The 1995 Walter Hubert Lecture - molecular epidemiology of human cancer: insights from the mutational analysis of the p53 tumour-suppressor gene

p53 Mutations in Human Cancers

1991 • 8,133 citations

The p53 tumour suppressor gene

1991 • 3,871 citations

Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis.

1994 • 3,536 citations

A Single Ataxia Telangiectasia Gene with a Product Similar to PI-3 Kinase

1995 • 2,767 citations

Crystal Structure of a p53 Tumor Suppressor-DNA Complex: Understanding Tumorigenic Mutations

1994 • 2,460 citations

The p53 proto-oncogene can act as a suppressor of transformation

1989 • 2,019 citations

A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma.

1991 • 1,946 citations

p53 function and dysfunction

1992 • 1,918 citations

Suppression of Human Colorectal Carcinoma Cell Growth by Wild-Type p53

1990 • 1,796 citations

Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma.

1994 • 1,542 citations

Mutational hot spot in the p53 gene in human hepatocellular carcinomas

1991 • 1,525 citations

Sunburn and p53 in the onset of skin cancer

1994 • 1,501 citations

Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa

1991 • 1,418 citations

Clinical Implications of the p53 Tumor-Suppressor Gene

1993 • 1,341 citations

DNA Deaminating Ability and Genotoxicity of Nitric Oxide and its Progenitors

1991 • 1,223 citations

DNA damage and mutation in human cells exposed to nitric oxide in vitro.

1992 • 980 citations

Gain of function mutations in p53

1993 • 876 citations

Database of p53 gene somatic mutations in human tumors and cell lines.

1994 • 866 citations

Presence of a Potent Transcription Activating Sequence in the p53 Protein

1990 • 811 citations

p53 functions as a cell cycle control protein in osteosarcomas.

1990 • 774 citations

Wild-type p53 can inhibit oncogene-mediated focus formation.

1989 • 738 citations

Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity, and association with transcription factor ERCC3.

1994 • 666 citations

Association between Cigarette Smoking and Mutation of the p53 Gene in Squamous-Cell Carcinoma of the Head and Neck

1995 • 664 citations

Transcriptional Activation by Wild-Type but Not Transforming Mutants of the p53 Anti-Oncogene

1990 • 644 citations

Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein.

1994 • 644 citations

Structural aspects of the p53 protein in relation to gene evolution.

1990 • 618 citations

p53 modulation of TFIIH–associated nucleotide excision repair activity

1995 • 555 citations

Genetic Mechanisms of Tumor Suppression by the Human p53 Gene

1990 • 540 citations

Crystal Structure of the Tetramerization Domain of the p53 Tumor Suppressor at 1.7 Angstroms

1995 • 533 citations

Wild-type p53 binds to the TATA-binding protein and represses transcription.

1992 • 527 citations

Negative growth regulation in a glioblastoma tumor cell line that conditionally expresses human wild-type p53.

1990 • 502 citations

Gene deletions causing human genetic disease: mechanisms of mutagenesis and the role of the local DNA sequence environment

1991 • 491 citations

Aflatoxin B1 induces the transversion of G-->T in codon 249 of the p53 tumor suppressor gene in human hepatocytes.

1993 • 482 citations

p53: At the Crossroads of Molecular Carcinogenesis and Risk Sssessment

1993 • 477 citations

HBV X Protein Alters the DNA Binding Specificity of CREB and ATF-2 by Protein-Protein Interactions

1991 • 457 citations

p53 Transcriptional Activation Mediated by Coactivators TAF _II 40 and TAF _II 60

1995 • 438 citations

Chemical and physical carcinogenesis: advances and perspectives for the 1990s.

1991 • 433 citations

The 1993 Walter Hubert Lecture: the role of the p53 tumour-suppressor gene in tumorigenesis

1994 • 428 citations

Hepatitis B virus HBx protein activates Ras-GTP complex formation and establishes a Ras, Raf, MAP kinase signaling cascade.

1994 • 418 citations

Functional inactivation but not structural mutation of p53 causes liver cancer

1995 • 364 citations

Activation of p53 sequence-specific DNA bindingby short single strands of DNA requires the p53 C-terminus

1995 • 347 citations

Specific repression of TATA-mediated but not initiator-mediated transcription by wild-type p53

1993 • 329 citations

Abrogation of p53-Induced Apoptosis by the Hepatitis B Virus X Gene

2003 • 318 citations

trans-activation of viral enhancers by the hepatitis B virus X protein

1988 • 316 citations

Hepatitis B x antigen and p53 are associated in vitro and in liver tissues from patients with primary hepatocellular carcinoma.

