Anti-apoptotic activity of low levels of wild-type p53.

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

p53 Mutations in Human Cancers

1991 • 8,133 citations

Tight control of gene expression in mammalian cells by tetracycline-responsive promoters.

1992 • 4,885 citations

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1992 • 4,648 citations

Induction of apoptosis in fibroblasts by c-myc protein

1992 • 2,977 citations

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

1993 • 2,969 citations

p53 is required for radiation-induced apoptosis in mouse thymocytes

1993 • 2,911 citations

Social controls on cell survival and cell death

1992 • 2,641 citations

Thymocyte apoptosis induced by p53-dependent and independent pathways

1993 • 2,322 citations

Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

1996 • 2,304 citations

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

1991 • 2,127 citations

The p53-mdm-2 autoregulatory feedback loop.

1993 • 1,795 citations

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

1995 • 1,401 citations

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

1995 • 1,263 citations

Apoptotic cell death induced by c-myc is inhibited by bcl-2

1992 • 981 citations

p53-Dependent apoptosis suppresses tumor growth and progression in vivo

1994 • 883 citations

Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line.

1992 • 871 citations

p53-Dependent apoptosis in the absence of transcriptional activation of p53-target genes

1994 • 857 citations

Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53

1990 • 801 citations

Cooperative interaction between c-myc and bcl-2 proto-oncogenes

1992 • 766 citations

c-Myc-induced apoptosis in fibroblasts is inhibited by specific cytokines.

1994 • 747 citations

Mediation of c-Myc-Induced Apoptosis by p53

1994 • 741 citations

Loss of normal p53 function confers sensitization to Taxol by increasing G2/M arrest and apoptosis

1996 • 654 citations

A subset of p53-deficient embryos exhibit exencephaly

1995 • 577 citations

Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1.

1994 • 538 citations

p53: At the Crossroads of Molecular Carcinogenesis and Risk Sssessment

1993 • 477 citations

p53 alteration is a common event in the spontaneous immortalization of primary BALB/c murine embryo fibroblasts.

1991 • 455 citations

Growth factor modulation of p53-mediated growth arrest versus apoptosis.

1995 • 377 citations

Hematopoietic cells from mice deficient in wild-type p53 are more resistant to induction of apoptosis by some agents

1993 • 305 citations

Expression of p53 during mouse embryogenesis

1991 • 249 citations

Myc-mediated apoptosis is blocked by ectopic expression of Bcl-2.

1993 • 214 citations

A retroviral wild-type p53 expression vector penetrates human lung cancer spheroids and inhibits growth by inducing apoptosis

1994 • 195 citations

Identification and characterization of multiple mdm-2 proteins and mdm-2-p53 protein complexes.

1993 • 193 citations

Biochemical properties and biological effects of p53

1995 • 183 citations

Absence of p53 allows direct immortalization of hematopoietic cells by the myc and raf oncogenes

1995 • 126 citations

Myc-Mediated Apoptosis Is Blocked by Ectopic Expression of Bcl-2

1993 • 57 citations

Loss of TAL-1 protein activity induces premature apoptosis of Jurkat leukemic T cells upon medium depletion.

1995 • 50 citations

p53-independent death and p53-induced protection against apoptosis in fibroblasts treated with chemotherapeutic drugs

1995 • 48 citations

Cell-type- and promoter-dependent ts phenotype of p53 Val135.

1993 • 14 citations