Temperature sensitivity for conformation is an intrinsic property of wild-type p53

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

1992 • 3,110 citations

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1992 • 3,092 citations

Crystal Structure of a p53 Tumor Suppressor-DNA Complex: Understanding Tumorigenic Mutations

1994 • 2,460 citations

Activating mutations in p53 produce a common conformational effect. A monoclonal antibody specific for the mutant form.

1990 • 978 citations

Oncogenic forms of p53 inhibit p53-regulated gene expression

1992 • 933 citations

Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53

1990 • 801 citations

Differential induction of transcriptionally active p53 following UV or lonizing radiation: Defects in chromosome instability syndromes?

1993 • 799 citations

A transcriptionally active DNA-binding site for human p53 protein complexes.

1992 • 729 citations

Cellular localization and cell cycle regulation by a temperature-sensitive p53 protein.

1991 • 544 citations

The DNA-binding domain of p53 contains the four conserved regions and the major mutation hot spots.

1993 • 512 citations

Hyperthermia and Cancer

1982 • 474 citations

The 1993 Walter Hubert Lecture: the role of the p53 tumour-suppressor gene in tumorigenesis

1994 • 428 citations

Redox modulation of p53 conformation and sequence-specific DNA binding in vitro.

1993 • 406 citations

Wild-type but not mutant p53 immunopurified proteins bind to sequences adjacent to the SV40 origin of replication

1991 • 382 citations

Monoclonal antibody analysis of p53 expression in normal and transformed cells

1986 • 285 citations

Tumor suppressor p53: analysis of wild-type and mutant p53 complexes.

1991 • 242 citations

A Transcriptionally Active DNA-Binding Site for Human p53 Protein Complexes

1992 • 234 citations

Mutant conformation of p53

1992 • 214 citations

Conformational shifts propagate from the oligomerization domain of p53 to its tetrameric DNA binding domain and restore DNA binding to select p53 mutants.

1993 • 206 citations

A structural role for metal ions in the "wild-type" conformation of the tumor suppressor protein p53.

1993 • 182 citations

Molecular basis for heterogeneity of the human p53 protein.

1986 • 167 citations

Precise epitope mapping of the murine transformation-associated protein, p53.

1985 • 139 citations

Sensitivity of human cells to mild hyperthermia.

1993 • 139 citations

A temperature-sensitive mutant of human p53.

1994 • 128 citations

Modulation of the human interleukin-6 promoter (IL-6) and transcription factor C/EBP beta (NF-IL6) activity by p53 species

1993 • 123 citations

Heterogeneity of transcriptional activity of mutant p53 proteins and p53 DNA target sequences.

1993 • 110 citations

Addition of fresh medium induces cell cycle and conformation changes in p53, a tumour suppressor protein.

1990 • 95 citations

Temperature-dependent switching between “wild-type” and “mutant” forms of p53-Val135

1990 • 78 citations

Evidence for allosteric variants of wild-type p53, a tumour suppressor protein

1990 • 71 citations

Tumor Suppressor p53: Analysis of Wild-Type and Mutant p53 Complexes

1991 • 66 citations

Molecular Basis for Heterogeneity of the Human p53 Protein

1986 • 58 citations

A conformation hypothesis for the suppressor and promoter functions ofp53in cell growth control and in cancer

1991 • 54 citations

Analysis of a Protein-Binding Domain of p53

1993 • 51 citations

Cellular mechanisms associated with the lack of chronic thermotolerance expression in HeLa S3 cells.

1992 • 49 citations

Analysis of p53 quaternary structure in relation to sequence-specific DNA binding.

1994 • 31 citations

Analysis of a protein-binding domain of p53.

1993 • 31 citations

Temperature-sensitive mutants of p53 associated with human carcinoma of the lung.

1992 • 29 citations

Evidence that immunological variants of p53 represent alternative protein conformation

1988 • 26 citations

Partially transformed T3T3 cells express high levels of mutant p53 in the 'wild-type' immunoreactive form with defective oligomerization.

1993 • 11 citations