1993 • 307 citations

Allosteric activation of latent p53 tetramers

1994 • 302 citations

Slow Repair of Pyrimidine Dimers at p53 Mutation Hotspots in Skin Cancer

1994 • 301 citations

High-Resolution Structure of the Oligomerization Domain of p53 by Multidimensional NMR

1994 • 300 citations

Human TAFII31 protein is a transcriptional coactivator of the p53 protein.

1995 • 297 citations

The preS2/S region of integrated hepatitis B virus DNA encodes a transcriptional transactivator

1990 • 284 citations

Geographic Variation of p53 Mutational Profile in Nonmalignant Human Liver

1994 • 282 citations

Transcriptional trans-activating function of hepatitis B virus

1987 • 280 citations

p53 binds single-stranded DNA ends and catalyzes DNA renaturation and strand transfer.

1994 • 276 citations

Solution structure of the tetrameric minimum transforming domain of p53

1994 • 260 citations

Selective accumulation of the X transcript of hepatitis B virus in patients negative for hepatitis B surface antigen with hepatocellular carcinoma

1995 • 249 citations

The p53 Activation Domain Binds the TATA Box-Binding Polypeptide in Holo-TFIID, and a Neighboring p53 Domain Inhibits Transcription

1993 • 246 citations

FRAMESHIFT MUTATION: DETERMINANTS OF SPECIFICITY

1990 • 238 citations

p53 Functions as a Cell Cycle Control Protein in Osteosarcomas

1990 • 224 citations

Direct interaction between the transcriptional activation domain of human p53 and the TATA box-binding protein.

1993 • 209 citations

Molecular Epidemiology and the Genetics of Environmental Cancer

1991 • 187 citations

The × Gene of Hepatitis B Virus Induced Growth Stimulation and Tumorigenic Transformation of Mouse NIH3T3 Cells

1989 • 169 citations

Carcinogens leave fingerprints

1992 • 169 citations

Genetic heterogeneity of hepatocellular carcinoma.

1994 • 161 citations

p53 mutations cluster at codon 249 in hepatitis B virus-positive hepatocellular carcinomas from China.

1992 • 161 citations

A trans-activator function is generated by integration of hepatitis B virus preS/S sequences in human hepatocellular carcinoma DNA.

1990 • 145 citations

Gain-of-function mutations of the p53 gene induce lymphohematopoietic metastatic potential and tissue invasiveness.

1994 • 140 citations

How loops, β sheets, and α helices help us to understand p53

1994 • 140 citations

Recommendations on Predictive Testing for Germ Line p53 Mutations Among Cancer-Prone Individuals

1992 • 129 citations

Aberrations of p53 gene in human hepatocellular carcinoma from China

1993 • 115 citations

p53 binds to the TATA-binding protein-TATA complex

1993 • 113 citations

The p53 activation domain binds the TATA box-binding polypeptide in Holo-TFIID, and a neighboring p53 domain inhibits transcription.

1993 • 108 citations

Can we predict solar ultraviolet radiation as the causal event in human tumours by analysing the mutation spectra of the p53 gene?

1994 • 107 citations

Effects of p53 mutants on wild-type p53-mediated transactivation are cell type dependent.

1995 • 101 citations

Hepatocarcinoma-specific mutant p53-249ser induces mitotic activity but has no effect on transforming growth factor beta 1-mediated apoptosis.

1994 • 97 citations

Evidence for increased in vitro recombination with insertion of human hepatitis B virus DNA.

1991 • 86 citations

Short direct repeats flanking deletions, and duplicating insertions in p53 gene in human cancers.

1993 • 85 citations

Database and software for the analysis of mutations in the human p53 gene.

1994 • 82 citations

DNA strand bias in the repair of the p53 gene in normal human and xeroderma pigmentosum group C fibroblasts.

1993 • 65 citations

Selective accumulation of the X transcript of hepatitis B virus in patients negative for hepatitis B surface antigen with hepatocellular carcinoma*1

1995 • 53 citations

A SINGLE ATAXIA TELANGIECTASIA GENE WITH A PRODUCT SIMILAR TO PI-3 KINASE

1996 • 51 citations

Slow repair of pyrimidine dimers at p53 mutation hotspots in skin cancer

1994 • 48 citations

Molecular epidemiology and the genetics of environmental cancer

1991 • 36 citations

p53 — Oncogene or Anti-Oncogene?

1990 • 32 citations

Instability of integrated hepatitis B virus DNA with inverted repeat structure in a transgenic mouse

1989 • 25 citations

Molecular carcinogenesis in humans and rodents.

1992 • 17 citations