild-type p53-mediated transactivation are cell type dependent.

1995 • 101 citations

Involvement of p53 and p21 in Cellular Defects and Tumorigenesis in Atm^−/− Mice

1998 • 101 citations

Functional studies of a germ-line polymorphism at codon 47 within the p53 gene.

1993 • 101 citations

Binding of Ku and c-Abl at the Kinase Homology Region of DNA-dependent Protein Kinase Catalytic Subunit

1997 • 99 citations

Conditional Mutator Phenotypes in hMSH2-Deficient Tumor Cell Lines

1997 • 99 citations

The tumor suppressor protein p53

1995 • 98 citations

Hepatocarcinoma-specific mutant p53-249ser induces mitotic activity but has no effect on transforming growth factor beta 1-mediated apoptosis.

1994 • 97 citations

Germ-line mutations of the p53 tumor suppressor gene in patients with high risk for cancer inactivate the p53 protein.

1992 • 96 citations

The DNA damage response in DNA-dependent protein kinase-deficient SCID mouse cells: Replication protein A hyperphosphorylation and p53 induction

1996 • 94 citations

Two distinctp53 immunohistochemical patterns in human squamous-cell skin cancer, precursors and normal epidermis

1996 • 94 citations

Simple sequence repeat polymorphism within the p53 gene.

1993 • 93 citations

Determination of the allelic frequencies of an L-myc and a p53 polymorphism in human lung cancer

1994 • 93 citations

Detection of chromosome 3p alterations in serum DNA of non-small-cell lung cancer patients

1998 • 93 citations

A proline-rich motif in p53 is required for transactivation- independent growth arrest as induced by Gas1

1997 • 91 citations

Defective induction but normal activation and function of p53 in mouse cells lacking poly-ADP-ribose polymerase

1997 • 89 citations

Benign clonal keratinocyte patches with p53 mutations show no genetic link to synchronous squamous cell precancer or cancer in human skin.

1997 • 88 citations

New insights into p53 function from structural studies.

1996 • 88 citations

Tumor Necrosis Factor-induced Apoptosis Stimulates p53 Accumulation and p21WAF1 Proteolysis in ME-180 Cells

1998 • 87 citations

DNA adducts in urothelial cells: Relationship with biomarkers of exposure to arylamines and polycyclic aromatic hydrocarbons from tobacco smoke

1996 • 87 citations

Association of casein kinase II with immunopurified p53.

1991 • 86 citations

Short direct repeats flanking deletions, and duplicating insertions in p53 gene in human cancers.

1993 • 85 citations

Anti-p53 antibodies in patients with Barrett's esophagus or esophageal carcinoma can predate cancer diagnosis

1998 • 85 citations

Database and software for the analysis of mutations in the human p53 gene.

1994 • 82 citations

p53--An Acrobat in Tumorigenesis

1998 • 81 citations

In vivo evidence for binding of p53 to consensus binding sites in the p21 and GADD45 genes in response to ionizing radiation

1997 • 81 citations

Base excision repair of U:G mismatches at a mutational hotspot in the p53 gene is more efficient than base excision repair of T:G mismatches in extracts of human colon tumors.

1995 • 81 citations

High incidence of potential p53 inactivation in poor outcome childhood acute lymphoblastic leukemia at diagnosis

1996 • 80 citations

Excision of mismatched nucleotides from DNA: a potential mechanism for enhancing DNA replication fidelity by the wild-type p53 protein

1998 • 79 citations

The p53-Regulated Cyclin G Gene Promotes Cell Growth: p53 Downstream Effectors Cyclin G and Gadd45 Exert Different Effects on Cisplatin Chemosensitivity

1997 • 78 citations

Identification of human p53 mutations with differential effects on the bax and p21 promoters using functional assays in yeast

1998 • 78 citations

p53 Stimulates Transcription from the Human Transforming Growth Factor α Promoter: a Potential Growth-Stimulatory Role for p53

1995 • 77 citations

Mutated p53 Gene Is an Independent Adverse Predictor of Survival in Colon Carcinoma

1997 • 76 citations

The tumor suppressor protein p53

1995 • 74 citations

Transcriptional repression by p53 involves molecular interactions distinct from those with the TATA box binding protein

1996 • 74 citations

p53 represses Sp1 DNA binding and HIV-LTR directed transcription.

