5-Methylcytosine as an Endogenous Mutagen in the Human LDL Receptor and p53 Genes

Genomic sequencing.

1984 • 8,343 citations

Mutations in the p53 gene occur in diverse human tumour types

1989 • 2,765 citations

Identification of a Chromosome 18q Gene that Is Altered in Colorectal Cancers

1990 • 1,747 citations

Molecular basis of base substitution hotspots in Escherichia coli

1978 • 1,185 citations

DNA METHYLATION AND GENE ACTIVITY

1983 • 1,115 citations

Amount and distribution of 5-methylcytosine in human DNA from different types of tissues or cells

1982 • 1,002 citations

In Vivo Footprinting of a Muscle Specific Enhancer by Ligation Mediated PCR

1989 • 972 citations

The CpG dinucleotide and human genetic disease

1988 • 946 citations

CpG islands as gene markers in the vertebrate nucleus

1987 • 687 citations

Restriction sites containing CpG show a higher frequency of polymorphism in human DNA

1984 • 586 citations

DNA Glycosylases, Endonucleases for Apurinic/Apyrimidinic Sites, and Base Excision-Repair

1979 • 562 citations

Genomic Sequencing and Methylation Analysis by Ligation Mediated PCR

1989 • 408 citations

Allelic losses of chromosomes 9, 11, and 17 in human bladder cancer.

1990 • 327 citations

Methylation of the hypoxanthine phosphoribosyltransferase locus on the human X chromosome: implications for X-chromosome inactivation.

1984 • 305 citations

Oncogenic Point Mutations in the Human Retinoblastoma Gene: Their Application to Genetic Counseling

1989 • 288 citations

Use of restriction enzymes to study eukaryotic DNA methylation

1978 • 281 citations

Regulation of low density lipoprotein receptor activity in freshly isolated human lymphocytes.

1976 • 265 citations

The Role of Dna Methylation in Cancer

1990 • 244 citations

Methylation of DNA in developing sea urchin embryos

1968 • 214 citations

Two common low density lipoprotein receptor gene mutations cause familial hypercholesterolemia in Afrikaners.

1989 • 204 citations

DNA cytosine methylation and heat-induced deamination

1986 • 174 citations

Active X chromosome DNA is unmethylated at eight CCGG sites clustered in a guanine-plus-cytosine-rich island at the 5' end of the gene for phosphoglycerate kinase.

1986 • 164 citations

DNA methylation at asymmetric sites is associated with numerous transition mutations.

1985 • 148 citations

Signal for DNA methylation associated with tandem duplication in Neurospora crassa.

1987 • 65 citations

Expression, methylation and chromatin structure of the p53 gene in untransformed and human T-cell leukemia virus type I-transformed human T-lymphocytes.

1989 • 24 citations