Identification of BTG2, an antiproliferative p53–dependent component of the DNA damage cellular response pathway

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1992 • 4,648 citations

Participation of p53 protein in the cellular response to DNA damage.

1991 • 3,818 citations

Cell Cycle Control and Cancer

1994 • 2,575 citations

Thymocyte apoptosis induced by p53-dependent and independent pathways

1993 • 2,322 citations

Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

1995 • 2,115 citations

Definition of a consensus binding site for p53

1992 • 2,000 citations

p53 function and dysfunction

1992 • 1,918 citations

Suppression of Human Colorectal Carcinoma Cell Growth by Wild-Type p53

1990 • 1,796 citations

Cloning of Senescent Cell-Derived Inhibitors of DNA Synthesis Using an Expression Screen

1994 • 1,368 citations

Radiation-induced cell cycle arrest compromised by p21 deficiency

1995 • 1,249 citations

p21 is necessary for the p53-mediated G1 arrest in human cancer cells.

1995 • 1,193 citations

The RAD9 Gene Controls the Cell Cycle Response to DNA Damage in Saccharomyces cerevisiae

1988 • 1,174 citations

Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line.

1992 • 871 citations

p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts.

1995 • 865 citations

Presence of a Potent Transcription Activating Sequence in the p53 Protein

1990 • 811 citations

Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53

1990 • 801 citations

Identification of a p53-dependent negative response element in the bcl-2 gene.

1994 • 747 citations

Transcriptional Activation by Wild-Type but Not Transforming Mutants of the p53 Anti-Oncogene

1990 • 644 citations

Genetic and immunochemical analysis of mutant p53 in human breast cancer cell lines.

1990 • 607 citations

Topological control of p21WAF1/CIP1 expression in normal and neoplastic tissues.

1995 • 593 citations

p53 modulation of TFIIH–associated nucleotide excision repair activity

1995 • 555 citations

Abnormal structure and expression of p53 gene in human hepatocellular carcinoma.

1990 • 413 citations

Evidence for a second cell cycle block at G2/M by p53.

1995 • 306 citations

BTG1, a member of a new family of antiproliferative genes.

1992 • 298 citations

162 Differential sensitivity of P53+ and P53- cells to caffeine-induced radiosensitization and override of G2 delay

1995 • 268 citations

Deletion of genes on chromosome 1 in endocrine neoplasia

1987 • 265 citations

Contrasting patterns of retinoblastoma protein expression in mouse embryonic stem cells and embryonic fibroblasts.

1994 • 242 citations

Growth suppression of human breast cancer cells by the introduction of a wild-type p53 gene.

1991 • 195 citations

Tob, a novel protein that interacts with p185erbB2, is associated with anti-proliferative activity.

1996 • 190 citations

Molecular cloning of PC3, a putatively secreted protein whose mRNA is induced by nerve growth factor and depolarization.

1991 • 185 citations

Structure and expression of TIS21, a primary response gene induced by growth factors and tumor promoters

1991 • 166 citations

Retinoblastoma and p 53 tumor suppressor genes in human hepatoma cell lines

1993 • 128 citations

Loss of heterozygosity on chromosome 1q in human breast cancer.

1989 • 119 citations

Effects of Drugs on the Cell Nucleus

1980 • 118 citations

Simultaneous localization of cosmids and chromosome R-banding by fluorescence microscopy: application to regional mapping of human chromosome 11.

1990 • 106 citations

Accumulation of wild-type p53 protein upon gamma-irradiation induces a G2 arrest-dependent immunoglobulin kappa light chain gene expression.

1995 • 105 citations

A gene involved in control of human cellular senescence on human chromosome 1q.

1994 • 94 citations

A functional screen for germ line p53 mutations based on transcriptional activation.

1992 • 66 citations

Introduction of wild-type p53 in a human ovarian cancer cell line not expressing endogenous p53

1994 • 51 citations

Immortalization of a human colorectal adenoma cell line by continuous in vitro passage: Possible involvement of chromosome 1 in tumour progression

1988 • 51 citations

Protein synthesis—dependent cytoplasmic translocation of p53 protein after serum stimulation of growth‐arrested MCF‐7 cells

1993 • 39 citations

Synthesis, degradation, and subcellular localization of proteins encoded by the primary response genes TIS7/PC4 and TIS21/PC3

1994 • 38 citations

Effects of drugs on the cell nucleus

1979 • 27 citations