1997 • 74 citations

Databases and software for the analysis of mutations in the human p53 gene, human hprt gene and both the lacI and lacZ gene in transgenic rodents

1998 • 74 citations

Phosphorylation of p53 at the casein kinase II site selectively regulates p53-dependent transcriptional repression but not transactivation

1996 • 73 citations

Circulating anti-p53 antibodies in esophageal cancer patients are found predominantly in individuals with p53 core domain mutations in their tumors.

1996 • 72 citations

A mutant p21 cyclin-dependent kinase inhibitor isolated from a Burkitt's lymphoma.

1995 • 70 citations

Multiple mutations in human cancers

1996 • 70 citations

Genotoxic Drugs Induce Interaction of the c-Abl Tyrosine Kinase and the Tumor Suppressor Protein p53

1996 • 69 citations

Cyclin D1 and p21/waf1 are both involved in p53 growth suppression.

1996 • 68 citations

Idiotypic immunization induces immunity to mutated p53 and tumor rejection

1998 • 65 citations

Somatic mutation theory, DNA repair rates, and the molecular epidemiology of p53 mutations

1997 • 65 citations

p53 exon 5 mutations as a prognostic indicator of shortened survival in non-small-cell lung cancer

1997 • 63 citations

REVIEW ARTICLE. p53: GUARDIAN OF CELLULAR SENESCENCE

1996 • 62 citations

p53-dependent cell cycle arrests are preserved in DNA-activated protein kinase-deficient mouse fibroblasts.

1996 • 59 citations

Raf phosphorylates p53 in vitro and potentiates p53-dependent transcriptional transactivation in vivo.

1995 • 58 citations

Linear antigenic sites defined by the B-cell response to human p53 are localized predominantly in the amino and carboxy-termini of the protein.

1994 • 57 citations

A Novel Polymorphism in Intron 6 of the Human p53 Gene: A Possible Association with Cancer Predisposition and Susceptibility

1995 • 57 citations

p53 and PCNA expression in advanced colorectal cancer: Response to chemotherapy and long-term prognosis

1996 • 56 citations

The BAX gene maps to the glioma candidate region at 19q13.3, but is not altered in human gliomas

1996 • 56 citations

A dose-response relationship between the frequency of p53 mutations and tobacco consumption in lung cancer patients

1996 • 56 citations

Cell-cycle signaling: Atm displays its many talents

1997 • 55 citations

Mutation spectra of complex mixtures

1998 • 55 citations

Involvement of wild-type p53 protein in the cell cycle requires nuclear localization.

1991 • 53 citations

Silent and multiple mutations in p53 and the question of the hypermutability of tumors [published erratum appears in Carcinogenesis 1998 Jan;19(1):237]

1997 • 53 citations

Characterization of a frequent polymorphism in the coding sequence of the Tp53 gene in colonic cancer patients and a control population

1991 • 53 citations

The carboxy-terminal serine 392 phosphorylation site of human p53 is not required for wild-type activities.

1994 • 53 citations

ATF/CREB site mediated transcriptional activation and p53 dependent repression of the cyclin A promoter

1996 • 52 citations

Temperature sensitivity for conformation is an intrinsic property of wild-type p53

1995 • 51 citations

Hypermutability in Carcinogenesis

1998 • 50 citations

Proliferative lifespan checkpoints: Cell-type specificity and influence on tumour biology

1997 • 49 citations

Genomic analysis of single cells from human basal cell cancer using laser-assisted capture microscopy

1997 • 48 citations

Polymerase chain reaction detection of a highly polymorphic VNTR segment in intron 1 of the human p53 gene

1993 • 47 citations

Chromosome instability is a predominant trait of fibroblasts from Li-Fraumeni families

1998 • 46 citations

Cellular adhesion regulates p53 protein levels in primary human keratinocytes.

1997 • 45 citations

E1B 55K sequesters WT1 along with p53 within a cytoplasmic body in adenovirus-transformed kidney cells

1998 • 45 citations

p53 mutations in bladder tumors from arylamine-exposed workers.

1996 • 45 citations

Worrying about p53

1992 • 44 citations

Serum, plasma and paraffin-embedded tissues as sources of DNA for studying cancer susceptibility genes

1997 • 44 citations

MDM2 expression during mouse embryogenesis and the requirement of p53

1998 • 43 citations

The role of Ataxia telangiectasia and the DNA-dependent protein kinase in the p53-mediated cellular response to ionising radiation.

