Analysis of p53, p16MTS1, p21WAF1 and H-ras in archived bladder tumours from workers exposed to aromatic amines

p53, the Cellular Gatekeeper for Growth and Division

1997 • 7,621 citations

Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis.

1994 • 3,536 citations

Estimates of the worldwide incidence of eighteen major cancers in 1985

1993 • 1,680 citations

Preferential Formation of Benzo[ a ]pyrene Adducts at Lung Cancer Mutational Hotspots in P53

1996 • 1,636 citations

The Use of Antiavidin Antibody and Avidin-Biotin-Peroxidase Complex in Immunoperoxidase Technics

1981 • 1,067 citations

Estimates of the worldwide mortality from eighteen major cancers in 1985. Implications for prevention and projections of future burden

1993 • 595 citations

p53 Mutations in human immortalized epithelial cell lines

1993 • 441 citations

p53 mutations, ras mutations, and p53-heat shock 70 protein complexes in human lung carcinoma cell lines.

1991 • 349 citations

Database of p53 gene somatic mutations in human tumors and cell lines: updated compilation and future prospects

1997 • 305 citations

Allelotype of human bladder cancer.

1994 • 265 citations

p53-independent induction of WAF1/CIP1 in human leukemia cells is correlated with growth arrest accompanying monocyte/macrophage differentiation.

1995 • 264 citations

Elevated Levels of the Angiogenic Peptide Basic Fibroblast Growth Factor in Urine of Bladder Cancer Patients

1993 • 246 citations

Heterogeneity of erbB-2 gene amplification in bladder cancer.

1993 • 197 citations

Mechanisms of regulation of WAF1/Cip1 gene expression in human breast carcinoma: role of p53-dependent and independent signal transduction pathways.

1994 • 196 citations

Altered Patterns of MDM2 and TP53 Expression in Human Bladder Cancer

1994 • 192 citations

Microsatellite instability in bladder cancer.

1993 • 187 citations

p16 (CDKN2) is a major deletion target at 9p21 in bladder cancer

1995 • 178 citations

Distinct pattern of p53 mutations in bladder cancer: relationship to tobacco usage.

1993 • 170 citations

From gene to carcinogen: a rapidly evolving field in molecular epidemiology.

1991 • 146 citations

Influence of cigarette smoking and schistosomiasis on p53 gene mutation in urothelial cancer.

1993 • 115 citations

Mutation of H-ras is infrequent in bladder cancer: confirmation by single-strand conformation polymorphism analysis, designed restriction fragment length polymorphisms, and direct sequencing.

1993 • 114 citations

Codeletion of the genes for p16INK4, methylthioadenosine phosphorylase, interferon-α1, interferon-β1, and other 9p21 markers in human malignant cell lines

1996 • 96 citations

Retinoblastoma gene mutations in primary human bladder cancer

1995 • 88 citations

DNA adducts in urothelial cells: Relationship with biomarkers of exposure to arylamines and polycyclic aromatic hydrocarbons from tobacco smoke

1996 • 87 citations

CDKN2A (p16INK4A) somatic and germline mutations

1996 • 86 citations

Detection and characterization of carcinogen—DNA adducts in exfoliated urothelial cells from 4-aminobiphenyl-treated dogs by ³²P-postlabelling and subsequent thin-layer and high-pressure liquid chromatography

1990 • 71 citations

Occupation and the Risk of Bladder Cancer

1990 • 65 citations

Mutational spectrum in the p53 gene in bladder tumors from the endemic area of black foot disease in Taiwan

1994 • 64 citations

Decreased connexin expression and intercellular communication in human bladder cancer cells.

1994 • 60 citations

Frequent homozygous deletion of cyclin-dependent kinase inhibitor 2 (MTS1, p16) in superficial bladder cancer detected by fluorescence in situ hybridization

1997 • 58 citations

The spectrum of TP53 mutations in bladder carcinoma

1994 • 55 citations

p53 mutations have no additional prognostic value over stage in bladder cancer

1994 • 53 citations

The 9p21 region in bladder cancer cell lines: large homozygous deletions inactivate the CDKN2, CDKN2B and MTAP genes

1996 • 46 citations

Low frequency ofp16/CDKN2 gene mutations in esophageal carcinomas

1996 • 45 citations

p53 mutations in bladder tumors from arylamine-exposed workers.

1996 • 45 citations

Correlation of p53 mutations with epidermal growth factor receptor overexpression and absence of mdm2 amplification in human esophageal carcinomas

1993 • 40 citations

A molecular genetic model of human bladder carcinogenesis.

1993 • 39 citations

Specificity of mutagenesis by 4-aminobiphenyl. A possible role for N-(deoxyadenosin-8-yl)-4-aminobiphenyl as a premutational lesion.

1988 • 38 citations

CDKN2 in HPV‐positive and HPV‐negative cervical‐carcinoma cell lines

1995 • 37 citations

Homozygous deletions but no sequence mutations in coding regions of p15 or p16 in human primary bladder tumors

1995 • 34 citations

Screening for p53 Gene Mutations in Archived Tumors of Workers Occupationally Exposed to Carcinogens: Examples from Analysis of Bladder Tumors

1995 • 30 citations

Loss of cyclin-dependent kinase inhibitor genes and chromosome 9 karyotypic abnormalities in human bladder cancer cell lines

1995 • 29 citations

The relationship between the chemical structures and mutagenic specificities of the DNA lesions formed by chemical and physical mutagens

1993 • 29 citations

Constant Denaturant Gel Electrophoresis (CDGE) in Mutation Screening

1996 • 23 citations

Bladder Cancer in Dye Manufacturing Workers

1985 • 20 citations

Infrequent Somatic Mutation of the MTS1 Gene in Primary Bladder Carcinomas

1995 • 20 citations

Infrequent somatic alteration of p16/MTS1 in human primary superficial bladder cancers

1996 • 19 citations

DNA adducts in urothelial cells: Relationship with biomarkers of exposure to arylamines and polycyclic aromatic hydrocarbons from tobacco smoke

1996 • 13 citations