Activation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal Domain

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

p53 Mutations in Human Cancers

1991 • 8,133 citations

p53, the Cellular Gatekeeper for Growth and Division

1997 • 7,621 citations

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

1995 • 4,043 citations

Participation of p53 protein in the cellular response to DNA damage.

1991 • 3,818 citations

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1992 • 3,092 citations

p53: puzzle and paradigm.

1996 • 2,363 citations

A CBP Integrator Complex Mediates Transcriptional Activation and AP-1 Inhibition by Nuclear Receptors

1996 • 2,183 citations

Phosphorylated CREB binds specifically to the nuclear protein CBP

1993 • 2,039 citations

Definition of a consensus binding site for p53

1992 • 2,000 citations

The p53-mdm-2 autoregulatory feedback loop.

1993 • 1,795 citations

The CBP co-activator is a histone acetyltransferase

1996 • 1,773 citations

Max: A Helix-Loop-Helix Zipper Protein That Forms a Sequence-Specific DNA-Binding Complex with Myc

1991 • 1,650 citations

A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A

1996 • 1,457 citations

Nuclear protein CBP is a coactivator for the transcription factor CREB

1994 • 1,447 citations

mdm2 expression is induced by wild type p53 activity.

1993 • 1,286 citations

Nuclear Receptor Repression Mediated by a Complex Containing SMRT, mSin3A, and Histone Deacetylase

1997 • 1,251 citations

A complex containing N-CoR, mSln3 and histone deacetylase mediates transcriptional repression

1997 • 1,218 citations

Transcriptional activation by recruitment

1997 • 1,163 citations

Histone Deacetylases Associated with the mSin3 Corepressor Mediate Mad Transcriptional Repression

1997 • 945 citations

Role of CBP/P300 in nuclear receptor signalling

1996 • 935 citations

Regulation of the specific DNA binding function of p53

1992 • 914 citations

Induction of the growth inhibitor IGF-binding protein 3 by p53

1995 • 884 citations

Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression

1997 • 856 citations

What's Up and Down with Histone Deacetylation and Transcription?

1997 • 831 citations

CREB-binding protein/p300 are transcriptional coactivators of p65

1997 • 819 citations

Histone Deacetylase Activity Is Required for Full Transcriptional Repression by mSin3A

1997 • 739 citations

Activation of cAMP and mitogen responsive genes relies on a common nuclear factor

1994 • 730 citations

A transcriptionally active DNA-binding site for human p53 protein complexes.

1992 • 729 citations

Trichostatin A and trapoxin: Novel chemical probes for the role of histone acetylation in chromatin structure and function

1995 • 719 citations

The TAFII250 Subunit of TFIID Has Histone Acetyltransferase Activity

1996 • 705 citations

Binding and modulation of p53 by p300/CBP coactivators

1997 • 698 citations

Structural aspects of the p53 protein in relation to gene evolution.

1990 • 618 citations

Synergistic activation of transcription by CBP and p53

1997 • 599 citations

The adenovirus major late transcription factor USF is a member of the helix-loop-helix group of regulatory proteins and binds to DNA as a dimer.

1990 • 584 citations

Adenoviral ElA-associated protein p300 as a functional homologue of the transcriptional co-activator CBP

1995 • 578 citations

Transcriptional activation and chromatin remodeling of the HIV-1 promoter in response to histone acetylation.

1996 • 571 citations

Histone Deacetylases and SAP18, a Novel Polypeptide, Are Components of a Human Sin3 Complex

1997 • 565 citations

Repression by Ume6 Involves Recruitment of a Complex Containing Sin3 Corepressor and Rpd3 Histone Deacetylase to Target Promoters

1997 • 546 citations

A family of transcriptional adaptor proteins targeted by the E1A oncoprotein

1995 • 534 citations

Special HATs for special occasions: linking histone acetylation to chromatin assembly and gene activation

1996 • 525 citations

Trapoxin, an antitumor cyclic tetrapeptide, is an irreversible inhibitor of mammalian histone deacetylase.