1996 • 43 citations

Nucleotide sequence polymorphism in a hotspot mutation region of the p53 gene.

1992 • 40 citations

Human thymine-DNA glycosylase maps at chromosome 12q22-q24.1: a region of high loss of heterozygosity in gastric cancer.

1997 • 39 citations

Biallelic Apal polymorphism of the human p53 gene (TP53)

1991 • 38 citations

Simple identification of dominant p53 mutants by a yeast functional assay

1997 • 38 citations

Mutation of conserved domain II alters the sequence specificity of DNA binding by the p53 protein.

1994 • 36 citations

p53 in complex with DNA is resistant to ubiquitin-dependent proteolysis in the presence of HPV-16 E6.

1995 • 35 citations

p21WAF1/CIP1 response to genotoxic agents in wild-type TP53 expressing breast primary tumours

1997 • 35 citations

Molecular precursor lesions in oesophageal cancer.

1998 • 35 citations

The apoptotic and transcriptional transactivation activities of p53 can be dissociated.

1997 • 35 citations

The influence of cell context on the selection pressure for p53 mutation in human cancer

1998 • 34 citations

Analysis of p53, p16MTS1, p21WAF1 and H-ras in archived bladder tumours from workers exposed to aromatic amines

1998 • 34 citations

Polymorphism at codon 72 of the p53 gene in human acute myelogenous leukemia

1992 • 33 citations

Effects of p53 mutation on tumor progression: recent insights from mouse tumor models

1996 • 33 citations

Signalling to p53: where does it all start?

1996 • 32 citations

p53 mutations in matched primary and metastatic human tumors

1995 • 32 citations

Relationship of H-ras-1, L-myc, and p53 polymorphisms with lung cancer risk and prognosis.

1992 • 32 citations

Genetic instability in animal tumorigenesis models.

1997 • 31 citations

Bst NI/Ncil polymorphism of the human p53 gene (TP53)

1991 • 30 citations

Enhanced p53 activity and accumulation in response to DNA damage upon DNA transfection.

1995 • 30 citations

Screening for p53 Gene Mutations in Archived Tumors of Workers Occupationally Exposed to Carcinogens: Examples from Analysis of Bladder Tumors

1995 • 30 citations

The relationship between the chemical structures and mutagenic specificities of the DNA lesions formed by chemical and physical mutagens

1993 • 29 citations

Induction of −2 frameshift mutations within alternating GC sequences by carcinogens that bind to the C8 position of guanine residues Development of a specific mutation assay

1990 • 28 citations

Gene replacement strategies for lung cancer

1998 • 28 citations

Variation in the protein coding region of the human p53 gene.

1990 • 28 citations

The apoptotic and transcriptional transactivation activities of p53 can be dissociated

1997 • 27 citations

A functional analysis of p53 during early development of xenopus laevis

1997 • 26 citations

Identification of a polymorphism in intron 2 of the p53 gene

1994 • 25 citations

Alterations of the p53 Gene in Occupational Bladder Cancer in Workers Exposed to Aromatic Amines

1998 • 24 citations

Another p53 Doppelgänger?

1998 • 24 citations

A polymorphism but no mutations in the GADD45 gene in breast cancers

1996 • 23 citations

Genetic and environmental factors in the etiology of human brain tumors

1995 • 22 citations

HaeIII polymorphism in intron 1 of the human p53 gene

1994 • 22 citations

Specificity of mutagenesis by 4-aminobiphenyl: mutations at G residues in bacteriophage M13 DNA and G-->C transversions at a unique dG(8-ABP) lesion in single-stranded DNA

1997 • 17 citations

Specific DNA binding by p53 is independent of mutation at serine 389, the casein kinase II site.

1994 • 17 citations

hMLH1 and hMSH2 expression and BAX frameshift mutations in ovarian cancer cell lines and tumors

1998 • 15 citations

PCR detection of a Bg/ll polymorphism in intron I of the human p53 gene (TP53)

1992 • 9 citations

Absence of frameshift mutations in the bax gene in renal cell cancer (RCC) and transitional cell cancer (TCC).

1998 • 5 citations