1993 • 510 citations

Cooperation of Stat2 and p300/CBP in signalling induced by interferon-α

1996 • 492 citations

p53 in growth control and neoplasia

1996 • 488 citations

Two contact regions between Stat1 and CBP/p300 in interferon γ signaling

1996 • 486 citations

The p300/CBP family: integrating signals with transcription factors and chromatin

1997 • 482 citations

Transcription-linked acetylation by Gcn5p of histones H3 and H4 at specific lysines

1997 • 480 citations

Acetylation of histone H4 plays a primary role in enhancing transcription factor binding to nucleosomal DNA in vitro.

1996 • 469 citations

Cyclin G is a transcriptional target of the p53 tumor suppressor protein.

1994 • 450 citations

Small peptides activate the latent sequence-specific DNA binding function of p53

1995 • 444 citations

p53 Transcriptional Activation Mediated by Coactivators TAF _II 40 and TAF _II 60

1995 • 438 citations

Sequence-specific transcriptional activation is essential for growth suppression by p53.

1994 • 412 citations

Transcription Factor Loading on the MMTV Promoter: A Bimodal Mechanism for Promoter Activation

1992 • 411 citations

p53 and its 14 kDa C-terminal domain recognize primary DNA damage in the form of insertion/deletion mismatches

1995 • 409 citations

Structure of the FGF Receptor Tyrosine Kinase Domain Reveals a Novel Autoinhibitory Mechanism

1996 • 376 citations

Targeting Chromatin Disruption: Transcription Regulators that Acetylate Histones

1996 • 369 citations

Activation of p53 sequence-specific DNA bindingby short single strands of DNA requires the p53 C-terminus

1995 • 347 citations

CBP as a transcriptional coactivator of c-Myb.

1996 • 347 citations

Restoration of the growth suppression function of mutant p53 by a synthetic peptide derived from the p53 C-terminal domain

1997 • 346 citations

Decoding the nucleosome

1993 • 342 citations

CBP-induced stimulation of c-Fos activity is abrogated by E1A.

1995 • 342 citations

Human p300 Protein Is a Coactivator for the Transcription Factor MyoD

1996 • 319 citations

Allosteric activation of latent p53 tetramers

1994 • 302 citations

Human TAFII31 protein is a transcriptional coactivator of the p53 protein.

1995 • 297 citations

Reactivation of silenced, virally transduced genes by inhibitors of histone deacetylase

1997 • 250 citations

Binding and Suppression of the Myc Transcriptional Activation Domain by p107

1994 • 242 citations

Transcriptional activation by p53 correlates with suppression of growth but not transformation

1994 • 237 citations

Analysis of a cAMP-responsive activator reveals a two-component mechanism for transcriptional induction via signal-dependent factors.

1997 • 236 citations

p53; from inductive signal to cellular effect

1997 • 214 citations

Interaction of the co-activator CBP with Myb proteins: effects on Myb-specific transactivation and on the cooperativity with NF-M.

1996 • 213 citations

A functionally inactive p53 protein interatocarcinoma cells is activated by either DNA damage or cellular differentiation

1996 • 209 citations

Histone acetyltransferase activity and interaction with ADA2 are critical for GCN5 function invivo

1997 • 208 citations

Regulation of specific DNA binding by p53: evidence for a role for O-glycosylation and charged residues at the carboxy-terminus.

1996 • 203 citations

Post-translational modification of p53.

1994 • 140 citations

Constitutive Activation of Mitogen-activated Protein Kinase-activated Protein Kinase 2 by Mutation of Phosphorylation Sites and an A-helix Motif

1995 • 115 citations

Histone deacetylase is a component of the internal nuclear matrix.

1991 • 110 citations

Expression and purification of general transcription factors by FLAG epitope-tagging and peptide elution.

1993 • 84 citations

Phosphorylation of p53 at the casein kinase II site selectively regulates p53-dependent transcriptional repression but not transactivation

1996 • 73 citations

Interaction of p53 with MDM2 is independent of E6 and does not mediate wild type transformation suppressor function.

1994 • 70 citations

The carboxy-terminal serine 392 phosphorylation site of human p53 is not required for wild-type activities.

1994 • 53 citations

Oddball p53 in testicular tumors

1996 • 25 citations

Alterations in pim-1 and c-myc expression associated with sodium butyrate-induced growth factor dependency in autonomous rat Nb2 lymphoma cells.

1996 • 23 citations

Transcriptional Coactivator

2008 • 1 citations